{"id":257350,"date":"2026-03-04T21:58:45","date_gmt":"2026-03-04T20:58:45","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-acs%e6%82%a3%e8%80%85%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e3%83%aa%e3%82%b9%e3%82%af%e4%bd%8e%e6%b8%9b\/"},"modified":"2026-03-09T16:02:09","modified_gmt":"2026-03-09T15:02:09","slug":"%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-acs%e6%82%a3%e8%80%85%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e3%83%aa%e3%82%b9%e3%82%af%e4%bd%8e%e6%b8%9b","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-acs%e6%82%a3%e8%80%85%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e3%83%aa%e3%82%b9%e3%82%af%e4%bd%8e%e6%b8%9b\/","title":{"rendered":"\u30d5\u30a9\u30fc\u30ab\u30b9-ACS\u60a3\u8005\u306b\u304a\u3051\u308b\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u6e1b\u306e\u305f\u3081\u306e\u65b0\u305f\u306a\u6a19\u7684\u304b\uff1f"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]<\/p>\n

ACS\u60a3\u8005\u306b\u304a\u3051\u308b\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u6e1b\u306e\u305f\u3081\u306e\u65b0\u305f\u306a\u6a19\u7684\u304b\uff1f<\/h2>\n

2026\u5e742\u6708<\/span><\/h5>\n
\n

\u51dd\u56fa\u304a\u3088\u3073\u7dda\u6eb6\u7cfb\u7d4c\u8def\u3092\u8abf\u7bc0\u3059\u308b\u51a0\u52d5\u8108\u75be\u60a3\u95a2\u9023\u30b8\u30e3\u30f3\u30af\u30b7\u30e7\u30ca\u30eb\u86cb\u767d (JCAD) \u306f\u3001\u6025\u6027\u51a0\u75c7\u5019\u7fa4 (ACS) \u60a3\u8005\u306b\u304a\u3051\u308b\u9ad8\u3044\u5fc3\u8840\u7ba1\u6b8b\u5b58\u30ea\u30b9\u30af\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306e\u65b0\u305f\u306a\u6a19\u7684\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/em><\/p>\n

Kraler S, Liberale L, Tirandi A, et al. The junctional protein associated with coronary artery disease predicts adverse cardiovascular events in patients with acute coronary syndromes at high residual risk. Eur Heart J 2025; doi.org\/10.1093\/eurheartj\/ehaf979. <\/em><\/p>\n

\u7814\u7a76\u6982\u8981\u3002<\/strong><\/p>\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\n\n

\u76ee\u7684 \u51dd\u56fa\u304a\u3088\u3073\u7dda\u6eb6\u306b\u95a2\u4e0e\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308bJCAD\u304c\u3001ACS\u60a3\u8005\u306b\u304a\u3051\u308b\u9ad8\u3044\u6b8b\u5b58\u30ea\u30b9\u30af\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306e\u65b0\u898f\u30de\u30fc\u30ab\u30fc\u3001\u307e\u305f\u306f\u6f5c\u5728\u7684\u306a\u6cbb\u7642\u6a19\u7684\u3068\u306a\u308a\u5f97\u308b\u304b\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3002<\/p>\n

 <\/p>\n<\/td>\n

\u00a0<\/td>\n<\/tr>\n
\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/strong><\/td>\n\n

SPUM-ACS\u7814\u7a76\u306f\u3001\u30b9\u30a4\u30b9\u306e\u591a\u65bd\u8a2d\u5171\u540c\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3067\u3042\u308a\u30014,787\u540d\u306eACS\u60a3\u8005\u304c\u53c2\u52a0\u3057\u305f\u3002\u3053\u308c\u3092\u767a\u898b\u30b3\u30db\u30fc\u30c8\u3068\u3057\u305f\u3002<\/p>\n

 <\/p>\n

RISK-PPCI\u7814\u7a76\u306f\u3001\u82f1\u56fd\u306e\u5358\u65bd\u8a2d\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3067\u3042\u308a\u3001\u521d\u56de\u7d4c\u76ae\u7684\u51a0\u52d5\u8108\u30a4\u30f3\u30bf\u30fc\u30d9\u30f3\u30b7\u30e7\u30f3\uff08PCI\uff09\u65bd\u884c\u524d\u306b\u8840\u6813\u72b6\u614b\u306e\u8a55\u4fa1\u3092\u53d7\u3051\u305f496\u540d\u306eACS\u60a3\u8005\u304c\u53c2\u52a0\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u306f\u3001JCAD\u3068\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8 (MACE) \u3068\u306e\u95a2\u9023\u6027\u306e\u5916\u90e8\u691c\u8a3c\u306b\u7528\u3044\u3089\u308c\u305f\u3002<\/p>\n

 <\/p>\n<\/td>\n

\u00a0<\/td>\n<\/tr>\n
\u7814\u7a76\u5bfe\u8c61\u96c6\u56e3 <\/strong><\/td>\n\n

SPUM-ACS\u8a66\u9a13\u306e\u5bfe\u8c61\u306f\u3001ACS\u3068\u8a3a\u65ad\u3055\u308c\u305f\u6210\u4eba\u60a3\u8005\u3067\u3042\u308b\u3002\u3053\u308c\u3089\u306e\u60a3\u8005\u306f\u3001\u6b8b\u5b58\u8102\u8cea\u30ea\u30b9\u30af\uff08RLR\u3001\u6cbb\u7642\u4e0a\u306e\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb[LDL-C]\u304c70mg\/dL\u4ee5\u4e0a\u307e\u305f\u306f1.8mmol\/L\u4ee5\u4e0a\uff09\u3001\u6b8b\u5b58\u708e\u75c7\u30ea\u30b9\u30af\uff08RIR\u3001\u6cbb\u7642\u4e0a\u306e\u9ad8\u611f\u5ea6CRP[hs-CRP]\u304c2.0mg\/L\u4ee5\u4e0a\uff09\u3001\u307e\u305f\u306f\u4e21\u65b9\u306e\u57fa\u6e96\u3092\u6e80\u305f\u3059\u60a3\u8005\uff08RILR\uff09\u306b\u5206\u985e\u3055\u308c\u305f\u3002<\/p>\n

 <\/p>\n

SPUM-ACS\u304a\u3088\u3073RISK-PPCI\u306e\u4e21\u30b3\u30db\u30fc\u30c8\u306e\u60a3\u8005\u306f\u3001\u51a0\u52d5\u8108\u9020\u5f71\u524d\u306e\u6297\u8840\u6813\u7642\u6cd5\u306e\u8ca0\u8377\u6295\u4e0e\u3092\u542b\u3080\u3001\u73fe\u5728\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u63a8\u5968\u306b\u5f93\u3063\u3066\u6cbb\u7642\u3055\u308c\u305f\u3002<\/p>\n

 <\/p>\n<\/td>\n

\u00a0<\/td>\n<\/tr>\n
\n

\u4e3b\u8981\u7814\u7a76\u5909\u6570<\/strong><\/p>\n

<\/strong><\/p>\n<\/td>\n

\n

\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f1\u5e74\u9593\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u306eMACE\u3067\u3042\u308a\u3001\u975e\u81f4\u6b7b\u6027\u5fc3\u7b4b\u6897\u585e\u3001\u975e\u81f4\u6b7b\u6027\u8133\u5352\u4e2d\u3001\u304a\u3088\u3073\u5fc3\u8840\u7ba1\u6b7b\u306e\u8907\u5408\u8a55\u4fa1\u9805\u76ee\u3068\u5b9a\u7fa9\u3055\u308c\u305f\u3002<\/p>\n

 <\/p>\n<\/td>\n

\u00a0<\/td>\n<\/tr>\n
\u65b9\u6cd5<\/strong><\/td>\nRLR\u3001RIR\u3001RILR\u3092\u6709\u3059\u308b\u60a3\u8005\u3092\u3001\u50be\u5411\u30b9\u30b3\u30a2\u30de\u30c3\u30c1\u30f3\u30b0\u3092\u884c\u3063\u305f\u5bfe\u7167\u7fa4\u3068\u6bd4\u8f03\u3057\u305f\u3002RLR\u3001RIR\u3001\u307e\u305f\u306fRILR\u3092\u6709\u3059\u308b\u60a3\u8005\u306b\u304a\u3051\u308bLDL-C\u3001hs-CRP\u3001\u304a\u3088\u3073JCAD\u306e\u4e88\u6e2c\u6709\u7528\u6027\u306f\u3001\u5358\u5909\u91cf\u304a\u3088\u3073\u591a\u5909\u91cf\u8abf\u6574Cox\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u56de\u5e30\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u8a55\u4fa1\u3055\u308c\u305f\u3002\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u30c7\u30fc\u30bf\u3068\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3068\u306e\u95a2\u4fc2\u306f\u3001log2\u5909\u63db\u30c7\u30fc\u30bf\uff08\u3059\u306a\u308f\u3061\u30011\u5358\u4f4d\u306e\u5897\u52a0\u306f\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u30ec\u30d9\u30eb\u306e2\u500d\u5316\u306b\u76f8\u5f53\uff09\u3092\u7528\u3044\u305f\u7dda\u5f62\u30e2\u30c7\u30eb\u3001\u304a\u3088\u3073\u5236\u9650\u4ed8\u304d\u4e09\u6b21\u30b9\u30d7\u30e9\u30a4\u30f3\u89e3\u6790\u3092\u7528\u3044\u305f\u975e\u7dda\u5f62\u30e2\u30c7\u30eb\u3067\u8a55\u4fa1\u3055\u308c\u305f\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n
\u7d50\u679c<\/strong><\/td>\n\n

\u5404\u6b8b\u5b58\u30ea\u30b9\u30af\u30ab\u30c6\u30b4\u30ea\u30fc\u306e\u60a3\u8005\u306e\u4e3b\u306a\u7279\u5fb4\u3092\u88681\u306b\u8981\u7d04\u3059\u308b\u30021\u5e74\u6642\u70b9\u306b\u304a\u3044\u3066\u3001RLR\u3001RIR\u3001\u304a\u3088\u3073\u4e21\u65b9\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\uff08RILR\uff09\u3092\u6709\u3059\u308b\u60a3\u8005\u306f\u3001\u50be\u5411\u30b9\u30b3\u30a2\u30de\u30c3\u30c1\u30f3\u30b0\u3055\u308c\u305f\u5bfe\u7167\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u3001MACE\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u304b\u3063\u305f\uff08\u88681\uff09<\/p>\n

\u88681. SPUM-ACS\u30b3\u30db\u30fc\u30c8\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u30ab\u30c6\u30b4\u30ea\u30fc\u306e\u7279\u5fb4\u304a\u3088\u3073MACE\u30ea\u30b9\u30af<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n
\u00a0<\/td>\nRLR (n=892, 18.6%)<\/strong><\/td>\nRIR\uff08n=683\u300114\uff0e\uff09<\/strong><\/td>\nRILR (n=460, 9.6%)<\/strong><\/td>\n<\/tr>\n
\u5e74\u9f62\u226765\u6b73\u3001n (%)<\/td>\n482 (54)<\/td>\n407 (59.6)<\/td>\n248 (53.9)<\/td>\n<\/tr>\n
\u5973\u6027; n (%)<\/td>\n182 (20.9)<\/td>\n152 (22.3)<\/td>\n113 (24.6)<\/td>\n<\/tr>\n
PAD\uff1bn\uff08\uff05\uff09\u3002<\/td>\n92 (10.3)<\/td>\n98 (14.3)<\/td>\n58 (12.6)<\/td>\n<\/tr>\n
\u8133\u5352\u4e2d; n (%)<\/td>\n61 (6.8)<\/td>\n59 (8.6)<\/td>\n38 (8.3)<\/td>\n<\/tr>\n
\u30b9\u30bf\u30c1\u30f3\uff08\u6700\u9ad8\u7528\u91cf\uff09<\/td>\n322 (36.1)<\/td>\n248 (36.3)<\/td>\n169 (36.7)<\/td>\n<\/tr>\n
\n

hs-CRP, mg\/L<\/p>\n

\u4e2d\u592e\u5024\uff08IQR\uff09<\/p>\n<\/td>\n

2.5 (1.00\u20137.50)<\/td>\n7.00 (3.55\u201319.20)<\/td>\n6.05 (3.50\u201316.22)<\/td>\n<\/tr>\n
\n

JCAD, ng\/mL<\/p>\n

\u4e2d\u592e\u5024\uff08IQR\uff09<\/p>\n<\/td>\n

1.18 (0.46\u20131.88)<\/td>\n1.05 (0.41\u20131.91)<\/td>\n1.05 (0.42\u20131.92)<\/td>\n<\/tr>\n
\n

MACE*\u30ea\u30b9\u30af*<\/p>\n

HR\uff0895% CI)<\/p>\n<\/td>\n

1.55 (1.08\u20132.23)<\/td>\n1.80 (1.24\u20132.61)<\/td>\n1.75 (1.12\u20132.75)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

*\u50be\u5411\u30b9\u30b3\u30a2\u30de\u30c3\u30c1\u30f3\u30b0\u5bfe\u7167\u7fa4\u3068\u306e\u6bd4\u8f03<\/p>\n

RLR\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u304a\u3044\u3066\u3001hs-CRP\u306f\u5358\u5909\u91cf\u89e3\u6790\u30671\u5e74MACE\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u304a\u308a\uff08HR 1.17, 95% CI 1.06\u20131.30, p=0.002\uff09\u3001\u3053\u306e\u95a2\u9023\u306f\u591a\u5909\u91cf\u89e3\u6790\u3067\u3082\u78ba\u8a8d\u3067\u304d\u305f\u3002RIR\u304a\u3088\u3073RILR\u30ab\u30c6\u30b4\u30ea\u30fc\u3067\u306f\u3001\u591a\u5909\u91cf\u8abf\u6574\u89e3\u6790\u306b\u304a\u3044\u3066LDL-C\u3082hs-CRP\u30821\u5e74MACE\u30ea\u30b9\u30af\u3068\u306f\u95a2\u9023\u3057\u306a\u304b\u3063\u305f\u3002<\/p>\n

\u5404\u6b8b\u5b58\u30ea\u30b9\u30af\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u304a\u3044\u3066\u3001JCAD\u306elog2\u5897\u52a0\u3054\u3068\u306bMACE\u30ea\u30b9\u30af\u306f\u5358\u5909\u91cf\u304a\u3088\u3073\u591a\u5909\u91cf\u8abf\u6574\u30e2\u30c7\u30eb\u306e\u4e21\u65b9\u3067\u5897\u52a0\u3057\u305f\uff08\u88682\uff09\u3002JCAD\u3068MACE\u306e\u95a2\u9023\u306f\u3001\u5916\u90e8\u691c\u8a3c\u30b3\u30db\u30fc\u30c8\u3067\u3082\u540c\u69d8\u3067\u3042\u3063\u305f\u3002<\/p>\n

\u88682. JCAD\u306elog2\u5897\u52a0\u3042\u305f\u308a\u306eMACE\u30ea\u30b9\u30af; \u30cf\u30b6\u30fc\u30c9\u6bd4 (95% CI) <\/strong><\/p>\n\n\n\n\n\n\n
\u00a0<\/td>\nRLR (n=892, 18.6%)<\/strong><\/td>\nRIR (n=683, 14.3%)<\/strong><\/td>\nRILR (n=460, 9.6%)<\/strong><\/td>\n<\/tr>\n
\u5358\u5909\u91cf\u89e3\u6790<\/td>\n\n

1.29 (1.03\u20131.62)<\/p>\n

p=0.015<\/p>\n<\/td>\n

\n

1.28 (1.03\u20131.59)<\/p>\n

p=0.026<\/p>\n<\/td>\n

\n

1.45 (1.09-1.92)<\/p>\n

p=0.01<\/p>\n<\/td>\n<\/tr>\n

\u591a\u5909\u91cf\u8abf\u6574\u89e3\u6790<\/td>\n\n

1.27 (1.01\u20131.60)<\/p>\n

p=0.039<\/p>\n<\/td>\n

\n

1.31 (1.04\u20131.65)<\/p>\n

p=0.022<\/p>\n<\/td>\n

\n

1.47 (1.11\u20131.97)<\/p>\n

p=0.008<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

RISK-PPCI\u30b3\u30db\u30fc\u30c8\u3067\u306f\u3001JCAD\u30ec\u30d9\u30eb\u306e\u4e0a\u6607\u3068MACE\u30ea\u30b9\u30af\u3068\u306e\u9593\u306b\u72ec\u7acb\u3057\u305f\u95a2\u9023\u304c\u793a\u3055\u308c\u305f\u3002\u307e\u305f\u3001JCAD\u30ec\u30d9\u30eb\u306e\u4e0a\u6607\u306f\u3001\u7d44\u7e54\u56e0\u5b50 (TF)\u3001\u30c8\u30ed\u30f3\u30d3\u30f3\u6d3b\u6027\u5316\u7dda\u6eb6\u963b\u5bb3\u56e0\u5b50 (TAFI)\u3001\u30d7\u30e9\u30b9\u30df\u30ce\u30fc\u30b2\u30f3\u6d3b\u6027\u5316\u56e0\u5b50\u963b\u5bb3\u56e0\u5b50-1 (PAI-1) \u306a\u3069\u306e\u8840\u6813\u4fc3\u9032\u6027\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u306e\u9ad8\u5024\u3001\u304a\u3088\u3073\u5185\u56e0\u6027\u7dda\u6eb6\u80fd\u306e\u969c\u5bb3\u3068\u3082\u95a2\u9023\u3057\u3066\u3044\u305f\u3002<\/p>\n<\/td>\n<\/tr>\n

\u8457\u8005\u306e\u7d50\u8ad6<\/strong><\/td>\nRLR\u3001RIR\u3001\u307e\u305f\u306f\u305d\u306e\u4e21\u65b9\u3092\u6709\u3059\u308b\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u60a3\u8005\u306f\u3001\u9ad8\u3044\u865a\u8840\u30ea\u30b9\u30af\u306b\u3042\u308b\u3002\u51dd\u56fa\u304a\u3088\u3073\u5185\u56e0\u6027\u7dda\u6eb6\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001JCAD\u306f\u3001\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u63a8\u5968\u306e\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308bACS\u60a3\u8005\u306b\u6b8b\u5b58\u3059\u308b\u9ad8\u3044\u30ea\u30b9\u30af\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306e\u6709\u671b\u306a\u5019\u88dc\u3068\u306a\u308b\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/strong><\/p>\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

ACS\u60a3\u8005\u306f\u3001\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u6cbf\u3063\u305f\u81e8\u5e8a\u7ba1\u7406\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u9ad8\u3044\u5fc3\u8840\u7ba1\u6b8b\u5b58\u30ea\u30b9\u30af\u3092\u62b1\u3048\u305f\u307e\u307e\u3067\u3042\u308b\u3002\u672c\u7814\u7a76\u306f\u3053\u306e\u70b9\u3092\u88dc\u5f37\u3059\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u50be\u5411\u30b9\u30b3\u30a2\u30de\u30c3\u30c1\u30f3\u30b0\u3055\u308c\u305f\u5bfe\u7167\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u3001RLR\u60a3\u8005\u3067\u306fMACE\u30ea\u30b9\u30af\u304c55%\u3001RIR\u60a3\u8005\u3067\u306f80%\u3001\u8102\u8cea\u304a\u3088\u3073\u708e\u75c7\u306e\u4e21\u65b9\u306e\u30ea\u30b9\u30af\u3092\u6301\u3064\u60a3\u8005\u3067\u306f75%\u9ad8\u304b\u3063\u305f\u3002LDL-C\u306e\u7a4d\u6975\u7684\u306a\u4f4e\u4e0b\u3001\u3042\u308b\u3044\u306f\u6297\u708e\u75c7\u7642\u6cd5\u3084\u6297\u51dd\u56fa\u7642\u6cd5\u306b\u3088\u3063\u3066\u3053\u306e\u30ea\u30b9\u30af\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3067\u3001\u518d\u767a\u6027MACE\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b (1-4)\u3002\u3057\u304b\u3057\u3001LDL-C\u4e2d\u592e\u5024<1.4 mmol\/L (\u307e\u305f\u306f50 mg\/dL) \u672a\u6e80\u3092\u9054\u6210\u3057\u305f\u60a3\u8005\u306b\u304a\u3044\u3066\u3055\u3048\u3001\u7d045%\u304c1\u5e74\u9593\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u306bMACE\u3092\u7d4c\u9a13\u3059\u308b (1,2)\u3002\u7dcf\u5408\u3059\u308b\u3068\u3001\u3053\u308c\u3089\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u3001\u3053\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u3078\u306e\u5bc4\u4e0e\u56e0\u5b50\u3068\u3057\u3066\u4ed6\u306e\u7d4c\u8def\u306e\u95a2\u4e0e\u3092\u793a\u5506\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u3088\u3046\u306a\u7d4c\u8def\u304a\u3088\u3073\u6cbb\u7642\u4ecb\u5165\u306e\u95a2\u9023\u6a19\u7684\u3092\u7279\u5b9a\u3059\u308b\u7dca\u6025\u306e\u5fc5\u8981\u6027\u3092\u5f37\u8abf\u3057\u3066\u3044\u308b\u3002<\/p>\n

 <\/p>\n

JCAD\u306f\u3001\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\u306b\u304a\u3044\u3066\u51a0\u52d5\u8108\u75be\u60a3\u306e\u30ea\u30b9\u30af\u5ea7\u4f4d\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u3066\u3044\u308b (5,6)\u3002\u30e1\u30ab\u30cb\u30ba\u30e0\u7814\u7a76\u3067\u306f\u3001\u8840\u7ba1\u708e\u75c7\u306e\u8abf\u7bc0 (7)\u3001\u8840\u6813\u4fc3\u9032\u6027\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u306e\u4fc3\u9032\u3001\u304a\u3088\u3073\u7dda\u6eb6\u306e\u963b\u5bb3 (8) \u3092\u90e8\u5206\u7684\u306b\u4ecb\u3057\u305fJCAD\u306e\u6297\u52d5\u8108\u786c\u5316\u4f5c\u7528\u304c\u5b9f\u8a3c\u3055\u308c\u3066\u304a\u308a\u3001LDL-C\u3084hs-CRP\u306b\u306f\u53cd\u6620\u3055\u308c\u306a\u3044\u5371\u967a\u56e0\u5b50\u306b\u5bfe\u51e6\u3057\u3066\u3044\u308b\u3002
\u4eca\u56de\u306e\u7814\u7a76\u306f\u3001\u6b8b\u5b58\u30ea\u30b9\u30af\u306e\u65b0\u898f\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u304a\u3088\u3073\u6f5c\u5728\u7684\u306a\u6cbb\u7642\u6a19\u7684\u3068\u3057\u3066\u306eJCAD\u3092\u652f\u6301\u3059\u308b\u91cd\u8981\u306a\u77e5\u898b\u3092\u63d0\u4f9b\u3057\u3066\u3044\u308b\u3002\u7b2c\u4e00\u306b\u3001SPUM-ACS\u304a\u3088\u3073RISK-PPCI\u306e\u4e21\u30b3\u30db\u30fc\u30c8\u306b\u304a\u3044\u3066\u3001JCAD\u306e\u8840\u6f3f\u30ec\u30d9\u30eb\u304c\u6b8b\u5b58\u30ea\u30b9\u30af\u306e\u7a2e\u985e\u306b\u304b\u304b\u308f\u3089\u305a\u4e00\u8cab\u3057\u3066MACE\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002\u3055\u3089\u306b\u3001RISK-PPCI\u7814\u7a76\u30b3\u30db\u30fc\u30c8\u306b\u304a\u3044\u3066\u3001JCAD\u306fTF\u3001TAFI\u3001PAI-1\u3092\u542b\u3080\u8840\u6813\u4fc3\u9032\u6027\u56e0\u5b50\u3068\u76f8\u95a2\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u306fJCAD\u304c\u5b9f\u9a13\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u52d5\u8108\u8840\u6813\u5f62\u6210\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u5148\u884c\u7814\u7a76\u3068\u4e00\u81f4\u3057\u3066\u3044\u308b (8)\u3002<\/p>\n

 <\/p>\n

\u672c\u7814\u7a76\u306b\u306f\u3001\u3053\u308c\u3089\u306e\u77e5\u898b\u306e\u9811\u5065\u6027\u3092\u9ad8\u3081\u308b\u3044\u304f\u3064\u304b\u306e\u5f37\u307f\u304c\u3042\u308b\u3002\u3053\u308c\u306b\u306f\u3001SPUM-ACS\u30b3\u30db\u30fc\u30c8\u306e\u5927\u898f\u6a21\u304b\u3064\u524d\u5411\u304d\u306a\u6027\u8cea\u3001\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\uff08JCAD\u304a\u3088\u3073hs-CRP\uff09\u306e\u4e2d\u592e\u6e2c\u5b9a\u3001\u304a\u3088\u3073\u691c\u8a3c\u6e08\u307f\u306eSampson\u5f0f\u3092\u7528\u3044\u305fLDL-C\u30ec\u30d9\u30eb\u306e\u5c0e\u51fa\u304c\u542b\u307e\u308c\u308b\u3002\u6b8b\u5b58\u30ea\u30b9\u30af\u306f\u3001\u521d\u56de\u5165\u9662\u6642\u306b\u6e2c\u5b9a\u3055\u308c\u305f\u8102\u8cea\u304a\u3088\u3073\u708e\u75c7\u30de\u30fc\u30ab\u30fc\u306b\u3088\u3063\u3066\u5b9a\u7fa9\u3055\u308c\u305f\u304c\u3001\u3053\u308c\u306f\u6cbb\u7642\u5f8c\u306e\u5b9a\u5e38\u72b6\u614b\u306e\u30ec\u30d9\u30eb\u3092\u53cd\u6620\u3057\u3066\u304a\u3089\u305a\u3001\u7570\u306a\u308b\u30ea\u30b9\u30af\u5c64\u5225\u5316\u306b\u6709\u5229\u306b\u50cd\u304f\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u7814\u7a76\u8005\u3089\u306f\u3001\u3053\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u6cbb\u7642\u6c7a\u5b9a\u3092\u8fc5\u901f\u306b\u884c\u3046\u5fc5\u8981\u304c\u3042\u308b\u5b9f\u81e8\u5e8a\u306eACS\u8a2d\u5b9a\u306b\u3088\u308a\u95a2\u9023\u6027\u304c\u3042\u308b\u3068\u4e3b\u5f35\u3057\u305f\u3002<\/p>\n

 <\/p>\n

\u7d50\u8ad6\u3068\u3057\u3066\u3001\u672c\u7814\u7a76\u306e\u77e5\u898b\u306f\u3001\u6700\u8fd1ACS\u3092\u767a\u75c7\u3057\u305f\u60a3\u8005\u306b\u5bfe\u3059\u308b\u3088\u308a\u7a4d\u6975\u7684\u306a\u81e8\u5e8a\u7ba1\u7406\u306e\u5fc5\u8981\u6027\u3092\u518d\u78ba\u8a8d\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u8102\u8cea\u3084\u708e\u75c7\u3092\u8d85\u3048\u305f\u65b0\u305f\u306a\u6a19\u7684\u3092\u7279\u5b9a\u3059\u308b\u5fc5\u8981\u6027\u3092\u5f37\u8abf\u3057\u3066\u3044\u308b\u3002JCAD\u306f\u6709\u671b\u306a\u6a19\u7684\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u6b63\u5f53\u5316\u3055\u308c\u308b\u3002<\/p>\n

 <\/p>\n

\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

    \n
  1. Sabatine MS\u3001Giugliano RP\u3001Keech AC\u3001\u4ed6\uff1a\u5fc3\u8840\u7ba1\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u3068\u81e8\u5e8a\u8ee2\u5e30\u3002N Engl J Med 2017;376:1713-22.<\/li>\n
  2. Schwartz GG, Steg PG, Szarek M, et al. \u30a2\u30ea\u30ed\u30af\u30de\u30d6\u3068\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u5f8c\u306e\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u3002N Engl J Med 2018;379:2097-107.<\/li>\n
  3. Liberale L, Montecucco F, Schwarz L, Luscher TF, Camici GG.\u708e\u75c7\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\uff1a\u91cd\u8981\u306a\u81e8\u5e8a\u8a66\u9a13\u304b\u3089\u306e\u6559\u8a13\u3002Cardiovasc Res 2021;117:411-22.<\/li>\n
  4. Fiolet ATL, Thompson PL, Mosterd A. \u51a0\u52d5\u8108\u75be\u60a3\u306b\u304a\u3051\u308b\u30b3\u30eb\u30d2\u30c1\u30f3\uff1a\u3082\u3046\u4e00\u3064\u306e\u30eb\u30cd\u30c3\u30b5\u30f3\u30b9<\/li>\n<\/ol>\n

    \u53e4\u4ee3\u306e\u85ac\u7269\u306eCardiovasc Res 2021;117:e4-e6.<\/p>\n

      \n
    1. Erdmann J, Willenborg C, Nahrstaedt J, et al. Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23. Eur Heart J 2011;32:158\u201368.<\/li>\n
    2. Coronary Artery Disease (C4D) Genetics Consortium. A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nat Genet 2011;43:339\u201344.<\/li>\n
    3. Guzik TJ, Channon KM.JCAD\uff1a\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u308b\u65b0\u305f\u306aGWAS\u6a19\u7684\u304b\uff1fEur Heart J 2023;44:1834-6.<\/li>\n
    4. Liberale L, Puspitasari YM, Ministrini S, et al. JCAD promotes arterial thrombosis through PI3K\/Akt modulation: a translational study. Eur Heart J 2023;44:1818\u201333.<\/li>\n<\/ol>\n

      \u30ad\u30fc\u30ef\u30fc\u30c9\u6025\u6027\u51a0\u75c7\u5019\u7fa4\uff1b\u6b8b\u5b58\u30ea\u30b9\u30af\uff1b\u708e\u75c7\uff1b\u8102\u8cea\uff1b\u51a0\u52d5\u8108\u75be\u60a3\u306b\u95a2\u9023\u3059\u308b\u63a5\u5408\u86cb\u767d\uff1bJCAD<\/em><\/p>\n<\/div>\n

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