\n| \n \u76ee\u7684<\/strong><\/p>\n<\/td>\n| \n ASCVD\u3092\u767a\u75c7\u3057\u3066\u3044\u306a\u3044\u60a3\u8005\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u65e5\u5e38\u7684\u306a\u81e8\u5e8a\u7684\u4e88\u6e2c\u56e0\u5b50\u3068\u3057\u3066\u306ehsCRP\u306e\u6709\u7528\u6027\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3002 <\/p>\n <\/p>\n<\/td>\n | \n <\/p>\n<\/td>\n<\/tr>\n | \n| \n \u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/strong><\/p>\n<\/td>\n| \n UK Biobank\u306eASCVD\u306e\u306a\u3044\u4eba\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u305f\u96c6\u56e3\u30d9\u30fc\u30b9\u306e\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3002<\/p>\n <\/p>\n<\/td>\n | \n <\/p>\n<\/td>\n<\/tr>\n | \n| \n \u7814\u7a76\u5bfe\u8c61\u8005 <\/strong><\/p>\n<\/td>\n| \n UK Biobank\u88ab\u9a13\u8005448,653\u4f8b\uff08\u5e74\u9f62\u4e2d\u592e\u502457\u6b73\u3001\u5973\u602755.4\uff05\uff09\u3001ASCVD\u65e2\u5f80\u306a\u3057\u3001hsCRP\u30c7\u30fc\u30bf\u3042\u308a\u3002hsCRP\u5024\u306e\u4e2d\u592e\u5024\u306f1.32\uff3b\u56db\u5206\u4f4d\u7bc4\u56f20.65\u30012.74\uff3dmg\/L\u3067\u3042\u3063\u305f\u3002 <\/p>\n <\/p>\n<\/td>\n | \n <\/p>\n<\/td>\n<\/tr>\n | \n| \n \u4e3b\u306a\u7814\u7a76\u5909\u6570<\/strong><\/p>\n <\/strong><\/p>\n<\/td>\n| \n \u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u7684\u5fc3\u7b4b\u6897\u585e\u3001\u975e\u81f4\u6b7b\u7684\u8133\u5352\u4e2d\u306e\u8907\u5408\uff08\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3001MACE\uff09\u3002\u8ffd\u52a0\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u5fc3\u8840\u7ba1\u6b7b\u3068\u5168\u6b7b\u4ea1\u3067\u3042\u3063\u305f\u3002 <\/p>\n <\/p>\n<\/td>\n | \n <\/p>\n<\/td>\n<\/tr>\n | \n| \n \u65b9\u6cd5<\/strong><\/p>\n<\/td>\n| \n MACE\u3001\u5fc3\u8840\u7ba1\u6b7b\u3001\u5168\u6b7b\u56e0\u6b7b\u4ea1\u306e\u767a\u751f\u307e\u3067\u306e\u6642\u9593\u30c7\u30fc\u30bf\u306e\u8a55\u4fa1\u306b\u306fKaplan-Meier\u751f\u5b58\u89e3\u6790\u3092\u7528\u3044\u305f\u3002\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306b\u95a2\u3059\u308bhsCRP\u306e\u30cf\u30b6\u30fc\u30c9\u6bd4\u304a\u3088\u307395\uff05\u4fe1\u983c\u533a\u9593\uff08CI\uff09\u306f\u3001\u5358\u5909\u91cf\u304a\u3088\u3073\u591a\u5909\u91cf\u306eCox\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u7b97\u51fa\u3057\u305f\u3002\u89e3\u6790\u306fhsCRP\u3092\u9023\u7d9a\u5909\u6570\uff08\u56db\u5206\u4f4d\u6570\u30cf\u30b6\u30fc\u30c9\u6bd4\uff09\u3068\u3057\u3066\u884c\u3044\u3001hsCRP\u306e\u30ab\u30c6\u30b4\u30ea\u30fc\uff08<1mg\/L\u30011\uff5e3mg\/L\u3001>3mg\/L\uff1b\u22672mg\/L\u3001<2mg\/L\uff09\u306e\u4e2d\u592e\u5024\u3092\u6bd4\u8f03\u3057\u305f\u3002\u591a\u5909\u91cf\u8abf\u6574\u89e3\u6790\u306f\u3001\u78ba\u7acb\u3055\u308c\u305f\u5fc3\u8840\u7ba1\u5371\u967a\u56e0\u5b50\u3092\u542b\u3080\u30e2\u30c7\u30eb\uff08\u30e2\u30c7\u30eb1\uff09\u3068\u3001hsCRP\u5024\u306e\u6f5c\u5728\u7684\u4ea4\u7d61\u56e0\u5b50\u3092\u8ffd\u52a0\u3057\u305f\u5b8c\u5168\u8abf\u6574\u30e2\u30c7\u30eb\uff08\u30e2\u30c7\u30eb2\uff09\u306e2\u6bb5\u968e\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u884c\u3063\u305f\u3002 <\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\n \n\n\n| \n \u7d50\u679c<\/strong><\/p>\n<\/td>\n| \n \u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u502413.7\u5e74\u306e\u9593\u306b\u3001MACE\u306f23,624\u4eba\u306b\u3001\u5fc3\u8840\u7ba1\u6b7b\u306f6,176\u4eba\u306b\u3001\u5168\u6b7b\u4ea1\u306f35,983\u4eba\u306b\u767a\u751f\u3057\u305f\u3002MACE\u767a\u751f\u7387\u306fhsCRP\u5024\u306e\u5897\u52a0\u3068\u3068\u3082\u306b\u6bb5\u968e\u7684\u306b\u5897\u52a0\u3057\u3001hsCRP\u5024>3mg\/L\u306e\u88ab\u9a13\u8005\u3067\u6700\u3082\u9ad8\u3044\u30a4\u30d9\u30f3\u30c8\u767a\u751f\u7387\u304c\u89b3\u5bdf\u3055\u308c\u305f\uff08p< 0.001\uff09\u3002\u3055\u3089\u306b\u3001hsCRP\u5024\u22672mg\/L\u306e\u88ab\u9a13\u8005\u306f\u3001hsCRP<2mg\/L\u306e\u88ab\u9a13\u8005\u3088\u308a\u3082\u30a4\u30d9\u30f3\u30c8\u767a\u751f\u7387\u304c\u9ad8\u304b\u3063\u305f\uff08p< 0.001\uff09\u3002\u540c\u69d8\u306e\u7d50\u679c\u304c\u5fc3\u8840\u7ba1\u6b7b\u3068\u5168\u6b7b\u56e0\u6b7b\u3067\u3082\u89b3\u5bdf\u3055\u308c\u305f\u3002\u8abf\u6574\u30e2\u30c7\u30eb\u3067\u306f\u3001hsCRP\u5024>3mg\/L\u306e\u88ab\u9a13\u8005\u306f\u3001hsCRP<1mg\/L\u306e\u88ab\u9a13\u8005\u3068\u6bd4\u8f03\u3057\u3066\u3001MACE\u306e\u30ea\u30b9\u30af\u304c34\uff05\u9ad8\u304f\u3001\u5fc3\u8840\u7ba1\u6b7b\u306e\u30ea\u30b9\u30af\u304c61\uff05\u9ad8\u304f\u3001\u5168\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u304c54\uff05\u9ad8\u304b\u3063\u305f\u3002\u3055\u3089\u306b\u3001hsCRP\u5024<2mg\/L\u306e\u88ab\u9a13\u8005\u3068\u6bd4\u8f03\u3059\u308b\u3068\u3001hsCRP\u5024\u304c\u9ad8\u3044\u88ab\u9a13\u8005\u3067\u306fMACE\u30ea\u30b9\u30af\u304c22\uff05\u3001\u5fc3\u8840\u7ba1\u6b7b\u30ea\u30b9\u30af\u304c37\uff05\u3001\u5168\u6b7b\u4ea1\u30ea\u30b9\u30af\u304c34\uff05\u9ad8\u304b\u3063\u305f\uff08\u88681\uff09\u3002\u4e88\u5f8c\u4e88\u6e2c\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u3001hsCRP\u306f\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u3092\u542b\u3080\u5f93\u6765\u306e\u5371\u967a\u56e0\u5b50\u3088\u308a\u3082\u4e0a\u4f4d\u306b\u4f4d\u7f6e\u3057\u305f\u3002 <\/p>\n \u88681. hsCRP\u3068\u5fc3\u8840\u7ba1\u7cfb\u306e\u8ee2\u5e30\u3068\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\u306e\u76f8\u5bfe\u30ea\u30b9\u30af\u63a8\u5b9a\u5024<\/strong><\/p>\n\n\n\n| \n \u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8<\/p>\n<\/td>\n | \n hsCRP\u30ab\u30c6\u30b4\u30ea\u30fc(mg\/L)<\/p>\n<\/td>\n | \n \u88ab\u9a13\u8005\u6570 <\/p>\n<\/td>\n | \n \u30a4\u30d9\u30f3\u30c8\u6570 <\/p>\n<\/td>\n | \n \u8abf\u6574\u30cf\u30b6\u30fc\u30c9\u6bd4\uff0895\uff05CI\uff09<\/p>\n<\/td>\n<\/tr>\n | \n| \n MACE<\/strong><\/p>\n<\/td>\n| \n <1<\/p>\n<\/td>\n | \n 142554<\/p>\n<\/td>\n | \n 5458<\/p>\n<\/td>\n | \n \u53c2\u8003<\/p>\n<\/td>\n<\/tr>\n | \n| \n <\/p>\n<\/td>\n | \n 1-3<\/p>\n<\/td>\n | \n 132859<\/p>\n<\/td>\n | \n 7335<\/p>\n<\/td>\n | \n 1.16 (1.14, 1.18)<\/p>\n<\/td>\n<\/tr>\n | \n| \n <\/p>\n<\/td>\n | \n >3<\/p>\n<\/td>\n | \n 74312<\/p>\n<\/td>\n | \n 5129<\/p>\n<\/td>\n | \n 1.34 (1.29, 1.39)<\/p>\n<\/td>\n<\/tr>\n | \n| \n <\/p>\n<\/td>\n | \n <2<\/p>\n<\/td>\n | \n 232143<\/p>\n<\/td>\n | \n 10171<\/p>\n<\/td>\n | \n \u53c2\u8003<\/p>\n<\/td>\n<\/tr>\n | \n| \n <\/p>\n<\/td>\n | \n \u22652<\/p>\n<\/td>\n | \n 117582<\/p>\n<\/td>\n | \n 7751<\/p>\n<\/td>\n | \n 1.22 (1.19, 1.24)<\/p>\n<\/td>\n<\/tr>\n | \n| \n \u5fc3\u81d3\u8840\u7ba1<\/strong><\/p>\n<\/td>\n| \n <1<\/p>\n<\/td>\n | \n 142554<\/p>\n<\/td>\n | \n 1172<\/p>\n<\/td>\n | \n \u53c2\u8003<\/p>\n<\/td>\n<\/tr>\n | \n| \n \u6b7b<\/strong><\/p>\n<\/td>\n| \n 1-3<\/p>\n<\/td>\n | \n 132859<\/p>\n<\/td>\n | \n 1789<\/p>\n<\/td>\n | \n 1.27 (1.23, 1.31)<\/p>\n<\/td>\n<\/tr>\n | \n| \n <\/p>\n<\/td>\n | \n >3<\/p>\n<\/td>\n | \n 74312<\/p>\n<\/td>\n | \n 1577<\/p>\n<\/td>\n | \n 1.61 (1.50, 1.72)<\/p>\n<\/td>\n<\/tr>\n | \n| \n <\/p>\n<\/td>\n | \n <2<\/p>\n<\/td>\n | \n 232143<\/p>\n<\/td>\n | \n 2288<\/p>\n<\/td>\n | \n \u53c2\u8003<\/p>\n<\/td>\n<\/tr>\n | \n| \n <\/p>\n<\/td>\n | \n \u22652<\/p>\n<\/td>\n | \n 117582<\/p>\n<\/td>\n | \n 2250<\/p>\n<\/td>\n | \n 1.37 (1.31, 1.44)<\/p>\n<\/td>\n<\/tr>\n | \n| \n \u5168\u539f\u56e0 <\/strong><\/p>\n<\/td>\n| \n <1<\/p>\n<\/td>\n | \n 142554<\/p>\n<\/td>\n | \n 7766<\/p>\n<\/td>\n | \n \u53c2\u8003<\/p>\n<\/td>\n<\/tr>\n | \n| \n \u6b7b<\/strong><\/p>\n<\/td>\n| \n 1-3<\/p>\n<\/td>\n | \n 132859<\/p>\n<\/td>\n | \n 10259<\/p>\n<\/td>\n | \n 1.24 (1.22, 1.26)<\/p>\n<\/td>\n<\/tr>\n | \n| \n <\/p>\n<\/td>\n | \n >3<\/p>\n<\/td>\n | \n 74312<\/p>\n<\/td>\n | \n 8554<\/p>\n<\/td>\n | \n 1.54 (1.50, 1.58)<\/p>\n<\/td>\n<\/tr>\n | \n| \n <\/p>\n<\/td>\n | \n <2<\/p>\n<\/td>\n | \n 232143<\/p>\n<\/td>\n | \n 14222<\/p>\n<\/td>\n | \n \u53c2\u8003<\/p>\n<\/td>\n<\/tr>\n | \n| \n <\/p>\n<\/td>\n | \n \u22652<\/p>\n<\/td>\n | \n 117582<\/p>\n<\/td>\n | \n 12357<\/p>\n<\/td>\n | \n 1.34 (1.31, 1.36)<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\n \u6700\u5f8c\u306b\u3001hsCRP\u3092\u8ffd\u52a0\u3059\u308b\u3053\u3068\u3067\u3001SCORE2\u306e10\u5e74MACE\u30ea\u30b9\u30af\u4e88\u6e2c\u80fd\u304c\u5411\u4e0a\u3057\u3001ASCVD\u3092\u767a\u75c7\u3057\u3066\u3044\u306a\u3044\u88ab\u9a13\u8005\u306e\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4e88\u6e2c\u80fd\u3082\u5411\u4e0a\u3057\u305f\u3002<\/p>\n <\/p>\n<\/td>\n<\/tr>\n | \n| \n \u8457\u8005\u7d50\u8ad6<\/strong><\/p>\n<\/td>\n| \n \u672c\u7814\u7a76\u306e\u30c7\u30fc\u30bf\u306f\u3001hsCRP\u304cASCVD\u306e\u65e2\u77e5\u306e\u306a\u3044\u4eba\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u81e8\u5e8a\u7684\u306b\u9069\u5207\u306a\u4e88\u6e2c\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u3001\u4e00\u6b21\u4e88\u9632\u306b\u304a\u3051\u308bhsCRP\u306e\u8a55\u4fa1\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/strong><\/p>\n 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\u5fc3\u8840\u7ba1\u75be\u60a3\u3068\u30ea\u30b9\u30af\u306e\u4e16\u754c\u7684\u8ca0\u62c52023\u5e74\u5171\u540c\u7814\u7a76\u8005\u3002204\u306e\u56fd\u3068\u5730\u57df\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u75be\u60a3\u3068\u5371\u967a\u56e0\u5b50\u306e\u4e16\u754c\u7684\u3001\u5730\u57df\u7684\u3001\u56fd\u5bb6\u7684\u8ca0\u62c5\u30011990-2023\u5e74\u3002J Am Coll Cardiol 2025;86:2167-2143. <\/li>\n
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- Libby P, Ridker PM, Hansson GK.\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306b\u304a\u3051\u308b\u708e\u75c7\uff1a\u75c5\u614b\u751f\u7406\u304b\u3089\u8a3a\u7642\u307e\u3067\u3002J Am Coll Cardiol 2009;54:2129-38. <\/li>\n
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