{"id":257630,"date":"2026-04-08T16:55:41","date_gmt":"2026-04-08T14:55:41","guid":{"rendered":"https:\/\/r3i.org\/?page_id=257630"},"modified":"2026-04-08T16:55:44","modified_gmt":"2026-04-08T14:55:44","slug":"%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9%e3%80%80%e5%a4%a7%e8%a1%80%e7%ae%a1%e3%83%aa%e3%82%b9%e3%82%af","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9%e3%80%80%e5%a4%a7%e8%a1%80%e7%ae%a1%e3%83%aa%e3%82%b9%e3%82%af\/","title":{"rendered":"\u30d5\u30a9\u30fc\u30ab\u30b9\u3000\u5927\u8840\u7ba1\u30ea\u30b9\u30af"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]<\/p>\n

\u8133\u5352\u4e2d\u306e\u4e8c\u6b21\u4e88\u9632\u306b\u304a\u3051\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068\u708e\u75c7\u306e\u4e21\u65b9\u3092\u6a19\u7684\u3068\u3059\u308b<\/h2>\n

2026\u5e743\u6708<\/span><\/h5>\n
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\u6771\u4eac\u5973\u5b50\u533b\u79d1\u5927\u5b66\u8133\u5352\u4e2d\u30ec\u30b8\u30b9\u30c8\u30ea\u304b\u3089\u306e\u672c\u5831\u544a\u306f\u3001\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3068\u708e\u75c7\u304c\u4f75\u767a\u3059\u308b\u3068\u3001\u6b8b\u4f59\u8133\u5352\u4e2d\u30ea\u30b9\u30af\u304c\u76f8\u52a0\u7684\u306b\u5897\u5927\u3059\u308b\u3053\u3068\u3092\u5b9f\u8a3c\u3057\u3066\u3044\u308b\u3002<\/p>\n

Hoshino T, Mizuno T, Arai S, et al. Cumulative association of triglycerides and interleukin-6 with recurrent vascular events after ischemic stroke . J Clin Lipidol 2026; <\/em> doi.org: 10.1016\/j.jacl.2026.01.001. <\/em><\/p>\n

\u7814\u7a76\u6982\u8981\u3002<\/strong><\/p>\n\n\n\n\n\n\n\n
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\u76ee\u7684<\/strong><\/p>\n<\/td>\n

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\u8133\u5352\u4e2d\u5f8c\u306e\u518d\u767a\u6027\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u3068\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u304a\u3088\u3073\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-6\uff08IL-6\uff09\u5024\u3068\u306e\u7d2f\u7a4d\u7684\u306a\u4e88\u5f8c\u7684\u95a2\u9023\u3092\u8abf\u67fb\u3059\u308b\u3053\u3068\u3002<\/p>\n

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\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/strong><\/p>\n<\/td>\n

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\u6771\u4eac\u5973\u5b50\u533b\u79d1\u5927\u5b66\u8133\u5352\u4e2d\u30ec\u30b8\u30b9\u30c8\u30ea\u306f\u3001\u9032\u884c\u4e2d\u306e\u524d\u5411\u304d\u5358\u4e00\u65bd\u8a2d\u89b3\u5bdf\u7814\u7a76\u3067\u3042\u308b\u3002<\/p>\n

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\u7814\u7a76\u5bfe\u8c61\u96c6\u56e3 <\/strong><\/p>\n<\/td>\n

\n

\u767a\u75c7\u304b\u30891\u9031\u9593\u4ee5\u5185\u306e\u6025\u6027\u865a\u8840\u6027\u8133\u5352\u4e2d\u307e\u305f\u306f\u9ad8\u30ea\u30b9\u30af\u4e00\u904e\u6027\u8133\u865a\u8840\u767a\u4f5c\u3092\u6709\u3059\u308b20\u6b73\u4ee5\u4e0a\u306e\u60a3\u8005\u3002\u60a3\u8005\u306f2014\u5e7410\u6708\u304b\u30892022\u5e745\u6708\u306e\u9593\u306b\u9023\u7d9a\u3057\u3066\u767b\u9332\u3055\u308c\u305f\u3002 <\/p>\n

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\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee<\/strong><\/p>\n

<\/strong><\/p>\n<\/td>\n

\n

\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f1\u5e74\u5f8c\u306e\u4e3b\u8981\u5fc3\u8840\u7ba1\u6709\u5bb3\u4e8b\u8c61\uff08MACE\uff09\u3067\u3042\u308a\u3001\u518d\u767a\u6027\u8133\u5352\u4e2d\u3001\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u3001\u307e\u305f\u306f\u8840\u7ba1\u6b7b\u3068\u5b9a\u7fa9\u3055\u308c\u305f\u3002\u8840\u7ba1\u6b7b\u306f\u3001\u81f4\u6b7b\u6027\u8133\u5352\u4e2d\u3001\u81f4\u6b7b\u6027\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u3001\u307e\u305f\u306f\u80ba\u585e\u6813\u75c7\u304a\u3088\u3073\u5fc3\u81d3\u7a81\u7136\u6b7b\u3092\u542b\u3080\u305d\u306e\u4ed6\u306e\u5fc3\u8840\u7ba1\u6b7b\u3068\u5b9a\u7fa9\u3055\u308c\u305f\u3002 <\/p>\n

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\u65b9\u6cd5<\/strong><\/p>\n<\/td>\n

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\u60a3\u8005\u306f\u3001TG\uff08150mg\/dL\uff09\u304a\u3088\u3073IL-6\uff08\u4e2d\u592e\u50244.0pg\/mL\uff09\u306e\u5b9a\u7fa9\u3055\u308c\u305f\u30ab\u30c3\u30c8\u30aa\u30d5\u5024\u3092\u7528\u3044\u3066\u3001\u4ee5\u4e0b\u306e\u3044\u305a\u308c\u304b\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u5206\u985e\u3055\u308c\u305f\uff1aLL\uff08TG<<150mg\/dL \/ IL-6<<4.0pg\/mL\uff09\u3001HL\uff08TG\u2265<150mg\/dL \/ IL-6<<4.0pg\/mL\uff09\u3001LH\uff08TG<150mg\/dL \/ IL-6\u22654.0pg\/mL\uff09\u3001\u304a\u3088\u3073HH\uff08TG\u2265150mg\/dL \/ IL-6\u22654.0pg\/mL\uff09\u3002\u30a4\u30d9\u30f3\u30c8\u767a\u751f\u7387\u306fKaplan-Meier\u6cd5\u3092\u7528\u3044\u3066\u63a8\u5b9a\u3055\u308c\u305f\u3002TG\/IL-6\u30ab\u30c6\u30b4\u30ea\u30fc\u3068\u518d\u767a\u6027MACE\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306b\u3001Cox\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u56de\u5e30\u30e2\u30c7\u30eb\u304c\u7528\u3044\u3089\u308c\u305f\u3002 <\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n
\n

\u7d50\u679c<\/strong><\/p>\n<\/td>\n

\n

\u89e3\u6790\u306b\u306f962\u4eba\u306e\u60a3\u8005\uff08\u5e73\u5747\u5e74\u9f6271.0\u6b73\u3001\u7537\u602761.1%\u3001\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u4e2d62.3%\uff09\u304c\u542b\u307e\u308c\u305f\u3002TG\/IL-6\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u57fa\u3065\u304f4\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u306e\u7279\u5fb4\u3068\u3001\u30a4\u30d9\u30f3\u30c8\u767a\u751f\u7387\u304a\u3088\u3073MACE\u306e\u30ea\u30b9\u30af\u306f\u88681\u306b\u8981\u7d04\u3055\u308c\u3066\u3044\u308b\u3002 <\/p>\n

 <\/p>\n

TG\u2265150mg\/dL\u307e\u305f\u306fIL-6\u22654.0pg\/mL\u306e\u5b58\u5728\u306f\u3001\u305d\u308c\u305e\u308c\u72ec\u7acb\u3057\u3066\u518d\u767a\u6027MACE\u306e\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3057\u305f\u3002TG\u3068IL-6\u306e\u4e21\u65b9\u304c\u4e0a\u6607\u3057\u3066\u3044\u308b\u60a3\u8005\u306f\u3001MACE\u30ea\u30b9\u30af\u306e\u7d2f\u7a4d\u7684\u306a\u5897\u52a0\u3092\u793a\u3057\u305f\uff08\u88681\uff09\u3002\u3053\u306e\u95a2\u9023\u306f\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u8840\u6813\u6027\u8133\u5352\u4e2d\u60a3\u8005\uff08p=0.001\uff09\u3001\u4e8c\u6b21\u4e88\u9632\u3068\u3057\u3066\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u60a3\u8005\uff08p=0.001\uff09\u3001\u304a\u3088\u3073LDL-C\u5024\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u60a3\u8005\uff08100mg\/dL<\u672a\u6e80\uff1ap=0.004\u300170mg\/dL<\u672a\u6e80\uff1ap=0.013\uff09\u306b\u304a\u3044\u3066\u3082\u8a8d\u3081\u3089\u308c\u305f \u3002 <\/p>\n

 <\/p>\n

\u88681. \u88681. TG\u304a\u3088\u3073IL-6\u5024\u3067\u5206\u985e\u3055\u308c\u305f\u60a3\u8005\u306e\u7279\u5fb4\u3068MACE\u30ea\u30b9\u30af<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n
\n

 <\/p>\n<\/td>\n

\n

Low TG\/<\/strong><\/p>\n

Low IL-6<\/strong><\/p>\n

(n = 362)<\/strong><\/p>\n<\/td>\n

\n

High TG\/<\/strong><\/p>\n

Low IL-6<\/strong><\/p>\n

(n = 124)<\/strong><\/p>\n<\/td>\n

\n

Low TG\/<\/strong><\/p>\n

High IL-6<\/strong><\/p>\n

(n = 352)<\/strong><\/p>\n<\/td>\n

\n

High TG\/<\/strong><\/p>\n

High IL-6<\/strong><\/p>\n

(n = 124)<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Mean (SD) LDL-C, mg\/dL<\/p>\n<\/td>\n

\n

116 (33)<\/p>\n<\/td>\n

\n

132 (35)<\/p>\n<\/td>\n

\n

104 (35)<\/p>\n<\/td>\n

\n

119 (40)<\/p>\n<\/td>\n<\/tr>\n

\n

\u4e2d\u592e\u5024\uff08IQR\uff09<\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

TG, mg\/dL<\/p>\n<\/td>\n

\n

90 (71-115)<\/p>\n<\/td>\n

\n

214 (174-285)<\/p>\n<\/td>\n

\n

90 (67-113)<\/p>\n<\/td>\n

\n

184 (163-221)<\/p>\n<\/td>\n<\/tr>\n

\n

IL-6, pg\/mL<\/p>\n<\/td>\n

\n

2.0 (1.3-2.8)<\/p>\n<\/td>\n

\n

2.1 (1.5-3.0)<\/p>\n<\/td>\n

\n

9.6 (5.7-19.6)<\/p>\n<\/td>\n

\n

8.2 (5.1-17.0)<\/p>\n<\/td>\n<\/tr>\n

\n

MACE at 1 year<\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

Incidence, n (%)<\/p>\n<\/td>\n

\n

28 (8.0)<\/p>\n<\/td>\n

\n

21 (17.5)<\/p>\n<\/td>\n

\n

51 (15.7)<\/p>\n<\/td>\n

\n

27 (23.8)<\/p>\n<\/td>\n<\/tr>\n

\n

\u30cf\u30b6\u30fc\u30c9\u6bd4\uff0895\uff05CI\uff09<\/p>\n<\/td>\n

\n

\u53c2\u7167<\/p>\n<\/td>\n

\n

2.12 (1.18-3.80)<\/p>\n<\/td>\n

\n

1.71 (1.05-2.77)<\/p>\n<\/td>\n

\n

2.43 (1.40-4.23)<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n

\n

<\/strong><\/p>\n

<\/strong><\/p>\n

<\/strong><\/p>\n

\u8457\u8005\u306e\u7d50\u8ad6<\/strong><\/p>\n<\/td>\n

\n

CI \u4fe1\u983c\u533a\u9593\u3001IQR \u56db\u5206\u4f4d\u7bc4\u56f2\u3001LDL-C \u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001SD \u6a19\u6e96\u504f\u5dee\u3002<\/p>\n

 <\/p>\n

TG\u304a\u3088\u3073IL-6\u5024\u306b\u3088\u308b\u5c64\u5225\u5316\u306f\u3001\u8133\u5352\u4e2d\u5f8c\u306eMACE\u30ea\u30b9\u30af\u306e\u7d2f\u7a4d\u7684\u306a\u5897\u52a0\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3068\u5168\u8eab\u6027\u708e\u75c7\u306e\u4e8c\u91cd\u306e\u8ca0\u62c5\u3092\u6301\u3064\u60a3\u8005\u306b\u304a\u3044\u3066\u6700\u3082\u30ea\u30b9\u30af\u304c\u9ad8\u304b\u3063\u305f\u3002<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/strong><\/p>\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

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 <\/p>\n

\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

    \n
  1. Khan F, Yogendrakumar V, Lun R, et al. Long-term risk of stroke after transient ischemic attack or minor stroke: a systematic review and meta-analysis. JAMA 2025;333:1508\u201319. <\/li>\n
  2. Amarenco P, Kim JS, Labreuche J, et al. A comparison of two LDL cholesterol targets after ischemic stroke. N Engl J Med 2020;382:9. <\/li>\n
  3. Nordestgaard BG, Varbo A. \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u3002Lancet 2014;384:626-35. <\/li>\n
  4. Kelly PJ, Lemmens R, Tsivgoulis G. Inflammation and stroke risk: a new target for prevention. Stroke 2021; 52: 2697-706. <\/li>\n
  5. McCabe JJ, Walsh C, Gorey S, et al. C-reactive protein, interleukin-6, and vascular recurrence after stroke: an individual participant data meta-analysis. Stroke 2023;54:1289\u201399. <\/li>\n
  6. Arai S, Hoshino T, Mizuno T, et al. Association between serum interleukin-6 <\/li>\n<\/ol>\n

    levels and long-term outcomes after ischemic stroke: a Prospective Cohort Study. J Atheroscler Thromb 2025: doi 10.5551\/jat.65842. <\/p>\n

      \n
    1. Georgakis MK, Malik R, Gill D, et al. Interleukin-6 signaling effects on ischemic stroke and other cardiovascular outcomes: a Mendelian Randomization Study. Circ Genom Precis Med 2020;13:e002872.<\/li>\n
    2. Ridker PM, Bhatt DL, Pradhan AD, et al. Inflammation and cholesterol as predictors of cardiovascular events among patients receiving statin therapy: a collaborative analysis of three randomised trials. Lancet 2023;401:1293\u2013301. <\/li>\n
    3. Doi T, Langsted A, Nordestgaard BG. Dual elevated remnant cholesterol and C-reactive protein in myocardial infarction, atherosclerotic cardiovascular disease, and mortality. Atherosclerosis 2023;379:117141.<\/li>\n
    4. Kitagawa K, Hosomi N, Nagai Y, et al. Cumulative effects of LDL cholesterol and CRP levels on recurrent stroke and TIA. J Atheroscler Thromb 2019;26:432\u2013441. <\/li>\n
    5. Kurt B, Reugels M, Schneider KM, et al. C-reactive protein and cardiovascular risk in the general population. Eur Heart J 2025: doi: 10.1093\/eurheartj\/ehaf937. <\/li>\n<\/ol>\n

      Key words: Stroke; triglycerides; interleukin-6; residual vascular risk<\/em><\/p>\n

      AD<\/em><\/p>\n<\/div>\n

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