{"id":257427,"date":"2025-11-18T19:01:48","date_gmt":"2025-11-18T18:01:48","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-reduce-it%ef%bc%9a%e3%82%a4%e3%82%b3%e3%82%b5%e3%83%9a%e3%83%b3%e3%83%88%e3%82%a8%e3%83%81%e3%83%ab%e3%81%af%e4%bd%8eldl-c%e3%81%a7%e3%82%82\/"},"modified":"2026-03-05T18:01:59","modified_gmt":"2026-03-05T17:01:59","slug":"%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-reduce-it%ef%bc%9a%e3%82%a4%e3%82%b3%e3%82%b5%e3%83%9a%e3%83%b3%e3%83%88%e3%82%a8%e3%83%81%e3%83%ab%e3%81%af%e4%bd%8eldl-c%e3%81%a7%e3%82%82","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-reduce-it%ef%bc%9a%e3%82%a4%e3%82%b3%e3%82%b5%e3%83%9a%e3%83%b3%e3%83%88%e3%82%a8%e3%83%81%e3%83%ab%e3%81%af%e4%bd%8eldl-c%e3%81%a7%e3%82%82\/","title":{"rendered":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af – REDUCE-IT\uff1a\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306f\u4f4eLDL-C\u3067\u3082\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]<\/p>\n

REDUCE-IT\uff1a\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306f\u4f4eLDL-C\u3067\u3082\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b<\/h2>\n

2025\u5e748\u6708<\/span><\/h5>\n
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\u3053\u306eREDUCE-IT\u306e\u89e3\u6790\u3067\u306f\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306e\u9ad8\u7528\u91cf\u6295\u4e0e\u306b\u3088\u308a\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u304c\u9ad8\u5024\u306e\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u305f\u3068\u3048\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u63a8\u5968\u76ee\u6a19\u5024\u4ee5\u4e0b\u3067\u3042\u3063\u3066\u3082\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u304c34\uff05\u6e1b\u5c11\u3057\u305f\u3002<\/em><\/p>\n

Aggarwal R, Bhatt DL, Steg PG, et al. Cardiovascular outcomes with icosapent ethyl by baseline low-density lipoprotein cholesterol: a secondary analysis of the REDUCE-IT randomized trial. J Am Heart Assoc. 2025;14(5):e038656. <\/em><\/p>\n

<\/em><\/p>\n

\u7814\u7a76\u6982\u8981<\/strong><\/p>\n\n\n\n\n\n\n\n
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\u76ee\u7684<\/strong><\/p>\n<\/td>\n

\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u3067\u5c64\u5225\u5316\u3057\u305f\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u6291\u5236\u306b\u5bfe\u3059\u308bicosapent ethyl\u306e\u6709\u52b9\u6027\u3092\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u691c\u8a0e\u3059\u308b\u3053\u3068\u3002<\/p>\n

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\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/strong><\/p>\n<\/td>\n

\n

REDUCE-IT\uff08Reduction of Cardiovascular Events With Icosapent Ethyl-Intervention Trial\uff09\u306f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u8005\uff0845\u6b73\u4ee5\u4e0a\u3067\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3059\u308b\u60a3\u8005\u3001\u307e\u305f\u306f50\u6b73\u4ee5\u4e0a\u3067\u7cd6\u5c3f\u75c5\u3092\u6709\u30571\u3064\u4ee5\u4e0a\u306e\u5fc3\u8840\u7ba1\u5371\u967a\u56e0\u5b50\u3092\u6709\u3059\u308b\u60a3\u8005\uff09\u3092\u5bfe\u8c61\u3068\u3057\u305f\u4e8c\u91cd\u76f2\u691c\u7121\u4f5c\u70ba\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3067\u3042\u308b\u3002\u60a3\u8005\u306f\u5c11\u306a\u304f\u3068\u30824\u9031\u9593\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u3066\u304a\u308a\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u304c135\u301c499mg\/dL\u3001LDL-C\u5024\u304c41\u301c100mg\/dL\u3067\u3042\u308b\u3053\u3068\u304c\u5fc5\u8981\u3067\u3042\u3063\u305f\u3002\u5bfe\u8c61\u60a3\u8005\u306f\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\uff082g\u30011\u65e52\u56de\uff09\u3068\u30d7\u30e9\u30bb\u30dc\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002\u672c\u5831\u544a\u306fREDUCE-IT\u306e\u4e8b\u5f8c\u4e8c\u6b21\u89e3\u6790\u306b\u3064\u3044\u3066\u8ff0\u3079\u305f\u3082\u306e\u3067\u3042\u308b\u3002 <\/p>\n

 <\/p>\n<\/td>\n

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 <\/p>\n<\/td>\n<\/tr>\n

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\u4e3b\u306a\u7814\u7a76\u5909\u6570<\/strong><\/p>\n

<\/strong><\/p>\n<\/td>\n

\n

\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u3001\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u7684\u5fc3\u7b4b\u6897\u585e\u3001\u975e\u81f4\u6b7b\u7684\u8133\u5352\u4e2d\u3001\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u3001\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u306e\u8907\u5408\u3067\u3042\u3063\u305f\u3002<\/p>\n

 <\/p>\n<\/td>\n

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 <\/p>\n<\/td>\n<\/tr>\n

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\u65b9\u6cd5<\/strong><\/p>\n<\/td>\n

\n

\u60a3\u8005\u306f\u3001\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u63a8\u5968\u3055\u308c\u3066\u3044\u308b\u8d85\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306eLDL-C\u76ee\u6a19\u5024\u306b\u5f93\u3063\u3066\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLDL-C\uff08<55mg\/dL\u307e\u305f\u306f\u226755mg\/dL\uff09\u306b\u3088\u3063\u3066\u5c64\u5225\u5316\u3055\u308c\u305f\u3002\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08HR\uff09\u306895\uff05\u4fe1\u983c\u533a\u9593\uff08CI\uff09\u306fCox\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u3001\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u305ficosapent ethyl\u306e\u4f7f\u7528\u306b\u3088\u308b\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u3092\u6c7a\u5b9a\u3057\u305f\u3002\u30e2\u30c7\u30eb\u306b\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLDL-C\u7fa4\u3068\u6cbb\u7642\u7fa4\u3068\u306e\u4ea4\u4e92\u4f5c\u7528\u9805\u304c\u542b\u307e\u308c\u3066\u3044\u305f\u3002 <\/p>\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u4e3b\u306a\u7d50\u679c<\/strong><\/p>\n<\/td>\n

\n

\u7814\u7a76\u5bfe\u8c61\u306f8175\u4f8b\u3067\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLDL-C\u304c55mg\/dL\u4ee5\u4e0a\u306e\u60a3\u8005\u306f7117\u4f8b\uff0887.1\uff05\uff09\u3001LDL-C<55mg\/dL\u306e\u60a3\u8005\u306f1058\u4f8b\uff0812.9\uff05\uff09\u3067\u3042\u3063\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u7279\u5fb4\u306f\u8868<\/strong>1\u306b\u307e\u3068\u3081\u3089\u308c\u3066\u3044\u308b\u3002 <\/p>\n

 <\/p>\n

 <\/p>\n

\u88681. \u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u7279\u5fb4\u3092\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3LDL-C\u7fa4\u5225\u306b\u5c64\u5225\u5316\u3057\u305f\u3002 <\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

 <\/p>\n<\/td>\n

\n

LDL-C 55mg\/dL\u4ee5\u4e0a<\/p>\n

(n=7117)<\/p>\n<\/td>\n

\n

LDL-C<55 mg\/dL<\/p>\n

(n=1058)<\/p>\n<\/td>\n<\/tr>\n

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 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u5e74\u9f62\u4e2d\u592e\u5024\uff08\u56db\u5206\u4f4d\u7bc4\u56f2\u3001IQR\uff09\u3001\u6b73<\/p>\n<\/td>\n

\n

64.0 (57.0-69.0)<\/p>\n<\/td>\n

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64.0 (58.0-70.0)<\/p>\n<\/td>\n<\/tr>\n

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\u5e74\u9f62\u226765\u6b73\u3001n (%)<\/p>\n<\/td>\n

\n

3241 (45.5)<\/p>\n<\/td>\n

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521 (49.2)<\/p>\n<\/td>\n<\/tr>\n

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\u5973\u6027, n (%)<\/p>\n<\/td>\n

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2091 (29.4)<\/p>\n<\/td>\n

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265 (25.0)<\/p>\n<\/td>\n<\/tr>\n

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 <\/p>\n<\/td>\n

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 <\/p>\n<\/td>\n

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 <\/p>\n<\/td>\n<\/tr>\n

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\u4e8c\u6b21\u4e88\u9632, n (%)<\/p>\n<\/td>\n

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5055 (71.0)<\/p>\n<\/td>\n

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726 (68.6)<\/p>\n<\/td>\n<\/tr>\n

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2\u578b\u7cd6\u5c3f\u75c5, n (%)<\/p>\n<\/td>\n

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4042 (56.8)<\/p>\n<\/td>\n

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684 (64.7)<\/p>\n<\/td>\n<\/tr>\n

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\u9ad8\u5f37\u5ea6\u30b9\u30bf\u30c1\u30f3, n (%)<\/p>\n<\/td>\n

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2155 (30.3)<\/p>\n<\/td>\n

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359 (33.9)<\/p>\n<\/td>\n<\/tr>\n

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 <\/p>\n<\/td>\n

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 <\/p>\n<\/td>\n

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 <\/p>\n<\/td>\n<\/tr>\n

\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08mg\/dL\uff09\u3001\u4e2d\u592e\u5024\uff08IQR\uff09<\/p>\n<\/td>\n

\n

215.5 (175.0-270.0)<\/p>\n<\/td>\n

\n

228.0 (182.0-300.5)<\/p>\n<\/td>\n<\/tr>\n

\n

\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u2267200mg\/dL\u3001HDL-C\u226635mg\/dL\u3001n\uff08\uff05\uff09\u3002<\/p>\n<\/td>\n

\n

1302 (18.3)<\/p>\n<\/td>\n

\n

315 (29.8)<\/p>\n<\/td>\n<\/tr>\n

\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3LDL-C\uff08mg\/dL\uff09\u3001\u4e2d\u592e\u5024\uff08IQR\uff09<\/p>\n<\/td>\n

\n

78.0 (67.0-91.0)<\/p>\n<\/td>\n

\n

47.5 (42.0-52.0)<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u6cbb\u7642\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLDL-C\u304c55mg\/dL\u4ee5\u4e0a\u307e\u305f\u306fLDL-C<55mg\/dL\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3082\u540c\u69d8\u306b\u6709\u52b9\u3067\u3042\u3063\u305f\u3002LDL-C<55mg\/dL\u306e\u60a3\u8005\u3067\u306f\u3001\u4e3b\u8981\u8907\u5408\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u304c34\uff05\u6e1b\u5c11\u3057\u305f\uff08\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u6295\u4e0e\u7fa416.2\uff05 vs \u30d7\u30e9\u30bb\u30dc\u7fa422.8\uff05\u3001HR 0.66 [95\uff05 CI, 0.50-0.87]\uff09\u3002\u7d76\u5bfe\u30ea\u30b9\u30af\u6e1b\u5c11\uff08ARR\uff09\u306f6.6\uff05\u3001\u6cbb\u7642\u5fc5\u8981\u6570\uff08NNT\uff09\u306f15\u3067\u3042\u3063\u305f\uff08p=0.003\uff09\u3002LDL-C\u304c55mg\/dL\u4ee5\u4e0a\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3082\uff0817.4\uff05 vs \u30d7\u30e9\u30bb\u30dc21.9\uff05\u3001HR 0.76\uff3b95\uff05CI\u30010.69-0.85\uff3d\uff09\u3001\u540c\u69d8\u306e\u76f8\u5bfe\u7684\u30fb\u7d76\u5bfe\u7684\u30ea\u30b9\u30af\u4f4e\u4e0b\u304c\u89b3\u5bdf\u3055\u308c\u3001ARR\u306f4.5\uff05\u3001NNT\u306f22\u3067\u3042\u3063\u305f\uff08p<0.0001\uff09\u3002 <\/p>\n

 <\/p>\n

\u78ba\u7acb\u3057\u305f\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3059\u308b\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306e\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306b\u304a\u3051\u308b\u76f8\u5bfe\u7684\u30fb\u7d76\u5bfe\u7684\u30ea\u30b9\u30af\u4f4e\u4e0b\u306f\u3001LDL-C<55mg\/dL\u306e\u60a3\u8005\uff08HR 0.56 [95% CI 0.41-0.77]\u3001ARR 11.6\uff05\u3001p=0.0002\uff09\u306b\u304a\u3044\u3066\u3001LDL-C\u226755mg\/dL\u306e\u60a3\u8005\uff08HR 0.75 [95% CI 0.67-0.85]\u3001ARR 5.4\uff05\u3001p<0.0001\uff09\u3088\u308a\u3082\u6570\u5024\u7684\u306b\u9855\u8457\u3067\u3042\u3063\u305f\u3002<\/p>\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u8457\u8005\u306e\u7d50\u8ad6<\/strong><\/p>\n<\/td>\n

\n

\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u305f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u9ad8\u5024\u3067\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLDL-C\u306b\u304b\u304b\u308f\u3089\u305a\u5fc3\u8840\u7ba1\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u767a\u751f\u7387\u3092\u4f4e\u4e0b\u3055\u305b\u305f\u3002<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

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 <\/p>\n

\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

    \n
  1. \u8102\u8cea\u7570\u5e38\u75c7\u306e\u7ba1\u7406\u306b\u95a2\u3059\u308b2019\u5e74ESC\/EAS\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\uff1a\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u6e1b\u306e\u305f\u3081\u306e\u8102\u8cea\u4fee\u98fe\uff1a\u6b27\u5dde\u5fc3\u81d3\u75c5\u5b66\u4f1a\uff08ESC\uff09\u306e\u8102\u8cea\u7570\u5e38\u75c7\u7ba1\u7406\u30bf\u30b9\u30af\u30d5\u30a9\u30fc\u30b9\u3068EAS\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3<\/li>\n<\/ol>\n

    \u6b27\u5dde\u52d5\u8108\u786c\u5316\u5b66\u4f1a\uff08EAS\uff09\u3002Eur Heart J 2020;41:111-88. <\/p>\n

      \n
    1. Lloyd- Jones DM, Morris PB, Ballantyne CM, et al. ACC expert consensus decision pathway on role of nonstatin therapies for LDL-cholesterol lowering in management of atherosclerotic cardiovascular disease risk: a report of the American College of Cardiology Solution set Oversight Committee.J Am Coll Cardiol 2022;80:1366-418. <\/li>\n
    2. Bhatt DL\u3001Steg PG\u3001Miller M\u3001\u4ed6\uff1a\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4e09\u5206\u4f4d\u3092\u8d85\u3048\u305f\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u521d\u56de\u304a\u3088\u3073\u5168\u865a\u8840\u30a4\u30d9\u30f3\u30c8\u306e\u6e1b\u5c11\u3002J Am Coll Cardiol 2019;74:1159-61. <\/li>\n
    3. \u30e1\u30a4\u30bd\u30f3RP\u3001\u30ea\u30d3\u30fcP\u3001\u30d0\u30c3\u30c8DL\u3002\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\u306e\u5fc3\u8840\u7ba1\u4fdd\u8b77\u306b\u95a2\u3059\u308b\u65b0\u305f\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3002Arterioscler Thromb Vasc Biol 2020;40:1135-47. <\/li>\n
    4. Sherratt SCR, Libby P, Budoff MJ, et al. \u5fc3\u8840\u7ba1\u7cfb\u75be\u60a3\u306b\u304a\u3051\u308b\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u306e\u5f79\u5272\uff1a\u8b70\u8ad6\u306f\u7d9a\u304f\u3002Curr Atheroscler Rep 2023;25:1-17. <\/li>\n
    5. \u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306b\u3088\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4f4e\u4e0b\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3002N Engl J Med 2022;387:1923-34. <\/li>\n
    6. Nicholls SJ, Lincoff AM, Garcia M, et al. \u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u8005\u306b\u304a\u3051\u308b\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306b\u5bfe\u3059\u308b\u9ad8\u7528\u91cf\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u5bfe\u30b3\u30fc\u30f3\u6cb9\u306e\u52b9\u679c\uff1aSTRENGTH\u7121\u4f5c\u70ba\u5316\u81e8\u5e8a\u8a66\u9a13\u3002JAMA 2020;324:2268-80. <\/li>\n
    7. Gaba P, Bhatt DL, Boden WE.\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3068\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306b\u5bfe\u3059\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\uff1a\u6cbb\u7642\u4f7f\u7528\u5897\u52a0\u306e\u305f\u3081\u306e\u3088\u308a\u5927\u304d\u306aRESPECT\u3002Eur Heart J 2023;45:ehad668. <\/li>\n
    8. Rallidis LS, Tsamoulis D, Papathanasiou KA, et al. \u6025\u6027\u51a0\u75c7\u5019\u7fa4\u5f8c1-3\u30f5\u6708\u306b\u304a\u3051\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306e\u6295\u4e0e\u9069\u683c\u6027\u3068\u5fc3\u7b4b\u6897\u585e\u306e\u518d\u767a\u30ea\u30b9\u30af\uff1aCALLINICUS-Hellas Registry\u306e\u30c7\u30fc\u30bf\u3002Int J Cardiol 2025; 440: 133684\u3002 <\/li>\n<\/ol>\n

      \u30ad\u30fc\u30ef\u30fc\u30c9REDUCE-IT\uff0c\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\uff0c\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff1b<\/em><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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