{"id":257392,"date":"2025-11-07T10:00:21","date_gmt":"2025-11-07T09:00:21","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e6%80%a5%e6%80%a7%e5%86%a0%e7%97%87%e5%80%99%e7%be%a4%e6%82%a3%e8%80%85%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bd\/"},"modified":"2026-03-05T17:57:46","modified_gmt":"2026-03-05T16:57:46","slug":"%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e6%80%a5%e6%80%a7%e5%86%a0%e7%97%87%e5%80%99%e7%be%a4%e6%82%a3%e8%80%85%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bd","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e6%80%a5%e6%80%a7%e5%86%a0%e7%97%87%e5%80%99%e7%be%a4%e6%82%a3%e8%80%85%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bd\/","title":{"rendered":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af-\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u60a3\u8005\u306b\u304a\u3051\u308b\u30ea\u30dd\u86cb\u767d(a)\u4e0a\u6607\u306e\u6a19\u7684"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]<\/p>\n

\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u60a3\u8005\u306b\u304a\u3051\u308b\u30ea\u30dd\u86cb\u767d(a)\u4e0a\u6607\u306e\u6a19\u7684<\/h2>\n

2025\u5e7410\u6708<\/span><\/h5>\n
\n
\n

\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u3068\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u9ad8\u5024\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u6295\u4e0e\u306b\u3088\u308a\u3001\u4e3b\u8981\u306a\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3068\u56db\u80a2\u306e\u6709\u5bb3\u30a4\u30d9\u30f3\u30c8\u306e\u4e21\u65b9\u306e\u30ea\u30b9\u30af\u304c\u3088\u308a\u65e9\u671f\u306b\u3001\u3088\u308a\u5927\u304d\u304f\u6e1b\u5c11\u3057\u305f\uff1aODYSSEY OUTCOMES\u304b\u3089\u306e\u77e5\u898b\u3002 <\/em><\/p>\n

Ray KK, Szarek M, Bhatt DL, et al. Lipoprotein(a) identifies patients with acute coronary syndromes who derive cardiovascular benefit from alirocumab, particularly for limb events. J Am Coll Cardiol 2025; https:\/\/doi.org\/10.1016\/j.jacc.2025.08.043<\/a> <\/em><\/p>\n

<\/em><\/p>\n

\u7814\u7a76\u6982\u8981<\/strong><\/p>\n\n\n\n\n\n\n\n\n
\n

\u76ee\u7684<\/strong><\/p>\n<\/td>\n

\n

ODYSSEY OUTCOMES\u8a66\u9a13\u306e\u3053\u308c\u307e\u3067\u306e\u5831\u544a\u3067\u306f\u3001\u6025\u6027\u51a0\u75c7\u5019\u7fa4\uff08ACS\uff09\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30ea\u30dd\u86cb\u767d\uff08Lp(a)\uff09\u304c\u9ad8\u5024\u306e\u5834\u5408\u3001\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u6cbb\u7642\u306b\u3088\u308a\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08MACE\uff09\u304a\u3088\u3073\u4e3b\u8981\u6709\u5bb3\u80a2\u30a4\u30d9\u30f3\u30c8\uff08MALE\uff09\u304c\u3088\u308a\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u3053\u306e\u6700\u65b0\u306e\u89e3\u6790\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u60a3\u8005\u304c\u6cbb\u7642\u958b\u59cb\u5f8c\u3069\u306e\u7a0b\u5ea6\u3067\u52b9\u679c\u304c\u5f97\u3089\u308c\u308b\u304b\u304c\u691c\u8a0e\u3055\u308c\u305f\u3002 <\/p>\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/strong><\/p>\n<\/td>\n

\n

ODYSSEY OUTCOMES\u8a66\u9a13\u306e\u30dd\u30b9\u30c8\u30db\u30c3\u30af\u30fb\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u6642\u9593\u5206\u6790<\/p>\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u7814\u7a76\u5bfe\u8c61\u8005<\/strong><\/p>\n<\/td>\n

\n

ODYSSEY OUTCOMES\u306b\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u8102\u8cea\u304c\u4e0a\u6607\u3057\u305f\u60a3\u800518,924\u4f8b\uff08\u5e73\u5747\u5e74\u9f6258\u6b73\u300189\uff05\u304c\u9ad8\u5f37\u5ea6\u30b9\u30bf\u30c1\u30f3\u670d\u7528\u4e2d\uff09\u304c\u7d44\u307f\u5165\u308c\u3089\u308c\u305f\u3002\u60a3\u8005\u306fACS\u5f8c1\u301c12\u30f5\u6708\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u3001\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u304c2\u9031\u9593\u3054\u3068\u306b\u76ae\u4e0b\u6295\u4e0e\u3055\u308c\u305f\u3002 <\/p>\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u4e3b\u306a\u7814\u7a76\u5909\u6570<\/strong><\/p>\n<\/td>\n

\n

– MACE\u3068\u306f\uff0c\u5fc3\u8840\u7ba1\u6b7b\uff0c\u5fc3\u7b4b\u6897\u585e\uff0c\u865a\u8840\u6027\u8133\u5352\u4e2d\uff0c\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\uff0c\u865a\u8840\u306b\u3088\u308b\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u306e\u8907\u5408\u3067\u3042\u308b\u3002<\/p>\n

– MALE\u3001\u91cd\u75c7\u865a\u8840\u80a2\u3001\u8840\u884c\u518d\u5efa\u8853\u3001\u865a\u8840\u306b\u3088\u308b\u5207\u65ad\u306e\u8907\u5408\u3002<\/p>\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u65b9\u6cd5<\/strong><\/p>\n<\/td>\n

\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLp(a)\u6fc3\u5ea6\u306b\u3088\u308a\u3001i) 30mg\/dL\u4ee5\u4e0a\uff08n=8051\uff09\u5bfe<30mg\/dL\uff08n=10,873\uff09\u3001ii) 50mg\/dL\u4ee5\u4e0a\uff08n=5709\uff09\u5bfe<50mg\/dL\uff08n=13,215\uff09\u306b\u5c64\u5225\u5316\u3057\u305f\u3002\u3053\u308c\u30892\u3064\u306eLp(a)\u306e\u95be\u5024\u306f\u300130mg\/dL\u304c\u30ea\u30b9\u30af\u4e0a\u6607\u3092\u8003\u616e\u3059\u308b\u66ab\u5b9a\u7684\u306a\u7bc4\u56f2\u306e\u4e0b\u9650\u3068\u3055\u308c(1)\u300150mg\/dL\u304c\u73fe\u5728\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u304a\u3051\u308b\u30ea\u30b9\u30af\u5897\u5f37\u56e0\u5b50\u3068\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u9078\u629e\u3055\u308c\u305f\u3002\u6cbb\u7642\u306e\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08HR\uff09\u306895\uff05\u4fe1\u983c\u533a\u9593\uff08CI\uff09\u306f\u3001\u7121\u4f5c\u70ba\u5316\u5f8c\u306e\u9023\u7d9a\u3057\u305f\u65e5\u6570\u3067\u8ffd\u8de1\u3092\u5207\u308a\u6368\u3066\u305f\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30eb\u304b\u3089\u63a8\u5b9a\u3057\u305f\u3002Time-to-benefit\u306f\u7121\u4f5c\u70ba\u5316\u5f8c\u3001\u6cbb\u7642HR+95%CI\u304c<1\u3068\u306a\u3063\u305f\u65e5\u3068\u3057\u305f\u3002 <\/p>\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u4e3b\u306a\u7d50\u679c<\/strong><\/p>\n<\/td>\n

\n

\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u3068Lp(a)\u6fc3\u5ea6\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u5024\u3068\u5909\u5316\u3092\u88681\u306b\u307e\u3068\u3081\u305f\u3002<\/p>\n

\u88681. Lp(a)\u30ab\u30c6\u30b4\u30ea\u30fc\u5225\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u5024\u30684\u30f5\u6708\u5f8c\u306eLDL-C\u304a\u3088\u3073Lp(a)\u306e\u6e1b\u5c11\u3002 <\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

<\/strong><\/p>\n<\/td>\n

\n

\u226530mg\/dL\u4ee5\u4e0a\uff08n=8051\uff09<\/strong><\/p>\n<\/td>\n

\n

<30mg\/dL\uff08n=10,873\uff09 <\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

LDL-C\u3001mg\/dL\uff1b\u4e2d\u592e\u5024\uff08IQR\uff09<\/strong><\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3<\/p>\n<\/td>\n

\n

89 (76, 107)<\/p>\n<\/td>\n

\n

85 (71, 102)<\/p>\n<\/td>\n<\/tr>\n

\n

4\u30f5\u6708\u5f8c\u306e\u6e1b\u5c11-\u30a2\u30ea\u30ed\u30af\u30de\u30d6<\/p>\n<\/td>\n

\n

-53 (-71, -36)<\/p>\n<\/td>\n

\n

-54 (-70, -37)<\/p>\n<\/td>\n<\/tr>\n

\n

4\u30f5\u6708\u5f8c\u306e\u6e1b\u5c11 – \u30d7\u30e9\u30bb\u30dc<\/p>\n<\/td>\n

\n

1 (-11, 14)<\/p>\n<\/td>\n

\n

0 (-13, 14)<\/p>\n<\/td>\n<\/tr>\n

\n

Lp(a)\u3001mg\/dL\uff1b\u4e2d\u592e\u5024\uff08IQR\uff09<\/strong><\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3<\/p>\n<\/td>\n

\n

67 (47, 99)<\/p>\n<\/td>\n

\n

8 (2, 15)<\/p>\n<\/td>\n<\/tr>\n

\n

4\u30f5\u6708\u5f8c\u306e\u6e1b\u5c11-\u30a2\u30ea\u30ed\u30af\u30de\u30d6<\/p>\n<\/td>\n

\n

-14.9 (-26.5, -4.6)<\/p>\n<\/td>\n

\n

-2.5 (-6.3, 0)<\/p>\n<\/td>\n<\/tr>\n

\n

4\u30f5\u6708\u5f8c\u306e\u6e1b\u5c11 – \u30d7\u30e9\u30bb\u30dc<\/p>\n<\/td>\n

\n

-2.8 (-12.6, 7)<\/p>\n<\/td>\n

\n

0 (-2.1, 1.5)<\/p>\n<\/td>\n<\/tr>\n

\n

<\/strong><\/p>\n<\/td>\n

\n

\u226550mg\/dL\u4ee5\u4e0a <\/strong><\/p>\n

(n=5709)<\/strong><\/p>\n<\/td>\n

\n

<50mg\/dL <\/strong><\/p>\n

(n=13,215)<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

LDL-C\u3001mg\/dL\uff1b\u4e2d\u592e\u5024\uff08IQR\uff09<\/strong><\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3<\/p>\n<\/td>\n

\n

90 (77, 109)<\/p>\n<\/td>\n

\n

85 (71, 102)<\/p>\n<\/td>\n<\/tr>\n

\n

4\u30f5\u6708\u5f8c\u306e\u6e1b\u5c11-\u30a2\u30ea\u30ed\u30af\u30de\u30d6<\/p>\n<\/td>\n

\n

-54 (-71, -37)<\/p>\n<\/td>\n

\n

-54 (-70, -36)<\/p>\n<\/td>\n<\/tr>\n

\n

4\u30f5\u6708\u5f8c\u306e\u6e1b\u5c11 – \u30d7\u30e9\u30bb\u30dc<\/p>\n<\/td>\n

\n

1 (-11, +14)<\/p>\n<\/td>\n

\n

0 (-13, +14)<\/p>\n<\/td>\n<\/tr>\n

\n

Lp(a)\u3001mg\/dL\uff1b<\/strong> \u4e2d\u592e\u5024\uff08IQR\uff09<\/strong><\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3<\/p>\n<\/td>\n

\n

84 (64, 113)<\/p>\n<\/td>\n

\n

11 (4, 24)<\/p>\n<\/td>\n<\/tr>\n

\n

4\u30f5\u6708\u5f8c\u306e\u6e1b\u5c11-\u30a2\u30ea\u30ed\u30af\u30de\u30d6<\/p>\n<\/td>\n

\n

-18.2 (-31.5, -6.7)<\/p>\n<\/td>\n

\n

-3.1 (-7.9, 0)<\/p>\n<\/td>\n<\/tr>\n

\n

4\u30f5\u6708\u5f8c\u306e\u6e1b\u5c11 – \u30d7\u30e9\u30bb\u30dc<\/p>\n<\/td>\n

\n

-4.1 (-15.4, +7.4)<\/p>\n<\/td>\n

\n

0 (-2.6, +2.1)<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

\u4e2d\u592e\u50242.8\u5e74\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u3001MACE\u306f2775\u4f8b\u3001MALE\u306f246\u4f8b\u3067\u3042\u3063\u305f\u3002<\/p>\n

MACE\u306b\u5bfe\u3059\u308b\u6cbb\u7642HR\uff0b95\uff05CI\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3Lp(a)\u304c30mg\/dl\u4ee5\u4e0a\u306e\u60a3\u8005\u3067\u306f1.31\u5e74\u3001Lp(a)\u304c50mg\/dL\u4ee5\u4e0a\u306e\u60a3\u8005\u3067\u306f1.25\u5e74\u304b\u30891\u672a\u6e80\uff08\u6cbb\u7642\u52b9\u679c\u3092\u793a\u3059\uff09\u3067\u3042\u3063\u305f\u3002\u3057\u304b\u3057\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3Lp(a)\u304c<30mg\/dL\u307e\u305f\u306f<50mg\/dL\u306e\u60a3\u8005\u3067\u306f\u3001\u8ffd\u8de1\u671f\u9593\u4e2d\u3001MACE\u306e\u6cbb\u7642HR\uff0b95\uff05CI\u306f1\u3092\u8d85\u3048\u305f\u3002 <\/p>\n

 <\/p>\n

\u540c\u69d8\u306b\u3001MALE\u306b\u5bfe\u3059\u308btime-to-event\u89e3\u6790\u3067\u306f\u3001Lp(a)\u304c30mg\/dL\u4ee5\u4e0a\u307e\u305f\u306f50mg\/dL\u4ee5\u4e0a\u306e\u60a3\u8005\u3067\u306f\u3001MALE\u306b\u5bfe\u3059\u308b\u6cbb\u7642HR+95%CI\u306f\u305d\u308c\u305e\u308c0.18\u5e74\u304a\u3088\u30730.24\u5e74\u3067\u306f1\u672a\u6e80\u3067\u3042\u3063\u305f\u304c\u3001Lp(a)\u6fc3\u5ea6\u304c\u4f4e\u3044\u60a3\u8005\u3067\u306f\u8ffd\u8de1\u671f\u9593\u4e2d1\u3092\u8d85\u3048\u305f\u3002<\/p>\n<\/td>\n<\/tr>\n

\n

\u8457\u8005\u306e\u7d50\u8ad6<\/strong><\/p>\n<\/td>\n

\n

\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u306b\u3088\u308bPCSK9\u963b\u5bb3\u306f\u3001\u30ea\u30dd\u86cb\u767d(a)\u304c\u9ad8\u5024\u3067\u3042\u3063\u305f\u60a3\u8005\u306b\u304a\u3044\u3066\u3001MACE\u304a\u3088\u3073MALE\u304c\u65e9\u671f\u306b\u6539\u5584\u3059\u308b\u3053\u3068\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/strong><\/p>\n


<\/strong><\/p>\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

ACS\u60a3\u8005\u306f\u3001\u7279\u306b\u9000\u9662\u5f8c\u65e9\u671f\u306b\u3001\u975e\u5e38\u306b\u9ad8\u3044\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u6b8b\u5b58\u3059\u308b(2)\u3002ODYSSEY OUTCOMES\u8a66\u9a13\u3067\u306f\u3001PCSK9\u963b\u5bb3\u85ac\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u306b\u3088\u308b\u96c6\u4e2d\u7684\u306aLDL-C\u4f4e\u4e0b\u304c\u3053\u306e\u30ea\u30b9\u30af\u3092\u6709\u610f\u306b\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\uff083\uff09\u3002\u3055\u3089\u306b\u3001Lp(a)\u306f\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u306e\u6709\u76ca\u6027\u3092\u4fee\u98fe\u3059\u308b\u3088\u3046\u3067\u3042\u308a\u3001Lp(a)\u304c\u9ad8\u5024\u306e\u60a3\u8005\u3067\u306f\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3068\u56db\u80a2\u306e\u6709\u5bb3\u4e8b\u8c61\u306e\u4e21\u65b9\u306e\u30ea\u30b9\u30af\u304c\u76f8\u5bfe\u7684\u3001\u7d76\u5bfe\u7684\u306b\u5927\u304d\u304f\u6e1b\u5c11\u3057\u305f(4,5)\u3002ACS\u60a3\u8005\u306b\u304a\u3051\u308b\u30a4\u30d9\u30f3\u30c8\u518d\u767a\u306e\u30ea\u30b9\u30af\u304c\u975e\u5e38\u306b\u9ad8\u3044\u3053\u3068\u3092\u8003\u616e\u3059\u308b\u3068\u3001\u3053\u308c\u3089\u306e\u60a3\u8005\u304cPCSK9\u6307\u5411\u6027\u6cbb\u7642\u306e\u958b\u59cb\u306b\u3088\u3063\u3066\u3069\u306e\u7a0b\u5ea6\u65e9\u304f\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u3092\u5f97\u3089\u308c\u308b\u304b\u3092\u8abf\u3079\u308b\u3053\u3068\u306f\u9069\u5207\u3067\u3042\u308b\u3002 <\/p>\n

 <\/p>\n

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 <\/p>\n

\u4e8b\u5f8c\u89e3\u6790\u306e\u6ce8\u610f\u70b9\u3092\u8003\u616e\u3059\u308b\u3068\u3001\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u63a2\u7d22\u7684\u306a\u3082\u306e\u3068\u307f\u306a\u3059\u3079\u304d\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u7279\u306b\u56db\u80a2\u306e\u6709\u5bb3\u4e8b\u8c61\u306b\u5bfe\u3057\u3066\u65e9\u671f\u306b\u52b9\u679c\u304c\u793a\u3055\u308c\u305f\u3053\u3068\u304b\u3089\u3001\u524d\u5411\u304d\u8a66\u9a13\u3067\u3055\u3089\u306b\u691c\u8a0e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002 <\/p>\n

 <\/p>\n

\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

    \n
  1. \u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u3068\u5927\u52d5\u8108\u5f01\u72ed\u7a84\u75c7\u306b\u304a\u3051\u308b\u30ea\u30dd\u86cb\u767d\uff08a\uff09\uff1a\u6b27\u5dde\u52d5\u8108\u786c\u5316\u5b66\u4f1a\u306e\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u30fb\u30b9\u30c6\u30fc\u30c8\u30e1\u30f3\u30c8\u3002Eur Heart J 2022;43:3925-46. <\/li>\n
  2. Steen DL, Khan I, Andrade K, et al. 2005\u5e74\u304b\u30892018\u5e74\u306b\u304b\u3051\u3066\u7c73\u56fd\u3067239 234\u4eba\u306e\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u73fe\u4ee3\u306e\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u5f8c\u306e\u96c6\u56e3\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u518d\u767a\u304a\u3088\u3073\u6b7b\u4ea1\u306e\u30a4\u30d9\u30f3\u30c8\u767a\u751f\u7387\u3068\u30ea\u30b9\u30af\u56e0\u5b50\u3002J Am Heart Assoc 2022; 11: https:\/\/doi.org\/10.1161\/JAHA.121.022198<\/a> <\/li>\n
  3. Schwartz GG, Steg PG, Szarek M et al. Alirocumab and cardiovascular outcomes after acute coronary syndrome. N Engl J Med 2018;379:2097-107. <\/li>\n
  4. Szarek M\uff0cBittner VA\uff0cAylward P\u3089\uff1a\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u306b\u3088\u308b\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u4f4e\u4e0b\u306f\uff0c\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b\u3068\u306f\u7121\u95a2\u4fc2\u306b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u7dcf\u8ca0\u62c5\u3092\u6e1b\u5c11\u3055\u305b\u308b\uff1aODYSSEY OUTCOMES\u8a66\u9a13\u3002Eur Heart J 2020;41:4245-55. <\/li>\n
  5. \u6025\u6027\u51a0\u75c7\u5019\u7fa4\u5f8c\u306e\u672b\u68a2\u52d5\u8108\u75be\u60a3\u3068\u9759\u8108\u8840\u6813\u585e\u6813\u30a4\u30d9\u30f3\u30c8\uff1a\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u306e\u5f79\u5272\u3068\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u306b\u3088\u308b\u4fee\u98fe\uff1a\u7121\u4f5c\u70ba\u5316\u81e8\u5e8a\u8a66\u9a13ODYSSEY OUTCOMES\u306e\u4e8b\u524d\u898f\u5b9a\u89e3\u6790\u3002Circulation 2020;141:1608-17. <\/li>\n
  6. Mach F, Koskinas KC, Roeters van Lennep JE, et al. 2025 Focused Update of the 2019 ESC\/EAS Guidelines for the management of dyslipidaemias\uff1a\u6b27\u5dde\u5fc3\u81d3\u75c5\u5b66\u4f1a\uff08ESC\uff09\u3068\u6b27\u5dde\u52d5\u8108\u786c\u5316\u5b66\u4f1a\uff08EAS\uff09\u306e\u8102\u8cea\u7570\u5e38\u75c7\u7ba1\u7406\u30bf\u30b9\u30af\u30d5\u30a9\u30fc\u30b9\u306b\u3088\u308a\u4f5c\u6210 Eur Heart J 2025; https:\/\/doi.org\/10.1093\/eurheartj\/ehaf190<\/a><\/li>\n
  7. \u8102\u8cea\u7570\u5e38\u75c7\u306e\u7ba1\u7406\u306b\u95a2\u3059\u308b2019\u5e74ESC\/EAS\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\uff1a\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u6e1b\u306e\u305f\u3081\u306e\u8102\u8cea\u4fee\u98fe\uff1a\u6b27\u5dde\u5fc3\u81d3\u75c5\u5b66\u4f1a\uff08ESC\uff09\u306e\u8102\u8cea\u7570\u5e38\u75c7\u7ba1\u7406\u30bf\u30b9\u30af\u30d5\u30a9\u30fc\u30b9\u3068EAS\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3<\/li>\n<\/ol>\n

    \u6b27\u5dde\u52d5\u8108\u786c\u5316\u5b66\u4f1a\uff08EAS\uff09\u3002Eur Heart J 2020;41:111-88. <\/p>\n

      \n
    1. Koschinsky ML, Bajaj A, Boffa MB et al. A focused update to the 2019 NLA scientific statement on use of lipoprotein(a) in clinical practice.J Clin Lipidol 2024;18:e308-e319. <\/li>\n<\/ol>\n

      \u30ad\u30fc\u30ef\u30fc\u30c9ODYSSEY OUTCOMES\uff1b\u30ea\u30dd\u86cb\u767d\uff08a\uff09\uff1b\u6025\u6027\u51a0\u75c7\u5019\u7fa4\uff1b\u6709\u52b9\u671f\u9593\uff1bMACE\uff1b\u7537\u6027<\/em><\/p>\n<\/div>\n<\/div>\n

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