{"id":257767,"date":"2026-05-11T04:05:04","date_gmt":"2026-05-11T02:05:04","guid":{"rendered":"https:\/\/r3i.org\/?page_id=257767"},"modified":"2026-05-11T04:05:07","modified_gmt":"2026-05-11T02:05:07","slug":"vesalius-cv%ef%bc%9a%e7%b3%96%e5%b0%bf%e7%97%85%e3%82%92%e6%9c%89%e3%81%99%e3%82%8b%e4%b8%80%e6%ac%a1%e4%ba%88%e9%98%b2%e6%82%a3%e8%80%85%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bpcsk9%e9%98%bb","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/vesalius-cv%ef%bc%9a%e7%b3%96%e5%b0%bf%e7%97%85%e3%82%92%e6%9c%89%e3%81%99%e3%82%8b%e4%b8%80%e6%ac%a1%e4%ba%88%e9%98%b2%e6%82%a3%e8%80%85%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bpcsk9%e9%98%bb\/","title":{"rendered":"VESALIUS\u2011CV\uff1a\u7cd6\u5c3f\u75c5\u3092\u6709\u3059\u308b\u4e00\u6b21\u4e88\u9632\u60a3\u8005\u306b\u304a\u3051\u308bPCSK9\u963b\u5bb3"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}”]<\/p>\n

VESALIUS\u2011CV\uff1a\u7cd6\u5c3f\u75c5\u3092\u6709\u3059\u308b\u4e00\u6b21\u4e88\u9632\u60a3\u8005\u306b\u304a\u3051\u308bPCSK9\u963b\u5bb3<\/h2>\n

2026\u5e744\u6708<\/span><\/h5>\n
\n

\u65e2\u77e5\u306e\u6709\u610f\u306a\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u3092\u6709\u3057\u306a\u3044\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u3001evolocumab\u6cbb\u7642\u306f\u521d\u56de\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u305f\u3002\u3053\u308c\u3089\u306e\u77e5\u898b\u306b\u57fa\u3065\u3051\u3070\u3001\u3053\u306e\u60a3\u8005\u7fa4\u3067\u306f\u3088\u308a\u4f4e\u3044LDL\u2011C\u76ee\u6a19\u3092\u76ee\u6307\u3059\u3079\u304d\u3067\u3042\u308d\u3046\u304b\u3002 <\/em><\/p>\n

Marston NA, Bohula EA, Bhatia AK , et al. Evolocumab to reduce first major cardiovascular events in patients without known significant atherosclerosis and with diabetes. Results from the VESALIUS-CV Trial. JAMA 2026.doi:10.1001\/jama.2026.3277 . <\/em><\/p>\n

\u7814\u7a76\u6982\u8981<\/strong><\/p>\n\n\n\n\n\n\n\n\n
\n

\u76ee\u7684<\/strong><\/p>\n<\/td>\n

\n

\u65e2\u77e5\u306e\u6709\u610f\u306a\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u3092\u6709\u3057\u306a\u3044\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u3001evolocumab\u304c\u521d\u56de\u4e3b\u8981\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08MACE\uff09\u3092\u4e88\u9632\u3057\u5f97\u308b\u304b\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3002<\/p>\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/strong><\/p>\n<\/td>\n

\n

VESALIUS\u2011CV\uff08Effect of Evolocumab in Patients at High Cardiovascular Risk without Prior Myocardial Infarction or Stroke\uff09\u306f\u3001\u65e2\u5f80\u306e\u5fc3\u7b4b\u6897\u585e\u307e\u305f\u306f\u8133\u5352\u4e2d\u3092\u6709\u3055\u305a\u3001LDL\u2011C \u226590 mg\/dL\u3067\u3001\u9069\u683c\u3068\u306a\u308b\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u307e\u305f\u306f\u9ad8\u30ea\u30b9\u30af\u7cd6\u5c3f\u75c5\u3092\u6709\u3059\u308b12,257\u4f8b\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3001evolocumab\u306e\u7121\u4f5c\u70ba\u5316\u3001\u4e8c\u91cd\u76f2\u691c\u3001\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3067\u3042\u3063\u305f\u3002\u4e2d\u592e\u30d6\u30ed\u30c3\u30af\u7121\u4f5c\u70ba\u5316\u3092\u7528\u3044\u3066\u3001\u60a3\u8005\u3092evolocumab 140 mg\u76ae\u4e0b\u6ce8\u5c042\u9031\u3054\u3068\u6295\u4e0e\u307e\u305f\u306f\u5bfe\u5fdc\u3059\u308b\u30d7\u30e9\u30bb\u30dc\u306b1:1\u306e\u5272\u5408\u3067\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u305f\u3002\u7121\u4f5c\u70ba\u5316\u306fLDL\u2011C\u5024\uff08<160\u307e\u305f\u306f\u2265160 mg\/dL\uff09\u304a\u3088\u3073\u5730\u57df\u3067\u5c64\u5225\u5316\u3055\u308c\u305f\u3002 <\/p>\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u7814\u7a76\u5bfe\u8c61\u8005<\/strong><\/p>\n<\/td>\n

\n

\u3053\u306e\u4e8b\u524d\u898f\u5b9a\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u306b\u306f\u3001\u7cd6\u5c3f\u75c5\u3092\u6709\u3057\u3001\u65e2\u77e5\u306e\u6709\u610f\u306a\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u3092\u6709\u3057\u306a\u30443,655\u4f8b\uff08evolocumab\u7fa41,849\u4f8b\u3001\u30d7\u30e9\u30bb\u30dc\u7fa41,806\u4f8b\uff09\u304c\u542b\u307e\u308c\u305f\u3002\u65e2\u77e5\u306e\u6709\u610f\u306a\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u306a\u3057\u3068\u306f\u3001\u904e\u53bb\u306e\u52d5\u8108\u8840\u884c\u518d\u5efa\u3001\u52d5\u8108\u72ed\u7a84 \u226550%\u3001\u51a0\u52d5\u8108\u77f3\u7070\u5316\u30b9\u30b3\u30a2 \u2265100 Agatston units\u306e\u3044\u305a\u308c\u3082\u306a\u3044\u3053\u3068\u3068\u5b9a\u7fa9\u3055\u308c\u305f\u3002\u8102\u8cea\u306b\u95a2\u3059\u308b\u7d44\u307f\u5165\u308c\u57fa\u6e96\u306f\u3001LDL\u2011C \u226590 mg\/dL\uff08\u22652.3 mmol\/L\uff09\u3001non-HDL\u2011C \u2265120 mg\/dL\uff08\u22653.1 mmol\/L\uff09\u3001\u307e\u305f\u306fapolipoprotein B \u226580 mg\/dL\uff08\u22651.56 \u03bcmol\/L\uff09\u3067\u3042\u308a\u3001\u5c11\u306a\u304f\u3068\u30822\u9031\u9593\u3001\u5b89\u5b9a\u3057\u305f\u6700\u9069\u5316\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u308b\u3053\u3068\u304c\u6761\u4ef6\u3067\u3042\u3063\u305f\u3002 <\/p>\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee<\/strong><\/p>\n<\/td>\n

\n

\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f2\u3064\u3067\u3042\u3063\u305f\u30021\uff093\u2011point MACE\uff08\u51a0\u52d5\u8108\u75be\u60a3\uff3bCHD\uff3d\u6b7b\u3001\u5fc3\u7b4b\u6897\u585e\uff3bMI\uff3d\u3001\u307e\u305f\u306f\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u8907\u5408\uff09\u3001\u304a\u3088\u30732\uff094\u2011point MACE\u3001\u3059\u306a\u308f\u30613\u2011point MACE\u306b\u865a\u8840\u4e3b\u5c0e\u306e\u52d5\u8108\u8840\u884c\u518d\u5efa\u3092\u52a0\u3048\u305f\u3082\u306e\u3067\u3042\u308b\u3002\u526f\u6b21\u6709\u52b9\u6027\u8a55\u4fa1\u9805\u76ee\u306b\u306f\u30014\u3064\u306e\u8907\u5408\u8a55\u4fa1\u9805\u76ee\u3001\u3059\u306a\u308f\u30611\uff09MI\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u3001\u307e\u305f\u306f\u865a\u8840\u4e3b\u5c0e\u306e\u52d5\u8108\u8840\u884c\u518d\u5efa\u30012\uff09CHD\u6b7b\u3001MI\u3001\u307e\u305f\u306f\u865a\u8840\u4e3b\u5c0e\u306e\u52d5\u8108\u8840\u884c\u518d\u5efa\u30013\uff09\u5fc3\u8840\u7ba1\u6b7b\u3001MI\u3001\u307e\u305f\u306f\u865a\u8840\u6027\u8133\u5352\u4e2d\u30014\uff09CHD\u6b7b\u307e\u305f\u306fMI\u304c\u542b\u307e\u308c\u3001\u3055\u3089\u306bMI\u3001\u865a\u8840\u4e3b\u5c0e\u306e\u52d5\u8108\u8840\u884c\u518d\u5efa\u3001CHD\u6b7b\u3001\u5fc3\u8840\u7ba1\u6b7b\u3001\u5168\u6b7b\u4ea1\u3001\u304a\u3088\u3073\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u500b\u5225\u8a55\u4fa1\u9805\u76ee\u3082\u542b\u307e\u308c\u305f\u3002 <\/p>\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u65b9\u6cd5<\/strong><\/p>\n<\/td>\n

\n

\u4e3b\u8981\u89e3\u6790\u304a\u3088\u3073\u526f\u6b21\u89e3\u6790\u306fintention-to-treat\u3067\u884c\u308f\u308c\u305f\u3002\u8102\u8cea\u30b5\u30d6\u30b9\u30bf\u30c7\u30a3\u3067\u306f\u3001\u7121\u4f5c\u70ba\u5316\u3055\u308c\u305f\u60a3\u8005\u306e\u3046\u3061\u3001\u5c11\u306a\u304f\u3068\u30821\u56de\u306e\u8a66\u9a13\u85ac\u6295\u4e0e\u3092\u53d7\u3051\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u5f8c\u306b\u5c11\u306a\u304f\u3068\u30821\u56de\u306e\u8102\u8cea\u6e2c\u5b9a\u3092\u6709\u3059\u308b\u5168\u60a3\u8005\u304c\u8a55\u4fa1\u3055\u308c\u305f\u3002 <\/p>\n

 <\/p>\n

\u30a4\u30d9\u30f3\u30c8\u767a\u751f\u307e\u3067\u306e\u6642\u9593\u89e3\u6790\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3LDL\u2011C\u304a\u3088\u3073\u5730\u57df\u3067\u5c64\u5225\u5316\u3057\u305flog-rank\u691c\u5b9a\u3092\u7528\u3044\u3066\u884c\u308f\u308c\u305f\u300295%\u4fe1\u983c\u533a\u9593\uff08CI\uff09\u3092\u4f34\u3046\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08HR\uff09\u306fCox\u30e2\u30c7\u30eb\u304b\u3089\u63a8\u5b9a\u3055\u308c\u305f\u3002 <\/p>\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u4e3b\u306a\u7d50\u679c<\/strong><\/p>\n<\/td>\n

\n

\u30a4\u30d9\u30f3\u30c8\u767a\u751f\u307e\u3067\u306e\u6642\u9593\u89e3\u6790\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3LDL\u2011C\u304a\u3088\u3073\u5730\u57df\u3067\u5c64\u5225\u5316\u3057\u305flog-rank\u691c\u5b9a\u3092\u7528\u3044\u3066\u884c\u308f\u308c\u305f\u300295%\u4fe1\u983c\u533a\u9593\uff08CI\uff09\u3092\u4f34\u3046\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08HR\uff09\u306fCox\u30e2\u30c7\u30eb\u304b\u3089\u63a8\u5b9a\u3055\u308c\u305f\u3002 <\/p>\n

 <\/p>\n

48\u9031\u5f8c\u3001evolocumab\u6cbb\u7642\u306b\u3088\u308aLDL\u2011C\u306f\u6700\u5c0f\u4e8c\u4e57\u5e73\u5747\u306751%\u4f4e\u4e0b\u3057\uff0895% CI 57%\u201345%\uff09\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e111 mg\/dL\uff08IQR 90\u2013149\uff09\u3068\u6bd4\u8f03\u3057\u3066\u3001\u9054\u6210LDL\u2011C\u4e2d\u592e\u5024\u306f52 mg\/dL\uff08IQR 31\u201375\uff09\u3067\u3042\u3063\u305f\u300296\u9031\u5f8c\u3001\u9054\u6210LDL\u2011C\u4e2d\u592e\u5024\u306fevolocumab\u7fa4\u306744 mg\/dL\uff08IQR 29\u201368\uff09\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067105 mg\/dL\uff08IQR 79\u2013137\uff09\u3067\u3042\u3063\u305f\u3002 <\/p>\n

 <\/p>\n

evolocumab\u6cbb\u7642\u306f\u30013\u2011point\u304a\u3088\u30734\u2011point MACE\u8a55\u4fa1\u9805\u76ee\u306e\u30ea\u30b9\u30af31%\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u305f\uff08\u88681\uff09\u3002evolocumab\u306e\u52b9\u679c\u306f\u6cbb\u7642\u958b\u59cb1\u5e74\u5f8c\u4ee5\u964d\u3067\u3088\u308a\u660e\u77ad\u3068\u306a\u308a\u3001\u305d\u306e\u5f8c\u306e\u5e74\u3067\u306f\u30013\u2011point MACE\u306741%\uff08HR 0.59\uff3b95% CI 0.43\u20130.81\uff3d\uff09\u30014\u2011point MACE\u306739%\uff08HR 0.61\uff3b95% CI 0.48\u20130.79\uff3d\uff09\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u304c\u307f\u3089\u308c\u305f\u3002\u65e2\u77e5\u306e\u6709\u610f\u306a\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u3092\u6709\u3059\u308b\u60a3\u8005\u3068\u6709\u3057\u306a\u3044\u60a3\u8005\u306b\u304a\u3051\u308bevolocumab\u306e\u52b9\u679c\u306f\u3001\u4e21\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306b\u3064\u3044\u3066\u985e\u4f3c\u3057\u3066\u3044\u305f\u3002 <\/p>\n

 <\/p>\n

\u88681. \u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306b\u5bfe\u3059\u308bevolocumab\u6cbb\u7642\u306e\u52b9\u679c<\/strong><\/p>\n\n\n\n\n\n\n\n\n
\n

Endpoint, n (%)<\/p>\n<\/td>\n

\n

\u30a8\u30dc\u30ed\u30af\u30de\u30d6<\/p>\n

(n=1849)<\/p>\n<\/td>\n

\n

\u30d7\u30e9\u30bb\u30dc<\/p>\n

(n=1806)<\/p>\n<\/td>\n

\n

HR\uff0895% CI)<\/p>\n<\/td>\n<\/tr>\n

\n

3\u30dd\u30a4\u30f3\u30c8MACE<\/p>\n<\/td>\n

\n

83 (4.5)<\/p>\n<\/td>\n

\n

117 (6.5)<\/p>\n<\/td>\n

\n

0.69 (0.52-0.91), p=0.009<\/p>\n<\/td>\n<\/tr>\n

\n

4-point MACE<\/p>\n<\/td>\n

\n

127 (6.9)<\/p>\n<\/td>\n

\n

178 (9.9)<\/p>\n<\/td>\n

\n

0.69 (0.55-0.86), p=0.001<\/p>\n<\/td>\n<\/tr>\n

\n

\u5fc3\u81d3\u8840\u7ba1\u6b7b<\/p>\n<\/td>\n

\n

44 (2.4)<\/p>\n<\/td>\n

\n

63 (3.5)<\/p>\n<\/td>\n

\n

0.68 (0.46-0.99)<\/p>\n<\/td>\n<\/tr>\n

\n

\u5168\u6b7b\u56e0\u6b7b\u4ea1<\/p>\n<\/td>\n

\n

136 (7.4)<\/p>\n<\/td>\n

\n

172 (9.5)<\/p>\n<\/td>\n

\n

0.76 (0.61-0.95)\u00a7<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n

\n

<\/strong><\/p>\n

<\/strong><\/p>\n

\u8457\u8005\u306e\u7d50\u8ad6<\/strong><\/p>\n<\/td>\n

\n

evolocumab\u6cbb\u7642\u306f\u3001\u5fc3\u8840\u7ba1\u6b7b\u304a\u3088\u3073\u5168\u6b7b\u4ea1\u306e\u4f4e\u4e0b\u3068\u3082\u95a2\u9023\u3057\u3066\u3044\u305f\uff08\u88681\uff09\u304c\u3001\u4e8b\u524d\u898f\u5b9a\u3055\u308c\u305f\u968e\u5c64\u7684\u691c\u5b9a\u9806\u5e8f\u3092\u8e0f\u307e\u3048\u308b\u3068\u3001\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u63a2\u7d22\u7684\u3068\u8003\u3048\u308b\u3079\u304d\u3067\u3042\u308b\u3002<\/p>\n

\u65e2\u77e5\u306e\u6709\u610f\u306a\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u3092\u6709\u3057\u306a\u3044\u9ad8\u30ea\u30b9\u30af\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u3001evolocumab\u306f\u521d\u56de\u4e3b\u8981\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u305f<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

VESALIUS\u2011CV\u8a66\u9a13\u306f\u4ee5\u524d\u3001\u80cc\u666f\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306bPCSK9\u963b\u5bb3\u85acevolocumab\u3092\u8ffd\u52a0\u3059\u308b\u3053\u3068\u3067\u3001\u4e00\u6b21\u4e88\u9632\u60a3\u8005\u306b\u304a\u3051\u308b\u521d\u56de\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002\u4eca\u56de\u306e\u4e8b\u524d\u898f\u5b9a\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u306f\u3053\u308c\u3089\u306e\u77e5\u898b\u3092\u62e1\u5f35\u3057\u3001\u65e2\u77e5\u306e\u6709\u610f\u306a\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u3092\u6709\u3057\u306a\u3044\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u3053\u306e\u6cbb\u7642\u6226\u7565\u306e\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u3092\u793a\u3057\u305f\u3002\u80cc\u666f\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3001\u4e3b\u3068\u3057\u3066\u30b9\u30bf\u30c1\u30f3\uff08\u60a3\u8005\u306e84%\u3001\u7d043\u5206\u306e2\u304c\u9ad8\u5f37\u5ea6\u30b9\u30bf\u30c1\u30f3\uff09\u306bevolocumab\u3092\u8ffd\u52a0\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001MACE\uff083\u2011point\u307e\u305f\u306f4\u2011point MACE\u306e\u3044\u305a\u308c\u3082\uff09\u306f31%\u4f4e\u4e0b\u3057\u3001\u3057\u305f\u304c\u3063\u3066\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u63a8\u5968\u3055\u308c\u308b\u30b9\u30bf\u30c1\u30f3\u5358\u5264\u7642\u6cd5\u306b\u5bfe\u3059\u308b\u672c\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u512a\u8d8a\u6027\u304c\u78ba\u7acb\u3055\u308c\u305f\u3002\u3055\u3089\u306b\u3001evolocumab\u6cbb\u7642\u958b\u59cb1\u5e74\u5f8c\u4ee5\u964d\u306b\u660e\u3089\u304b\u3068\u306a\u3063\u305f\u81e8\u5e8a\u7684\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u306e\u9045\u5ef6\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\u306e\u8a66\u9a13\u3067\u3082\u4ee5\u524d\u89b3\u5bdf\u3055\u308c\u3066\u304a\u308a\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u306e\u5f62\u6210\u304a\u3088\u3073\u95a2\u9023\u3059\u308b\u81e8\u5e8a\u5408\u4f75\u75c7\u3092\u4e88\u9632\u307e\u305f\u306f\u9045\u5ef6\u3055\u305b\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3059\u308b\u3002 <\/p>\n

\u5f37\u529b\u306a\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306f\u3001\u4e00\u822c\u306b\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3059\u308b\u60a3\u8005\u307e\u305f\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u60a3\u8005\u306b\u9650\u3089\u308c\u308b\u3002\u4e8c\u6b21\u4e88\u9632\u306e\u72b6\u6cc1\u3067\u306f\u3001\u53b3\u683c\u306aLDL\u2011C\u76ee\u6a19 <55 mg\/dL\uff08<1.4 mmol\/L\uff09\u3092\u9054\u6210\u3059\u308b\u305f\u3081\u3001PCSK9\u963b\u5bb3\u306f\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u63a8\u5968\u3055\u308c\u308b\u660e\u78ba\u306a\u5f79\u5272\u3092\u6709\u3059\u308b\u3002\u4e00\u65b9\u3001\u4e00\u6b21\u4e88\u9632\u3067\u306f\u3001PCSK9\u963b\u5bb3\u85ac\u306b\u3088\u308b\u6cbb\u7642\u306f\u3001\u6700\u5927\u8010\u7528\u91cf\u306e\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\u3067\u3082LDL\u2011C\u76ee\u6a19\u3092\u9054\u6210\u3067\u304d\u306a\u3044\u30d8\u30c6\u30ed\u63a5\u5408\u6027\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u60a3\u8005\u306e\u7ba1\u7406\u306b\u9650\u5b9a\u3055\u308c\u308b\u3002\u672c\u4e8b\u524d\u898f\u5b9a\u89e3\u6790\u3067\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u5358\u5264\u7642\u6cd5\u306bevolocumab\u3092\u8ffd\u52a0\u3059\u308b\u3053\u3068\u3067\u300196\u9031\u6642\u70b9\u306eLDL\u2011C\u4e2d\u592e\u5024\u306f44 mg\/dL\u3068\u306a\u308a\u3001\u4e8c\u6b21\u4e88\u9632\u3067\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u304c\u63a8\u5968\u3059\u308b\u76ee\u6a19\u5024\u3068\u6574\u5408\u3057\u305f\u3002\u307e\u305f\u3001\u65e2\u77e5\u306e\u6709\u610f\u306a\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u3092\u6709\u3057\u306a\u3044\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u7d043\u5206\u306e1\u306b\u304a\u3044\u3066\u3001\u521d\u56de\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u304c\u6e1b\u5c11\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u77e5\u898b\u306b\u57fa\u3065\u304d\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u3092\u6709\u3057\u306a\u3044\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u63a8\u5968\u304a\u3088\u3073LDL\u2011C\u76ee\u6a19\u306e\u518d\u8003\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002 <\/p>\n

 <\/p>\n

\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

    \n
  1. Bohula EA, Marston NA, BhatiaAK, et al. Evolocumab in patients without a previous myocardial infarction or stroke. N Engl J Med 2026;394:117-27. <\/li>\n
  2. Collins R, Reith C, Emberson J, et al. Interpretation of the evidence for the efficacy and safety of statin therapy. Lancet 2016;388:2532-61. <\/li>\n
  3. Blumenthal RS, Morris PB, Gaudino M, et al. 2026 ACC\/AHA\/AACVPR\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA guideline on the management of dyslipidemia: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation 2026. doi:10.1161\/CIR.0000000000001423.<\/li>\n
  4. Mach F, Baigent C, Catapano AL,et al. 2019 ESC\/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J2020;41:111-188. <\/li>\n
  5. Mach F, Koskinas KC, Roeters van Lennep JE, et al. 2025 Focused update of the 2019 ESC\/EAS guidelines for the management of dyslipidaemias. Eur Heart J 2025;46:4359-78. <\/li>\n<\/ol>\n

    Key words: VESALIUS-CV trial; diabetes; primary prevention; LDL-C target; evolocumab<\/em><\/p>\n<\/div>\n

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