New meta-analysis: triglycerides and cardiovascular risk in type 2 diabetes
Findings from a systematic review and meta-analysis of 31 prospective studies reaffirmed that elevated triglycerides are associated with increased risk of cardiovascular disease in individuals with type 2 diabetes mellitus (T2DM). Researchers interrogated the literature database for studies published until June 2018 that evaluated the association between triglycerides and cardiovascular disease in T2DM. In total, 31 studies involving 132,044 T2DM individuals with 10,733 incident cardiovascular events (follow-up duration 1-13 years) were identified. Stepwise increases in triglycerides were associated with a stepwise increase in incident cardiovascular disease. For each 1 mmol/L increase in triglycerides, the pooled maximum-adjusted relative risk (95% CI) for incident cardiovascular disease in T2DM was 1.30 (1.18, 1.42). The researchers make the point, however, that triglycerides levels are a surrogate marker for triglyceride-rich lipoproteins and their remnants, the true target of therapeutic intervention.
Serum triglycerides as a risk factor for cardiovascular diseases in type 2 diabetes mellitus: a systematic review and meta-analysis of prospective studies.
Ye X, Kong W, Zafar MI, Chen LL.