{"id":257720,"date":"2026-05-08T18:58:44","date_gmt":"2026-05-08T16:58:44","guid":{"rendered":"https:\/\/r3i.org\/?page_id=257720"},"modified":"2026-05-08T18:58:48","modified_gmt":"2026-05-08T16:58:48","slug":"r3i-editorial-03-26","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/r3i-editorial-03-26\/","title":{"rendered":"R3i Editorial 03\/26"},"content":{"rendered":"

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R3i\u793e\u8aac<\/h2>\n

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2026\u5e743\u6708<\/span><\/h5>\n
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Prof. Peter Libby<\/a>, <\/span>Prof. Michel Hermans<\/a>, Prof. Pierre Amarenco<\/a>, Prof. Lale Tokg\u00f6zoglu <\/a><\/span> <\/h6>\n

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    \n
  1. Ginsberg HN, Packard CJ, Chapman MJ, et al. Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies-a consensus statement from the European Atherosclerosis Society. Eur Heart J 2021;42:4791\u2013806.
    2. Nordestgaard BG. Triglyceride-rich lipoproteins and atherosclerotic cardiovascular disease: new insights from epidemiology, genetics, and biology. Circ Res 2016;118:547\u201363.
    3. ACCORD Study Group; Ginsberg HN, Elam MB, Lovato LC, et al. Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med 2010;362:1563\u201374.
    4. Scott R, O\u2019Brien R, Fulcher G, et al; Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study Investigators. Effects of fenofibrate treatment on cardiovascular disease risk in 9,795 individuals with type 2 diabetes and various components of the metabolic syndrome: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. Diabetes Care 2009;32:493\u20138.
    5. Nicholls SJ, Lincoff AM, Garcia M, et al. Effect of high-dose omega-3 fatty acids vs corn oil on major adverse cardiovascular events in patients at high cardiovascular risk: the STRENGTH randomized clinical trial. JAMA 2020;324:2268\u201380.
    6. Das Pradhan A, Glynn RJ, Fruchart JC, et al. Triglyceride lowering with pemafibrate to reduce cardiovascular risk. N Engl J Med 2022;387:1923-34.
    7. Bhatt DL, Steg PG, Miller M, et al. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. N Engl J Med 2019;380:11\u201322.
    8. Szarek M, Bhatt D, Miller M, et al. Eicosapentaenoic acid, arachidonic acid, and triglyceride levels mediate most of the benefit of icosapent ethyl in REDUCE-IT. Eur Heart J 2023; doi: 10.1093\/eurheartj\/ehad655.1309.
    9. Sherratt SCR, Mason RP, Libby P, Steg PG, Bhatt DL. Do patients benefit from omega-3 fatty acids? Cardiovasc Res 2024; 119:2884\u2013901.
    10. Ballena-Caicedo J, Zuzunaga-Montoya FE, Loayza-Castro JA, et al. Global prevalence of dyslipidemias in the general adult population: a systematic review and meta-analysis. J Health Popul Nutr 2025; 44: 308.
    11. Schubert J, Hagstr\u00f6m E, Westerbergh J, et al. Triglyceride reduction after MI and major adverse outcomes in SWEDEHEART\u2014insights for future trials. Eur J Prev Cardiol 2026; doi: 10.1093\/eurjpc\/zwag076.
    12. Nordestgaard AT, Pradhan AD, Everett BM, et al. Expanding the triglyceride range in clinical trials: therapeutic opportunities. Eur Heart J 2025;46:1835-48.
    13. Bergmark BA, Marston NA, Bramson CR, et al. Effect of vupanorsen on non\u2013high-density lipoprotein cholesterol levels in statin-treated patients with elevated cholesterol: TRANSLATE-TIMI 70. Circulation 2022;145:1377\u201386.
    14. Rosenson RS, Gaudet D, Hegele RA, et al. Zodasiran, an RNAi therapeutic targeting ANGPTL3, for mixed hyperlipidemia. N Engl J Med 2024;391:913\u201325.
    15. Tardif J-C, Karwatowska-Prokopczuk E, Amour ES, et al. Apolipoprotein C-III reduction in subjects with moderate hypertriglyceridaemia and at high cardiovascular risk. Eur Heart J 2022;43:1401\u201312.
    16. Ballantyne CM, Vasas S, Azizad M, et al. Plozasiran, an RNA interference agent targeting APOC3, for mixed hyperlipidemia. N Engl J Med 2024;391:899\u2013912.
    17. Gao Y, Bai Y, Mu X. Pang X. Efficacy and safety of small interfering RNA (siRNA) therapies for hypertriglyceridemia and mixed dyslipidemia: an updated systematic review and meta-analysis. Front Pharmacol 2026;17:1736821. doi: 10.3389\/fphar.2026.1736821
    18. Cummings BB, Joing MP, Bouchard PR, et al. Safety and efficacy of a novel ANGPTL4 inhibitory antibody for lipid lowering: results from phase 1 and phase 1b\/2a clinical studies. Lancet 2025;405:1923-34. <\/li>\n
  2. Key words: Triglycerides; clinical trials; residual cardiovascular risk; APOC3; ANGPTL3<\/li>\n<\/ol>\n

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