{"id":257441,"date":"2025-07-31T00:05:54","date_gmt":"2025-07-30T22:05:54","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-lodoco2%ef%bc%88%e4%bd%8e%e7%94%a8%e9%87%8f%e3%82%b3%e3%83%ab%e3%83%92%e3%83%81%e3%83%b32%ef%bc%89%e8%a9%a6%e9%a8%93%e3%81%8b%e3%82%89%e3%81%ae-2\/"},"modified":"2026-03-05T18:07:57","modified_gmt":"2026-03-05T17:07:57","slug":"%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-lodoco2%ef%bc%88%e4%bd%8e%e7%94%a8%e9%87%8f%e3%82%b3%e3%83%ab%e3%83%92%e3%83%81%e3%83%b32%ef%bc%89%e8%a9%a6%e9%a8%93%e3%81%8b%e3%82%89%e3%81%ae-2","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-lodoco2%ef%bc%88%e4%bd%8e%e7%94%a8%e9%87%8f%e3%82%b3%e3%83%ab%e3%83%92%e3%83%81%e3%83%b32%ef%bc%89%e8%a9%a6%e9%a8%93%e3%81%8b%e3%82%89%e3%81%ae-2\/","title":{"rendered":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af-LoDoCo2\uff08\u4f4e\u7528\u91cf\u30b3\u30eb\u30d2\u30c1\u30f32\uff09\u8a66\u9a13\u304b\u3089\u306e\u3055\u3089\u306a\u308b\u77e5\u898b"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]<\/p>\n

LoDoCo2\uff08\u4f4e\u7528\u91cf\u30b3\u30eb\u30d2\u30c1\u30f32\uff09\u8a66\u9a13\u304b\u3089\u306e\u8003\u5bdf<\/h2>\n

2025\u5e747\u6708<\/span><\/h5>\n
\n
\n

\u3053\u306e\u6700\u65b0\u306e\u89e3\u6790\u306f<\/span><\/i> \u6162\u6027\u51a0\u75c7\u5019\u7fa4\u60a3\u8005\u306b\u304a\u3051\u308b\u30b3\u30eb\u30d2\u30c1\u30f3\u306e\u4f7f\u7528\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u30ea\u30b9\u30af\u306e\u7bc4\u56f2\u306b\u308f\u305f\u3063\u3066\u652f\u6301\u3055\u308c\u308b\u3002 <\/span><\/i> <\/p>\n

Mohammadnia N, Wesselink BE, Bax WA, et al. Cardiovascular benefit of colchicine in relation to baseline risk: a secondary analysis of the LoDoCo2 Trial. J Am Heart Assoc 2025;14:e038687. DOI: 10.1161\/JAHA.124.038687. <\/span><\/i><\/p>\n<\/p>\n

\u7814\u7a76\u6982\u8981<\/b><\/p>\n\n\n\n\n\n\n\n\n
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\u76ee\u7684<\/b><\/p>\n<\/td>\n

\n

LoDoCo2\u8a66\u9a13\u306e\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u304d\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u30ea\u30b9\u30af\u306b\u5fdc\u3058\u305f\u30b3\u30eb\u30d2\u30c1\u30f3\u306e\u76f8\u5bfe\u7684\u30fb\u7d76\u5bfe\u7684\u6709\u76ca\u6027\u3092\u691c\u8a0e\u3059\u308b\u3002 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/b><\/p>\n<\/td>\n

\n

LoDoCo2\u8a66\u9a13\u306f\u3001\u6162\u6027\u51a0\u75c7\u5019\u7fa4\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7121\u4f5c\u70ba\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u4e8c\u91cd\u76f2\u691c\u8a66\u9a13\u3067\u3042\u308a\u3001\u30b3\u30eb\u30d2\u30c1\u30f30.5mg1\u65e51\u56de\u6295\u4e0e\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b1\uff1a1\u3067\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u7814\u7a76\u5bfe\u8c61\u96c6\u56e3 <\/b><\/p>\n<\/td>\n

\n

\u6162\u6027\u51a0\u75c7\u5019\u7fa4\u60a3\u80055522\u4f8b\u3002 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4e3b\u306a\u7814\u7a76\u5909\u6570<\/b><\/p>\n<\/td>\n

\n

\u3053\u306e\u8a66\u9a13\u3067\u306f\u3001\u4e00\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u5fc3\u8840\u7ba1\u6b7b\u3001\u81ea\u7136\u767a\u75c7\u5fc3\u7b4b\u6897\u585e\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u3001\u865a\u8840\u6027\u51a0\u8840\u884c\u518d\u5efa\u8853\u306e\u8907\u5408\u3001\u4e8c\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u5fc3\u8840\u7ba1\u6b7b\u3001\u81ea\u7136\u767a\u75c7\u5fc3\u7b4b\u6897\u585e\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u8907\u5408\u3068\u3057\u305f\u3002<\/span><\/p>\n

\u3053\u306e\u89e3\u6790\u306b\u306f\u3001\u3042\u3089\u3086\u308b\u539f\u56e0\u306b\u3088\u308b\u6b7b\u4ea1\u3068\u975e\u5fc3\u8840\u7ba1\u6b7b\u3068\u3044\u3046\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3082\u542b\u307e\u308c\u305f\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u65b9\u6cd5<\/b><\/p>\n<\/td>\n

\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u30ea\u30b9\u30af\u306e\u5c64\u5225\u5316\u306b\u306f2\u3064\u306e\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\u304c\u7528\u3044\u3089\u308c\u305f\u3002\u6700\u521d\u306e\u30b9\u30b3\u30a2\u306fLoDoCo2\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\uff08LoDoCo2\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\uff09\u306b\u57fa\u3065\u304f\u3082\u306e\u3067\u3001\u6587\u732e\u3067\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3068\u306e\u95a2\u9023\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3059\u3079\u3066\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u7279\u6027\u3092\u542b\u3093\u3067\u3044\u305f\u3002\u6cbb\u7642\u5272\u308a\u4ed8\u3051\uff0c\u5e74\u9f62\u226775\u6b73\uff0c\u6027\u5225\uff0c\u73fe\u5728\u55ab\u7159\u8005\uff0c\u9ad8\u8840\u5727\uff0c\u7cd6\u5c3f\u75c5\uff0c\u75db\u98a8\u306e\u65e2\u5f80\uff0c\u63a8\u5b9a\u7cf8\u7403\u4f53\u6ffe\u904e\u91cf<60 mL\/\u5206\/1.73m2\u3002 <\/span>2<\/span>\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u306e\u65e2\u5f80\u3001\u51a0\u8840\u884c\u518d\u5efa\u8853\u306e\u65e2\u5f80\u3001\u5fc3\u623f\u7d30\u52d5\u306e\u65e2\u5f80\u304c\u3053\u306e\u30e2\u30c7\u30eb\u306b\u542b\u307e\u308c\u305f\u3002Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention\uff08TRS 2\u00b0P\uff09\u306f2\u756a\u76ee\u306e\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\u3067\u3042\u308a\u3001\u7d50\u679c\u306e\u9811\u5065\u6027\u3092\u691c\u8a0e\u3059\u308b\u305f\u3081\u306b\u7528\u3044\u3089\u308c\u305f\u3002\u3053\u306e\u30b9\u30b3\u30a2\u306b\u306f\u3001\u3046\u3063\u8840\u6027\u5fc3\u4e0d\u5168\u3001\u9ad8\u8840\u5727\u300175\u6b73\u4ee5\u4e0a\u3001\u7cd6\u5c3f\u75c5\u3001\u8133\u5352\u4e2d\u306e\u65e2\u5f80\u3001\u51a0\u52d5\u8108\u30d0\u30a4\u30d1\u30b9\u8853\u306e\u65e2\u5f80\u3001\u672b\u68a2\u52d5\u8108\u75be\u60a3\u3001\u63a8\u7b97\u7cf8\u7403\u4f53\u6ffe\u904e\u91cf<60 mL\/\u5206\/1.73 m <\/span>2<\/span>\u55ab\u7159\u8005\uff1a\u305f\u3060\u3057\u3001\u8133\u5352\u4e2d\u3001\u3046\u3063\u8840\u6027\u5fc3\u4e0d\u5168\u3001\u672b\u68a2\u52d5\u8108\u75be\u60a3\u306e\u65e2\u5f80\u306b\u95a2\u3059\u308b\u30c7\u30fc\u30bf\u306fLoDoCo2\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306b\u306f\u53ce\u96c6\u3055\u308c\u3066\u3044\u306a\u3044\u3002 <\/span> <\/p>\n<\/td>\n<\/tr>\n

\n

\u4e3b\u306a\u7d50\u679c<\/b><\/p>\n<\/td>\n

\n

LoDoCo2\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\u3067\u306f\u3001\u9ad8\u30ea\u30b9\u30af\u306e\u7279\u5fb4\u306f75\u6b73\u4ee5\u4e0a\u3001\u7cd6\u5c3f\u75c5\u3001\u55ab\u7159\u8005\u3067\u3042\u3063\u305f\u3002\u3053\u308c\u3089\u306e\u7279\u5fb4\u3092\u5c11\u306a\u304f\u3068\u30821\u3064\u6709\u3059\u308b\u60a3\u8005\u306f\u9ad8\u30ea\u30b9\u30af\u306b\u5206\u985e\u3055\u308c\u3001\u3053\u308c\u3089\u306e\u7279\u5fb4\u306e\u306a\u3044\u60a3\u8005\u306f\u4f4e\u30ea\u30b9\u30af\u306b\u5206\u985e\u3055\u308c\u305f\u3002TRS 2\u00b0P\u30b9\u30b3\u30a2\u3067\u306f\u3001\u9ad8\u30ea\u30b9\u30af\u306f2\u3064\u4ee5\u4e0a\u306e\u30ea\u30b9\u30af\u7279\u5fb4\u3092\u6709\u3059\u308b\u3082\u306e\u3001\u4e2d\u30ea\u30b9\u30af\u306f1\u3064\u306e\u30ea\u30b9\u30af\u7279\u5fb4\u3092\u6709\u3059\u308b\u3082\u306e\u3001\u4f4e\u30ea\u30b9\u30af\u306f\u30ea\u30b9\u30af\u7279\u5fb4\u3092\u6709\u3057\u306a\u3044\u3082\u306e\u3068\u5b9a\u7fa9\u3055\u308c\u305f\u3002\u3044\u305a\u308c\u306e\u30b9\u30b3\u30a2\u3092\u7528\u3044\u305f\u89e3\u6790\u3067\u3082\u3001\u30b3\u30eb\u30d2\u30c1\u30f3\u6cbb\u7642\u306e\u76f8\u5bfe\u7684\u30fb\u7d76\u5bfe\u7684\u6709\u76ca\u6027\u306f\u30ea\u30b9\u30af\u306e\u30b9\u30da\u30af\u30c8\u30eb\u306b\u304b\u304b\u308f\u3089\u305a\u4e00\u8cab\u3057\u3066\u3044\u305f( <\/span>\u88681<\/b>). \u6cbb\u7642\u5fc5\u8981\u6570\uff08NNT\uff09\u306f\u3001LoDoCo2\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\u3092\u7528\u3044\u305f\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306731\u3001\u4f4e\u30ea\u30b9\u30af\u60a3\u8005\u306743\u3001TRS 2\u00b0P\u3092\u7528\u3044\u305f\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u3068\u4f4e\u30ea\u30b9\u30af\u60a3\u8005\u306741\u3067\u3042\u3063\u305f\u3002<\/span><\/p>\n<\/p>\n

\u88681<\/b>. \u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u30ea\u30b9\u30af\u5225\u306b\u5206\u985e\u3057\u305f\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306b\u5bfe\u3059\u308b\u30b3\u30eb\u30d2\u30c1\u30f3\u6cbb\u7642\u306e\u52b9\u679c <\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n\n

\u30cf\u30b6\u30fc\u30c9\u6bd4 <\/span><\/p>\n

(95% CI)<\/span><\/p>\n<\/td>\n

\n

\u7d76\u5bfe\u30ea\u30b9\u30af\u6e1b\u5c11\u3001NNT<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

LoDoCo2\u30b9\u30b3\u30a2<\/b><\/p>\n<\/td>\n

<\/td>\n<\/td>\n<\/tr>\n
\n

\u30cf\u30a4\u30ea\u30b9\u30af<\/span><\/p>\n<\/td>\n

\n

0.72 <\/span><\/p>\n

(0.56-0.94)<\/span><\/p>\n<\/td>\n

\n

3.3%\u3001NNT=31<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u30ed\u30fc\u30ea\u30b9\u30af<\/span><\/p>\n<\/td>\n

\n

0.67 <\/span><\/p>\n

(0.52-0.88)<\/span><\/p>\n<\/td>\n

\n

2.4\uff05\u3001NNT=43<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u76f8\u4e92\u4f5c\u7528\u306e\u305f\u3081\u306eP <\/span><\/p>\n<\/td>\n

\n

0.73<\/span><\/p>\n<\/td>\n

<\/td>\n<\/tr>\n
\n

TRS 2\u00b0P\u30b9\u30b3\u30a2<\/b><\/p>\n<\/td>\n

<\/td>\n<\/td>\n<\/tr>\n
\n

\u30cf\u30a4\u30ea\u30b9\u30af<\/span><\/p>\n<\/td>\n

\n

0.79 (0.59-1.05)<\/span><\/p>\n<\/td>\n

\n

2.5%\u3001NNT=41<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4e2d\u9593\u30ea\u30b9\u30af<\/span><\/p>\n<\/td>\n

\n

0.65 (0.48-0.89)<\/span><\/p>\n<\/td>\n

\n

3.1%\u3001NNT=33<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u30ed\u30fc\u30ea\u30b9\u30af<\/span><\/p>\n<\/td>\n

\n

0.62 (0.41-0.94)<\/span><\/p>\n<\/td>\n

\n

2.5%\u3001NNT=41<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u76f8\u4e92\u4f5c\u7528\u306e\u305f\u3081\u306eP<\/span><\/p>\n<\/td>\n

\n

0.30<\/span><\/p>\n<\/td>\n

<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n
\n

\u8457\u8005\u306e\u7d50\u8ad6<\/b><\/p>\n<\/td>\n

\n

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\u30b3\u30e1\u30f3\u30c8<\/b><\/p>\n

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\u53c2\u8003\u6587\u732e<\/b><\/p>\n

    \n
  1. Ridker P, Bhatt D, Pradhan A, et al. \u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u60a3\u8005\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u4e88\u6e2c\u56e0\u5b50\u3068\u3057\u3066\u306e\u708e\u75c7\u3068\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff1a3\u3064\u306e\u7121\u4f5c\u70ba\u5316\u8a66\u9a13\u306e\u5171\u540c\u89e3\u6790\u3002Lancet 2023;401:1293-301. <\/span><\/li>\n
  2. \u6162\u6027\u51a0\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u30b3\u30eb\u30d2\u30c1\u30f3\u3002N Engl J Med 2020;383:1838-47. <\/span><\/li>\n
  3. Tardif JC, Kouz S, Waters D, et al. \u5fc3\u7b4b\u6897\u585e\u5f8c\u306e\u4f4e\u7528\u91cf\u30b3\u30eb\u30d2\u30c1\u30f3\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3002N Engl J Med 2019;381:2497-505. <\/span><\/li>\n
  4. Bittl JA, Maron DJ.\u5fc3\u8840\u7ba1\u533b\u7642\u306b\u304a\u3044\u3066\u4f55\u304c\u6709\u52b9\u304b\u3092\u78ba\u8a8d\u3059\u308b\u305f\u3081\u306b\u7d76\u5bfe\u30a4\u30d9\u30f3\u30c8\u7387\u3092\u4f7f\u7528\u3059\u308b\u3002J Am Coll Cardiol 2017;70:1376-8. <\/span><\/li>\n
  5. Marquis-Gravel G, Goodman S, Anderson T. et al. \u51a0\u52d5\u8108\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u30a2\u30c6\u30ed\u30fc\u30e0\u8840\u6813\u6027\u30a4\u30d9\u30f3\u30c8\u4e88\u9632\u306e\u305f\u3081\u306e\u30b3\u30eb\u30d2\u30c1\u30f3\uff1a\u81e8\u5e8a\u533b\u306e\u305f\u3081\u306e\u30ec\u30d3\u30e5\u30fc\u3068\u5b9f\u8df5\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u3002Can J Cardiol 2021;37:1837-45. <\/span><\/li>\n
  6. Visseren FLJ, Mach F, Smulders YM, et al. 2021 ESC guidelines on cardiovascular disease prevention in Clinical practice: developed by the task force for cardiovascular disease prevention in Clinical practice with representatives of the European Society of Cardiology and 12 medical societies with the special contribution of the European Association of Preventive Cardiology (EAPC).Eur Heart J 2021;42:3227-337. <\/span><\/li>\n
  7. Virani SS, Newby LK, Arnold SV, et al. 2023 AHA\/ACC\/ACCP\/ASPC\/NLA\/PCNA guideline for the Management of Patients with Chronic Coronary Disease: a report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical practice guidelines.Circulation 2023;148:e9-e119. <\/span><\/li>\n
  8. Nidorf SM\u3001Ben-Chetrit E\u3001Ridker PM\u3002\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306b\u5bfe\u3059\u308b\u4f4e\u7528\u91cf\u30b3\u30eb\u30d2\u30c1\u30f3\uff1a\u9577\u671f\u5b89\u5168\u6027\u3002Eur Heart J 2024;45:ehae208. <\/span><\/li>\n
  9. \u30aa\u30e9\u30f3\u30c0\u306e\u6162\u6027\u51a0\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u4f4e\u7528\u91cf\u30b3\u30eb\u30d2\u30c1\u30f3\u306e\u8cbb\u7528\u5bfe\u52b9\u679c\u3002Eur Heart J Qual Care Clin Outcomes 2024;11:89-96. <\/span><\/li>\n<\/ol>\n

    \u30ad\u30fc\u30ef\u30fc\u30c9\u30b3\u30eb\u30d2\u30c1\u30f3\uff1bLoDoCo 2\u8a66\u9a13\uff1b\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\uff1b\u76f8\u5bfe\u7684\u304a\u3088\u3073\u7d76\u5bfe\u7684\u81e8\u5e8a\u52b9\u679c<\/span><\/i><\/p>\n<\/div>\n<\/div>\n

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