{"id":257315,"date":"2025-04-12T01:14:29","date_gmt":"2025-04-11T23:14:29","guid":{"rendered":"https:\/\/r3i.org\/r3i%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9\/%e7%84%a6%e7%82%b9-apoc3%e3%81%a8ldl-c%e3%82%92%e6%a8%99%e7%9a%84%e3%81%a8%e3%81%97%e3%81%9f%e4%bd%b5%e7%94%a8%e7%99%82%e6%b3%95%e3%81%ae%e5%8f%af%e8%83%bd%e6%80%a7\/"},"modified":"2026-03-04T21:38:43","modified_gmt":"2026-03-04T20:38:43","slug":"%e7%84%a6%e7%82%b9-apoc3%e3%81%a8ldl-c%e3%82%92%e6%a8%99%e7%9a%84%e3%81%a8%e3%81%97%e3%81%9f%e4%bd%b5%e7%94%a8%e7%99%82%e6%b3%95%e3%81%ae%e5%8f%af%e8%83%bd%e6%80%a7","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/r3i%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9\/%e7%84%a6%e7%82%b9-apoc3%e3%81%a8ldl-c%e3%82%92%e6%a8%99%e7%9a%84%e3%81%a8%e3%81%97%e3%81%9f%e4%bd%b5%e7%94%a8%e7%99%82%e6%b3%95%e3%81%ae%e5%8f%af%e8%83%bd%e6%80%a7\/","title":{"rendered":"\u7126\u70b9 – APOC3\u3068LDL-C\u3092\u6a19\u7684\u3068\u3057\u305f\u4f75\u7528\u7642\u6cd5\u306e\u53ef\u80fd\u6027"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||||false|false” hover_enabled=”0″ global_colors_info=”{}” width=”57.2%” sticky_enabled=”0″][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”||||false|false” custom_padding=”|0px||8px||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]<\/p>\n

\u7126\u70b9 – APOC3\u3068LDL-C\u3092\u6a19\u7684\u3068\u3057\u305f\u4f75\u7528\u7642\u6cd5\u306e\u53ef\u80fd\u6027<\/h2>\n

2025\u5e744\u6708<\/span><\/h5>\n

40\u4e07\u4eba\u4ee5\u4e0a\u306eUK Biobank\u53c2\u52a0\u8005\u3092\u542b\u3080\u3053\u306e\u907a\u4f1d\u7684\u95a2\u9023\u7814\u7a76\u306e\u7d50\u679c\u306f\u3001APOC3\u304a\u3088\u3073LDL-C\u4f4e\u4e0b\u3092\u6a19\u7684\u3068\u3057\u305f\u4f75\u7528\u4ecb\u5165\u304c\u3001\u5358\u5264\u7642\u6cd5\u3068\u6bd4\u8f03\u3057\u3066\u8102\u8cea\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306e\u6539\u5584\u304a\u3088\u3073\u51a0\u52d5\u8108\u5fc3\u75be\u60a3\u30ea\u30b9\u30af\u306e\u4f4e\u6e1b\u306b\u304a\u3044\u3066\u3001\u3088\u308a\u5927\u304d\u306a\u5229\u76ca\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u521d\u3081\u3066\u793a\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001\u81e8\u5e8a\u8a66\u9a13\u3067\u306e\u691c\u8a3c\u306b\u5024\u3057\u307e\u3059\u3002 <\/span><\/i><\/p>\n

Wang W, Li R, Song Z, Huang N, et al. APOC3\u3068LDL-C\u4f4e\u4e0b\u30d0\u30ea\u30a2\u30f3\u30c8\u306e\u51a0\u52d5\u8108\u6027\u5fc3\u75be\u60a3\u30ea\u30b9\u30af\u3068\u306e\u5171\u540c\u95a2\u9023\u3002JAMA Cardiol\u8a8c\u3002 <\/span><\/i><\/p>\n

\u7814\u7a76\u6982\u8981<\/b><\/p>\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\n1\uff09\u907a\u4f1d\u5b66\u7684\u306b\u4e88\u6e2c\u3055\u308c\u308b\u30a2\u30dd\u30ea\u30dd\u86cb\u767dC3\uff08APOC3\uff09\u306e\u4f4e\u4e0b\u304c\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u4f4e\u4e0b\u3068\u95a2\u9023\u3059\u308b\u304b\u3069\u3046\u304b\uff0c2\uff09APOC3\u4f4e\u4e0b\u5909\u7570\u4f53\u3068\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u4f4e\u4e0b\u5909\u7570\u4f53\u3068\u306e\u8907\u5408\u66dd\u9732\u304c\u51a0\u52d5\u8108\u6027\u5fc3\u75be\u60a3\uff08CHD\uff09\u30ea\u30b9\u30af\u306e\u4f4e\u4e0b\u3068\u95a2\u9023\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3002<\/span><\/td>\n<\/tr>\n
\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff1a<\/strong><\/td>\n2\u00d72\u8981\u56e0\u30e1\u30f3\u30c7\u30eb\u30e9\u30f3\u30c0\u30e0\u5316\u3092\u7528\u3044\u305f\u96c6\u56e3\u30d9\u30fc\u30b9\u306e\u907a\u4f1d\u7684\u95a2\u9023\u7814\u7a76<\/span><\/td>\n<\/tr>\n
\u7814\u7a76\u5bfe\u8c61\u8005\uff1a<\/strong><\/td>\nUK Biobank\u7814\u7a76\u306b\u53c2\u52a0\u3057\u305f\u6b27\u5dde\u7cfb\u8840\u7d71\u306e401,548\u4eba\uff08\u5e73\u5747\u5e74\u9f6256.9\u6b73\u300154\uff05\u304c\u5973\u6027\uff09\u3002\u3053\u306e\u30b3\u30db\u30fc\u30c8\u306e\u5e73\u5747\uff08\u6a19\u6e96\u504f\u5dee\uff09LDL-C\u5024\u306f138.1\uff0833.7\uff09mg\/dL\u3001\u4e2d\u592e\u5024\uff08\u56db\u5206\u4f4d\u7bc4\u56f2\uff09\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u306f132.5\uff0893.6-191.6\uff09mg\/dL\u3067\u3042\u3063\u305f\u3002 <\/span><\/td>\n<\/tr>\n
\u4e3b\u306a\u7814\u7a76\u5909\u6570\uff1a<\/strong><\/td>\n\u8840\u6f3f\u8102\u8cea\u304a\u3088\u3073\u30ea\u30dd\u86cb\u767d\u30ec\u30d9\u30eb\u3068CHD\u30ea\u30b9\u30af\u3002<\/span><\/td>\n<\/tr>\n
\u65b9\u6cd5\uff1a<\/strong><\/td>\n\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3092\u4f4e\u4e0b\u3055\u305b\u308bAPOC3\u3001LDL-C\u3092\u4f4e\u4e0b\u3055\u305b\u308b3-\u30d2\u30c9\u30ed\u30ad\u30b7-3-\u30e1\u30c1\u30eb\u30b0\u30eb\u30bf\u30ea\u30eb\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0A\u9084\u5143\u9175\u7d20\uff08HMGCR\uff09\u3001\u30d7\u30ed\u30bf\u30f3\u30d1\u30af\u8cea\u8ee2\u63db\u9175\u7d20\u30b5\u30d6\u30c1\u30ea\u30b7\u30f3-\u30b1\u30ad\u30b7\u30f39\u578b\uff08PCSK9\uff09\u963b\u5bb3\u85ac\u306e\u52b9\u679c\u3092\u6a21\u5023\u3059\u308b\u907a\u4f1d\u5b50\u30b9\u30b3\u30a2\u3092\u958b\u767a\u3057\u305f\u3002\u907a\u4f1d\u5b66\u7684\u306b\u4e88\u6e2c\u3055\u308c\u308bAPOC3\uff0cPCSK9\uff0cHMGCR\u6fc3\u5ea6\u306e\u4f4e\u4e0b\u3068\u8102\u8cea\u304a\u3088\u3073\u81e8\u5e8a\u8ee2\u5e30\u3068\u306e\u56e0\u679c\u95a2\u4fc2\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306b\u30e1\u30f3\u30c7\u30eb\u30e9\u30f3\u30c0\u30e0\u5316\u30c7\u30b6\u30a4\u30f3\u3092\u7528\u3044\u305f\u3002\u6b21\u306b\u30012\u00d72\u8981\u56e0\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13\u3092\u884c\u3044\u3001\u4e2d\u592e\u5024\u3067\u4e8c\u5206\u3055\u308c\u305fAPOC3\u907a\u4f1d\u5b50\u30b9\u30b3\u30a2\u3068HMGCR\/PCSK9\u907a\u4f1d\u5b50\u30b9\u30b3\u30a2\u3068\u5faa\u74b0\u8102\u8cea\u3001\u30ea\u30dd\u86cb\u767d\u3001CHD\u3068\u306e\u95a2\u9023\u3092\u8a55\u4fa1\u3057\u305f\u3002 <\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7d50\u679c<\/strong><\/p>\n

\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u502412.5\u5e74\u3067\u3001CHD\u75c7\u4f8b\u306f25,199\u4f8b\u3067\u3042\u3063\u305f\u3002\u907a\u4f1d\u7684\u306b\u4f4e\u3044APOC3\u6fc3\u5ea6\u306f\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3001LDL-C\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\uff08apoB\uff09\u3001\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304a\u3088\u3073\u6b8b\u4f59\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4f4e\u5024\u3001HDL-C\u306e\u9ad8\u5024\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u907a\u4f1d\u7684\u306b\u4f4e\u3044PCSK9\u3068HMGCR\u3068\u306e\u95a2\u9023\u306f\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068HDL-C\u3092\u9664\u3044\u3066\u3001APOC3\u306e\u305d\u308c\u3068\u540c\u69d8\u3067\u3042\u3063\u305f\u3002 <\/span>
\u907a\u4f1d\u7684\u306b\u4f4e\u3044APOC3\u304a\u3088\u3073LDL-C\u76ee\u6a19\u5024\uff08HMGCR\u304a\u3088\u3073PCSK9\uff09\u306f\u3001\u30a2\u30ddB\u304c10mg\/dL\u6e1b\u5c11\u3059\u308b\u3054\u3068\u306bCHD\u30ea\u30b9\u30af\u304c\u540c\u7a0b\u5ea6\u306b\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\uff08\u8868<\/span>\u88681<\/b>). \u907a\u4f1d\u7684\u306b\u4f4e\u5024\u306eAPOC3\u3068PCSK9\u3001\u3042\u308b\u3044\u306f\u907a\u4f1d\u7684\u306b\u4f4e\u5024\u306eAPOC3\u3068HMGCR\u306e\u8907\u5408\u66b4\u9732\u306f\u3001\u305d\u308c\u305e\u308cCHD\u30ea\u30b9\u30af\u306e\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002<\/span><\/p>\n

 <\/p>\n

\u88681. \u907a\u4f1d\u7684\u306b\u4f4e\u3044AP0C3\u3001PCSK9\u304a\u3088\u3073HMGCR\u3068\u8102\u8cea\u5024\u304a\u3088\u3073CHD\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u6027<\/b><\/strong><\/p>\n\n\n\n\n\n\n\n\n\n
<\/td>\n\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08mg\/dL\uff09\u306e\u5909\u5316\uff0895\uff05CI\uff09<\/span><\/td>\nLDL-C\u306e\u5909\u5316\uff0895\uff05CI\uff09\uff08mg\/dL\uff09<\/span><\/td>\n\u30aa\u30c3\u30ba\u6bd4\uff0895\uff05CI\uff09<\/span><\/td>\n<\/tr>\n
APOC3*\u306e\u4f4e\u4e0b<\/span><\/td>\n\n

-142.99 <\/span><\/p>\n

(-146.74, -139.24)<\/span><\/p>\n<\/td>\n

\n

-11.33 <\/span><\/p>\n

(-12.76, -9.91)<\/span><\/p>\n<\/td>\n

0.70 (0.59-0.83)<\/span><\/td>\n<\/tr>\n
PCSK9*\u306e\u4f4e\u4e0b<\/span><\/td>\n\n

1.54 <\/span><\/p>\n

(-0.37, 3.45)<\/span><\/p>\n<\/td>\n

\n

-14.52 <\/span><\/p>\n

(-15.24, -13.80)<\/span><\/p>\n<\/td>\n

0.71 (0.65-0.77)<\/span><\/td>\n<\/tr>\n
HMGCR*\u306e\u4f4e\u4e0b<\/span><\/td>\n\n

-3.27 <\/span><\/p>\n

(-6.48, -0.06)<\/span><\/p>\n<\/td>\n

\n

-16.01 <\/span><\/p>\n

(-17.22, -14.80)<\/span><\/p>\n<\/td>\n

0.85 (0.73, 0.98)<\/span><\/td>\n<\/tr>\n
\u5171\u540c\u7d44\u5408<\/b><\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\n

APOC3 <\/span><\/p>\n

PCSK9<\/span><\/p>\n

APOC3\/PCSK9 <\/b><\/p>\n<\/td>\n

<\/td>\n<\/td>\n\n

0.96 (0.92-0.99)<\/span><\/p>\n

0.93 (0.90-0.97)<\/span><\/p>\n

0.90 (0.86-0.93)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

HMGCR<\/span><\/p>\n

HMGCR\/APOC3<\/b><\/p>\n<\/td>\n

<\/td>\n<\/td>\n\n

0.97 (0.94-1.01)<\/span><\/p>\n

0.93 (0.90-0.97)<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

* \u30a2\u30ddB\u304c10mg\/dL\u6e1b\u5c11\u3059\u308b\u3054\u3068\u306b\uff1bCI\u4fe1\u983c\u533a\u9593 <\/span><\/b><\/strong><\/p>\n\n\n\n
\u8457\u8005\u306e\u7d50\u8ad6<\/strong><\/td>\n\u907a\u4f1d\u5b66\u7684\u306b\u4e88\u6e2c\u3055\u308c\u305fAPOC3\u306e\u4f4e\u5024\u306f\u3001ApoB\u306e\u5358\u4f4d\u6e1b\u5c11\u3042\u305f\u308a\u306ePCSK9\u306e\u4f4e\u5024\u3068\u540c\u7a0b\u5ea6\u306eCHD\u30ea\u30b9\u30af\u306e\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002APOC3\u3068LDL-C\u4f4e\u4e0b\u30d0\u30ea\u30a2\u30f3\u30c8\u306e\u4f75\u7528\u306fCHD\u30ea\u30b9\u30af\u306e\u76f8\u52a0\u7684\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u4eca\u5f8c\u3001\u7279\u306b\u65e2\u5b58\u306e\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3067\u6cbb\u7642\u76ee\u6a19\u3092\u9054\u6210\u3067\u304d\u306a\u3044\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u3001\u3053\u308c\u3089\u306e\u4f75\u7528\u7642\u6cd5\u306e\u6cbb\u7642\u53ef\u80fd\u6027\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002 <\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

\u8102\u8cea\u95a2\u9023\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u7ba1\u7406\u306f\u3001\u4e3b\u306b\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3001\u5f8c\u306b\u306fPCSK9\u963b\u5bb3\u306b\u3088\u308bLDL-C\u306b\u7126\u70b9\u304c\u5f53\u3066\u3089\u308c\u3066\u304d\u305f\u3002\u3053\u308c\u3089\u306e\u52b9\u679c\u7684\u306a\u6cbb\u7642\u3067LDL-C\u306e\u76ee\u6a19\u5024\u3092\u9054\u6210\u3057\u305f\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u7279\u306b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u304c\u9ad8\u3044\u60a3\u8005\u3067\u306f\u9ad8\u3044\u6b8b\u5b58\u30ea\u30b9\u30af\u304c\u6301\u7d9a\u3057\u3066\u3044\u308b(1-4)\u3002\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u306f\u3001\u5fc3\u8840\u7ba1\u5371\u967a\u56e0\u5b50\u3068\u3057\u3066\u95a2\u4e0e\u3057\u3066\u3044\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u3068\u305d\u306e\u6b8b\u6e23\u306e\u4ee3\u7528\u3068\u3057\u3066\u8a8d\u3081\u3089\u308c\u3066\u3044\u308b\u305f\u3081(5)\u3001\u3053\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u3092\u6a19\u7684\u3068\u3057\u305f\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002 <\/span><\/p>\n

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\u53c2\u8003\u6587\u732e<\/strong><\/td>\n1.Nordestgaard BG\u3002Triglyceride-rich lipoproteins and atherosclerotic cardiovascular disease: new insights from epidemiology, genetics, and biology.Circ Res 2016;118:547-63.
2.Langsted A, Madsen CM, Nordestgaard BG.\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308b\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5bc4\u4e0e\u3002J Intern Med 2020;288:116-27.
3.\u865a\u8840\u6027\u5fc3\u75be\u60a3\u306e\u539f\u56e0\u5371\u967a\u56e0\u5b50\u3068\u3057\u3066\u306e\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3002J Am Coll Cardiol 2013;61:427-36.
4.Schwartz GG, Abt M, Bao W, et al. \u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u305f\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u7a7a\u8179\u6642\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306f\u865a\u8840\u30a4\u30d9\u30f3\u30c8\u306e\u518d\u767a\u3092\u4e88\u6e2c\u3059\u308b\u3002J Am Coll Cardiol 2015;65:2267-75.
5.Ginsberg HN, Packard CJ, Chapman MJ, et al. Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies – a consensus statement from the European Atherosclerosis Society.Eur Heart J 2021;42:4791-806.
6.J\u00f8rgensen AB, Frikke-Schmidt R, Nordestgaard BG, Tybj\u00e6rg-Hansen A. APOC3\u306e\u6a5f\u80fd\u55aa\u5931\u5909\u7570\u3068\u865a\u8840\u6027\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3002N Engl J Med 2014;371:32-41.
7.TG and HDL Working Group of the Exome Sequencing Project, National Heart, Lung, and Blood Institute.APOC3\u306e\u6a5f\u80fd\u55aa\u5931\u5909\u7570\u3001\u4e2d\u6027\u8102\u80aa\u3001\u51a0\u75be\u60a3\u3002N Engl J Med 2014;371:22-31.
8.Tardif JC, Karwatowska-Prokopczuk E, Amour ES, et al. \u4e2d\u7b49\u5ea6\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3067\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u88ab\u9a13\u8005\u306b\u304a\u3051\u308b\u30a2\u30dd\u30ea\u30dd\u86cb\u767dC-III\u306e\u6e1b\u5c11\u3002Eur Heart J 2022;43:1401-12.
9.Kosmas CE, Bousvarou MD, Tsamoulis D, et al. Novel RNA-Based Therapies in the management of dyslipidemias.Int J Mol Sci 2025; 26: 1026.
10.Ahmad M, Hegele RA.\u9ad8\u30ea\u30dd\u86cb\u767d\u8840\u75c7\u3092\u6cbb\u7642\u3059\u308b\u305f\u3081\u306b\u958b\u767a\u4e2d\u306e\u5206\u5b50\u6cbb\u7642\u85ac\u3002Mol Diagn Ther 2025; doi: 10.1007\/s40291-024-00768-0. <\/td>\n<\/tr>\n
\u30ad\u30fc\u30ef\u30fc\u30c9<\/strong><\/td>\n\u30a2\u30dd\u30ea\u30dd\u86cb\u767dC3\uff1b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u30ea\u30c3\u30c1\u30ea\u30dd\u86cb\u767d\uff1b\u30e1\u30f3\u30c7\u30ea\u30a2\u30f3\u7121\u4f5c\u70ba\u5316\uff1b\u5fc3\u8840\u7ba1\u6b8b\u5b58\u30ea\u30b9\u30af<\/span><\/i><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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