{"id":257197,"date":"2025-09-12T16:14:26","date_gmt":"2025-09-12T14:14:26","guid":{"rendered":"https:\/\/r3i.org\/r3i%e7%a4%be%e8%aa%ac\/%e7%a4%be%e8%aa%ac-07-25-%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e4%bd%8e%e4%b8%8b%e3%81%b8%e3%81%ae%e6%96%b0%e3%81%9f%e3%81%aa%e3%82%a2%e3%83%97%e3%83%ad%e3%83%bc%e3%83%81\/"},"modified":"2026-03-04T18:43:42","modified_gmt":"2026-03-04T17:43:42","slug":"%e7%a4%be%e8%aa%ac-07-25-%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e4%bd%8e%e4%b8%8b%e3%81%b8%e3%81%ae%e6%96%b0%e3%81%9f%e3%81%aa%e3%82%a2%e3%83%97%e3%83%ad%e3%83%bc%e3%83%81","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/r3i%e7%a4%be%e8%aa%ac\/%e7%a4%be%e8%aa%ac-07-25-%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e4%bd%8e%e4%b8%8b%e3%81%b8%e3%81%ae%e6%96%b0%e3%81%9f%e3%81%aa%e3%82%a2%e3%83%97%e3%83%ad%e3%83%bc%e3%83%81\/","title":{"rendered":"\u793e\u8aac 07\/25 – \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4f4e\u4e0b\u3078\u306e\u65b0\u305f\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\uff1aANGPTL4\u3067\u672a\u6765\u306b\u623b\u308b\uff1f"},"content":{"rendered":"

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R3i\u793e\u8aac<\/h2>\n

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2025\u5e747\u6708<\/span><\/h5>\n
\u4e2d\u6027\u8102\u80aa\u4f4e\u4e0b\u3078\u306e\u65b0\u305f\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\uff1aANGPTL4\u3067\u672a\u6765\u306b\u623b\u308b\uff1f <\/b><\/h5>\n
Prof. Peter Libby<\/a>, Prof. Michel Hermans<\/a>, Prof. Pierre Amarenco<\/a><\/h6>\n

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\u30a2\u30f3\u30b8\u30aa\u30dd\u30a8\u30c1\u30f3\u69d8\u30bf\u30f3\u30d1\u30af\u8cea4\uff08ANGPTL4\uff09\u306f\u3001\u65e9\u304f\u304b\u3089\u95a2\u5fc3\u3092\u96c6\u3081\u3066\u3044\u305f\u6a19\u7684\u306e\u4e00\u3064\u3067\u3042\u308b\u3002\u8102\u80aa\u7d44\u7e54\u3068\u809d\u81d3\u3067\u4e3b\u306b\u767a\u73fe\u3057\u3066\u3044\u308bANGPTL4\u306f\u3001\u30ea\u30dd\u86cb\u767d\u30ea\u30d1\u30fc\u30bc\u306b\u5bfe\u3059\u308b\u963b\u5bb3\u4f5c\u7528\u3092\u4ecb\u3057\u3066\u8102\u8cea\u4ee3\u8b1d\u306e\u8abf\u7bc0\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u304a\u308a\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3092\u591a\u304f\u542b\u3080\u30ea\u30dd\u86cb\u767d\u306e\u5faa\u74b0\u304b\u3089\u306e\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u3092\u4fc3\u9032\u3059\u308b\u53ef\u80fd\u6027\u3082\u3042\u308b(4)\u3002\u907a\u4f1d\u5b66\u7684\u7814\u7a76\u306b\u3088\u308a\u3001\u3053\u306e\u6a19\u7684\u306e\u53ef\u80fd\u6027\u304c\u652f\u6301\u3055\u308c\u3066\u3044\u308b\u3002 <\/span>ANGPTL4<\/span><\/i> \u306f\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3001\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u306e\u30ec\u30d9\u30eb\u304c\u4f4e\u304f\u3001ASCVD\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b(5-7)\u3002\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u9ad8\u98fd\u548c\u8102\u80aa\u98df\u3092\u4e0e\u3048\u305fAngptl4\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u306f\u8178\u9593\u819c\u30ea\u30f3\u30d1\u7bc0\u3078\u306e\u8102\u8cea\u84c4\u7a4d\u3068\u5168\u8eab\u6027\u708e\u75c7\u3092\u793a\u3057\u3001\u751f\u5b58\u7387\u3082\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u8a3c\u660e\u3055\u308c\u3001\u6cbb\u7642\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u3057\u3066\u306eANGPTL4\u963b\u5bb3\u306b\u5bfe\u3059\u308b\u71b1\u610f\u306f\u8584\u308c\u3066\u304d\u3066\u3044\u308b(8,9)\u3002 <\/span><\/p>\n

\u3053\u306e\u3088\u3046\u306a\u80cc\u666f\u304b\u3089\u3001\u65b0\u898f\u306eANGPLT4\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u306b\u3088\u308b\u521d\u671f\u306e\u7d50\u679c\u306f\u3001\u3053\u306e\u6cbb\u7642\u6a19\u7684\u306e\u6709\u7528\u6027\u306e\u518d\u8a55\u4fa1\u3092\u4fc3\u3057\u3066\u3044\u308b\u3002\u30b0\u30e9\u30b9\u30b4\u30fc\u3067\u6700\u8fd1\u958b\u50ac\u3055\u308c\u305f\u6b27\u5dde\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u5b66\u4f1a\uff08European Atherosclerosis Society\uff09\u306e\u5e74\u6b21\u7dcf\u4f1a\u3067\u5f8c\u671f\u30d6\u30ec\u30fc\u30af\u30b9\u30eb\u30fc\u3068\u3057\u3066\u767a\u8868\u3055\u308c\u3001\u3053\u306e\u5ea6\u3001\u4ee5\u4e0b\u306e\u8ad6\u6587\u3067\u767a\u8868\u3055\u308c\u305f\u3002 <\/span>\u30e9\u30f3\u30bb\u30c3\u30c8<\/span><\/i>(10)\u306b\u3088\u308c\u3070\u3001MAR001\u306e\u6700\u521d\u306e\u30d2\u30c8\u3067\u306e\u30c7\u30fc\u30bf\u306f\u3001ANGPTL4\u963b\u5bb3\u306e\u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u3053\u308c\u307e\u3067\u306e\u61f8\u5ff5\u3092\u6255\u62ed\u3059\u308b\u3082\u306e\u3067\u3042\u3063\u305f\u3002 <\/span> <\/p>\n

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    \n
  1. \n
      \n
    1. Vaduganathan M, Mensah GA, Turco JV, et al. The global burden of cardiovascular diseases and risk: a compass for future health.JAC 2022; 80: 2361-71. <\/span><\/li>\n
    2. GBD 2021 Adolescent BMI Collaborators.1990-2021\u5e74\u30012050\u5e74\u307e\u3067\u306e\u4e88\u6e2c\uff1aGlobal Burden of Disease Study 2021\u306e\u305f\u3081\u306e\u4e88\u6e2c\u7814\u7a76\u3002Lancet 2025;405:785-812. <\/span><\/li>\n
    3. Ginsberg HN, Packard CJ, Chapman MJ, et al. \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u3068\u305d\u306e\u6b8b\u4f59\u7269\uff1a\u4ee3\u8b1d\u7684\u6d1e\u5bdf\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u306b\u304a\u3051\u308b\u5f79\u5272\u3001\u304a\u3088\u3073\u65b0\u305f\u306a\u6cbb\u7642\u6226\u7565-\u6b27\u5dde\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u5b66\u4f1a\u306e\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u30b9\u30c6\u30fc\u30c8\u30e1\u30f3\u30c8\u3002Eur Heart J 2021; 42:4791-806\u3002 <\/span><\/li>\n
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    10. \u8102\u8cea\u4f4e\u4e0b\u306b\u5bfe\u3059\u308b\u65b0\u898fANGPTL4\u963b\u5bb3\u6297\u4f53\u306e\u5b89\u5168\u6027\u3068\u6709\u52b9\u6027\uff1a\u7b2c1\u76f8\u304a\u3088\u3073\u7b2c1b\/2a\u76f8\u81e8\u5e8a\u8a66\u9a13\u306e\u7d50\u679c\u3002Lancet 2025; doi: 10.1016\/S0140-6736(25)00825-6. <\/span><\/li>\n
    11. ANGPTL4 \u963b\u5bb3\u6297\u4f53\u306f\u3001\u30d2\u30c8\u4ee5\u5916\u306e\u970a\u9577\u985e\u306e\u8102\u8cea\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u5b89\u5168\u306b\u6539\u5584\u3059\u308b\u3002BioMedicine 2025; doi: 10.1016\/j.ebiom.2025.105748. <\/span><\/li>\n<\/ol>\n<\/li>\n<\/ol>\n

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