{"id":257264,"date":"2025-12-13T19:30:09","date_gmt":"2025-12-13T18:30:09","guid":{"rendered":"https:\/\/r3i.org\/%e7%84%a6%e7%82%b9-angptl3%e3%82%92%e6%a8%99%e7%9a%84%e3%81%a8%e3%81%99%e3%82%8b%e6%96%b0%e3%81%9f%e3%81%aa%e6%88%a6%e7%95%a5%ef%bc%9f\/"},"modified":"2026-03-04T21:26:17","modified_gmt":"2026-03-04T20:26:17","slug":"%e7%84%a6%e7%82%b9-angptl3%e3%82%92%e6%a8%99%e7%9a%84%e3%81%a8%e3%81%99%e3%82%8b%e6%96%b0%e3%81%9f%e3%81%aa%e6%88%a6%e7%95%a5%ef%bc%9f","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e7%84%a6%e7%82%b9-angptl3%e3%82%92%e6%a8%99%e7%9a%84%e3%81%a8%e3%81%99%e3%82%8b%e6%96%b0%e3%81%9f%e3%81%aa%e6%88%a6%e7%95%a5%ef%bc%9f\/","title":{"rendered":"\u7126\u70b9 &#8211; ANGPTL3\u3092\u6a19\u7684\u3068\u3059\u308b\u65b0\u305f\u306a\u6226\u7565\uff1f"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;1px|||||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; header_2_text_color=&#8221;gcid-primary-color&#8221; header_5_text_color=&#8221;gcid-secondary-color&#8221; text_orientation=&#8221;center&#8221; width=&#8221;99%&#8221; custom_margin=&#8221;|-147px||||&#8221; custom_padding=&#8221;|0px||||&#8221; global_colors_info=&#8221;{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}&#8221;]<\/p>\n<h2>ANGPTL3\u3092\u6a19\u7684\u3068\u3059\u308b\u65b0\u3057\u3044\u6226\u7565\uff1f<\/h2>\n<h5><span>November 2025<\/span><\/h5>\n<p><em>\u7b2cI\u76f8\u8a66\u9a13\u3067\u306f\u3001\u96e3\u6cbb\u6027\u8102\u8cea\u7570\u5e38\u75c7\u60a3\u8005\u306b\u304a\u3044\u3066\u3001CRISPR-Cas9\u6280\u8853\u3092\u7528\u3044\u3066\u30a2\u30f3\u30b8\u30aa\u30dd\u30a8\u30c1\u30f3\u69d8\u30bf\u30f3\u30d1\u30af\u8cea3\uff08ANGPTL3\uff09\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u3092\u7de8\u96c6\u3059\u308b\u6cbb\u7642\u306e\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/em><\/p>\n<p><em>Laffin LJ, Nicholls SJ, Scott RS, et al. Phase 1 trial of CRISPR-Cas9 gene editing targeting ANGPTL3. N Engl J Med 2025; DOI: 10.1056\/NEJMoa2511778  <\/em><\/p>\n<p><strong>\u7814\u7a76\u6982\u8981<\/strong><\/p>\n<table width=\"655\">\n<tbody>\n<tr>\n<td width=\"123\">\n<p><strong>\u76ee\u7684<\/strong><\/p>\n<\/td>\n<td width=\"519\">\n<p>\u6a19\u7684\u907a\u4f1d\u5b50<em>ANGPTL<\/em>3\u306ein vivo\u907a\u4f1d\u5b50\u7de8\u96c6\u306e\u305f\u3081\u306eCRISPR-Cas9\uff08clustered regularly interspaced short palindromic repeats-Cas9\u30a8\u30f3\u30c9\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\uff09\u6210\u5206\u3092\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u3067\u30ab\u30d7\u30bb\u30eb\u5316\u3057\u305f\u88fd\u5264\u3067\u3042\u308bCTX310\u306e\u5358\u56de\u4e0a\u6607\u7528\u91cf\u306e\u5b89\u5168\u6027\u3001\u526f\u4f5c\u7528\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u304a\u3088\u3073\u6709\u52b9\u6027\u3092\u691c\u8a0e\u3059\u308b\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"14\">\n<p>&nbsp;<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"123\">\n<p><strong>\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/strong><\/p>\n<\/td>\n<td width=\"519\">\n<p>CTX310\u306e\u5358\u56de\u4e0a\u884c\u6295\u4e0e\u306b\u3088\u308b\u591a\u65bd\u8a2d\u5171\u540c\u975e\u76f2\u691c\u7b2c1\u76f8\u8a66\u9a13\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"14\">\n<p>&nbsp;<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"123\">\n<p><strong>\u7814\u7a76\u5bfe\u8c61\u8005  <\/strong><\/p>\n<\/td>\n<td width=\"519\">\n<p>18\uff5e75\u6b73\u306e\u6210\u4eba\u3067\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u4e0d\u80fd\u306a\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u3001\u4e2d\u7b49\u5ea6\uff5e\u91cd\u5ea6\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3001\u307e\u305f\u306f\u6df7\u5408\u578b\u8102\u8cea\u7570\u5e38\u75c7\u3068\u8a3a\u65ad\u3055\u308c\u305f\u60a3\u8005\u3002\u4ee5\u4e0b\u306e\u57fa\u6e96\u306e\u3046\u3061\u5c11\u306a\u304f\u3068\u30821\u3064\u306b\u3088\u308a\u5b9a\u7fa9\u3055\u308c\u308b\u3001\u6700\u5927\u8010\u5bb9\u91cf\u306e\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306b\u62b5\u6297\u6027\u306e\u88ab\u9a13\u8005\uff1a\u7a7a\u8179\u6642\u8840\u6e05\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09&gt;150mg\/dL\uff081.7mmol\/L\uff09\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09&gt;100mg\/dL\uff082.6mmol\/L\uff09\u307e\u305f\u306f 70mg\/dL\uff082.6mmol\/L\uff09\u30026mmol\/L\uff09\u307e\u305f\u306f&gt;70mg\/dL\uff081.8mmol\/L\uff09\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3059\u308b\u88ab\u9a13\u8005\u3067\u306f\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB&gt;100mg\/dL\u3001\u307e\u305f\u306f\u975e\u9ad8\u5bc6\u5ea6\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08\u975eHDL-C\uff09&gt;160mg\/dL\uff084.1mmol\/L\uff09\u3002\u4e3b\u306a\u9664\u5916\u57fa\u6e96\u306f\u3001\u598a\u5a20\u53ef\u80fd\u306a\u5973\u6027\u3001\u5bb6\u65cf\u6027\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u8840\u75c7\u75c7\u5019\u7fa4\u3067\u30ea\u30dd\u86cb\u767d\u30ea\u30d1\u30fc\u30bc\u6d3b\u6027\u304c&lt;5\uff05\u306e\u4eba\u3001\u307e\u305f\u306f\u63a8\u5b9a\u7cf8\u7403\u4f53\u6ffe\u904e\u91cf\u304c&lt;60ml\/\u5206\/\u4f53\u8868\u9762\u7a4d1.73<sup>m<\/sup>2\u306e\u4eba\u3067\u3042\u3063\u305f\u3002  <\/p>\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"14\">\n<p>&nbsp;<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"123\">\n<p><strong>\u4e3b\u306a\u7814\u7a76\u5909\u6570<\/strong><\/p>\n<p><strong> <\/strong><\/p>\n<\/td>\n<td width=\"519\">\n<p><strong>&#8211; \u5b89\u5168\u6027\u306e\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee<\/strong>\uff1a\u6709\u5bb3\u4e8b\u8c61\u306f\u3001\u7c73\u56fd\u56fd\u7acb\u304c\u3093\u7814\u7a76\u6240\u306eCommon Terminology Criteria for Adverse Events\uff08CTCAE\uff09\u30d0\u30fc\u30b8\u30e7\u30f35.0\u306b\u5f93\u3063\u3066\u8a55\u4fa1\u3055\u308c\u305f\u3002\u4e8b\u8c61\u306f1\uff5e5\u3067\u8a55\u4fa1\u3055\u308c\u3001\u30b0\u30ec\u30fc\u30c9\u304c\u9ad8\u3044\u307b\u3069\u91cd\u75c7\u5ea6\u304c\u9ad8\u3044\u3053\u3068\u3092\u793a\u3059\u3002\u7528\u91cf\u5236\u9650\u6bd2\u6027\u306f\u4ee5\u4e0b\u306e\u3044\u305a\u308c\u304b\u3068\u5b9a\u7fa9\u3055\u308c\u305f\uff1a\u809d\u30a2\u30df\u30ce\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\u5024\u304cCTCAE\u30b0\u30ec\u30fc\u30c93\u4ee5\u4e0a\u306b\u4e0a\u6607\u3057\u3001\u305d\u306e\u4e0a\u6607\u304c\u70b9\u6ef4\u5f8c14\u65e5\u4ee5\u4e0a\u6301\u7d9a\u3059\u308b\u3082\u306e\u3001\u30d3\u30ea\u30eb\u30d3\u30f3\u5024\u307e\u305f\u306f\u56fd\u969b\u6a19\u6e96\u5316\u6bd4\u304cCTCAE\u30b0\u30ec\u30fc\u30c93\u4ee5\u4e0a\u306b\u4e0a\u6607\u3059\u308b\u3082\u306e\u3001\u30b0\u30ec\u30fc\u30c93\u306e\u81e8\u5e8a\u691c\u67fb\u5024\u7570\u5e38\u304c7\u65e5\u4ee5\u4e0a\u6301\u7d9a\u3059\u308b\u3082\u306e\u3001\u307e\u305f\u306fCTCAE\u30b0\u30ec\u30fc\u30c94\u306b\u76f8\u5f53\u3059\u308b\u91cd\u75c7\u5ea6\u306e\u81e8\u5e8a\u691c\u67fb\u5024\u7570\u5e38\u3002  <\/p>\n<p><strong>&#8211; \u526f\u6b21\u7684\u5b89\u5168\u6027\u8a55\u4fa1\u9805\u76ee<\/strong>\uff1a\u7279\u306b\u6ce8\u76ee\u3059\u3079\u304d\u6709\u5bb3\u4e8b\u8c61\uff08\u8f38\u6db2\u95a2\u9023\u53cd\u5fdc\u3001\u7570\u5e38\u51fa\u8840\u3001\u8840\u6813\u6027\u4e8b\u8c61\u3001\u51fa\u8840\u6027\u4e8b\u8c61\u3001\u30a2\u30df\u30ce\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\u5024\u306e\u4e0a\u6607\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3001\u5c40\u6240\u53cd\u5fdc\u3001\u65b0\u305f\u306a\u60aa\u6027\u72b6\u614b\uff09\u3092\u542b\u3080\u6709\u5bb3\u4e8b\u8c61\u306e\u983b\u5ea6\u3068\u91cd\u75c7\u5ea6\u3002<\/p>\n<p><strong>&#8211; \u526f\u6b21\u7684\u6709\u52b9\u6027\u8a55\u4fa1\u9805\u76ee<\/strong>\uff1aLDL-C\u3001TG\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u3001HDL-C\u3001\u975eHDL-C\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u7d4c\u6642\u7684\u5909\u5316\u7387\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"14\">\n<p>&nbsp;<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"123\">\n<p><strong>\u65b9\u6cd5<\/strong><\/p>\n<\/td>\n<td colspan=\"2\" width=\"533\">\n<p>\u88ab\u9a13\u8005\u306f\u3001\u6700\u521d\u306b4\u3064\u306e\u4e0a\u884c\u6027CTX310\u6295\u4e0e\u30b3\u30db\u30fc\u30c8\uff080.1mg\/kg\u30010.3mg\/kg\u30010.6mg\/kg\u30010.8mg\/kg\uff09\u306e\u3044\u305a\u308c\u304b\u306b\u767b\u9332\u3055\u308c\u305f\u3002\u6295\u4e0e\u91cf\u306f\u3001\u6295\u4e0e\u3055\u308c\u305fRNA\u306e\u7dcf\u91cf\u3068\u63a8\u5b9a\u9664\u8102\u80aa\u4f53\u91cd\u306b\u57fa\u3065\u3044\u3066\u8a08\u7b97\u3055\u308c\u305f\u3002CTX310\u306f\u5358\u56de\u70b9\u6ef4\u9759\u6ce8\u3067\u6295\u4e0e\u3055\u308c\u305f\u3002\u6295\u4e0e\u91cf\u306e\u30a8\u30b9\u30ab\u30ec\u30fc\u30b7\u30e7\u30f3\u306f\u3001\u5404\u6295\u4e0e\u91cf\u30ec\u30d9\u30eb\u3067\u6700\u4f4e3\u4eba\u306e\u88ab\u9a13\u8005\u3092\u6cbb\u7642\u3057\u3001\u5c11\u306a\u304f\u3068\u308230\u65e5\u9593\u306e\u8ffd\u8de1\u3092\u5b8c\u4e86\u3057\u305f\u5f8c\u306b\u5b89\u5168\u6027\u5be9\u67fb\u59d4\u54e1\u4f1a\u306b\u3088\u3063\u3066\u627f\u8a8d\u3055\u308c\u305f\u3002\u305d\u306e\u5f8c\u3001\u7528\u91cf\u53cd\u5fdc\u95a2\u4fc2\u3092\u3088\u308a\u660e\u78ba\u306b\u3059\u308b\u305f\u3081\u306b\u30010.7mg\/kg\u3092\u6295\u4e0e\u3059\u308b\u30b3\u30db\u30fc\u30c8\u304c\u8ffd\u52a0\u3055\u308c\u30010.8mg\/kg\u3092\u6295\u4e0e\u3059\u308b\u30b3\u30db\u30fc\u30c8\u306f\u6700\u521d\u306e3\u4eba\u306e\u88ab\u9a13\u8005\u304cCTX310\u306e\u70b9\u6ef4\u3092\u5b8c\u4e86\u3057\u305f\u5f8c\u306b\u62e1\u5927\u3055\u308c\u305f\u3002    <\/p>\n<p>&nbsp;<\/p>\n<p>\u3059\u3079\u3066\u306e\u88ab\u9a13\u8005\u306f\u70b9\u6ef4\u5f8c\u5c11\u306a\u304f\u3068\u308224\u6642\u9593\u89b3\u5bdf\u3055\u308c\u3001\u6295\u4e0e\u5f8c3\u65e5\u9593\u306f\u6bce\u65e5\u5b89\u5168\u6027\u8a55\u4fa1\u304c\u884c\u308f\u308c\u3001\u6295\u4e0e\u5f8c30\u65e5\u9593\u306f\u6bce\u9031\u8ffd\u8de1\u8abf\u67fb\u304c\u884c\u308f\u308c\u3001\u305d\u306e\u5f8c60\u65e5\u76ee\u300190\u65e5\u76ee\u3001180\u65e5\u76ee\u3001270\u65e5\u76ee\u3001360\u65e5\u76ee\u306b\u9762\u4f1a\u304c\u4e88\u5b9a\u3055\u308c\u3066\u3044\u305f\u3002\u767a\u8868\u6642\u70b9\u3067\u306f\u3001\u3059\u3079\u3066\u306e\u88ab\u9a13\u8005\u304c\u5c11\u306a\u304f\u3068\u308260\u65e5\u9593\u306e\u8ffd\u8de1\u3092\u5b8c\u4e86\u3057\u3066\u3044\u308b\u3002 <\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<table width=\"643\">\n<tbody>\n<tr>\n<td width=\"123\">\n<p><strong>\u7d50\u679c<\/strong><\/p>\n<\/td>\n<td width=\"520\">\n<p>\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u53d7\u3051\u305f27\u4eba\u306e\u3046\u3061\u300115\u4eba\u306bCTX310\u304c\u6295\u4e0e\u3055\u308c\u305f\uff080.1mg\/kg\u30010.3mg\/kg\u30010.6mg\/kg\u304c\u54043\u4eba\u30010.7mg\/kg\u304c2\u4eba\u30010.8mg\/kg\u304c4\u4eba\uff09\u3002\u7814\u7a76\u30b3\u30db\u30fc\u30c8\u306e\u5e74\u9f62\u4e2d\u592e\u5024\u306f53\u6b73\uff08\u7bc4\u56f2\u300131\u301c68\u6b73\uff09\uff1b6\u4eba\uff0840\uff05\uff09\u304c\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75c5\u3092\u6709\u3057\u30016\u4eba\uff0840\uff05\uff09\u304c\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u3068\u81e8\u5e8a\u8a3a\u65ad\u3055\u308c\u3001\u3046\u30615\u4eba\u306f\u75c5\u539f\u6027\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002\u6cbb\u7642\u524d\u306eLDL-C\u306e\u5e73\u5747\u5024\uff08\u00b1\u6a19\u6e96\u504f\u5dee\uff09\u306f155\u00b179mg\/dL\u3001TG\u5024\u306e\u4e2d\u592e\u5024\u306f192mg\/dL\uff08\u56db\u5206\u4f4d\u7bc4\u56f2\u3001109\uff5e252mg\/dL\uff09\u3067\u3042\u3063\u305f\u3002  <\/p>\n<p>CTX310\u306e\u5358\u56de\u6295\u4e0e\u306b\u3088\u308b\u6709\u5bb3\u4e8b\u8c61\u306f\u307b\u3068\u3093\u3069\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f<strong>\uff08\u88681\uff09<\/strong>\u3002<\/p>\n<p>ANGPLT3\u5024\u306f0.6mg\/kg\u6295\u4e0e\u3067\u5e73\u574732.7\uff05\u6e1b\u5c11\u3057\u30010.7mg\/kg\u6295\u4e0e\u3067\u306f79.7\uff05\u30010.8mg\/kg\u6295\u4e0e\u3067\u306f73.2\uff05\u6e1b\u5c11\u3057\u305f\u3002LDL-C\u5024\u3068TG\u5024\u306f\u30010.6mg\/kg\u4ee5\u4e0a\u306e\u7528\u91cf\u3067\u3001\u305d\u308c\u305e\u308c\u6700\u592750\uff05\u3068\u6700\u592760\uff05\u4f4e\u4e0b\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u8102\u8cea\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u306e\u4f4e\u4e0b\u306f\u6cbb\u7642\u958b\u59cb\u5f8c2\u9031\u9593\u4ee5\u5185\u306b\u73fe\u308c\u3001\u672c\u89e3\u6790\u306b\u542b\u307e\u308c\u308b\u6700\u65b0\u306e\u8ffd\u8de1\u8abf\u67fb\u30c7\u30fc\u30bf\u3067\u3042\u308b\u5c11\u306a\u304f\u3068\u308260\u65e5\u307e\u3067\u6301\u7d9a\u3057\u305f\u3002  <\/p>\n<p><strong> <\/strong><\/p>\n<p><strong>\u88681. \u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u4e3b\u306a\u7d50\u679c<\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"295\">\n<p><strong>\u6709\u5bb3\u4e8b\u8c61<\/strong><\/p>\n<\/td>\n<td width=\"95\">\n<p><strong>\u88ab\u9a13\u8005\u6570<\/strong><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"295\">\n<p>CTX310\u306b\u95a2\u9023\u3059\u308b\u7528\u91cf\u5236\u9650\u6bd2\u6027\u4f5c\u7528<\/p>\n<\/td>\n<td width=\"95\">\n<p>0<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"295\">\n<p>\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61<\/p>\n<\/td>\n<td width=\"95\">\n<p>2 (13)*<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"295\">\n<p> \u6b7b<\/p>\n<\/td>\n<td width=\"95\">\n<p>1 (7)<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"295\">\n<p>CTX310\u306b\u95a2\u3059\u308b\u7279\u8a18\u3059\u3079\u304d\u6709\u5bb3\u4e8b\u8c61<\/p>\n<\/td>\n<td width=\"95\">\n<p>4 (27)<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"295\">\n<p> \u8f38\u6db2\u95a2\u9023\u53cd\u5fdc<\/p>\n<\/td>\n<td width=\"95\">\n<p>3 (20)**<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"295\">\n<p> \u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u307e\u305f\u306f\u5c40\u6240\u53cd\u5fdc<\/p>\n<\/td>\n<td width=\"95\">\n<p>1 (7)<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"295\">\n<p> AST\u307e\u305f\u306fALT\u306e\u4e0a\u6607<\/p>\n<\/td>\n<td width=\"95\">\n<p>1 (7)<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>* \u88ab\u9a13\u80051\u540d\u304cCTX310 0.3mg\/kg\u3092\u6295\u4e0e\u3055\u308c\u3001\u6295\u4e0e7\u30f5\u6708\u5f8c\u306b\u810a\u690e\u690e\u9593\u677f\u30d8\u30eb\u30cb\u30a2\u306e\u305f\u3081\u5165\u9662\u3001\u88ab\u9a13\u80051\u540d\u304cCTX310 0.1mg\/kg\u6295\u4e0e179\u65e5\u5f8c\u306b\u6b7b\u4ea1\u3057\u305f\u3002<\/p>\n<p>** CTX310 0.6mg\/kg\u3092\u6295\u4e0e\u3055\u308c\u305f2\u4f8b\u3068CTX310 0.8mg\/kg\u3092\u6295\u4e0e\u3055\u308c\u305f1\u4f8b<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"123\">\n<p><strong>\u8457\u8005\u7d50\u8ad6<\/strong><\/p>\n<\/td>\n<td width=\"520\">\n<p>ANGPTL3\u306e\u7de8\u96c6\u306b\u306f\u6709\u5bb3\u4e8b\u8c61\u306f\u307b\u3068\u3093\u3069\u306a\u304f\u3001ANGPTL3\u5024\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u6e1b\u5c11\u3057\u305f\u3002<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n<p>\u7b2cI\u76f8\u8a66\u9a13\u304c\u30d5\u30a9\u30fc\u30ab\u30b9\u30fb\u30ec\u30dd\u30fc\u30c8\u3067\u53d6\u308a\u4e0a\u3052\u3089\u308c\u308b\u3053\u3068\u306f\u7a00\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001CTX310\u306e\u5358\u56de\u70b9\u6ef4\u306b\u3088\u308aLDL-C\u3068TG\u306e\u4e21\u65b9\u304c\u5927\u5e45\u306b\u4f4e\u4e0b\u3057\u305f\u3068\u3044\u3046\u70b9\u3067\u3001\u672c\u8a66\u9a13\u306e\u7d50\u679c\u306f\u524d\u4f8b\u306e\u306a\u3044\u3082\u306e\u3067\u3042\u308b\u3002\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306b\u62b5\u6297\u6027\u306e\u8102\u8cea\u7570\u5e38\u75c7\u60a3\u8005\u306e\u7ba1\u7406\u306e\u305f\u3081\u306e\u65b0\u305f\u306a\u6226\u7565\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u308b\u3082\u306e\u3067\u3042\u308b\u3002  <\/p>\n<p>\u5f53\u7136\u306a\u304c\u3089\u3001\u30d5\u30a1\u30fc\u30b9\u30c8\u30fb\u30a4\u30f3\u30fb\u30de\u30f3\u8a66\u9a13\u3067\u306f\u3001\u5b89\u5168\u6027\u304c\u7b2c\u4e00\u306e\u7126\u70b9\u3067\u3042\u3063\u305f\u3002\u3053\u306e\u5c0f\u898f\u6a21\u30b3\u30db\u30fc\u30c8\u3067\u306f\u3001CTX310\u306e\u5358\u56de\u9759\u8108\u5185\u6ce8\u5165\u306f\u307b\u3068\u3093\u3069\u6709\u5bb3\u4e8b\u8c61\u3068\u95a2\u9023\u3057\u3066\u3044\u306a\u304b\u3063\u305f\u3002FDA\u304c\u3059\u3079\u3066\u306eCRISPR\u30d9\u30fc\u30b9\u306e\u6cbb\u7642\u306b\u5bfe\u3057\u3066\u63a8\u5968\u3057\u3066\u3044\u308b\u3088\u3046\u306b\u3001\u5b89\u5168\u6027\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u306f\u7d99\u7d9a\u3055\u308c\u308b\u3002  <\/p>\n<p>&nbsp;<\/p>\n<p>ANGPTL3\u306f\u30ea\u30dd\u86cb\u767d\u30ea\u30d1\u30fc\u30bc\u3068\u5185\u76ae\u30ea\u30d1\u30fc\u30bc\u3092\u963b\u5bb3\u3057\u3001\u3044\u305a\u308c\u3082\u8102\u8cea\u8abf\u7bc0\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b(1)\u3002\u907a\u4f1d\u5b66\u7684\u7814\u7a76\u306b\u3088\u308a\u3001\u6a5f\u80fd\u55aa\u5931\u578b<em>ANGPTL3 <\/em>\u5909\u7570\u4f53\u306e\u4fdd\u6709\u306f\u3001LDL-C\u3068TG\u306e\u30ec\u30d9\u30eb\u3092\u751f\u6daf\u306b\u308f\u305f\u3063\u3066\u4f4e\u4e0b\u3055\u305b\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u7cfb\u75be\u60a3\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u3068\u3082\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f(2)\u3002\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53evinacumab\u3084RNA\u6cbb\u7642\u85ac\u3092\u7528\u3044\u3066ANGPTL3\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u304c\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u30ea\u30dd\u86cb\u767d\u306e\u6e1b\u5c11\u306b\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f(3-5)\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306e\u9577\u671f\u6295\u4e0e\u306b\u304a\u3044\u3066\u306f\u3001\u30a2\u30c9\u30d2\u30a2\u30e9\u30f3\u30b9\u306e\u4f4e\u4e0b\u304c\u3088\u304f\u8a8d\u8b58\u3055\u308c\u3066\u3044\u308b\u554f\u984c\u3067\u3042\u308b\u3002\u3057\u305f\u304c\u3063\u3066\u3001&#8221;\u4e00\u5ea6\u304d\u308a\u306e &#8220;\u907a\u4f1d\u5b50\u7de8\u96c6\u3092\u5229\u7528\u3057\u3066\u3001LDL-C\u3068TG\u30ec\u30d9\u30eb\u306e\u4e21\u65b9\u3092\u4f4e\u4e0b\u3055\u305b\u308bANGPTL3\u306e\u6c38\u7d9a\u7684\u306a\u6a5f\u80fd\u55aa\u5931\u5909\u7570\u3092\u8a98\u5c0e\u3059\u308b\u53ef\u80fd\u6027\u306f\u3001\u751f\u6daf\u306b\u308f\u305f\u308b\u8102\u8cea\u7570\u5e38\u75c7\u60a3\u8005\u306e\u81e8\u5e8a\u7ba1\u7406\u3092\u4e00\u5909\u3055\u305b\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u3001\u30a8\u30ad\u30b5\u30a4\u30c6\u30a3\u30f3\u30b0\u306a\u5c55\u671b\u3067\u3042\u308b\u3002    <\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<ol>\n<li>1.\u6cbb\u7642\u6a19\u7684\u3068\u3057\u3066\u306eANGPTL3\u3002Curr Opin Lipidol 2021; 32: 335-41. <\/li>\n<li>Dewey FE, Gusarova V, Dunbar RL, et al. ANGPTL3\u306e\u907a\u4f1d\u7684\u304a\u3088\u3073\u85ac\u7406\u5b66\u7684\u4e0d\u6d3b\u6027\u5316\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u3002N Engl J Med 2017; 377: 211-21.  <\/li>\n<li>\u30db\u30e2\u63a5\u5408\u6027\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306b\u5bfe\u3059\u308b\u30a8\u30d3\u30ca\u30af\u30de\u30d6\u3002N Engl J Med 2020; 383: 711-20.  <\/li>\n<li>\u6df7\u5408\u578b\u9ad8\u8102\u8840\u75c7\u306b\u5bfe\u3059\u308bANGPTL3\u3092\u6a19\u7684\u3068\u3057\u305fRNAi\u6cbb\u7642\u85acZodasiran\u3002N Engl J Med 2024; 391: 913-25.  <\/li>\n<li>\u6df7\u5408\u578b\u8102\u8cea\u7570\u5e38\u75c7\u3092\u6709\u3059\u308b\u6210\u4eba\u306b\u304a\u3051\u308b\u3001ANGPTL3\u3092\u6a19\u7684\u3068\u3057\u305fGalNAc\u7d50\u5408siRNA\u3067\u3042\u308b\u30bd\u30eb\u30d3\u30f3\u30b7\u30e9\u30f3\u306e\u8010\u4e45\u6027\u3068\u6709\u52b9\u6027\uff08PROLONG-ANG3\uff09\uff1a\u4e8c\u91cd\u76f2\u691c\u7121\u4f5c\u70ba\u5316\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u7b2c2\u76f8\u8a66\u9a13\u3002Lancet 2025; 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