\n| \n \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9<\/span><\/p>\n<\/td>\n | \n 36.3% (-45.8 to -) <\/span><\/p>\n-25.1) p<0.0001<\/span><\/p>\n<\/td>\n | \n -50.3% (-56.-4 \uff5e) <\/span><\/p>\n-43.3) p<0.0001<\/span><\/p>\n<\/td>\n | \n 52.5% (-58.4 to -) <\/span><\/p>\n-45.9) p<0.0001<\/span><\/p>\n<\/td>\n<\/tr>\n\n| \n VLDL-C<\/span><\/p>\n<\/td>\n | \n 41.6% (-52.4 to -) <\/span><\/p>\n28.3) p<0.0001<\/span><\/p>\n<\/td>\n | \n -50.1% (-57.-8\uff5e) <\/span><\/p>\np<0.0001<\/span><\/p>\n<\/td>\n | \n 49.6% (-57.4 to -) <\/span><\/p>\n-40.4) p<0.0001<\/span><\/p>\n<\/td>\n<\/tr>\n\n| \n LDL-C<\/span><\/p>\n<\/td>\n | \n -1.3% (-14.6 to 14.0) p=0.85<\/span><\/p>\n<\/td>\n | \n 16.8% ( -26.0 \uff5e ) <\/span><\/p>\n-6.4) p=0.0025<\/span><\/p>\n<\/td>\n | \n 12.1% (-21.9 to -) <\/span><\/p>\n-1.1) p=0.033<\/span><\/p>\n<\/td>\n<\/tr>\n\n| \n \u975eHDL-C<\/span><\/p>\n<\/td>\n | \n -10.8% (-21.1 to 0.9) p=0.068<\/span><\/p>\n<\/td>\n | \n 25.5% (-32.6\uff5e) <\/span><\/p>\n-17.6) p<0.0001<\/span><\/p>\n<\/td>\n | \n -23.8% (-31.1\uff5e) <\/span><\/p>\n-15.7) p<0.0001<\/span><\/p>\n<\/td>\n<\/tr>\n\n| <\/td>\n | <\/td>\n | <\/td>\n | <\/td>\n<\/tr>\n | \n| \n 270\u65e5\u76ee<\/b><\/p>\n<\/td>\n | <\/td>\n | <\/td>\n | <\/td>\n<\/tr>\n | \n| \n \u30a2\u30ddB<\/span><\/p>\n<\/td>\n | \n -10.8% (-22.2 to 2.3) p=0.10<\/span><\/p>\n<\/td>\n | \n -11.3% (-20.6\uff5e) <\/span><\/p>\n-1.0) p=0.033<\/span><\/p>\n<\/td>\n | \n 10.9% (-20.3 to -) <\/span><\/p>\n-0.6) p=0.040<\/span><\/p>\n<\/td>\n<\/tr>\n\n| \n \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9<\/span><\/p>\n<\/td>\n | \n -28.3% ( -40.5 \uff5e )<\/span><\/p>\n -13.6) p=0.0005<\/span><\/p>\n<\/td>\n | \n 42.5% (CI -50.5 to -33.2) p<0.0001<\/span><\/p>\n<\/td>\n | \n -44.8% (-52.5\uff5e) <\/span><\/p>\n-35.9) p<0.0001<\/span><\/p>\n<\/td>\n<\/tr>\n\n| \n VLDL-C<\/span><\/p>\n<\/td>\n | \n -26.7% (-40.3 \uff5e) <\/span><\/p>\n-10.1) p=0.0031<\/span><\/p>\n<\/td>\n | \n -43.2% (-51.7\uff5e) <\/span><\/p>\np<0.0001<\/span><\/p>\n<\/td>\n | \n -43.5% (-52.0\uff5e) <\/span><\/p>\np<0.0001<\/span><\/p>\n<\/td>\n<\/tr>\n\n| \n LDL-C<\/span><\/p>\n<\/td>\n | \n 6.5% (-8.4 to 23.7)<\/span><\/p>\np=0.041<\/span><\/p>\n<\/td>\n | \n -9.5% (-19.7 to 2.1) p=0.10<\/span><\/p>\n<\/td>\n | \n -5.4% (-16.2 to 6.7) p=0.36<\/span><\/p>\n<\/td>\n<\/tr>\n\n| \n \u975eHDL-C<\/span><\/p>\n<\/td>\n | \n -4.1% (-15.2 to 8.5) p=0.51<\/span><\/p>\n<\/td>\n | \n -19.7% ( -27.2 \uff5e ) <\/span><\/p>\n11.3) p<0.0001<\/span><\/p>\n<\/td>\n | \n -19.4% (-27.0\uff5e) <\/span><\/p>\n11.0) p<0.0001<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\u30bd\u30eb\u30d3\u30f3\u30b7\u30e9\u30f3\u306e\u5fcd\u5bb9\u6027\u306f\u6982\u3057\u3066\u826f\u597d\u3067\u3042\u308a\u30013\u3064\u306e\u7528\u91cf\u304a\u3088\u3073\u30d7\u30e9\u30bb\u30dc\u7fa4\u3059\u3079\u3066\u306b\u304a\u3044\u3066\u6709\u5bb3\u4e8b\u8c61\u306e\u767a\u751f\u7387\u306f\u540c\u7a0b\u5ea6\u3067\u3042\u3063\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089180\u65e5\u76ee\u307e\u3067\u306e\u809d\u8102\u80aa\u306e\u6e1b\u5c11\u306f\u3001\u3059\u3079\u3066\u306e\u7528\u91cf\u7fa4\u3067\u8a8d\u3081\u3089\u308c\u305f\uff08100mg\u6295\u4e0e\u7fa4\u306726.8\uff05\u3001400mg\u6295\u4e0e\u7fa4\u306742.4\uff05\u3001800mg\u6295\u4e0e\u7fa4\u306735.9\uff05\uff1b\u3059\u3079\u3066p<0.0001\uff09\u3002 <\/span><\/p>\n<\/td>\n<\/tr>\n\n| \n \u8457\u8005\u7d50\u8ad6<\/b><\/p>\n<\/td>\n | \n \u30bd\u30eb\u30d3\u30f3\u30b7\u30e9\u30f3400mg\u306f\u6df7\u5408\u578b\u8102\u8cea\u7570\u5e38\u75c7\u60a3\u8005\u306e\u30a2\u30ddB\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u4e00\u822c\u306b\u5fcd\u5bb9\u6027\u306f\u826f\u597d\u3067\u3042\u3063\u305f\u3002\u30bd\u30eb\u30d3\u30f3\u30b7\u30e9\u30f3\u304c\u5fc3\u8840\u7ba1\u7cfb\u306e\u8ee2\u5e30\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306b\u3064\u3044\u3066\u306f\u307e\u3060\u691c\u8a0e\u3055\u308c\u3066\u3044\u306a\u3044\u3002 <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\u30b3\u30e1\u30f3\u30c8<\/b><\/p>\n LDL-C\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304c\u826f\u597d\u3067\u3042\u3063\u3066\u3082\u3001\u6df7\u5408\u578b\u8102\u8cea\u7570\u5e38\u75c7\u60a3\u8005\u3067\u306f\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u3084\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u306b\u4f34\u3046\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u307e\u307e\u3067\u3042\u308b(1-3)\u3002\u3057\u304b\u3057\u3001\u73fe\u5728\u307e\u3067\u306e\u3068\u3053\u308d\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306e\u4e0a\u6607\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u6cd5\u3067\u306f\u3001\u7121\u4f5c\u70ba\u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3044\u3066\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u6e1b\u5c11\u3092\u793a\u3057\u305f\u3082\u306e\u306f\u307b\u3068\u3093\u3069\u306a\u304f\u3001\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u5fc5\u8981\u6027\u304c\u5f37\u8abf\u3055\u308c\u3066\u3044\u308b\u3002\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3092\u591a\u304f\u542b\u3080\u30ea\u30dd\u86cb\u767d\u306e\u4ee3\u8b1d\u3092\u5236\u5fa1\u3059\u308b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059ANGPTL3\u306f\u3001\u6f5c\u5728\u7684\u306a\u6a19\u7684\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u304a\u308a\u3001\u907a\u4f1d\u5b66\u7684\u7814\u7a76\u306b\u3088\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u305d\u306e\u591a\u304f\u3092\u88cf\u4ed8\u3051\u3066\u3044\u308b(4-7)\u3002 <\/span><\/p>\n <\/span><\/p>\nANGPTL3\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u3067\u3042\u308bvupanorsen\u306e\u7d50\u679c\u306f\u3001\u809d\u8102\u80aa\u7387\u306e\u5897\u52a0\u3084\u809d\u30a2\u30df\u30ce\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\u306e\u9855\u8457\u306a\u4e0a\u6607\u306b\u3088\u308a\u3001\u809d\u306e\u5b89\u5168\u6027\u304c\u61f8\u5ff5\u3055\u308c\u3001\u958b\u767a\u4e2d\u6b62\u306b\u81f3\u3063\u305f(8)\u304c\u3001RNA\u5e72\u6e09\u3092\u7528\u3044\u305f\u5225\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u306f\u3001\u6709\u671b\u306a\u7d50\u679c\u304c\u5f97\u3089\u308c\u3066\u3044\u308b(9)\u3002\u3053\u308c\u3089\u306e\u85ac\u5264\u306e\u6700\u65b0\u306e\u3082\u306e\u3067\u3042\u308b\u30bd\u30eb\u30d3\u30f3\u30b7\u30e9\u30f3\u306f\u3001ANGPTL3\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fcRNA\u306e\u809d\u7ffb\u8a33\u3092\u963b\u5bb3\u3059\u308b\u305f\u3081\u306b\u958b\u767a\u3055\u308c\u3001\u30d2\u30c8\u3092\u5bfe\u8c61\u3068\u3057\u305f\u521d\u671f\u306e\u7814\u7a76\u3067\u306f\u3001\u6df7\u5408\u578b\u8102\u8cea\u7570\u5e38\u75c7\u306b\u304a\u3051\u308b\u3059\u3079\u3066\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u30ea\u30dd\u86cb\u767d\u306e\u6709\u610f\u306a\u6e1b\u5c11\u3092\u793a\u3057\u305f(10)\u3002 <\/span><\/p>\n <\/b><\/p>\n \u672c\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u30bd\u30eb\u30d3\u30f3\u30b7\u30e9\u30f3400mg\u306f\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u304a\u3088\u3073\u30ea\u30dd\u86cb\u767d\uff08\u30a2\u30ddB\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3001\u975eHDL-C\u3001LDL-C\uff09\u306e\u6301\u7d9a\u7684\u306a\u4f4e\u4e0b\u3092\u3082\u305f\u3089\u3057\u3001\u5fcd\u5bb9\u6027\u3082\u826f\u597d\u3067\u3001\u6709\u5bb3\u306a\u809d\u5b89\u5168\u6027\u30b7\u30b0\u30ca\u30eb\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u6df7\u5408\u578b\u8102\u8cea\u7570\u5e38\u75c7\u60a3\u8005\u306b\u304a\u3051\u308b\u30bd\u30eb\u30d3\u30f3\u30b7\u30e9\u30f3\u306e\u3055\u3089\u306a\u308b\u8a55\u4fa1\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002 <\/span><\/p>\n <\/b><\/p>\n \u53c2\u8003\u6587\u732e<\/b><\/p>\n\n- Nordestgaard BG.\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u3068\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff1a\u75ab\u5b66\u3001\u907a\u4f1d\u5b66\u3001\u751f\u7269\u5b66\u304b\u3089\u306e\u65b0\u305f\u306a\u6d1e\u5bdf\u3002Circ Res 2016;118:547-63. <\/span><\/li>\n
- Langsted A, Madsen CM, Nordestgaard BG.\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308b\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5bc4\u4e0e\u3002J Intern Med 2020;288:116-27. <\/span><\/li>\n
- Ginsberg HN, Packard CJ, Chapman MJ, et al. \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u3068\u305d\u306e\u6b8b\u4f59\u7269\uff1a\u4ee3\u8b1d\u7684\u6d1e\u5bdf\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u306b\u304a\u3051\u308b\u5f79\u5272\u3001\u304a\u3088\u3073\u65b0\u305f\u306a\u6cbb\u7642\u6226\u7565-\u6b27\u5dde\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u5b66\u4f1a\u306e\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u30b9\u30c6\u30fc\u30c8\u30e1\u30f3\u30c8\u3002\u6b27\u5dde\u5fc3\u81d3J 2021;42:4791-806\u3002 <\/span><\/li>\n
- Graham MJ, Lee RG, Brandt TA, et al. ANGPTL3\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306e\u5fc3\u8840\u7ba1\u304a\u3088\u3073\u4ee3\u8b1d\u52b9\u679c\u3002N Engl J Med 2017;377: 222-32. <\/span><\/li>\n<\/ol>\n
5 Stitziel NO, Khera AV, Wang X, et al. ANGPTL3\u306e\u6b20\u640d\u3068\u51a0\u52d5\u8108\u75be\u60a3\u306b\u5bfe\u3059\u308b\u4e88\u9632\u3002J Am Coll Cardiol 2017;69: 2054-63. <\/span><\/p>\n\n- J\u00f8rgensen AB, Frikke-Schmidt R, Nordestgaard BG, Tybj\u00e6rg-Hansen A. APOC3\u306e\u6a5f\u80fd\u55aa\u5931\u5909\u7570\u3068\u865a\u8840\u6027\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3002N Engl J Med 2014;371:32-41. <\/span><\/li>\n
- \u7c73\u56fd\u56fd\u7acb\u5fc3\u80ba\u8840\u6db2\u7814\u7a76\u6240\u30a8\u30af\u30bd\u30fc\u30e0\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306eTG\u304a\u3088\u3073HDL\u30ef\u30fc\u30ad\u30f3\u30b0\u30b0\u30eb\u30fc\u30d7\u3002APOC3\u306e\u6a5f\u80fd\u55aa\u5931\u5909\u7570\u3001\u4e2d\u6027\u8102\u80aa\u3001\u51a0\u75be\u60a3\u3002N Engl J Med 2014;371:22-31. <\/span><\/li>\n
- Bergmark BA, Marston NA, Bramson CR, et al.\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u9ad8\u5024\u306e\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u306b\u304a\u3051\u308b\u975e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306b\u5bfe\u3059\u308b\u30d6\u30d1\u30ce\u30eb\u30bb\u30f3\u306e\u52b9\u679c\uff1aTRANSLATE-TIMI 70\u3002Circulation 2022; 145: 1377-86. <\/span><\/li>\n
- Kosmas CE, Bousvarou MD, Tsamoulis D, et al. \u8102\u8cea\u7570\u5e38\u75c7\u7ba1\u7406\u306b\u304a\u3051\u308b\u65b0\u898fRNA\u30d9\u30fc\u30b9\u6cbb\u7642\u6cd5\u3002Int J Mol Sci 2025; 26: 1026. <\/span><\/li>\n
- \u30bd\u30eb\u30d3\u30f3\u30b7\u30e9\u30f3\u306b\u3088\u308bANGPTL3\u963b\u5bb3\u306e\u524d\u81e8\u5e8a\u8a66\u9a13\u304a\u3088\u3073\u521d\u671f\u30d2\u30c8\u8a66\u9a13\u306b\u304a\u3051\u308b\u52b9\u679c\u3002J Am Coll Cardiol 2025; doi.org\/10.1016\/j.jacc.2025.03.005. . <\/span><\/li>\n<\/ol>\n
\u30ad\u30fc\u30ef\u30fc\u30c9\u30bd\u30eb\u30d3\u30f3\u30b7\u30e9\u30f3\uff1bANGPTL3\uff1b\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\uff1b\u6df7\u5408\u578b\u8102\u8cea\u7570\u5e38\u75c7<\/span><\/i><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" \u30d5\u30a9\u30fc\u30ab\u30b9 – ANGPTL3\u3092\u6a19\u7684\u3068\u3059\u308bsiRNA\u30bd\u30eb\u30d3\u30f3\u30b7\u30e9\u30f3\u304c\u6df7\u5408\u578b\u8102\u8cea\u7570\u5e38\u75c7\u306b\u6709\u671b 2025 \u5e74 7 […]<\/p>\n","protected":false},"author":258497324,"featured_media":0,"parent":254338,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-257303","page","type-page","status-publish","hentry"],"yoast_head":"\n \u30bd\u30eb\u30d3\u30f3\u30b7\u30e9\u30f3\u3068ANGPTL3\uff1aPROLONG-ANG3\u8a66\u9a13\u306e\u30a4\u30f3\u30b5\u30a4\u30c8 - 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