{"id":257124,"date":"2026-03-04T16:18:31","date_gmt":"2026-03-04T15:18:31","guid":{"rendered":"https:\/\/r3i.org\/r3i-editorials-2025%e5%b9%b4%e3%82%92%e6%8c%af%e3%82%8a%e8%bf%94%e3%81%a3%e3%81%a6%ef%bc%9a%e3%83%8b%e3%83%a5%e3%83%bc%e3%82%b9%e3%81%a8%e3%81%aa%e3%81%a3%e3%81%9f%e8%a9%b1%e9%a1%8c\/"},"modified":"2026-03-05T18:08:51","modified_gmt":"2026-03-05T17:08:51","slug":"r3i-editorials-2025%e5%b9%b4%e3%82%92%e6%8c%af%e3%82%8a%e8%bf%94%e3%81%a3%e3%81%a6%ef%bc%9a%e3%83%8b%e3%83%a5%e3%83%bc%e3%82%b9%e3%81%a8%e3%81%aa%e3%81%a3%e3%81%9f%e8%a9%b1%e9%a1%8c","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/r3i-editorials-2025%e5%b9%b4%e3%82%92%e6%8c%af%e3%82%8a%e8%bf%94%e3%81%a3%e3%81%a6%ef%bc%9a%e3%83%8b%e3%83%a5%e3%83%bc%e3%82%b9%e3%81%a8%e3%81%aa%e3%81%a3%e3%81%9f%e8%a9%b1%e9%a1%8c\/","title":{"rendered":"R3i Editorials – 2025\u5e74\u3092\u632f\u308a\u8fd4\u3063\u3066\uff1a\u30cb\u30e5\u30fc\u30b9\u3068\u306a\u3063\u305f\u8a71\u984c"},"content":{"rendered":"

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R3i\u793e\u8aac<\/h2>\n

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R3i\u793e\u8aac\u306f\u3001R3i\u7406\u4e8b\u4f1a\u306e\u30e1\u30f3\u30d0\u30fc\u306b\u3088\u3063\u3066\u4f5c\u6210\u3055\u308c\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\u3068\u3044\u3046\u6c38\u7d9a\u7684\u306a\u8ab2\u984c\u3078\u306e\u5bfe\u51e6\u306b\u7126\u70b9\u3092\u5f53\u3066\u3066\u3044\u308b\u3002\u3053\u308c\u3089\u306e\u8ad6\u8aac\u306f\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u30ea\u30c3\u30c1\u30ea\u30dd\u86cb\u767d\u3084\u30ea\u30dd\u86cb\u767d(a)\u306a\u3069\u306e\u8102\u8cea\u95a2\u9023\u5371\u967a\u56e0\u5b50\u306b\u95a2\u3059\u308b\u65b0\u305f\u306a\u77e5\u898b\u3084\u6cbb\u7642\u6226\u7565\u306b\u3064\u3044\u3066\u3001\u533b\u7642\u5c02\u9580\u5bb6\u3092\u6559\u80b2\u3059\u308b\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3002 <\/span><\/p>\n

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2025\u5e7412\u6708<\/span><\/h5>\n
2025\u5e74\u3092\u632f\u308a\u8fd4\u3063\u3066\uff1a\u30cb\u30e5\u30fc\u30b9\u3068\u306a\u3063\u305f\u8a71\u984c<\/h5>\n
Prof. Peter Libby<\/a>, <\/span>Prof. Michel Hermans<\/a>, Prof. Pierre Amarenco<\/a>, Prof. Lale Tokg\u00f6zoglu <\/a><\/span> <\/h6>\n

2025\u5e74\u3092\u7de0\u3081\u304f\u304f\u308b\u306b\u3042\u305f\u308a\u3001\u672c\u5e74\u3001\u6211\u3005\u306f\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u3064\u3044\u3066\u4f55\u3092\u5b66\u3093\u3060\u3060\u308d\u3046\u304b\uff1f<\/p>\n

\u6975\u3081\u3066\u91cd\u8981\u306a\u70b9\u3068\u3057\u3066\u3001\u8102\u8cea\u95a2\u9023\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u306b\u95a2\u3059\u308b\u77e5\u898b\u306f\u62e1\u5927\u3057\u7d9a\u3051\u3066\u3044\u308b\u3002VESALIUS-CV<\/a>\u8a66\u9a13\u306e\u7d50\u679c\u306f\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u65e2\u5f80\u304c\u306a\u3044\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3051\u308b\u5f37\u529b\u306a\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306e\u81e8\u5e8a\u7684\u6709\u7528\u6027\u3092\u5b9f\u8a3c\u3057\u305f\u3002\u5f93\u6765\u306e\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306b\u52a0\u3048\u3066PCSK9\u963b\u5bb3\u85acEvolocumab\u3092\u4f7f\u7528\u3057\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u5024\u3092\u4e2d\u592e\u502445 mg\/dL\u307e\u3067\u4f4e\u4e0b\u3055\u305b\u305f\u7d50\u679c\u3001\u521d\u56de\u4e3b\u8981\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u304c25%\u6e1b\u5c11\u3057\u305f\uff081\uff09\u3002PCSK9\u963b\u5bb3\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u4e8c\u6b21\u4e88\u9632\u304b\u3089\u4e00\u6b21\u4e88\u9632\u306e\u8a2d\u5b9a\u3078\u3068\u62e1\u5f35\u3057\u305f\uff082,3\uff09\u3053\u308c\u3089\u306e\u753b\u671f\u7684\u306a\u77e5\u898b\u306f\u3001\u3042\u3089\u3086\u308b\u30ea\u30b9\u30af\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u306b\u304a\u3044\u3066LDL-C\u306e\u300cLower is better\uff08\u4f4e\u3051\u308c\u3070\u4f4e\u3044\u307b\u3069\u826f\u3044\uff09\u300d\u3068\u3044\u3046\u539f\u5247\u3092\u518d\u78ba\u8a8d\u3055\u305b\u308b\u3082\u306e\u3067\u3042\u308b\u3002
\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea(a) [Lp(a)] \u306f\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u307f\u306a\u3089\u305a\u3001<\/a>\u4e0b\u80a2\u306e\u6709\u5bb3\u4e8b\u8c61\u3068\u306e\u95a2\u9023\u306b\u304a\u3044\u3066\u3082\u5f15\u304d\u7d9a\u304d\u6ce8\u76ee\u306e\u7684\u3068\u306a\u3063\u3066\u3044\u308b\u3002Mass General Brigham Lp(a)\u30ec\u30b8\u30b9\u30c8\u30ea\u306e21,000\u4eba\u3092\u8d85\u3048\u308b\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30ea\u30a2\u30eb\u30ef\u30fc\u30eb\u30c9\u30c7\u30fc\u30bf\u306b\u304a\u3044\u3066\u3001\u672b\u68a2\u52d5\u8108\u75be\u60a3\uff08PAD\uff09\u3092\u6709\u3057Lp(a)\u6fc3\u5ea6\u304c\u6700\u3082\u9ad8\u3044\uff08\u7b2c4\u56db\u5206\u4f4d\u3001132\u2013855 nmol\/L\uff09\u60a3\u8005\u306f\u3001\u53c2\u7167\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u304c36%\u9ad8\u304f\u3001\u672b\u68a2\u8840\u884c\u518d\u5efa\u8853\u3092\u542b\u3080\u4e3b\u8981\u4e0b\u80a2\u6709\u5bb3\u4e8b\u8c61\u306e\u30ea\u30b9\u30af\u308219%\u9ad8\u3044\uff08\u672b\u68a2\u8840\u884c\u518d\u5efa\u8853\u30ea\u30b9\u30af\u306f20%\u5897\uff09\u3053\u3068\u304c\u793a\u3055\u308c\u305f\uff084\uff09\u3002\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001\u81e8\u5e8a\u8ee2\u5e30\u6539\u5584\u306e\u305f\u3081\u306e\u5f37\u529b\u306a\u4ecb\u5165\u306b\u3088\u308b\u5229\u76ca\u3092\u4eab\u53d7\u3067\u304d\u308b\u6700\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u3092\u7279\u5b9a\u3059\u308b\u305f\u3081\u306b\u3001Lp(a)\u3092\u4e00\u5ea6\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u306e\u610f\u7fa9\u3092\u5f37\u5316\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002 <\/p>\n

\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u30ea\u30c3\u30c1\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u306f\u3001\u7d99\u7d9a\u7684\u306a\u8ab2\u984c\u3067\u3042\u308b\u30022025\u5e74\u306b\u306f\u3001TG\u4ee3\u8b1d\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u30a2\u30f3\u30b8\u30aa\u30dd\u30a8\u30c1\u30f3\u69d8\u30bf\u30f3\u30d1\u30af\u8cea3\uff08ANGPTL3\uff09\u304a\u3088\u3073\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaCIII\uff08APOC3\uff09<\/a>\u3092\u6a19\u7684\u3068\u3057\u305f\u65b0\u898f\u6cbb\u7642\u6cd5\u306b\u95a2\u3059\u308b\u91cd\u8981\u306a\u9032\u5c55\u304c\u5831\u544a\u3055\u308c\u305f\u3002\u809d\u81d3\u306eANGPTL3\u3092\u6a19\u7684\u3068\u3059\u308b\u4f4e\u5206\u5b50\u5e72\u6e09RNA\uff08siRNA\uff09\u3067\u3042\u308bSolbinsiran<\/a>\u306f\u3001\u6df7\u5408\u578b\u8102\u8cea\u7570\u5e38\u75c7\u306b\u304a\u3044\u3066\u6709\u671b\u306a\u7d50\u679c\u3092\u793a\u3057\u3001\u9ad8\u7528\u91cf\u3067TG\u304a\u3088\u3073\u8d85\u4f4e\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\uff08VLDL\uff09\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u309250%\u4ee5\u4e0a\u6e1b\u5c11\u3055\u305b\u308b\u3068\u3068\u3082\u306b\u3001LDL-C\u4f4e\u4e0b\u306b\u304a\u3044\u3066\u3082\u4e2d\u7a0b\u5ea6\u306e\u52b9\u679c\u3092\u793a\u3057\u305f\uff085\uff09\u3002APOC3\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u3067\u3042\u308bOlezarsen\u306f\u3001\u4e2d\u7b49\u5ea6\u304a\u3088\u3073\u91cd\u5ea6\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9<\/a>\u8840\u75c7\u306e\u4e21\u65b9\u306b\u304a\u3044\u3066\u6709\u7528\u6027\u3092\u793a\u3057\u305f\uff086,7\uff09\u3002\u4e2d\u7b49\u5ea6\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\uff08150-499 mg\/dL\uff09\u304b\u3064\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305fESSENCE-TIMI 73b\u8a66\u9a13\u3067\u306f\u3001Olezarsen\u6cbb\u7642\u306b\u3088\u308a85%\u4ee5\u4e0a\u306e\u60a3\u8005\u304cTG\u5024 <150 mg\/dL\u3092\u9054\u6210\u3057\u305f\uff086\uff09\u3002\u3055\u3089\u306b\u3001\u91cd\u5ea6\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3092\u5bfe\u8c61\u3068\u3057\u305fCORE\u8a66\u9a13\uff08CORE-TIMI 72a\u304a\u3088\u3073CORE2-TIMI 72b\uff09\u3067\u306f\u300186%\u306e\u60a3\u8005\u304cTG\u5024 <500 mg\/dL\u3092\u9054\u6210\u3057 \u3001TG\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e\u6539\u5584\u306b\u4f34\u3044\u3001\u81b5\u708e\u306e\u767a\u75c7\u7387\u306f\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u306685%\u6e1b\u5c11\u3057\u305f\uff087\uff09\u3002 <\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” text_font_size=”14px” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22text_text_color%22%93}”]<\/p>\n

\u304a\u305d\u3089\u304f2025\u5e74\u306e\u6700\u3082\u8208\u596e\u3059\u3079\u304d\u30cb\u30e5\u30fc\u30b9\u306e\u4e00\u3064\u306f\u3001CRISPR-Cas9\u6280\u8853\u3092\u7528\u3044ANGPTL3<\/a>\u3092\u6a19\u7684\u3068\u3059\u308b\u65b0\u898f\u30b2\u30ce\u30e0\u7de8\u96c6\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u95a2\u3059\u308b\u3082\u306e\u3067\u3042\u308d\u3046\u3002\u96e3\u6cbb\u6027\u8102\u8cea\u7570\u5e38\u75c7\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305fFirst-in-human\uff08\u30d2\u30c8\u521d\u56de\u6295\u4e0e\uff09\u30c7\u30fc\u30bf\u306b\u304a\u3044\u3066\u3001CTX310\u306f\u6700\u9ad8\u7528\u91cf\u3067LDL-C\u304a\u3088\u3073TG\u30ec\u30d9\u30eb\u3092\u6700\u592760%\u6e1b\u5c11\u3055\u305b\u305f\uff088\uff09\u3002\u9577\u671f\u7684\u306a\u5b89\u5168\u6027\u306b\u3064\u3044\u3066\u306f\u3055\u3089\u306a\u308b\u7814\u7a76\u3092\u8981\u3059\u308b\u7406\u89e3\u53ef\u80fd\u306a\u61f8\u5ff5\u4e8b\u9805\u3068\u3057\u3066\u6b8b\u308b\u3082\u306e\u306e\u3001\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u8102\u8cea\u7570\u5e38\u75c7\u306e\u81e8\u5e8a\u7ba1\u7406\u3092\u4e00\u5909\u3055\u305b\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u300cOnce-and-done\uff08\u5358\u56de\u6cbb\u7642\u3067\u5b8c\u7d50\u3059\u308b\uff09\u300d\u6cbb\u7642\u306e\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002 <\/p>\n

2025\u5e74\u3092\u7de0\u3081\u304f\u304f\u308b\u306b\u3042\u305f\u308a\u3001\u81e8\u5e8a\u533b\u304c\u76f4\u9762\u3059\u308b2\u3064\u306e\u91cd\u8981\u306a\u8ab2\u984c\u3001\u3059\u306a\u308f\u3061\u300c\u80a5\u6e80\u95a2\u9023\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u300d\u3068\u300c\u6b8b\u5b58\u708e\u75c7\u30ea\u30b9\u30af\u300d\u304c\u6d6e\u304d\u5f6b\u308a\u3068\u306a\u3063\u305f<\/p>\n

\u6211\u3005\u306f\u6210\u4eba\u3001\u3055\u3089\u306b\u6182\u616e\u3059\u3079\u304d\u3053\u3068\u306b\u9752\u5e74\u304a\u3088\u3073\u5c0f\u5150\u306b\u304a\u3051\u308b\u80a5\u6e80\u306e\u30d1\u30f3\u30c7\u30df\u30c3\u30af\u306e\u7d99\u7d9a\u7684\u304b\u3064\u52a0\u901f\u5ea6\u7684\u306a\u62e1\u5927\u306b\u76f4\u9762\u3057\u3066\u3044\u308b\u3002Global Burden of Disease study<\/a>\u306e\u6700\u65b0\u30c7\u30fc\u30bf\u306b\u3088\u308c\u3070\u3001\u9752\u5e74\u304a\u3088\u3073\u5c0f\u5150\u306e\u80a5\u6e80\u6709\u75c5\u7387\u306f1990\u5e74\u304b\u30892021\u5e74\u306e\u9593\u306b3\u500d\u306b\u5897\u52a0\u3057\u3066\u304a\u308a\u3001\u5317\u30a2\u30d5\u30ea\u30ab\u3068\u4e2d\u6771\u3067\u6700\u3082\u9ad8\u3044\u6709\u75c5\u7387\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u3053\u306e\u50be\u5411\u304c\u7d9a\u3051\u3070\u30012050\u5e74\u307e\u3067\u306b\u4e16\u754c\u306e\u5c0f\u5150\u304a\u3088\u3073\u9752\u5e74\u306e\u7d043\u5206\u306e1\u304c\u904e\u4f53\u91cd\u307e\u305f\u306f\u80a5\u6e80\u306b\u306a\u308b\u3068\u4e88\u6e2c\u3055\u308c\u308b\uff089\uff09\u3002\u3053\u308c\u3089\u306e\u50be\u5411\u306f\u5c06\u6765\u4e16\u4ee3\u306e\u5fc3\u8840\u7ba1\u7cfb\u306e\u5065\u5eb7\u3092\u8105\u304b\u3059\u3082\u306e\u3067\u3042\u308a\u3001\u7dca\u6025\u306e\u884c\u52d5\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002 <\/p>\n

\u4e16\u754c\u7684\u306b\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306f\u904e\u4f53\u91cd\u307e\u305f\u306f\u80a5\u6e80\u306e\u500b\u4eba\u306e\u4e3b\u8981\u306a\u6b7b\u56e0\u3067\u3042\u308a\u3001\u305d\u306e\u767a\u751f\u7387\u306f1990\u5e74\u4ee5\u964d\u500d\u5897\u3057\u3066\u3044\u308b\uff0810\uff09\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u80a5\u6e80\u95a2\u9023\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3068\u3044\u3046\u30a2\u30f3\u30e1\u30c3\u30c8\u30fb\u30af\u30ea\u30cb\u30ab\u30eb\u30fb\u30cb\u30fc\u30ba\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306e\u65b0\u3057\u3044\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u5fc5\u8981\u3068\u3055\u308c\u3066\u3044\u308b\u3002FOURIER\u8a66\u9a13<\/a>\u304b\u3089\u306e\u6d1e\u5bdf\u306f\u3001Evolocumab\u6cbb\u7642\u304c\u6700\u3082\u9ad8\u3044BMI\uff08\u3057\u305f\u304c\u3063\u3066\u6700\u3082\u9ad8\u30ea\u30b9\u30af\uff09\u306e\u60a3\u8005\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3057\u305f\u3053\u3068\u3092\u793a\u3057\u305f\uff0811\uff09\u3002\u3057\u304b\u3057\u3001\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u306e\u8abf\u7bc0\u4e0d\u5168\u306b\u3088\u308a\u5f71\u97ff\u3092\u53d7\u3051\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u9593\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u8003\u616e\u3059\u308b\u3068\u3001\u80a5\u6e80\u95a2\u9023\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u7ba1\u7406\u306b\u306f\u3001\u7570\u306a\u308b\u6cbb\u7642\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u7d44\u307f\u5408\u308f\u305b\u304c\u5fc5\u8981\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3002\u7ba1\u7406\u306b\u304a\u3044\u3066\u91cd\u8981\u3068\u306a\u308b\u306e\u306f\u3001\u6700\u9ad8\u30ea\u30b9\u30af\u306e\u60a3\u8005\u3092\u3044\u304b\u306b\u7279\u5b9a\u3059\u308b\u304b\u3067\u3042\u308b\u3002 <\/p>\n

\u6700\u5f8c\u306b\u3001\u5f93\u6765\u306e\u5371\u967a\u56e0\u5b50\u3092\u8d85\u3048\u3066ASCVD\u4e88\u9632\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u3001\u9ad8\u611f\u5ea6C\u53cd\u5fdc\u6027\u30bf\u30f3\u30d1\u30af\u8cea\uff08hsCRP\uff09<\/a>\u306e\u30eb\u30fc\u30c1\u30f3\u6e2c\u5b9a\u306e\u610f\u7fa9\u3092\u660e\u78ba\u306b\u3057\u305f\u753b\u671f\u7684\u306a\u8a66\u9a13\u306b\u3088\u3063\u30662025\u5e74\u306f\u5e55\u3092\u9589\u3058\u305f\uff0812\uff09\u3002\u4eca\u5f8c\u306f\u3053\u308c\u3092\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u5b9f\u88c5\u3059\u308b\u305f\u3081\u306e\u884c\u52d5\u304c\u6c42\u3081\u3089\u308c\u308b\u3002hsCRP\u306e\u6e2c\u5b9a\u306f\u3001\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\u306b\u304a\u3051\u308b\u4e88\u5f8c\u7684\u4fa1\u5024\u3092\u4ed8\u52a0\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u6297\u708e\u75c7\u7642\u6cd5\u306e\u6069\u6075\u3092\u53d7\u3051\u308b\u9ad8\u3044\u6b8b\u5b58\u30ea\u30b9\u30af\u3092\u6709\u3059\u308b\u60a3\u8005\u306e\u7279\u5b9a\u306b\u3082\u5bc4\u4e0e\u3059\u308b\u3067\u3042\u308d\u3046\u3002 <\/p>\n

\u6211\u3005\u306f\u30012026\u5e74\u306b\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u95a2\u3059\u308b\u5730\u5e73\u304c\u3055\u3089\u306b\u5e83\u304c\u308b\u3053\u3068\u3092\u671f\u5f85\u3057\u3066\u3044\u308b\u3002We look forward to expanding horizons about residual cardiovascular risk in 2026.<\/p>\n

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      \n
    1. Bohula EA, Marston NA, Bhatia AK, et al. Evolocumab in patients without a previous myocardial Infarction or stroke. N Engl J Med 2025; DOI: 10.1056\/NEJMoa2514428. <\/li>\n
    2. Sabatine MS\u3001Giugliano RP\u3001Keech AC\u3001\u4ed6\uff1a\u5fc3\u8840\u7ba1\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u3068\u81e8\u5e8a\u8ee2\u5e30\u3002N Engl J Med 2017; 376: 1713-22. <\/li>\n
    3. Schwartz GG, Steg PG, Szarek M, et al. Alirocumab and cardiovascular outcomes after acute coronary syndrome. N Engl J Med 2018;379:2097-107. <\/li>\n
    4. McClintick DJ, Biery DW, Berman AN, et al. Association between lipoprotein(a) and cardiovascular events in patients with peripheral artery disease: the Mass General Brigham Lp(a) registry. Eur J Prevent Cardiol 2025; https:\/\/doi.org\/10.1093\/eurjpc\/zwaf475<\/a> <\/li>\n
    5. Ray KK, Oru E, Rosenson RS, et al. Durability and efficacy of solbinsiran, a GalNAc-conjugated siRNA targeting ANGPTL3, in adults with mixed dyslipidaemia (PROLONG-ANG3): a double-blind, randomised, placebo-controlled, phase 2 trial. The Lancet 2025; https:\/\/doi.org\/10.1016\/S0140-6736(25)00507-0<\/a>. <\/li>\n
    6. Bergmark BA, Marston NA, Prohaska TA, et al; Essence\u2013TIMI 73b Investigators. Targeting APOC3 with olezarsen in moderate hypertriglyceridemia. N Engl J Med 2025 Aug 30. doi: 10.1056\/NEJMoa2507227. <\/li>\n
    7. 7. Marston NA, Bergmark BA, Alexander VJ, et al. Olezarsen for managing severe hypertriglyceridemia and pancreatitis risk. N Engl J Med 2025; DOI: 10.1056\/NEJMoa2512761 <\/li>\n
    8. Laffin LJ, Nicholls SJ, Scott RS, et al. Phase 1 trial of CRISPR-Cas9 gene editing targeting ANGPTL3. N Engl J Med 2025; DOI: 10.1056\/NEJMoa2511778. <\/li>\n
    9. GBD 2021 Adolescent BMI Collaborators. Global, regional, and national prevalence of child and adolescent overweight and obesity, 1990\u20132021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021. Lancet 2025; 405: 785\u2013812 <\/li>\n
    10. Lopez-Jimenez F, Di Cesare M, Powis J, et al. \u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u91cd\u3055\uff1a\u80a5\u6e80\u306b\u4f34\u3046\u4e16\u754c\u7684\u306a\u5fc3\u8840\u7ba1\u5371\u6a5f\u3078\u306e\u5bfe\u5fdc\u3002Global Heart 2025; doi.org\/10.5334\/gh.1451. <\/li>\n
    11. Kang YM, Giugliano RP, Keech AC, et al. Obesity-associated cardiovascular risk and benefit from PCSK9 inhibition. A prespecified analysis from FOURIER. J Am Coll Cardiol 2025; doi.org\/10.1016\/j.jacc.2025.10.036. <\/li>\n
    12. Kurt B, Reugels M, Schneider KM, et al. C-reactive protein and cardiovascular risk in the general population. Eur Heart J 2025; doi.org\/10.1093\/eurheartj\/ehaf937. <\/li>\n<\/ol>\n

       <\/p>\n

      Key words: Residual risk; triglycerides; remnant cholesterol; inflammation; obesity; treatments<\/em><\/p>\n<\/li>\n<\/ol>\n

        \n
      1. \n<\/li>\n<\/ol>\n

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