{"id":257410,"date":"2025-09-12T16:43:01","date_gmt":"2025-09-12T14:43:01","guid":{"rendered":"https:\/\/r3i.org\/%e7%94%bb%e6%9c%9f%e7%9a%84-strength%e8%a9%a6%e9%a8%93%e3%81%af%e3%82%a2%e3%82%b8%e3%82%a2%e4%ba%ba%e6%82%a3%e8%80%85%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e6%9c%89%e7%9b%8a%e6%80%a7%e3%82%92%e7%a4%ba\/"},"modified":"2026-03-05T18:00:54","modified_gmt":"2026-03-05T17:00:54","slug":"%e7%94%bb%e6%9c%9f%e7%9a%84-strength%e8%a9%a6%e9%a8%93%e3%81%af%e3%82%a2%e3%82%b8%e3%82%a2%e4%ba%ba%e6%82%a3%e8%80%85%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e6%9c%89%e7%9b%8a%e6%80%a7%e3%82%92%e7%a4%ba","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e7%94%bb%e6%9c%9f%e7%9a%84-strength%e8%a9%a6%e9%a8%93%e3%81%af%e3%82%a2%e3%82%b8%e3%82%a2%e4%ba%ba%e6%82%a3%e8%80%85%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e6%9c%89%e7%9b%8a%e6%80%a7%e3%82%92%e7%a4%ba\/","title":{"rendered":"\u753b\u671f\u7684 – STRENGTH\u8a66\u9a13\u306f\u30a2\u30b8\u30a2\u4eba\u60a3\u8005\u306b\u304a\u3051\u308b\u6709\u76ca\u6027\u3092\u793a\u5506"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]<\/p>\n

STRENGTH\u8a66\u9a13\u306f\u30a2\u30b8\u30a2\u4eba\u60a3\u8005\u306b\u304a\u3051\u308b\u6709\u76ca\u6027\u3092\u793a\u5506<\/strong><\/h3>\n
2025\u5e749\u6708<\/strong><\/h5>\n

\u4e2d\u7acb\u7684\u306aSTRENGTH\u8a66\u9a13\u306e\u63a2\u7d22\u7684\u89e3\u6790\u306b\u3088\u308b\u3068\u3001\u30aa\u30e1\u30ac-3\uff08\u03c9-3\uff09\u30ab\u30eb\u30dc\u30f3\u9178\u88fd\u5264\u306b\u3088\u308b\u6cbb\u7642\u306f\u3001\u30a2\u30b8\u30a2\u4eba\u60a3\u8005\u306b\u304a\u3051\u308b\u4e3b\u8981\u306a\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u6709\u610f\u306a\u6e1b\u5c11\u306b\u95a2\u9023\u3057\u305f\u304c\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u975e\u30a2\u30b8\u30a2\u4eba\u60a3\u8005\u3067\u306f\u95a2\u9023\u3057\u306a\u304b\u3063\u305f\u3002<\/em><\/p>\n

Wang TKM, Nicholls SJ, St John J, et al. Differential cardiovascular impact of \u03c9-3 fatty acid in patients at high cardiovascular risk in Asians versus non-Asians: Sub-analysis of the STRENGTH randomized clinical trial. Atherosclerosis 2025; <\/em> https:\/\/doi.org\/10.1016\/j.atherosclerosis.2025.120228<\/a>.
\n <\/em><\/p>\n

<\/em><\/p>\n

\u7814\u7a76\u6982\u8981<\/strong><\/p>\n\n\n\n\n\n\n\n\n
\n

\u76ee\u7684<\/strong><\/p>\n<\/td>\n

\n

STRENGTH\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u30a2\u30b8\u30a2\u4eba\u3068\u975e\u30a2\u30b8\u30a2\u4eba\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u03c9-3\u30ab\u30eb\u30dc\u30f3\u9178\uff08CA\uff09\u6295\u4e0e\u3068\u30b3\u30fc\u30f3\u6cb9\u30d7\u30e9\u30bb\u30dc\u6295\u4e0e\u3068\u306e\u5fc3\u8840\u7ba1\u8ee2\u5e30\u3092\u6bd4\u8f03\u3059\u308b\u3053\u3068\u3002<\/p>\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/strong><\/p>\n<\/td>\n

\n

STRENGTH\u8a66\u9a13\u306f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7121\u4f5c\u70ba\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u4e8c\u91cd\u76f2\u691c\u8a66\u9a13\u3067\u3042\u308a\u3001\u4e8c\u6b21\u4e88\u9632\uff0850\uff05\u4ee5\u4e0a\uff09\u307e\u305f\u306f\u4e00\u6b21\u4e88\u9632\u306e\u3044\u305a\u308c\u304b\u3092\u76ee\u7684\u3068\u3057\u305f\u3001\u6700\u5927\u8010\u5bb9\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\u30924\u9031\u9593\u4ee5\u4e0a\u53d7\u3051\u3066\u3044\u308b\u304b\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09<100mg\/dL\u3001\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08HDL-C\uff09<42mg\/dL\uff08\u7537\u6027\uff09\u3001<47mg\/dL\uff08\u5973\u6027\uff09\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9180-500mg\/dL\u3092\u6709\u3059\u308b\u60a3\u8005\u3002\u60a3\u8005\u306f1\uff1a1\u3067\u7121\u4f5c\u70ba\u306b4g\/\u65e5\u306e\u03c9-3CA\u307e\u305f\u306f\u30b3\u30fc\u30f3\u6cb9\u306e\u6295\u4e0e\u7fa4\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u3001\u6700\u9577\u30675\u5e74\u9593\u6295\u4e0e\u3055\u308c\u305f\u3002\u672c\u8a66\u9a13\u306f\u3001\u30b3\u30fc\u30f3\u6cb9\u306b\u5bfe\u3059\u308b\u03c9-3CA\u306e\u81e8\u5e8a\u7684\u6709\u7528\u6027\u3092\u8a3c\u660e\u3059\u308b\u53ef\u80fd\u6027\u304c\u4f4e\u304b\u3063\u305f\u305f\u3081\u3001\u72ec\u7acb\u30c7\u30fc\u30bf\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u306e\u30ec\u30d3\u30e5\u30fc\u5f8c\u30012020\u5e741\u67088\u65e5\u306b\u4e2d\u6b62\u3055\u308c\u305f\uff08\u3053\u306e\u6642\u70b9\u3067\u5224\u5b9a\u3055\u308c\u305f\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f1384\u9805\u76ee\uff09\u3002\u4eca\u56de\u306e\u5831\u544a\u306f\u3001\u63a2\u7d22\u7684\u306a\u4e8b\u5f8c\u89e3\u6790\u3067\u3042\u308b\u3002 <\/p>\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u7814\u7a76\u5bfe\u8c61\u96c6\u56e3 <\/strong><\/p>\n<\/td>\n

\n

13,078\u4eba\u306e\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u8005\u304c\u767b\u9332\u3055\u308c\u305f\u3002\u4eca\u56de\u306epost hoc\u89e3\u6790\u306f\u30011355\u4f8b\u306e\u30a2\u30b8\u30a2\u4eba\u60a3\u8005\u306811723\u4f8b\u306e\u975e\u30a2\u30b8\u30a2\u4eba\u60a3\u8005\u306e\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u3066\u3044\u308b\u3002 <\/p>\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u4e3b\u306a\u7814\u7a76\u5909\u6570<\/strong><\/p>\n

<\/strong><\/p>\n<\/td>\n

\n

\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u3001\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08MACE\uff09\u306e5\u6bb5\u968e\u8907\u5408\u3001\u3059\u306a\u308f\u3061\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u7684\u5fc3\u7b4b\u6897\u585e\u3001\u975e\u81f4\u6b7b\u7684\u8133\u5352\u4e2d\u3001\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u3001\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u306b\u3088\u308b\u5165\u9662\u3067\u3042\u3063\u305f\u3002<\/p>\n

\u305d\u306e\u4ed6\u306e\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u30013\u8981\u7d20MACE\uff08\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u7684\u5fc3\u7b4b\u6897\u585e\u3001\u975e\u81f4\u6b7b\u7684\u8133\u5352\u4e2d\uff09\u30015\u8981\u7d20MACE\u306e\u5404\u8981\u7d20\u3001\u5168\u6b7b\u4ea1\u3067\u3042\u3063\u305f\u3002<\/p>\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u65b9\u6cd5<\/strong><\/p>\n<\/td>\n

\n

Cox\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u56de\u5e30\u5206\u6790\u3092\u7528\u3044\u3066\u3001\u30a2\u30b8\u30a2\u4eba\u3068\u975e\u30a2\u30b8\u30a2\u4eba\u306e\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u5185\u3067\u3001\u5fc3\u8840\u7ba1\u7cfb\u306e\u8ee2\u5e30\u306b\u5bfe\u3059\u308b\u03c9-3 CA\u3068\u30b3\u30fc\u30f3\u6cb9\u306e\u52b9\u679c\u3092\u6bd4\u8f03\u3057\u305f\u3002\u30a2\u30b8\u30a2\u4eba\u3068\u975e\u30a2\u30b8\u30a2\u4eba\u306e\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u306b\u304a\u3044\u3066\u3001\u03c9-3 CA\u3068\u30b3\u30fc\u30f3\u6cb9\u3092\u6bd4\u8f03\u3057\u30015\u70b9\u8907\u5408MACE\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u7d2f\u7a4d\u767a\u751f\u7387\u306b\u3064\u3044\u3066Kaplan-Meier\u751f\u5b58\u66f2\u7dda\u3092\u4f5c\u6210\u3057\u305f\u3002\u6cbb\u7642\u7fa4\u306flog-rank\u691c\u5b9a\u3092\u7528\u3044\u3066\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u5185\u3067\u6bd4\u8f03\u3055\u308c\u305f\u3002 <\/p>\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u4e3b\u306a\u7d50\u679c<\/strong><\/p>\n<\/td>\n

\n

\u3053\u306e2\u3064\u306e\u30b3\u30db\u30fc\u30c8\u306b\u306f\u3001\u30a2\u30b8\u30a2\u8af8\u56fd\uff3b\u4e2d\u56fd\uff08n =712\u300152.5\uff05\uff09\u3001\u65e5\u672c\uff08n =305\u300122.5\uff05\uff09\u3001\u97d3\u56fd\uff08n =133\u30019.8\uff05\uff09\u3001\u53f0\u6e7e\uff08n =59\u30014.4\uff05\uff09\uff3d\u306e\u60a3\u80051355\u4eba\u3068\u3001\u975e\u30a2\u30b8\u30a2\u8af8\u56fd\uff0891\uff05\u304c\u767d\u4eba\uff09\u306e\u60a3\u800511723\u4eba\u304c\u542b\u307e\u308c\u3066\u3044\u305f\u3002\u975e\u30a2\u30b8\u30a2\u7cfb\u60a3\u8005\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30a2\u30b8\u30a2\u7cfb\u60a3\u8005\u306f\u7537\u6027\u3001\u82e5\u5e74\u3001\u4f4e\u4f53\u91cd\u6307\u6570\u3001\u51a0\u52d5\u8108\u75be\u60a3\u304a\u3088\u3073\u8133\u8840\u7ba1\u75be\u60a3\u306e\u6709\u75c5\u7387\u304c\u9ad8\u304b\u3063\u305f\u304c\u3001\u5fc3\u8840\u7ba1\u5371\u967a\u56e0\u5b50\uff08\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u5727\u3001\u6162\u6027\u55ab\u7159\u3001\u3046\u3063\u8840\u6027\u5fc3\u4e0d\u5168\u306e\u65e2\u5f80\u3092\u542b\u3080\uff09\u306e\u6709\u75c5\u7387\u306f\u4f4e\u304b\u3063\u305f\u3002\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u5024\u3082\u30a2\u30b8\u30a2\u4eba\u3067\u306f\u975e\u30a2\u30b8\u30a2\u4eba\u3088\u308a\u3082\u4f4e\u304b\u3063\u305f\uff08\u88681\uff09\u3002 <\/p>\n

\u88681. \u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u8102\u8cea\u30681\u5e74\u5f8c\u306e\u5909\u5316\u7387 <\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

 <\/p>\n<\/td>\n

\n

\u975e\u30a2\u30b8\u30a2\u4eba<\/p>\n

(n=11,723)<\/p>\n<\/td>\n

\n

\u30a2\u30b8\u30a2<\/p>\n

(n=1355)<\/p>\n<\/td>\n

\n

p\u5024<\/p>\n<\/td>\n<\/tr>\n

\n

\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb(mg\/dL)<\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3<\/p>\n<\/td>\n

\n

168.8 \u00b1 42.6<\/p>\n<\/td>\n

\n

153.2 \u00b1 30.9<\/p>\n<\/td>\n

\n

<0.001<\/p>\n<\/td>\n<\/tr>\n

\n

\u5909\u5316\u7387 (\u03c9-3 CA)<\/p>\n<\/td>\n

\n

-0.7 \u00b1 25.3<\/p>\n<\/td>\n

\n

2.0 \u00b1 21.7<\/p>\n<\/td>\n

\n

0.01<\/p>\n<\/td>\n<\/tr>\n

\n

\u5909\u5316\u7387\uff08\u30b3\u30fc\u30f3\u6cb9\uff09<\/p>\n<\/td>\n

\n

2.8 \u00b1 25.5<\/p>\n<\/td>\n

\n

5.2 \u00b1 23.4<\/p>\n<\/td>\n

\n

0.02<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

LDL-C (mg\/dL)<\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3<\/p>\n<\/td>\n

\n

82.9 \u00b1 37.6<\/p>\n<\/td>\n

\n

67.8 \u00b1 27.4<\/p>\n<\/td>\n

\n

<0.001<\/p>\n<\/td>\n<\/tr>\n

\n

\u5909\u5316\u7387 (\u03c9-3 CA)<\/p>\n<\/td>\n

\n

9.8 \u00b1 53.9<\/p>\n<\/td>\n

\n

19.0 \u00b1 48.7<\/p>\n<\/td>\n

\n

<0.001<\/p>\n<\/td>\n<\/tr>\n

\n

\u5909\u5316\u7387\uff08\u30b3\u30fc\u30f3\u6cb9\uff09<\/p>\n<\/td>\n

\n

7.6 \u00b1 52.7<\/p>\n<\/td>\n

\n

12.4 \u00b1 45.8<\/p>\n<\/td>\n

\n

0.03<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u975eHDL-C\uff08mg\/dL\uff09<\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3<\/p>\n<\/td>\n

\n

133.2 \u00b1 41.3<\/p>\n<\/td>\n

\n

116.4 \u00b1 29.7<\/p>\n<\/td>\n

\n

<0.001<\/p>\n<\/td>\n<\/tr>\n

\n

\u5909\u5316\u7387 (\u03c9-3 CA)<\/p>\n<\/td>\n

\n

-2.2 \u00b1 33.1<\/p>\n<\/td>\n

\n

2.1 \u00b1 28.4<\/p>\n<\/td>\n

\n

0.002<\/p>\n<\/td>\n<\/tr>\n

\n

\u5909\u5316\u7387\uff08\u30b3\u30fc\u30f3\u6cb9\uff09<\/p>\n<\/td>\n

\n

2.5 \u00b1 33.9<\/p>\n<\/td>\n

\n

6.9 \u00b1 31.8<\/p>\n<\/td>\n

\n

0.003<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9(mg\/dL)<\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3<\/p>\n<\/td>\n

\n

240 (192,309)<\/p>\n<\/td>\n

\n

236 (186,304)<\/p>\n<\/td>\n

\n

0.03<\/p>\n<\/td>\n<\/tr>\n

\n

\u5909\u5316\u7387 (\u03c9-3 CA)<\/p>\n<\/td>\n

\n

– 18.9 (-39.1,6.1)<\/p>\n<\/td>\n

\n

– 19.7 (-39.4,9.2)<\/p>\n<\/td>\n

\n

0.70<\/p>\n<\/td>\n<\/tr>\n

\n

\u5909\u5316\u7387\uff08\u30b3\u30fc\u30f3\u6cb9\uff09<\/p>\n<\/td>\n

\n

– 1.0 (-25.4,27.4)<\/p>\n<\/td>\n

\n

1.2 (-21.6,31.2)<\/p>\n<\/td>\n

\n

0.05<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

ApoB100\uff08\u00b5g\/mL\uff09<\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3<\/p>\n<\/td>\n

\n

617.1 \u00b1 256.5<\/p>\n<\/td>\n

\n

511.5 \u00b1 209.6<\/p>\n<\/td>\n

\n

<0.001<\/p>\n<\/td>\n<\/tr>\n

\n

\u5909\u5316\u7387 (\u03c9-3 CA)<\/p>\n<\/td>\n

\n

7.6 \u00b1 58.8<\/p>\n<\/td>\n

\n

13.8 \u00b1 58.7<\/p>\n<\/td>\n

\n

0.01<\/p>\n<\/td>\n<\/tr>\n

\n

\u5909\u5316\u7387\uff08\u30b3\u30fc\u30f3\u6cb9\uff09<\/p>\n<\/td>\n

\n

7.6 \u00b1 57.3<\/p>\n<\/td>\n

\n

22.0 \u00b1 99.2<\/p>\n<\/td>\n

\n

<0.001<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u30c7\u30fc\u30bf\u306f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08\u4e2d\u592e\u5024\u3001\u56db\u5206\u4f4d\u7bc4\u56f2\uff09\u3092\u9664\u304d\u3001\u5e73\u5747\u5024\u00b1\u6a19\u6e96\u504f\u5dee\u3067\u793a\u3057\u305f\u3002<\/p>\n

 <\/p>\n

\u4e21\u30b3\u30db\u30fc\u30c8\u306b\u304a\u3044\u3066\u3001\u03c9-3 CA\u7fa4\u306b\u304a\u3051\u308b\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u30891\u5e74\u5f8c\u307e\u3067\u306e\u5909\u5316\u7387\u306f\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3067\u540c\u69d8\u306b19\u301c20\uff05\u306e\u6e1b\u5c11\u3092\u793a\u3057\u305f\uff08\u88681\uff09\u3002\u975e\u30a2\u30b8\u30a2\u4eba\u30b3\u30db\u30fc\u30c8\u3068\u6bd4\u8f03\u3059\u308b\u3068\u3001\u30a2\u30b8\u30a2\u4eba\u60a3\u8005\u3067\u306fLDL-C\u306e\u5897\u52a0\u304c\u5927\u304d\u304f\uff0819.0\uff05\u5bfe9.8\uff05\uff09\uff08\u88681\uff09\u3001HDL-C\u306e\u5897\u52a0\u306f\u5c0f\u3055\u304b\u3063\u305f\uff083.7\uff05\u5bfe9.0\uff05\uff09\u3002 <\/p>\n

 <\/p>\n

\u5e73\u5747\u8ffd\u8de1\u671f\u95933.6\u00b10.7\u5e74\u306e\u9593\u306b\u3001\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3067\u3042\u308b5\u70b9MACE\u306f\u30a2\u30b8\u30a2\u4eba\u30b3\u30db\u30fc\u30c8\u3067\u306f184\u4f8b\uff0817.5\uff05\uff09\u3001\u975e\u30a2\u30b8\u30a2\u4eba\u30b3\u30db\u30fc\u30c8\u3067\u306f1396\u4f8b\uff0815.7\uff05\uff09\u306b\u767a\u751f\u3057\u305f\u3002\u30a2\u30b8\u30a2\u4eba\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u03c9-3 CA\u6295\u4e0e\u306f\u8ffd\u8de1\u671f\u9593\u4e2d\u306e\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u767a\u751f\u7387\u3092\u6709\u610f\u306b\u4f4e\u4e0b\u3055\u305b\u305f\uff1a14.8\uff05\u5bfe\u30b3\u30fc\u30f3\u6cb9\u7fa420.4\uff05\uff08\u30cf\u30b6\u30fc\u30c9\u6bd40.72\u300195\uff05\u4fe1\u983c\u533a\u95930.54-0.96\u3001p =0.026\uff09\u3002\u975e\u30a2\u30b8\u30a2\u4eba\u3067\u306f\u30012\u3064\u306e\u6cbb\u7642\u7fa4\u9593\u3067\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u767a\u751f\u7387\u306b\u6709\u610f\u5dee\u306f\u306a\u304b\u3063\u305f\uff08\u88682<\/strong>\uff09\u3002\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e5\u70b9MACE\uff08p =0.021\uff09\u304a\u3088\u30733\u6210\u5206MACE\uff08p =0.02\uff09\u306b\u304a\u3044\u3066\u3001\u30a2\u30b8\u30a2\u4eba\u307e\u305f\u306f\u975e\u30a2\u30b8\u30a2\u4eba\u306e\u4eba\u7a2e\u3068\u03c9-3 CA\u304a\u3088\u3073\u30b3\u30fc\u30f3\u6cb9\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u6cbb\u7642\u5272\u308a\u4ed8\u3051\u3068\u306e\u9593\u306b\u6709\u610f\u306a\u76f8\u4e92\u4f5c\u7528\u304c\u89b3\u5bdf\u3055\u308c\u305f\u3002\u3053\u306e\u6709\u610f\u6027\u306f\u591a\u5909\u91cf\u30e2\u30c7\u30eb\u3067\u3082\u6301\u7d9a\u3057\u305f\uff08p=0.01\uff09\u3002 <\/p>\n

 <\/p>\n

\u88682.\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306b\u5bfe\u3059\u308b\u8a66\u9a13\u6cbb\u7642\u306e\u5f71\u97ff <\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

 <\/p>\n<\/td>\n

\n

\u975e\u30a2\u30b8\u30a2\u4eba<\/p>\n

(n=11,723)<\/p>\n<\/td>\n

\n

\u30a2\u30b8\u30a2<\/p>\n

(n=1355)<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

\u03c9-3 CA<\/p>\n<\/td>\n

\n

\u30b3\u30fc\u30f3\u6cb9<\/p>\n<\/td>\n

\n

\u03c9-3 CA<\/p>\n<\/td>\n

\n

\u30b3\u30fc\u30f3\u6cb9<\/p>\n<\/td>\n<\/tr>\n

\n

\u30a4\u30d9\u30f3\u30c8\u767a\u751f\u60a3\u8005\u6570<\/p>\n<\/td>\n<\/tr>\n

\n

5\u70b9MACE<\/p>\n<\/td>\n

\n

704 (15.6)<\/p>\n<\/td>\n

\n

692 (15.9)<\/p>\n<\/td>\n

\n

81 (14.8)<\/p>\n<\/td>\n

\n

103 (20.4)<\/p>\n<\/td>\n<\/tr>\n

\n

\u30cf\u30b6\u30fc\u30c9\u6bd4\uff0895\uff05CI\uff09<\/p>\n<\/td>\n

\n

1.03 (0.93-1.14)<\/p>\n<\/td>\n

\n

0.72 (0.54-0.96)<\/p>\n<\/td>\n<\/tr>\n

\n

p\u5024 \u30a2\u30b8\u30a2\u4eba vs \u975e\u30a2\u30b8\u30a2\u4eba<\/p>\n<\/td>\n

\n

0.021<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u30a4\u30d9\u30f3\u30c8\u767a\u751f\u60a3\u8005\u6570<\/p>\n<\/td>\n<\/tr>\n

\n

3\u30dd\u30a4\u30f3\u30c8MACE<\/p>\n<\/td>\n

\n

498 (11.4)<\/p>\n<\/td>\n

\n

458 (10.7)<\/p>\n<\/td>\n

\n

43 (8.0)<\/p>\n<\/td>\n

\n

59 (13.7)<\/p>\n<\/td>\n<\/tr>\n

\n

\u30cf\u30b6\u30fc\u30c9\u6bd4<\/p>\n<\/td>\n

\n

1.10 (0.97-1.25)<\/p>\n<\/td>\n

\n

0.67 (0.45-0.99)<\/p>\n<\/td>\n<\/tr>\n

\n

p\u5024 \u30a2\u30b8\u30a2\u4eba vs \u975e\u30a2\u30b8\u30a2\u4eba<\/p>\n<\/td>\n

\n

0.02<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

CI \u4fe1\u983c\u533a\u9593<\/p>\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u8457\u8005\u306e\u7d50\u8ad6<\/strong><\/p>\n<\/td>\n

\n

\u3053\u306e\u4e2d\u7acb\u7684\u306aSTRENGTH\u8a66\u9a13\u306e\u63a2\u7d22\u7684\u89e3\u6790\u3067\u306f\u3001\u03c9-3 CA\u306f\u30a2\u30b8\u30a2\u4eba\u306b\u304a\u3044\u3066\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u6709\u610f\u306a\u6e1b\u5c11\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u304c\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u975e\u30a2\u30b8\u30a2\u4eba\u60a3\u8005\u3067\u306f\u305d\u3046\u3067\u306f\u306a\u304b\u3063\u305f\u3002\u3053\u308c\u3089\u306e\u4eee\u8aac\u3092\u751f\u307f\u51fa\u3059\u77e5\u898b\u3092\u8a55\u4fa1\u3057\u3001\u30a2\u30b8\u30a2\u4eba\u306b\u304a\u3051\u308b\u03c9-3 CA\u306e\u6709\u76ca\u306a\u52b9\u679c\u306e\u6f5c\u5728\u7684\u306a\u6a5f\u5e8f\u3092\u89e3\u660e\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u3055\u3089\u306a\u308b\u3001\u7406\u60f3\u7684\u306b\u306f\u7121\u4f5c\u70ba\u5316\u3055\u308c\u305f\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002 <\/p>\n

 <\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/strong><\/p>\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305fSTRENGTH\u8a66\u9a13\u306e\u3053\u306epost hoc\u89e3\u6790\u3067\u306f\u3001\u30b3\u30fc\u30f3\u6cb9\u3068\u6bd4\u8f03\u3057\u3066\u3001\u03c9-3 CA\u306b\u3088\u308b\u6cbb\u7642\u306f\u30a2\u30b8\u30a2\u4eba\u60a3\u8005\u306b\u304a\u3044\u3066\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\uff085\u70b9\u8907\u5408MACE\uff09\u306e\u767a\u751f\u7387\u306e\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u305f\u304c\u3001\u975e\u30a2\u30b8\u30a2\u4eba\u60a3\u8005\u3067\u306f\u95a2\u9023\u3057\u306a\u304b\u3063\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u30dd\u30b9\u30c8\u30db\u30c3\u30af\u89e3\u6790\u7279\u6709\u306e\u9650\u754c\u3001\u30a2\u30b8\u30a2\u4eba\u30b3\u30db\u30fc\u30c8\u304c\u5168\u30b5\u30f3\u30d7\u30eb\u306e\u7d0410\uff05\u3067\u3042\u3063\u305f\u3053\u3068\u3001STRENGTH\u304c\u65e9\u671f\u306b\u7d42\u4e86\u3057\u305f\u3053\u3068\u3092\u8003\u616e\u3059\u308b\u3068\u3001\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u3055\u3089\u306a\u308b\u7814\u7a76\u306e\u305f\u3081\u306e\u4eee\u8aac\u69cb\u7bc9\u3068\u307f\u306a\u3059\u3079\u304d\u3067\u3042\u308b\u3002 <\/p>\n

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 <\/p>\n

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\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

    \n
  1. Bhatt DL\u3001Steg PG\u3001Miller M\u3001\u4ed6\u3001\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u5bfe\u3059\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3002N Engl J Med 2019;380:11-22. <\/li>\n
  2. \u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u3068\u6bd4\u8f03\u9271\u7269\u6cb9\u306b\u3088\u308b\u30e9\u30f3\u30c0\u30e0\u5316\u6cbb\u7642\u304c\u3001\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-1\u03b2\u3001\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-6\u3001C\u53cd\u5fdc\u6027\u86cb\u767d\u3001\u9178\u5316\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u30db\u30e2\u30b7\u30b9\u30c6\u30a4\u30f3\u3001\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u3001\u30ea\u30dd\u86cb\u767d\u95a2\u9023\u30db\u30b9\u30db\u30ea\u30d1\u30fc\u30bcA2\u306b\u53ca\u307c\u3059\u5f71\u97ff\uff1aREDUCE-IT\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u30b5\u30d6\u30b9\u30bf\u30c7\u30a3\u3002Circulation 2022;146:372-9. <\/li>\n
  3. \u30cb\u30c3\u30bb\u30f3SE\u3002\u30d7\u30e9\u30bb\u30dc\u306f\u3044\u3064\u30d7\u30e9\u30bb\u30dc\u3067\u306a\u304f\u306a\u308b\u306e\u304b\u3002JAMA Cardiol 2022;7:1183-4. <\/li>\n
  4. \u30cf\u30ea\u30f3\u30c8\u30f3RA.\u7121\u4f5c\u70ba\u5316\u81e8\u5e8a\u8a66\u9a13\u306e\u8a66\u7df4\u3068\u82e6\u96e3\u3002Circulation 2022;146:380-2. <\/li>\n<\/ol>\n

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