{"id":257212,"date":"2025-07-30T23:09:54","date_gmt":"2025-07-30T21:09:54","guid":{"rendered":"https:\/\/r3i.org\/r3i%e7%a4%be%e8%aa%ac\/%e7%a4%be%e8%aa%ac-06-25-%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a8%93%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e5%80%a4-%e3%82%82%e3%81%a3%e3%81%a8\/"},"modified":"2026-03-05T18:02:00","modified_gmt":"2026-03-05T17:02:00","slug":"%e7%a4%be%e8%aa%ac-06-25-%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a8%93%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e5%80%a4-%e3%82%82%e3%81%a3%e3%81%a8","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/r3i%e7%a4%be%e8%aa%ac\/%e7%a4%be%e8%aa%ac-06-25-%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a8%93%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e5%80%a4-%e3%82%82%e3%81%a3%e3%81%a8\/","title":{"rendered":"\u793e\u8aac 06\/25- \u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3051\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024-\u3082\u3063\u3068\u9ad8\u3044\u5024\u3092\u76ee\u6307\u3059\u3079\u304d\u304b\uff1f"},"content":{"rendered":"

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R3i\u793e\u8aac<\/h2>\n

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2025\u5e744\u6708<\/span><\/h5>\n
\u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3051\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024 \u2015 \u76ee\u6a19\u5024\u3092\u3088\u308a\u9ad8\u304f\u8a2d\u5b9a\u3059\u3079\u304d\u304b\uff1f<\/h5>\n
Prof. Peter Libby<\/a>, Prof. Michel Hermans<\/a>, Prof. Pierre Amarenco<\/a><\/h6>\n

\u6570\u5341\u5e74\u306b\u308f\u305f\u308b\u89b3\u5bdf\u7814\u7a76\u306b\u3088\u308a\u3001TG\u30ea\u30c3\u30c1\u30ea\u30dd\u86cb\u767d\u3084\u305d\u306e\u6b8b\u6e23\u306e\u4ee3\u7528\u7269\u8cea\u3067\u3042\u308b\u8840\u6f3f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u306e\u4e0a\u6607\u3068\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u3092\u95a2\u9023\u3065\u3051\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u8c4a\u5bcc\u306b\u5f97\u3089\u308c\u3066\u3044\u308b(1)\u3002\u3055\u3089\u306b\u6700\u8fd1\u3067\u306f\u3001\u907a\u4f1d\u5b66\u7684\u7814\u7a76\u306b\u3088\u3063\u3066\u3001TG\u30ea\u30c3\u30c1\u30ea\u30dd\u86cb\u767d\u304cASCVD\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3053\u3068\u304c\u88cf\u4ed8\u3051\u3089\u308c\u305f\uff081,2\uff09\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001TG\u30ec\u30d9\u30eb\u306e\u4f4e\u4e0b\u304c\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u6e1b\u5c11\u306b\u3064\u306a\u304c\u308b\u304b\u3069\u3046\u304b\u3068\u3044\u3046\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u304a\u3051\u308b\u91cd\u5927\u306a\u30ae\u30e3\u30c3\u30d7\u304c\u6b8b\u3063\u3066\u3044\u308b\u3002\u73fe\u5728\u307e\u3067\u306e\u3068\u3053\u308d\uff0cREDUCE-IT\uff08Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial\uff09(3)\u306e\u307f\u304c\uff0c\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u542b\u3080\u6700\u65b0\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u3044\u305f\u6cbb\u7642\u3092\u80cc\u666f\u306b\uff0c\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306e<\/a>\u9ad8\u7528\u91cf\u6295\u4e0e\u306b\u3088\u308bTG\u5024\u306e\u4f4e\u4e0b\u304b\u3089\u6709\u610f\u306a\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u6291\u5236\u52b9\u679c\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u5bfe\u7167\u7684\u306b\u3001\u4ed6\u306e2\u3064\u306e\u4e3b\u8981\u306a\u8a66\u9a13-PROMINENT\uff08Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes\uff09\u3068STRENGTH\uff08Long-Term Outcomes Study to Assess Statin Residual Risk with Epanova in High Cardiovascular Risk Patients with Hypertriglyceridemia\uff09-\u3067\u306f\u3001TG\u5024\u3092\u305d\u308c\u305e\u308c26\uff05\u306819\uff05\uff08\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u88dc\u6b63\u5f8c\uff09\u4f4e\u4e0b\u3055\u305b\u305f\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u4e2d\u7acb\u3067\u3042\u3063\u305f(4,5)\u3002\u80cc\u666f\u3068\u306a\u308b\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u306e\u5f37\u3055\u3001\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u5272\u5408\u3001\u6b8b\u5b58\u708e\u75c7\u6027\u30ea\u30b9\u30af\u306e\u7a0b\u5ea6\u306a\u3069\u3001\u3053\u308c\u3089\u306e\u8a66\u9a13\u306e\u60a3\u8005\u96c6\u56e3\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306b\u304a\u3051\u308b\u7279\u5fb4\u306e\u9055\u3044\u306b\u3064\u3044\u3066\u591a\u304f\u306e\u3053\u3068\u304c\u8b70\u8ad6\u3055\u308c\u3066\u3044\u308b\u304c(6)\u3001\u5404\u8a66\u9a13\u304c\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u6642\u306b\u4e2d\u7b49\u5ea6\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u5ff5\u982d\u306b\u7f6e\u304f\u3079\u304d\u3067\u3042\u308b\u3002\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u6642\u306eTG\u5024\u306f\u307b\u307c\u540c\u7b49\u3067\u3042\u3063\u305f\uff1aREDUCE-IT\u3067\u306f1.5\u301c5.6mmol\/L\u3001PROMINENT\u3068STRENGTH\u3067\u306f2.0\u301c6.2mmol\/L\u3067\u3042\u3063\u305f(3-5)\u3002 <\/span><\/p>\n

\u3053\u308c\u3089\u306e\u76f8\u53cd\u3059\u308b\u30c7\u30fc\u30bf\u306f\u4e0d\u53ef\u89e3\u3067\u3042\u308b\u3002Nordestgaard\u306b\u3088\u308b\u6700\u8fd1\u306e\u7814\u7a76 <\/span>\u4ed6<\/span><\/i> (7)\u306f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304cTG\u5024\u306e\u7bc4\u56f2\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u304b\u3069\u3046\u304b\u3092\u8abf\u3079\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u3053\u306e\u96e3\u554f\u306b\u5bfe\u3059\u308b\u6d1e\u5bdf\u3092\u4e0e\u3048\u3066\u3044\u308b\u3002\u7814\u7a76\u8005\u3089\u306f\u3001Copenhagen General Population Study\uff08n=119,573\uff09\u306b\u304a\u3044\u3066\u3001\u5e83\u7bc4\u56f2\u306eTG\u5024\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3057\u305f\u3002\u6b21\u306b\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eTG\u5024\u304c2.3\u301c5.6mmol\/L\u306e2\u3064\u306e\u30b3\u30db\u30fc\u30c8\uff08Copenhagen General Population Study\u304a\u3088\u3073Women’s Health Study\u30b3\u30db\u30fc\u30c8\u3001n=27,757\uff09\u3001PROMINENT\u8a66\u9a13\u3001REDUCE-IT\u8a66\u9a13\u3001STRENGTH\u8a66\u9a13\u306e\u96c6\u56e3\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3068\u6bd4\u8f03\u3057\u305f\u3002 <\/span><\/p>\n

TG\u5024\u304c0.3\uff5e11.2mmol\/L\u307e\u3067\u4e0a\u6607\u3059\u308b\u3053\u3068\u306f\u3001\u4e3b\u8981\u5fc3\u8840\u7ba1\u7cfb\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u3068\u95a2\u9023\u3059\u308b\u3068\u3044\u3046\u660e\u78ba\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u5f97\u3089\u308c\u305f\u3002\u7279\u306b\u3001\u57fa\u6e96\u5024\uff08TG<1.0mmol\/L\uff09\u3068\u6bd4\u8f03\u3059\u308b\u3068\u3001TG\u5024\u304c7.0mmol\/L\u4ee5\u4e0a\u306e\u4eba\u306f\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u304c2\u500d\u4ee5\u4e0a\u9ad8\u304b\u3063\u305f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd42.03\uff1b95\uff05\u4fe1\u983c\u533a\u9593[CI] 1.66-2.53\uff09\u3002 <\/span><\/p>\n

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Copenhagen General Population study\u304a\u3088\u3073Women’s Health Study\u30b3\u30db\u30fc\u30c8\u306e\u4e2d\u7b49\u5ea6\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306f2.5\uff5e<3.0 mmol\/L\u306e\u7bc4\u56f2\u3067\u306f\u5897\u52a0\u305b\u305a\uff08\u30cf\u30b6\u30fc\u30c9\u6bd40.95\u300195\uff05\u4fe1\u983c\u533a\u95930.87-1.04\uff09\u3001\u57fa\u6e96\u56db\u5206\u4f4d\u7fa4\uff08<2.5 mmol\/L\uff09\u3068\u6bd4\u8f03\u3059\u308b\u3068\u3001TG\u5024\u304c3.0\uff5e<3.6 mmol\/L\u3067\u306f4\uff05\uff08\u30cf\u30b6\u30fc\u30c9\u6bd41.04\u300195\uff05\u4fe1\u983c\u533a\u95930.95-1.13\uff09\u30013.6 mmol\/L\u4ee5\u4e0a\u3067\u306f13\uff05\uff08\u30cf\u30b6\u30fc\u30c9\u6bd41.13\u300195\uff05\u4fe1\u983c\u533a\u95931.04-1.23\uff09\u3057\u304b\u5897\u52a0\u3057\u306a\u304b\u3063\u305f\uff085\uff09\u3002TG\u5024\u304c5.6mmol\/L\u3092\u8d85\u3048\u308b\u3068\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u306e\u5f37\u3055\u304c\u5897\u52a0\u3057\u305f\u3002PROMINENT\u8a66\u9a13\u3001REDUCE-IT\u8a66\u9a13\u3001STRENGTH\u8a66\u9a13\u306e\u96c6\u56e3\u304b\u3089\u5f97\u3089\u308c\u305f\u7d50\u679c\u306f\u3001\u3053\u308c\u3089\u306e\u89b3\u5bdf\u3068\u4e00\u81f4\u3057\u3066\u304a\u308a\u3001TG\u5024\u304c3.9\u30013.1\u30013.5mmol\/L\u3092\u8d85\u3048\u3066\u3082\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306f\u305d\u308c\u305e\u308c9\uff05\uff08\u30cf\u30b6\u30fc\u30c9\u6bd41.09\u300195\uff05CI 1.00-1.19\uff09\u3057\u304b\u4e0a\u6607\u3057\u306a\u304b\u3063\u305f(7)\u3002\u8457\u8005\u3089\u306f\u3001\u3053\u308c\u3089\u306e\u8a66\u9a13\u306b\u4e00\u8cab\u6027\u304c\u306a\u3044\u306e\u306f\u3001\u4e2d\u7b49\u5ea6\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u4f34\u3046\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u5897\u52a0\u304c\u308f\u305a\u304b\u3067\u3042\u308b\u3053\u3068\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u305f\u3002\u3053\u308c\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306b\u3001\u8457\u8005\u3089\u306f\u3001\u81b5\u708e\u306e\u65e2\u5f80\u306e\u3042\u308b\u60a3\u8005\u3084\u904e\u5ea6\u306e\u30a2\u30eb\u30b3\u30fc\u30eb\u6442\u53d6\u306e\u3042\u308b\u60a3\u8005\u306f\u9664\u5916\u3059\u308b\u3053\u3068\u3092\u6761\u4ef6\u3068\u3057\u3066\u3001\u4eca\u5f8c\u306eTG\u4f4e\u4e0b\u7642\u6cd5\u306e\u8a66\u9a13\u3067\u306f\u3001\u3088\u308a\u5e83\u3044\u7bc4\u56f2\u306eTG\u5024\u3092\u767b\u9332\u5bfe\u8c61\u3068\u3057\u3066\u8003\u616e\u3059\u308b\u3053\u3068\u3092\u63d0\u6848\u3057\u305f(7)\u3002Watts\u3068Chan(8)\u306f\u4ed8\u968f\u8ad6\u8aac\u3067\u3001TG\u4f4e\u4e0b\u7642\u6cd5\u3092\u8a66\u9a13\u3059\u308b\u5fc3\u8840\u7ba1\u7cfb\u30a2\u30a6\u30c8\u30ab\u30e0\u8a66\u9a13\u306b\u304a\u3044\u3066TG\u5024\u306e\u4e0a\u9650\u3092\u8a2d\u3051\u306a\u3044\u3053\u3068\u3092\u63d0\u6848\u3057\u305f\u304c\u3001\u4e00\u822c\u7684\u306bASCVD\u306e\u30ea\u30b9\u30af\u3082\u9ad8\u3044\u591a\u56e0\u5b50\u6027\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u8840\u75c7\u75c7\u5019\u7fa4\u306e\u60a3\u8005\u3067\u306f\u81b5\u708e\u3092\u907f\u3051\u308b\u5fc5\u8981\u6027\u3092\u8a8d\u3081\u305f(9)\u3002 <\/span><\/p>\n

\u3053\u308c\u3089\u306e\u8b70\u8ad6\u306f\u3001\u81e8\u5e8a\u958b\u767a\u4e2d\u306e\u65b0\u898f\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4f4e\u4e0b\u7642\u6cd5\u304c\u3044\u304f\u3064\u304b\u3042\u308b\u4e2d\u3067\u3001\u975e\u5e38\u306b\u91cd\u8981\u3067\u3042\u308b\u3002APOC3\u3084 <\/a> ANGPTL<\/a>3\u3092\u6a19\u7684\u3068\u3057\u305fRNA\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u7642\u6cd5\u306f\u3001\u4e2d\u7b49\u5ea6\u3084\u91cd\u5ea6\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u304a\u3044\u3066\u5927\u304d\u306a\u6709\u7528\u6027\u3092\u793a\u3059\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u3042\u308a\u3001\u91cd\u8981\u306a\u7126\u70b9\u3068\u306a\u3063\u3066\u3044\u308b(10-13)\u3002\u3053\u308c\u3089\u306e\u65b0\u898f\u85ac\u5264\u306e\u5fc3\u8840\u7ba1\u7cfb\u30a2\u30a6\u30c8\u30ab\u30e0\u8a66\u9a13\u306e\u30c7\u30b6\u30a4\u30f3\u306b\u3064\u3044\u3066\u306f\u3001\u307e\u3060\u591a\u304f\u306e\u8b70\u8ad6\u304c\u306a\u3055\u308c\u3066\u3044\u308b\u3002\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001Watts\u3068Chan(8)\u306f\u3001\u30d7\u30ed\u30b6\u30b7\u30e9\u30f3\u3092<\/a>\u7528\u3044\u305f1\u3064\u306e\u8a66\u9a13\uff08\u4ee5\u524d\u306fARO-APOC3\u3068\u547c\u3070\u308c\u3066\u3044\u305f\uff09\u306e\u521d\u671f\u8a08\u753b\u3068\u3057\u3066\u3001TG\u5024\u304c2\u301c10mmol\/L\u306e\u4e8c\u6b21\u4e88\u9632\u60a3\u8005\uff08\u304a\u3088\u3073\u975e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff3bnon-HDL-C\uff3d>2.6mmol\/L\uff09\u3068TG\u5024\u304c2.8\u301c9.0mmol\/L\u306e\u4e00\u6b21\u4e88\u9632\u60a3\u8005\uff08non-HDL-C>\u30013.4mmol\/L\uff09\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u6307\u6458\u3057\u3066\u3044\u308b\u304c\u3001\u8a66\u9a13\u30c7\u30b6\u30a4\u30f3\u306f\u307e\u3060\u78ba\u5b9a\u3057\u3066\u3044\u306a\u3044\u3002\u3057\u304b\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e\u60a3\u8005\u306b\u306f\u6025\u6027\u81b5\u708e\u306e\u30ea\u30b9\u30af\u304c\u3042\u308b\u305f\u3081\u3001\u4eca\u5f8c\u306e\u8a66\u9a13\u3067TG\u5024\u306e\u4e0a\u9650\u304c10.0mmol\/L\u3092\u8d85\u3048\u308b\u53ef\u80fd\u6027\u306f\u4f4e\u3044\u3002 <\/span><\/p>\n

\u3069\u306e\u7a0b\u5ea6\u306eTG\u30ec\u30d9\u30eb\u3067\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\uff08\u305d\u3057\u3066\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\uff09\u304c\u4e0a\u6607\u3059\u308b\u304b\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u306f\u3001ASCVD\u4e88\u9632\u306e\u91cd\u8981\u306a\u76ee\u6a19\u3067\u3042\u308b\u3002Nordestgaard\u535a\u58eb\u3089\u306e\u5831\u544a\u306f\u3001\u65b0\u898f\u306eTG\u4f4e\u4e0b\u7642\u6cd5\u306b\u95a2\u3059\u308b\u4eca\u5f8c\u306e\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u7814\u7a76\u306e\u30c7\u30b6\u30a4\u30f3\u306b\u9593\u9055\u3044\u306a\u304f\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3067\u3042\u308d\u3046\u3002\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306b\u304a\u3051\u308bTG\u30ea\u30c3\u30c1\u30ea\u30dd\u86cb\u767d\u3068\u305d\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8ca0\u8377\u306e\u5f79\u5272\u3092\u78ba\u8a8d\u3059\u308b\u4e0a\u3067\u4f9d\u7136\u3068\u3057\u3066\u6b8b\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u30ae\u30e3\u30c3\u30d7\u3092\u89e3\u6c7a\u3059\u308b\u305f\u3081\u306e\u63a2\u6c42\u306f\u3001\u65b0\u305f\u306b\u7d9a\u3044\u3066\u3044\u308b\u3002 <\/span><\/p>\n

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\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

    \n
  1. Nordestgaard BG\u3002Triglyceride-rich lipoproteins and atherosclerotic cardiovascular disease.Insights from epidemiology, genetics, and biology, Circ Res 2016;118:547-63.
    2.Ginsberg HN, Packard CJ, Chapman MJ, et al. Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies-a consensus statement from the European Atherosclerosis Society.Eur Heart J 2021; 42:4791-806\u3002
    3.Bhatt DL, Steg PG, Miller M, et al. \u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u5bfe\u3059\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3002N Engl J Med 2019; 380:11-22.
    4.Das Pradhan A, Glynn RJ, Fruchart JC, et al. \u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306b\u3088\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4f4e\u4e0b\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3002N Engl J Med 2022; 387:1923-34.
    5.Nicholls SJ, Lincoff AM, Garcia M, et al. \u9ad8\u7528\u91cf\u30aa\u30e1\u30ac3\u8102\u80aa\u9178vs\u30b3\u30fc\u30f3\u6cb9\u306e\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u8005\u306b\u304a\u3051\u308b\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306b\u5bfe\u3059\u308b\u52b9\u679c\uff1aSTRENGTH\u7121\u4f5c\u70ba\u5316\u81e8\u5e8a\u8a66\u9a13\u3002jama 2020; 324:2268-80.
    6.Fruchart JC, Fruchart-Najib J, Yamashita S, et al. PROMINENT\u306e\u6559\u8a13\u3068\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u5c55\u671b
    \u3002Cardiovasc Diabetol 2024; 23:279.
    7.Nordestgaard AT, Pradhan AD, Everett BM, et al. \u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3051\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u7bc4\u56f2\u306e\u62e1\u5927\uff1a\u6cbb\u7642\u306e\u6a5f\u4f1a\u3002Eur Heart J 2025; doi: 10.1093\/eurheartj\/ehaf074.
    8.\u30ef\u30c3\u30c4GF\u3001\u30c1\u30e3\u30f3DC\u3002Reaching for the stars: a wider perspective for designing future cardiovascular outcome trials of triglyceride-lowering therapies.Eur Heart J 2025; doi.org\/10.1093\/eurheartj\/ehae931.
    9.\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3002Endocrinol Metab Clin North Am 2022; 51:539-55.
    10.Bergmark BA, Marston NA, Prohaska TA, et al. \u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u8005\u306b\u304a\u3051\u308b\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u5bfe\u3059\u308b\u30aa\u30ec\u30b6\u30eb\u30bb\u30f3\u3002N Engl J Med 2024; 390:1770-80.
    11.\u6df7\u5408\u578b\u9ad8\u8102\u8840\u75c7\u306b\u5bfe\u3059\u308bANGPTL3\u3092\u6a19\u7684\u3068\u3057\u305fRNAi\u6cbb\u7642\u85ac\u30be\u30c0\u30b7\u30e9\u30f3\u3002N Engl J Med 2024; 391:913-25.
    12.APOC3 \u3092\u6a19\u7684\u3068\u3059\u308b RNAi \u6cbb\u7642\u85ac Plozasiran \u306b\u3088\u308b\u6df7\u5408\u578b\u9ad8\u8102\u8840\u75c7\u306e\u6cbb\u7642\u3002N Engl J Med 2024; 391:899-912\u3002
    13.\u91cd\u75c7\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u5bfe\u3059\u308b\u30d7\u30ed\u30b6\u30b7\u30e9\u30f3\uff08ARO-APOC3\uff09\uff1aSHASTA-2\u7121\u4f5c\u70ba\u5316\u81e8\u5e8a\u8a66\u9a13\u3002JAMA Cardiol 2024; 9:620-30. <\/li>\n<\/ol>\n

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