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href=\"https:\/\/r3i.org\/ja\/editorials-10-25-%e3%83%aa%e3%83%9d%e3%82%bf%e3%83%b3%e3%83%91%e3%82%afa%e3%81%af%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e3%83%aa%e3%82%b9%e3%82%af%e5%9b%a0%e5%ad%90%ef%bc%9a%e5%90%8c\/\">\u30ea\u30dd\u86cb\u767d(a)<\/a>\u306e\u5f71\u97ff\u3082\u8a8d\u8b58\u3055\u308c\u3066\u3044\u308b(19)\u3002\u751f\u6daf\u30ea\u30b9\u30af\u3092\u8003\u616e\u3057\u305f\u4eca\u56de\u306e\u66f4\u65b0\u306f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u8a55\u4fa1\u306e\u9032\u5316\u306b\u304a\u3051\u308b\u6b21\u306e\u6bb5\u968e\u3068\u3057\u3066\u3001\u500b\u5225\u5316\u533b\u7642\u306e\u6982\u5ff5\u306b\u6cbf\u3063\u305f\u3082\u306e\u3067\u3042\u308b\u3002   <\/p>\n<p>2019\u5e74\u306eESC\/EAS\u8102\u8cea\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306e\u66f4\u65b0\u306f\u3001\u9593\u9055\u3044\u306a\u304f\u8102\u8cea\u306b\u95a2\u9023\u3057\u305f\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6cbb\u7642\u306b\u5f79\u7acb\u3064\u3067\u3042\u308d\u3046\u3002\u6211\u3005\u306f\u3001\u3053\u306e\u30ea\u30b9\u30af\u306e\u975eLDL\u6210\u5206\u306e\u7ba1\u7406\u306b\u95a2\u3059\u308b\u6d1e\u5bdf\u3092\u5f97\u308b\u305f\u3081\u306b\u3001\u73fe\u5728\u9032\u884c\u4e2d\u306e\u8a66\u9a13\u306e\u7d50\u679c\u3092\u5f85\u3061\u305f\u3044\u3002 <\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;8px&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><b>\u53c2\u8003\u6587\u732e<\/b><\/p>\n<ol>\n<li style=\"list-style-type: none\">\n<p>1.Mach F, Baigent C, Catapano AL, et al. 2019 ESC\/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk.Atherosclerosis 2019;290:140\u2013205.<br \/>2.\u8102\u8cea\u7570\u5e38\u75c7\u306e\u7ba1\u7406\u306b\u95a2\u3059\u308b2019\u5e74ESC\/EAS\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306e\u91cd\u70b9\u7684\u66f4\u65b0\uff08Focused update of the 2019 ESC\/EAS guidelines for the management of dyslipidaemias\uff09\u3002https:\/\/doi.org\/10.1016\/j.atherosclerosis.2025.120479<br \/>3.Ference BA, Ginsberg HN, Graham I, et al. \u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u306f\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75c5\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002      1. \u907a\u4f1d\u5b66\u7684\u3001\u75ab\u5b66\u7684\u3001\u81e8\u5e8a\u7684\u7814\u7a76\u304b\u3089\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3002\u6b27\u5dde\u52d5\u8108\u786c\u5316\u5b66\u4f1a\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u30d1\u30cd\u30eb\u304b\u3089\u306e\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u30b9\u30c6\u30fc\u30c8\u30e1\u30f3\u30c8\u3002Eur Heart J 2017;38:2459-72.<br \/>4.Nissen SE, Lincoff AM, Brennan D, et al. Bempedoic acid and cardiovascular outcomes in statin-intolerant patients.N Engl J Med 2023;388:1353-64.<br \/>5.Ray KK, Wright RS, Kallend D, et al.LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4e0a\u6607\u60a3\u8005\u306b\u304a\u3051\u308b\u30a4\u30f3\u30af\u30ea\u30b7\u30e9\u30f3\u306e2\u3064\u306e\u7b2c3\u76f8\u8a66\u9a13\u3002N Engl J Med 2020;382:1507-19.<br \/>6.\u30db\u30e2\u63a5\u5408\u6027\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306b\u5bfe\u3059\u308b\u30a8\u30d3\u30ca\u30af\u30de\u30d6\u3002N Engl J Med 2020;383:711-20.<br \/>7.\u30db\u30e2\u63a5\u5408\u6027\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306e\u5c0f\u5150\u60a3\u8005\u306b\u5bfe\u3059\u308b\u30a8\u30d3\u30ca\u30af\u30de\u30d6\u3002Circulation 2024;149:343-53.<br \/>8.\u5927\u5185\u6d0b\u4e00\u3001\u8352\u4e95\u88d5\u4e4b\u3001\u4ed6 75\u6b73\u4ee5\u4e0a\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75c5\u4e88\u9632\u306b\u95a2\u3059\u308b\u30a8\u30bc\u30c1\u30df\u30d6\u8102\u8cea\u4f4e\u4e0b\u8a66\u9a13\uff08EWTOPIA 75\uff09\uff1a\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3002Circulation 2019;140:992-1003.<br \/>9.Cannon CP, Blazing MA, Giugliano RP, et al. Ezetimibe added to statin therapy after acute coronary syndromes.N Engl J Med 2015;372:2387-97.<br \/>10.Nicholls SJ, Kataoka Y, Nissen SE, et al. Effect of evolocumab on coronary plaque phenotype and burden in statin-treated patients after myocardial infarction.JACC Cardiovasc Imag 2022;15:1308-21.<br \/>11.\u6025\u6027\u5fc3\u7b4b\u6897\u585e\u60a3\u8005\u306e\u51a0\u52d5\u8108\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306b\u5bfe\u3059\u308b\u9ad8\u5f37\u5ea6\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\u306b\u8ffd\u52a0\u3057\u305f\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u306e\u52b9\u679c\uff1aPACMAN-AMI\u7121\u4f5c\u70ba\u5316\u81e8\u5e8a\u8a66\u9a13\u3002jama 2022; 27:1771-81.<br \/>12.HIV\u611f\u67d3\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u75be\u60a3\u4e88\u9632\u306e\u305f\u3081\u306e\u30d4\u30bf\u30d0\u30b9\u30bf\u30c1\u30f3\u3002N Engl J Med 2023;389:687-99.<br \/>13.\u30a2\u30f3\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u95a2\u9023\u5fc3\u6a5f\u80fd\u969c\u5bb3\u306b\u5bfe\u3059\u308b\u30a2\u30c8\u30eb\u30d0\u30b9\u30bf\u30c1\u30f3\uff1aSTOP-CA\u7121\u4f5c\u70ba\u5316\u81e8\u5e8a\u8a66\u9a13\u3002JAMA 2023; 330:528-36.<br \/>14.Nabati M, Janbabai G, Esmailian J, et al. \u4e73\u764c\u5973\u6027\u306b\u304a\u3051\u308b\u5316\u5b66\u7642\u6cd5\u8a98\u767a\u6027\u5fc3\u6bd2\u6027\u4e88\u9632\u306b\u304a\u3051\u308b\u30ed\u30b9\u30d0\u30b9\u30bf\u30c1\u30f3\u306e\u52b9\u679c\uff1a\u7121\u4f5c\u70ba\u5316\u5358\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3002J Cardiovasc Pharmacol Ther 2019;24:233-41.<br \/>15.Thavendiranathan P, Houbois C, Marwick TH, et al. \u30a2\u30f3\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u7cfb\u85ac\u5264\u3092\u6295\u4e0e\u3055\u308c\u5fc3\u6bd2\u6027\u30ea\u30b9\u30af\u304c\u4e0a\u6607\u3057\u305f\u304c\u3093\u60a3\u8005\u306b\u304a\u3051\u308b\u65e9\u671f\u5fc3\u6a5f\u80fd\u969c\u5bb3\u4e88\u9632\u306e\u305f\u3081\u306e\u30b9\u30bf\u30c1\u30f3\u3002Eur Heart J Cardiovasc Pharmacother 2023;9:515-25.<br \/>16.Bhatt DL, Steg PG,\u2219Miller M, et al. \u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u5bfe\u3059\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3002N Engl J Med 2019;380:11-22.<br \/>17.SCORE2\u30ef\u30fc\u30ad\u30f3\u30b0\u30b0\u30eb\u30fc\u30d7\u304a\u3088\u3073ESC\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u5171\u540c\u7814\u7a76\u3002SCORE2\u30ea\u30b9\u30af\u4e88\u6e2c\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\uff1a\u6b27\u5dde\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u75be\u60a3\u306e10\u5e74\u30ea\u30b9\u30af\u3092\u63a8\u5b9a\u3059\u308b\u65b0\u3057\u3044\u30e2\u30c7\u30eb\u3002Eur Heart J 2021;42:2439-54.<br \/>18.SCORE2-OP working group and ESC Cardiovascular risk collaboration; SCORE2-OP risk prediction algorithms: estimating incident cardiovascular event risk in older persons in four geographical risk regions.Eur Heart J 2021;42:2455-67.<br \/>19.Kronenberg F, Mora S, Stroes ESG, et al.                               \u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u3068\u5927\u52d5\u8108\u5f01\u72ed\u7a84\u75c7\u306b\u304a\u3051\u308b\u30ea\u30dd\u86cb\u767d\uff08a\uff09\uff1a\u6b27\u5dde\u52d5\u8108\u786c\u5316\u5b66\u4f1a\u306e\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u30fb\u30b9\u30c6\u30fc\u30c8\u30e1\u30f3\u30c8\u3002Eur Heart J 2022;43:3925-46. <\/p>\n<p>\u30ad\u30fc\u30ef\u30fc\u30c9\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\uff1b\u8102\u8cea\u4f4e\u4e0b\uff1b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff1b\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff1b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u8a55\u4fa1<\/p>\n<p>14.Aboyans V, Criqui MH, Denenberg JO, et al. \u5927\u5c0f\u8840\u7ba1\u306b\u304a\u3051\u308b\u672b\u68a2\u52d5\u8108\u75be\u60a3\u9032\u884c\u306e\u5371\u967a\u56e0\u5b50\u3002Circulation 2006;113:2623-9.  <\/li>\n<\/ol>\n<p><em>Key words: Lipoprotein(a); peripheral artery disease; ODYSSEY OUTCOMES; residual vascular risk<\/em><\/p>\n<ol>\n<li style=\"list-style-type: none\">\n<\/li>\n<\/ol>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>R3i\u793e\u8aacR3i\u793e\u8aac\u306f\u3001R3i\u7406\u4e8b\u4f1a\u306e\u30e1\u30f3\u30d0\u30fc\u306b\u3088\u3063\u3066\u4f5c\u6210\u3055\u308c\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\u3068\u3044\u3046\u6c38\u7d9a\u7684\u306a\u8ab2\u984c\u3078\u306e\u5bfe\u51e6\u306b [&hellip;]<\/p>\n","protected":false},"author":258497324,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_crdt_document":"","jetpack_post_was_ever_published":false,"footnotes":""},"class_list":["post-257191","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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