{"id":257846,"date":"2026-06-12T00:22:16","date_gmt":"2026-06-11T22:22:16","guid":{"rendered":"https:\/\/r3i.org\/?page_id=257846"},"modified":"2026-06-12T00:22:19","modified_gmt":"2026-06-11T22:22:19","slug":"focus-%e4%bd%8e%e6%82%aa%e6%80%a7%e5%ba%a6%e7%82%8e%e7%97%87%e3%81%af%e3%80%81%e9%ab%98%e3%83%ac%e3%83%a0%e3%83%8a%e3%83%b3%e3%83%88%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/focus-%e4%bd%8e%e6%82%aa%e6%80%a7%e5%ba%a6%e7%82%8e%e7%97%87%e3%81%af%e3%80%81%e9%ab%98%e3%83%ac%e3%83%a0%e3%83%8a%e3%83%b3%e3%83%88%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc\/","title":{"rendered":"Focus \u2013\u4f4e\u60aa\u6027\u5ea6\u708e\u75c7\u306f\u3001\u9ad8\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u4f34\u3046\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u4e00\u90e8\u3092\u8aac\u660e\u3059\u308b"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]<\/p>\n

\u4f4e\u60aa\u6027\u5ea6\u708e\u75c7\u306f\u3001\u9ad8\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u4f34\u3046\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u4e00\u90e8\u3092\u8aac\u660e\u3059\u308b<\/h2>\n

2026\u5e745\u6708<\/span><\/h5>\n
\n

\u30b3\u30da\u30f3\u30cf\u30fc\u30b2\u30f3\u4e00\u822c\u96c6\u56e3\u7814\u7a76\uff08Copenhagen General Population Study\uff09\u304b\u3089\u306e\u672c\u5831\u544a\u3067\u306f\u3001\u4f4e\u60aa\u6027\u5ea6\u306e\u5168\u8eab\u6027\u708e\u75c7\u304c\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u9ad8\u5024\u306b\u4f34\u3046\u672b\u68a2\u52d5\u8108\u75be\u60a3\u304a\u3088\u3073\u5fc3\u7b4b\u6897\u585e\u306e\u30ea\u30b9\u30af\u5897\u52a0\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u3002 <\/em><\/p>\n

Wadstrom BN, Wulff AB, Pedersen KM, Nordestgaard BG. Inflammation may explain part of atherosclerotic cardiovascular disease risk conferred by elevated remnant lipoproteins: a cohort and Mendelian randomization study. Atherosclerosis 2026; <\/em> doi.org\/10.1016\/j.atherosclerosis.2026.120772 . <\/em><\/p>\n

\u7814\u7a76\u6982\u8981\u3002<\/strong><\/p>\n\n\n\n\n\n\n\n
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\u76ee\u7684<\/strong><\/p>\n<\/td>\n

\n

\u30ec\u30e0\u30ca\u30f3\u30c8\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u9ad8\u5024\u306b\u3088\u3063\u3066\u3082\u305f\u3089\u3055\u308c\u308b\u672b\u68a2\u52d5\u8108\u75be\u60a3\uff08PAD\uff09\u304a\u3088\u3073\u5fc3\u7b4b\u6897\u585e\uff08MI\uff09\u306e\u30ea\u30b9\u30af\u5897\u52a0\u306e\u4e00\u90e8\u3092\u3001\u4f4e\u60aa\u6027\u5ea6\u708e\u75c7\u304c\u8aac\u660e\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3002\u3055\u3089\u306b\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u9ad8\u5024\u304c\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u5024\u306b\u53ca\u307c\u3059\u56e0\u679c\u7684\u5f71\u97ff\u3082\u691c\u8a3c\u3057\u305f\u3002 <\/p>\n

 <\/p>\n<\/td>\n

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 <\/p>\n<\/td>\n<\/tr>\n

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\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/strong><\/p>\n<\/td>\n

\n

\u30b3\u30db\u30fc\u30c8\u96c6\u56e3\u7814\u7a76\uff08\u30b3\u30da\u30f3\u30cf\u30fc\u30b2\u30f3\u4e00\u822c\u96c6\u56e3\u7814\u7a76\uff09\u3002\u30ec\u30e0\u30ca\u30f3\u30c8\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u9ad8\u5024\u304c\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u5024\u306b\u53ca\u307c\u3059\u56e0\u679c\u7684\u5f71\u97ff\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306b\u30e1\u30f3\u30c7\u30eb\u30e9\u30f3\u30c0\u30e0\u5316\u304c\u7528\u3044\u3089\u308c\u305f\u3002 <\/p>\n

 <\/p>\n<\/td>\n

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 <\/p>\n<\/td>\n<\/tr>\n

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\u7814\u7a76\u5bfe\u8c61\u96c6\u56e3 <\/strong><\/p>\n<\/td>\n

\n

\u30b9\u30bf\u30c1\u30f3\u4f7f\u7528\u6b74\u304c\u306a\u304f\u3001\u611f\u67d3\u75c7\u30fb\u304c\u3093\u30fb\u305d\u306e\u4ed6\u306e\u91cd\u5ea6\u306e\u708e\u75c7\u6027\u75be\u60a3\u306e\u6240\u898b\u304c\u306a\u3044\u3001\u30b3\u30da\u30f3\u30cf\u30fc\u30b2\u30f3\u4e00\u822c\u96c6\u56e3\u7814\u7a76\u306e90,789\u540d\uff08\u5e74\u9f62\u4e2d\u592e\u502456\u6b73\u3001\u7537\u602744%\uff09\u3002\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u9ad8\u5024\u304c\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u5024\u306b\u53ca\u307c\u3059\u56e0\u679c\u7684\u5f71\u97ff\u306f\u3001UK Biobank\u306e\u6b27\u5dde\u7cfb\u907a\u4f1d\u7684\u7956\u5148\u3092\u6301\u306440\uff5e69\u6b73\u306e43,400\u540d\u3067\u63a8\u5b9a\u3055\u308c\u305f\u3002 <\/p>\n

 <\/p>\n<\/td>\n

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 <\/p>\n<\/td>\n<\/tr>\n

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\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee<\/strong><\/p>\n

<\/strong><\/p>\n<\/td>\n

\n

\u30b3\u30da\u30f3\u30cf\u30fc\u30b2\u30f3\u4e00\u822c\u96c6\u56e3\u7814\u7a76\u306b\u57fa\u3065\u304f\u4e3b\u89e3\u6790\u3067\u306f\u3001\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306fPAD\u304a\u3088\u3073MI\u3067\u3042\u3063\u305f\u3002\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3001\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304b\u3089\u4f4e\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\uff08LDL\uff09\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u9ad8\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\uff08HDL\uff09\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u5dee\u3057\u5f15\u3044\u3066\u7b97\u51fa\u3055\u308c\u305f\u3002\u6838\u78c1\u6c17\u5171\u9cf4\uff08NMR\uff09\u5206\u5149\u6cd5\u3067\u6e2c\u5b9a\u3057\u305f\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u7c92\u5b50\u30b5\u30d6\u30d5\u30e9\u30af\u30b7\u30e7\u30f3\u308224,470\u540d\u3067\u8a55\u4fa1\u3055\u308c\u305f\u3002 <\/p>\n

 <\/p>\n

UK Biobank\u3067\u306f\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u3064\u3044\u306644\u500b\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u3064\u3044\u306673\u500b\u306e\u907a\u4f1d\u7684\u5909\u7570\u304b\u3089\u5c0e\u3044\u305f\u907a\u4f1d\u30b9\u30b3\u30a2\u3092\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u5024\u3078\u306e\u5f71\u97ff\u306b\u3064\u3044\u3066\u8a55\u4fa1\u3057\u305f\u3002<\/p>\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

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\u65b9\u6cd5<\/strong><\/p>\n<\/td>\n

\n

Cox\u56de\u5e30\u5206\u6790\u3092\u7528\u3044\u3066\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u30fbLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u30fb\u30ec\u30e0\u30ca\u30f3\u30c8\u7c92\u5b50\u30fbLDL\u7c92\u5b50\u3068PAD\u304a\u3088\u3073MI\u306e\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u3092\u3001log2\u5909\u63db\u3057\u305f\u9ad8\u611f\u5ea6C\u53cd\u5fdc\u6027\u30bf\u30f3\u30d1\u30af\uff08CRP\uff09\u3067\u8abf\u6574\u3057\u305f\u5834\u5408\u3068\u3057\u306a\u3044\u5834\u5408\u306b\u3064\u3044\u3066\u8a55\u4fa1\u3057\u305f\u3002UK Biobank\u3067\u306f\u3001\u4e8c\u6bb5\u968e\u6700\u5c0f\u4e8c\u4e57\u6cd5\u3092\u7528\u3044\u3066\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304a\u3088\u3073LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u5024\u306b\u53ca\u307c\u3059\u56e0\u679c\u7684\u5f71\u97ff\u3092\u63a8\u5b9a\u3059\u308b\u305f\u3081\u306b\u30e1\u30f3\u30c7\u30eb\u30e9\u30f3\u30c0\u30e0\u5316\u3092\u9069\u7528\u3057\u305f\u3002 <\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n
\n

\u7d50\u679c<\/strong><\/p>\n<\/td>\n

\n

15\u5e74\u9593\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u30011,045\u540d\u304cPAD\u3068\u8a3a\u65ad\u3055\u308c\u30011,966\u540d\u304cMI\u3092\u767a\u75c7\u3057\u305f\u3002\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304a\u3088\u3073\u30ec\u30e0\u30ca\u30f3\u30c8\u7c92\u5b50\u306e\u9ad8\u5024\u306fPAD\u304a\u3088\u3073MI\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3068\u95a2\u9023\u3057\u3001\u3053\u308c\u3089\u306e\u95a2\u9023\u306fCRP\u3067\u8abf\u6574\u5f8c\u306b\u6e1b\u5f31\u3057\u305f\u3002\u4f4e\u60aa\u6027\u5ea6\u708e\u75c7\u306f\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u9ad8\u5024\u306b\u4f34\u3046PAD\u30ea\u30b9\u30af\u306e17%\uff0895%\u4fe1\u983c\u533a\u959312-22%\uff09\u3001MI\u30ea\u30b9\u30af\u306e10%\uff086-14%\uff09\u3092\u8aac\u660e\u3057\u305f\uff08\u88681<\/strong>\uff09\u3002NMR\u30b3\u30db\u30fc\u30c8\u306b\u304a\u3044\u3066\u30ec\u30e0\u30ca\u30f3\u30c8\u7c92\u5b50\u306b\u4f34\u3046\u30ea\u30b9\u30af\u306b\u3064\u3044\u3066\u3082\u540c\u69d8\u306e\u5272\u5408\u304c\u8aac\u660e\u3055\u308c\u305f\u3002 <\/p>\n

 <\/p>\n

\u88681<\/strong>. \u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304a\u3088\u3073LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u9ad8\u5024\u3068\u306e\u95a2\u9023\u306b\u304a\u3044\u3066\u4f4e\u60aa\u6027\u5ea6\u708e\u75c7\u304c\u8aac\u660e\u3059\u308b\u30ea\u30b9\u30af<\/p>\n\n\n\n\n\n\n\n\n\n\n
\n

Diagnosis<\/p>\n<\/td>\n

\n

No. of individuals <\/p>\n<\/td>\n

\n

\u30a4\u30d9\u30f3\u30c8\u6570 <\/p>\n<\/td>\n

\n

Association from<\/p>\n<\/td>\n

\n

\u4f4e\u60aa\u6027\u5ea6\u708e\u75c7\u304c\u8aac\u660e\u3059\u308b\u30ea\u30b9\u30af\uff08%\uff09*<\/p>\n<\/td>\n<\/tr>\n

\n

\u30d1\u30c3\u30c9<\/p>\n<\/td>\n

\n

90,490<\/p>\n<\/td>\n

\n

1045<\/p>\n<\/td>\n

\n

\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb<\/p>\n<\/td>\n

\n

17 (12-22)<\/p>\n<\/td>\n<\/tr>\n

\n

LDL cholesterol<\/p>\n<\/td>\n

\n

0 (0-1)<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

24,312 (NMR cohort)<\/p>\n<\/td>\n

\n

585<\/p>\n<\/td>\n

\n

Remnant particles<\/p>\n<\/td>\n

\n

16 (10-22)<\/p>\n<\/td>\n<\/tr>\n

\n

MI<\/p>\n<\/td>\n

\n

90,210<\/p>\n<\/td>\n

\n

1,966<\/p>\n<\/td>\n

\n

\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb<\/p>\n<\/td>\n

\n

10 (6-14)<\/p>\n<\/td>\n<\/tr>\n

\n

LDL cholesterol<\/p>\n<\/td>\n

\n

0 (0-0)<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

24,162<\/p>\n

(NMR cohort)<\/p>\n<\/td>\n

\n

1739<\/p>\n<\/td>\n

\n

Remnant particles<\/p>\n<\/td>\n

\n

8 (3-13)<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

* \u63a8\u5b9a\u5024\u304a\u3088\u307395%\u4fe1\u983c\u533a\u9593<\/p>\n

 <\/p>\n

UK Biobank\u3092\u7528\u3044\u305f\u30e1\u30f3\u30c7\u30eb\u30e9\u30f3\u30c0\u30e0\u5316\u306b\u3088\u308a\u3001\u907a\u4f1d\u30b9\u30b3\u30a2\u304b\u3089\u4e88\u6e2c\u3055\u308c\u308b\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u9ad8\u5024\u306f\u3001CRP\u30fb\u816b\u760d\u58ca\u6b7b\u56e0\u5b50\uff08TNF\uff09\u30fbTNF\u30b9\u30fc\u30d1\u30fc\u30d5\u30a1\u30df\u30ea\u30fc\u30e1\u30f3\u30d0\u30fc12\u30fb\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3\uff08IL\uff09-16\u30fbIL-18\u30fbIL-27\u306e\u5024\u306e\u4e0a\u6607\u3001\u304a\u3088\u3073IL-32\u5024\u306e\u4f4e\u4e0b\u3068\u56e0\u679c\u7684\u306b\u95a2\u9023\u3057\u3066\u3044\u305f\u304c\u3001IL-6\u3084IL-1\u03b2\u306e\u5024\u306f\u5909\u5316\u3055\u305b\u306a\u304b\u3063\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002 <\/p>\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u8457\u8005\u306e\u7d50\u8ad6<\/strong><\/p>\n<\/td>\n

\n

LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u9ad8\u5024\u306f\u3001\u3044\u305a\u308c\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u9ad8\u5024\u3068\u3082\u95a2\u9023\u3057\u3066\u3044\u306a\u304b\u3063\u305f\u3002 <\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/strong><\/p>\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

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<\/strong><\/em><\/p>\n

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    \n
  1. Varbo A, Benn M, Tybjaerg-Hansen A, Nordestgaard BG. Elevated remnant cholesterol causes both low-grade inflammation and ischemic heart disease, whereas elevated low-density lipoprotein cholesterol causes ischemic heart disease without inflammation. Circulation 2013;128:1298\u2013309. <\/li>\n
  2. Doi T, Langsted A, Nordestgaard BG. Dual elevated remnant cholesterol and C-reactive protein in myocardial infarction, atherosclerotic cardiovascular disease, and mortality. Atherosclerosis 2023;379:117141.<\/li>\n
  3. Meng W, Wang C, Xu Z, et al. Association between remnant cholesterol and peripheral artery disease from multiple perspectives. Atherosclerosis 2026:417:120784.<\/li>\n
  4. Qiu X, Hu B, Ke J, et al. Global, regional, and national trends in peripheral arterial disease among older adults: findings from the global burden of disease study 2021. Aging Clin Exp Res 2025;37(1):150. <\/li>\n<\/ol>\n

    Key words: Remnant cholesterol; peripheral artery disease; low-grade inflammation; Copenhagen General Population Study<\/em><\/p>\n<\/div>\n

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