{"id":255914,"date":"2025-09-14T14:39:13","date_gmt":"2025-09-14T12:39:13","guid":{"rendered":"https:\/\/r3i.org\/?page_id=255914"},"modified":"2025-09-14T14:39:13","modified_gmt":"2025-09-14T12:39:13","slug":"%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e9%ab%98%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e8%a1%80%e7%97%87%e3%81%a8%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e9%ab%98%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e8%a1%80%e7%97%87%e3%81%a8%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1\/","title":{"rendered":"\u30d5\u30a9\u30fc\u30ab\u30b9 &#8211; \u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3068\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;1px|||||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; header_2_text_color=&#8221;gcid-primary-color&#8221; header_5_text_color=&#8221;gcid-secondary-color&#8221; text_orientation=&#8221;center&#8221; width=&#8221;99%&#8221; custom_margin=&#8221;|-147px||||&#8221; custom_padding=&#8221;|0px||||&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<h2>\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3068\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af<\/h2>\n<h5>2025\u5e749\u6708<\/h5>\n<div class=\"summary\"><\/div>\n<p><span>Utrecht Cardiovascular Cohort-Second Manifestations of Arterial Disease<\/span><span>\uff08<\/span><span>UCC-SMART<\/span><span>\uff09\u7814\u3088\u308b\u3068\u3001\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306f\u3001\u8102\u8cea\u7ba1\u7406\u76ee\u6a19\u5024\u3084\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306e\u5f37\u5ea6\u3068\u306f\u72ec\u7acb\u3057\u3066\u3001\u3088\u308a\u9ad8\u3044\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3002 <\/span><\/p>\n<p><em><span>Schuitema PCE, Visseren FLJ, Nordestgaard BG, et al. Elevated triglycerides are related to higher residual cardiovascular disease and mortality risk independent of lipid targets and intensity of lipid-lowering therapy in patients with established cardiovascular disease. Atherosclerosis 2025; <a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(25)00507-0\" rel=\"nofollow\">https:\/\/doi.org\/10.1016\/S0140-6736(25)00507-0<\/a>. <\/span><\/em><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><strong><span>\u7814\u7a76\u6982\u8981<\/span><\/strong><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><strong><span>\u76ee\u7684<\/span><\/strong><\/p>\n<p><span>\u4e8c\u6b21\u4e88\u9632\u3092\u53d7\u3051\u3066\u3044\u308b\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u304c\u9ad8\u3044\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3059\u308b\u304b\u3001\u307e\u305f\u3001\u3053\u306e\u95a2\u9023\u304c\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u63a8\u5968\u306e\u8102\u8cea\u7ba1\u7406\u76ee\u6a19\u5024\u3084\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306e\u5f37\u5ea6\u304b\u3089\u72ec\u7acb\u3057\u3066\u3044\u308b\u304b\u3092\u8abf\u67fb\u3059\u308b\u3053\u3068\u3002 <\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><strong><span>\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/span><\/strong><\/p>\n<p><span>UCC-SMART<\/span><span>\u7814\u7a76\u306f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3067\u3042\u308b\u3002\u4eca\u56de\u306e\u5831\u544a\u306f\u3001\u51a0\u72b6\u52d5\u8108\u75be\u60a3\u3001\u8133\u8840\u7ba1\u75be\u60a3\u3001\u672b\u68a2\u52d5\u8108\u75be\u60a3\u3001\u307e\u305f\u306f\u8179\u90e8\u5927\u52d5\u8108\u7624\u306e\u3044\u305a\u308c\u304b\u3092\u6709\u3059\u308b\u3001\u78ba\u7acb\u3055\u308c\u305f\u5fc3\u8840\u7ba1\u75be\u60a3\u60a3\u8005\u306e\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u304f\u3002<\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><strong><span>\u7814\u7a76\u96c6\u56e3<\/span><\/strong><\/p>\n<p><span>\u7814\u7a76\u30b3\u30db\u30fc\u30c8\u306f\u3001\u78ba\u7acb\u3055\u308c\u305f\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3057\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u304c<\/span><span>8 mmol\/L<\/span><span>\u672a\u6e80\u306e<\/span><span>9,436<\/span><span>\u4eba\u306e\u60a3\u8005\uff08\u5e73\u5747\u5e74\u9f62<\/span><span>61<\/span><span>\u6b73\u3001<\/span><span>73%<\/span><span>\u304c\u7537\u6027\uff09\u3067\u69cb\u6210\u3055\u308c\u305f\u5185\u8a33\u306f\u3001\u51a0\u72b6\u52d5\u8108\u75be\u60a3\u304c<\/span><span>62%<\/span><span>\u3001\u8133\u8840\u7ba1\u75be\u60a3\u304c<\/span><span>29%<\/span><span>\u3001\u672b\u68a2\u52d5\u8108\u75be\u60a3\u304c<\/span><span>17%<\/span><span>\u3001\u8179\u90e8\u5927\u52d5\u8108\u7624\u304c<\/span><span>8%<\/span><span>\u3067\u3042\u3063\u305f\u3002 <\/span><\/p>\n<p><strong><span>\u4e3b\u8981\u306a\u7814\u7a76\u5909\u6570<\/span><\/strong><\/p>\n<ul>\n<li><strong><span>\u4e3b\u8981\u6709\u52b9\u6027\u8a55\u4fa1\u9805\u76ee<\/span><\/strong><span>: <\/span><span>\u518d\u767a\u6027\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08\u5fc3\u7b4b\u6897\u585e\u3001\u8133\u5352\u4e2d\u3001\u5fc3\u8840\u7ba1\u6b7b\u306e\u8907\u5408\uff09\u3002 <\/span><\/li>\n<li><strong><span>\u526f\u6b21\u6709\u52b9\u6027\u8a55\u4fa1\u9805\u76ee<\/span><\/strong><span>: <\/span><span>\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306e\u5404\u69cb\u6210\u8981\u7d20\u304a\u3088\u3073\u5168\u6b7b\u4ea1\u3002 <\/span><\/li>\n<\/ul>\n<p><span>\u3059\u3079\u3066\u306e\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u6a19\u6e96\u5316\u3055\u308c\u305f\u5b9a\u7fa9\u306b\u5f93\u3063\u3066\u5224\u5b9a\u3055\u308c\u305f\u3002 <\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><strong><span>\u65b9\u6cd5<\/span><\/strong><\/p>\n<p><span>\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u30c7\u30fc\u30bf\u306f\u5bfe\u6570\u5909\u63db\u3055\u308c\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\uff08\u9023\u7d9a\u30c7\u30fc\u30bf\u307e\u305f\u306f\u56db\u5206\u4f4d\u6570\uff09\u3068\u518d\u767a\u6027\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3068\u306e\u95a2\u9023\u3092\u5206\u6790\u3059\u308b\u305f\u3081\u3001<\/span><span>Cox<\/span><span>\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30eb\u304c\u7528\u3044\u3089\u308c\u305f\u3002\u3055\u3089\u306b\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u3092<\/span><span>6<\/span><span>\u3064\u306e\u30ab\u30c6\u30b4\u30ea\u30fc\uff08<\/span><span>&lt;1<\/span><span>\u3001<\/span><span>1-1.99<\/span><span>\u3001<\/span><span>2-2.99<\/span><span>\u3001<\/span><span>3-3.99<\/span><span>\u3001<\/span><span>4-4.99<\/span><span>\u3001<\/span><span>5-8.00 mmol\/L<\/span><span>\uff09\u306b\u5c64\u5225\u5316\u3057\u3001\u6975\u3081\u3066\u9ad8\u3044\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u3068\u4f4e\u3044\u5024\u304c\u518d\u767a\u6027\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u304a\u3088\u3073\u5168\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u6bd4\u8f03\u691c\u8a0e\u3057\u305f\u3002\u307e\u305f\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08<\/span><span>LDL-C<\/span><span>\uff09\u304a\u3088\u3073\u975e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08<\/span><span>non-HDL-C<\/span><span>\uff09\u306e\u6cbb\u7642\u76ee\u6a19\u9054\u6210\u5ea6\u3001<\/span><span>HDL-C<\/span><span>\u5024\u3001\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306e\u5f37\u5ea6\u304c\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068\u518d\u767a\u6027\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u8abf\u67fb\u3059\u308b\u305f\u3081\u306b\u3082\u3001<\/span><span>Cox<\/span><span>\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30ea\u30f3\u30b0\u304c\u4f7f\u7528\u3055\u308c\u305f\u3002<\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><strong><span>\u7d50\u679c<\/span><\/strong><\/p>\n<p><span>\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u5024<\/span><span>9.0<\/span><span>\u5e74\uff08\u56db\u5206\u4f4d\u7bc4\u56f2<\/span><span>4.5-14.1<\/span><span>\u5e74\uff09\u306e\u9593\u306b\u3001<\/span><span>2,075<\/span><span>\u4ef6\u306e\u518d\u767a\u6027\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3001<\/span><span>736<\/span><span>\u4ef6\u306e\u5fc3\u7b4b\u6897\u585e\u3001<\/span><span>586<\/span><span>\u4ef6\u306e\u8133\u5352\u4e2d\u3001<\/span><span>1,231<\/span><span>\u4ef6\u306e\u5fc3\u8840\u7ba1\u6b7b\u3001\u304a\u3088\u3073<\/span><span>2,729<\/span><span>\u4ef6\u306e\u5168\u6b7b\u4ea1\u304c\u8a18\u9332\u3055\u308c\u305f\u3002\u5bfe\u6570\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u304c<\/span><span>1<\/span><span>\u5358\u4f4d\u4e0a\u6607\u3059\u308b\u3054\u3068\u306b\u3001\u518d\u767a\u6027\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u306f<\/span><span>1.17<\/span><span>\u500d\uff08<\/span><span>95%CI 1.07-1.28<\/span><span>\uff09\u9ad8\u304b\u3063\u305f\u3002\u500b\u3005\u306e\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306b\u5bfe\u3059\u308b\u30ea\u30b9\u30af\u306f\u3001\u5fc3\u7b4b\u6897\u585e\u3067<\/span><span>1.34<\/span><span>\u500d\uff08<\/span><span>95%CI 1.16-1.56<\/span><span>\uff09\u3001\u5fc3\u8840\u7ba1\u6b7b\u3067<\/span><span>1.23<\/span><span>\u500d\uff08<\/span><span>95%CI 1.09-1.38<\/span><span>\uff09\u3001\u5168\u6b7b\u4ea1\u3067<\/span><span>1.12<\/span><span>\u500d\uff08<\/span><span>95%CI 1.03-1.21<\/span><span>\uff09\u9ad8\u304b\u3063\u305f\u3002\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u304c<\/span><span>2<\/span><span>\u500d\u306b\u306a\u308b\u3068\u3001\u518d\u767a\u6027\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u306f<\/span><span>11%<\/span><span>\uff08\u30cf\u30b6\u30fc\u30c9\u6bd4<\/span><span> 1.11<\/span><span>\u3001<\/span><span>95%CI 1.05-1.19<\/span><span>\uff09\u3001\u5fc3\u8840\u7ba1\u6b7b\u306e\u30ea\u30b9\u30af\u306f<\/span><span>15%<\/span><span>\uff08\u30cf\u30b6\u30fc\u30c9\u6bd4<\/span><span> 1.15<\/span><span>\u3001<\/span><span>95%CI 1.06-1.25<\/span><span>\uff09\u4e0a\u6607\u3057\u305f\u3002\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u63a8\u5968\u306e\u8102\u8cea\u76ee\u6a19\u9054\u6210\u5ea6\uff08<\/span><span>LDL-C<\/span><span>\u307e\u305f\u306f<\/span><span>non-HDL-C<\/span><span>\uff09\u3084\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306e\u5f37\u5ea6\u304c\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068\u518d\u767a\u6027\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u307e\u305f\u306f\u5fc3\u8840\u7ba1\u6b7b\u306e\u30ea\u30b9\u30af\u3068\u306e\u95a2\u4fc2\u3092\u4fee\u98fe\u3059\u308b\u3068\u3044\u3046\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u5f97\u3089\u308c\u306a\u304b\u3063\u305f\u3002 <\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><strong><span>\u8457\u8005\u3089\u306e\u7d50\u8ad6<\/span><\/strong><\/p>\n<p><span>\u78ba\u7acb\u3055\u308c\u305f\u5fc3\u8840\u7ba1\u75be\u60a3\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306f\u3001\u3088\u308a\u9ad8\u3044\u6b8b\u5b58\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u304a\u3088\u3073\u6b7b\u4ea1\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3002\u3053\u308c\u3089\u306e\u95a2\u9023\u306f\u3001\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u63a8\u5968\u306e\u8102\u8cea\u76ee\u6a19\u9054\u6210\u5ea6\u3001<\/span><span>HDL-C<\/span><span>\u5024\u3001\u304a\u3088\u3073\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306e\u5f37\u5ea6\u3068\u306f\u7121\u95a2\u4fc2\u3067\u3042\u3063\u305f\u3002<\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><strong><span>\u30b3\u30e1\u30f3\u30c8<\/span><\/strong><\/p>\n<p><span>\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306f\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u30ea\u30c3\u30c1\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u304a\u3088\u3073\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4ee3\u7406\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308a\u3001\u89b3\u5bdf\u7814\u7a76\u304a\u3088\u3073\u907a\u4f1d\u5b66\u7684\u7814\u7a76\u306b\u3088\u3063\u3066\u88cf\u4ed8\u3051\u3089\u308c\u3066\u3044\u308b\u3088\u3046\u306b\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u3001\u4e00\u90e8\u306e\u7814\u7a76\u3067\u306f\u3001\u3053\u306e\u95a2\u9023\u304c\u78ba\u7acb\u3055\u308c\u305f\u5fc3\u8840\u7ba1\u75be\u60a3\u60a3\u8005\u306b\u304a\u3044\u3066\u5f31\u307e\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u304a\u308a\u3001<\/span><span>1<\/span><span>\uff09\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u304c\u518d\u767a\u6027\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u56e0\u679c\u7684\u30ea\u30b9\u30af\u56e0\u5b50\u3067\u3042\u308b\u304b\u3001\u305d\u3057\u3066\u3001\u3082\u3057\u305d\u3046\u3067\u3042\u308c\u3070<\/span><span> 2<\/span><span>\uff09\u3053\u306e\u95a2\u9023\u304c\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u63a8\u5968\u306e\u8102\u8cea\u76ee\u6a19\u9054\u6210\u5ea6\u3084\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306e\u5f37\u5ea6\u306b\u3088\u3063\u3066\u4fee\u98fe\u3055\u308c\u308b\u306e\u304b\u3001\u3068\u3044\u3046\u7591\u554f\u304c\u63d0\u8d77\u3055\u308c\u3066\u3044\u305f\u3002 <\/span><\/p>\n<p><span>\u3053\u306e\u5927\u898f\u6a21\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u306e\u7d50\u679c\u306f\u3001\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u304c\u518d\u767a\u6027\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002\u3055\u3089\u306b\u3001\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3068\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u306f\u3001<\/span><span>LDL-C<\/span><span>\u304a\u3088\u3073<\/span><span>non-HDL-C<\/span><span>\u306e\u76ee\u6a19\u9054\u6210\u5ea6\u3001<\/span><span>HDL-C<\/span><span>\u5024\u3001\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306e\u5f37\u5ea6\u304b\u3089\u72ec\u7acb\u3057\u3066\u3044\u305f\u3002\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001\u5927\u898f\u6a21\u306a\u60a3\u8005\u30b3\u30db\u30fc\u30c8\u3068\u9577\u671f\u306e\u8ffd\u8de1\u671f\u9593\u306b\u3088\u3063\u3066\u5f97\u3089\u308c\u305f\u591a\u6570\u306e\u30a4\u30d9\u30f3\u30c8\u6570\u306b\u88cf\u6253\u3061\u3055\u308c\u3066\u304a\u308a\u3001\u7814\u7a76\u306e\u9811\u5065\u6027\u3092\u9ad8\u3081\u3066\u3044\u308b\u3002\u305f\u3060\u3057\u8457\u8005\u3089\u306f\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u304c\u7d4c\u6642\u7684\u306b\u5897\u52a0\u3059\u308b\u50be\u5411\u304c\u3042\u308b\u305f\u3081\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u3092\u4e3b\u8981\u6307\u6a19\u3068\u3059\u308b\u3053\u3068\u304c\u3001\u9577\u671f\u7684\u306a\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u95a2\u9023\u30ea\u30b9\u30af\u3092\u904e\u5c0f\u8a55\u4fa1\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u8a8d\u8b58\u3057\u3066\u3044\u308b\u3002 <\/span><\/p>\n<p><span>\u81e8\u5e8a\u7684\u89b3\u70b9\u304b\u3089\u3001\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u95a2\u9023\u306e\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u7ba1\u7406\u3059\u308b\u3053\u3068\u306e\u91cd\u8981\u6027\u3092\u5f37\u8abf\u3059\u308b\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068<\/span><span>LDL-C<\/span><span>\u306e\u4e21\u65b9\u304c\u3001\u3053\u308c\u3089\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u6b8b\u5b58\u3059\u308b\u76f8\u5f53\u306a\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3059\u308b\u305f\u3081\u306e\u4e8c\u6b21\u4e88\u9632\u6226\u7565\u306b\u304a\u3044\u3066\u3001\u6975\u3081\u3066\u91cd\u8981\u306a\u69cb\u6210\u8981\u7d20\u3068\u306a\u308b\u306e\u3067\u3042\u308b\u3002 <\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><strong><span>References<\/span><\/strong><\/p>\n<ol>\n<li><span>Nordestgaard BG. Triglyceride-rich lipoproteins and atherosclerotic cardiovascular disease: new insights from epidemiology, genetics, and biology. Circ Res 2016;118:547-63. <\/span><\/li>\n<li><span>Langsted A, Madsen CM, Nordestgaard BG. Contribution of remnant cholesterol to cardiovascular risk. J Intern Med 2020;288:116-27. <\/span><\/li>\n<li><span>Ginsberg HN, Packard CJ, Chapman MJ, et al. Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies a consensus statement from the European Atherosclerosis Society. Eur Heart J 2021;42:4791-806. <\/span><\/li>\n<li><span>Ambrosy AP, Yang J, Sung SH, et al. Triglyceride levels and residual risk of atherosclerotic cardiovascular disease events and death in adults receiving statin therapy for primary or secondary prevention: Insights from the KP REACH Study. J Am Heart Assoc 2021:10:<\/span><span>\u3000<\/span><span><a href=\"https:\/\/doi.org\/10.1161\/JAHA.120.020377\">https:\/\/doi.org\/10.1161\/JAHA.120.020377<\/a>. <\/span><\/li>\n<\/ol>\n<p><span>\u00a0<\/span><\/p>\n<p><strong><span>\u30ad\u30fc\u30ef\u30fc\u30c9<\/span><span>:<\/span><\/strong> <span>\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9<\/span><span>; <\/span><span>\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af<\/span><span>; <\/span><span>\u4e8c\u6b21\u4e88\u9632<\/span><span>; <\/span><span>\u518d\u767a\u6027\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8<\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3068\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af 2025\u5e749\u6708 Utrecht Cardiovascular Coho [&hellip;]<\/p>\n","protected":false},"author":258497324,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"[et_pb_section fb_built=\"1\" _builder_version=\"4.27.4\" _module_preset=\"default\" custom_padding=\"1px|||||\" global_colors_info=\"{}\"][et_pb_row _builder_version=\"4.27.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.27.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.27.4\" _module_preset=\"default\" header_2_text_color=\"gcid-primary-color\" header_5_text_color=\"gcid-secondary-color\" text_orientation=\"center\" width=\"99%\" custom_margin=\"|-147px||||\" custom_padding=\"|0px||||\" hover_enabled=\"0\" global_colors_info=\"{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}\" sticky_enabled=\"0\"]<h2>ANGPTL3\u3092\u6a19\u7684\u3068\u3059\u308bsiRNA\u3067\u3042\u308bsolbinsiran\u304c\u6df7\u5408\u578b\u8102\u8cea\u7570\u5e38\u75c7\u306b\u5bfe\u3059\u308b\u6709\u52b9\u6027\u3092\u793a\u3059<\/h2>\n<h5>2025\u5e747\u6708<\/h5>\n<div class=\"summary\"><\/div>\n<p>PROLONG-ANG3\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u809d\u81d3\u306e\u30a2\u30f3\u30b8\u30aa\u30dd\u30a8\u30c1\u30f3\u69d8\u30bf\u30f3\u30d1\u30af\u8cea3\uff08ANGPTL3\uff09\u306e\u767a\u73fe\u3092\u6a19\u7684\u3068\u3059\u308bN-\u30a2\u30bb\u30c1\u30eb\u30ac\u30e9\u30af\u30c8\u30b5\u30df\u30f3\u7d50\u5408\u4f4e\u5206\u5b50\u5e72\u6e09RNA\uff08siRNA\uff09\u3001solbinsiran\u306f\u3001\u6df7\u5408\u578b\u8102\u8cea\u7570\u5e38\u75c7\u3092\u6709\u3059\u308b\u6210\u4eba\u306b\u304a\u3044\u3066\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaB\uff08apoB\uff09\u3092\u4f4e\u4e0b\u3055\u305b\u305f\u3002\u307e\u305f\u3001\u809d\u8102\u80aa\u5206\u753b\u306b\u5bfe\u3059\u308b\u6709\u5bb3\u306a\u5f71\u97ff\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u672c\u5264\u306e\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u5bfe\u3059\u308b\u52b9\u679c\u306b\u3064\u3044\u3066\u306f\u3001\u4eca\u5f8c\u306e\u66f4\u306a\u308b\u691c\u8a3c\u304c\u671f\u5f85\u3055\u308c\u308b\u3002<\/p>\n<p><em>Ray KK, Oru E, Rosenson RS, et al. Durability and efficacy of solbinsiran, a GalNAc-conjugated siRNA targeting ANGPTL3, in adults with mixed dyslipidaemia (PROLONG-ANG3): a double-blind, randomised, placebo-controlled, phase 2 trial. The Lancet 2025; <\/em><span><a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(25)00507-0\"><em>https:\/\/doi.org\/10.1016\/S0140-6736(25)00507-0<\/em><\/a><\/span><em>. <\/em><\/p>\n<p><strong>\u7814\u7a76\u6982\u8981<\/strong><\/p>\n<table width=\"671\">\n<tbody>\n<tr>\n<td width=\"123\">\n<p><strong>\u76ee\u7684<\/strong><\/p>\n<\/td>\n<td width=\"519\">\n<p>\u6df7\u5408\u578b\u8102\u8cea\u7570\u5e38\u75c7\u3092\u6709\u3059\u308b\u6210\u4eba\u3092\u5bfe\u8c61\u306b\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u60f9\u8d77\u6027\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6fc3\u5ea6\u3092\u4f4e\u4e0b\u3055\u305b\u308bsolbinsiran\u306e\u6709\u52b9\u6027\u3068\u4f5c\u7528\u306e\u6301\u7d9a\u6027\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f<\/p>\n<\/td>\n<td colspan=\"2\" width=\"29\">\n<p>&nbsp;<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"123\">\n<p><strong>\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/strong><\/p>\n<\/td>\n<td width=\"519\">\n<p>\u6df7\u5408\u578b\u8102\u8cea\u7570\u5e38\u75c7\u3092\u6709\u3059\u308b\u6210\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3001\u4e8c\u91cd\u76f2\u691c\u3001\u4e26\u884c\u7fa4\u9593\u3001\u7121\u4f5c\u70ba\u5316\u3001\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u3001\u7b2c2\u76f8\u81e8\u5e8a\u8a66\u9a13\u3002\u5bfe\u8a71\u578b\u30a6\u30a7\u30d6\u5fdc\u7b54\u30b7\u30b9\u30c6\u30e0\u3092\u4ecb\u3057\u3066\u3001\u60a3\u8005\u3092solbinsiran 100 mg\u3001400 mg\u3001800 mg\u3001\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u306e\u3044\u305a\u308c\u304b\u306e\u6295\u4e0e\u7fa4\u306b1:2:2:2\u306e\u6bd4\u7387\u3067\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u30010\u65e5\u76ee\u306890\u65e5\u76ee\u306b\u76ae\u4e0b\u6ce8\u5c04\u3067\u6295\u4e0e\u3057\u305f\u3002\u60a3\u8005\u306f\u5c11\u306a\u304f\u3068\u3082270\u65e5\u9593\u306e\u8ffd\u8de1\u8abf\u67fb\u3092\u53d7\u3051\u305f\u3002<\/p>\n<\/td>\n<td colspan=\"2\" width=\"29\">\n<p>&nbsp;<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"123\">\n<p><strong>\u7814\u7a76\u96c6\u56e3<\/strong><\/p>\n<\/td>\n<td width=\"519\">\n<p>\u7a7a\u8179\u6642\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u304c150\uff5e500 mg\/dL\u3001\u4f4e\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u5024\u304c70 mg\/dL\u4ee5\u4e0a\u3001\u304b\u3064\u975e\u9ad8\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08non-HDL-C\uff09\u5024\u304c130 mg\/dL\u4ee5\u4e0a\u3067\u3042\u308a\u3001\u5b89\u5b9a\u3057\u305f\u4e2d\u7b49\u5ea6\u307e\u305f\u306f\u9ad8\u5f37\u5ea6\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u308b\u6df7\u5408\u578b\u8102\u8cea\u7570\u5e38\u75c7\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3002<\/p>\n<\/td>\n<td colspan=\"2\" width=\"29\">\n<p>&nbsp;<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"123\">\n<p><strong>\u4e3b\u8981\u7814\u7a76\u5909\u6570<\/strong><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<\/td>\n<td width=\"519\">\n<p><strong>\u4e3b\u8981\u6709\u52b9\u6027\u8a55\u4fa1\u9805\u76ee<\/strong>\uff1a \u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089180\u65e5\u76ee\u307e\u3067\u306e\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\uff08apo\uff09B\u306e\u30d1\u30fc\u30bb\u30f3\u30c8\u5909\u5316\u91cf\u3002<\/p>\n<p><strong>\u526f\u6b21\u6709\u52b9\u6027\u8a55\u4fa1\u9805\u76ee<\/strong>\uff1a \u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089180\u65e5\u76ee\u307e\u3067\u3001\u304a\u3088\u3073\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089270\u65e5\u76ee\u307e\u3067\u306eANGPTL3\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3001non-HDL-C\u3001LDL-C\u3001\u304a\u3088\u3073HDL-C\u306e\u30d1\u30fc\u30bb\u30f3\u30c8\u5909\u5316\u91cf\u3002<\/p>\n<p><strong>\u5b89\u5168\u6027\u8a55\u4fa1\u9805\u76ee<\/strong>\uff1a\u6709\u5bb3\u4e8b\u8c61\u3001\u304a\u3088\u3073\u5b9a\u671f\u7684\u306a\u81e8\u5e8a\u8a55\u4fa1\u30fb\u81e8\u5e8a\u691c\u67fb\u3002<\/p>\n<p><strong>\u63a2\u7d22\u7684\u8a55\u4fa1\u9805\u76ee<\/strong>\uff1a\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089180\u65e5\u76ee\u307e\u3067\u306e\u78c1\u6c17\u5171\u9cf4\u753b\u50cf\u6cd5\uff08MRI\uff09\u306b\u3088\u308b\u809d\u8102\u80aa\u5206\u753b\u306e\u5909\u5316\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/td>\n<td colspan=\"2\" width=\"29\">\n<p>&nbsp;<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"123\">\n<p><strong>\u65b9\u6cd5<\/strong><\/p>\n<\/td>\n<td colspan=\"2\" width=\"533\">\n<p>\u8102\u8cea\u95a2\u9023\u306e\u6fc3\u5ea6\u30c7\u30fc\u30bf\u306f\u3059\u3079\u3066\u5bfe\u6570\u5909\u63db\u3057\u305f\u5f8c\u3001\u6cbb\u7642\u3001\u6765\u9662\u3001\u6cbb\u7642\u3068\u6765\u9662\u306e\u4ea4\u4e92\u4f5c\u7528\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6e2c\u5b9a\u5024\u3001\u304a\u3088\u3073\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u6642\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\uff08&lt;250 mg\/dL\u307e\u305f\u306f\u2265250 mg\/dL\uff09\u3092\u5171\u5909\u91cf\u3068\u3057\u305f\u53cd\u5fa9\u6e2c\u5b9a\u5171\u5206\u6563\u5206\u6790\uff08ANCOVA\uff09\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u89e3\u6790\u3057\u305f\u3002<\/p>\n<\/td>\n<td width=\"15\">\n<p>&nbsp;<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"123\">\n<p><strong>\u7d50\u679c<\/strong><\/p>\n<\/td>\n<td colspan=\"3\" width=\"548\">\n<p>585\u540d\u304c\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3055\u308c\u3001\u305d\u306e\u3046\u3061205\u540d\uff08\u5e74\u9f62\u4e2d\u592e\u502457\u6b73\u3001\u5973\u602754%\uff09\u304c\u767b\u9332\u3055\u308c\u3001solbinsiran 100 mg\u7fa4\uff08n=30\uff09\u3001solbinsiran 400 mg\u7fa4\uff08n=58\uff09\u3001solbinsiran 800 mg\u7fa4\uff08n=59\uff09\u3001\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\uff08n=58\uff09\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002\u5168\u4f53\u3067189\u540d\uff0892%\uff09\u304c\u8a66\u9a13\u6cbb\u7642\u3092\u5b8c\u9042\u3057\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306b\u304a\u3051\u308b\u30a2\u30c6\u30ed\u30fc\u30e0\u60f9\u8d77\u6027\u8102\u8cea\u306e\u6fc3\u5ea6\u306f\u9ad8\u304f\u3001\u4e2d\u592e\u5024\uff08\u56db\u5206\u4f4d\u7bc4\u56f2\uff09\u306fapoB\u304c111\uff0896-130\uff09mg\/dL\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u304c234\uff08182-291\uff09mg\/dL\u3001\u8d85\u4f4e\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08VLDL-C\uff09\u304c40\uff0831-53\uff09mg\/dL\u3001LDL-C\u304c122\uff08100-148\uff09mg\/dL\u3001non-HDL-C\u304c166\uff08142-201\uff09mg\/dL\u3067\u3042\u3063\u305f\u3002Solbinsiran\u306f180\u65e5\u76ee\u306b\u304a\u3044\u3066ANGPTL3\u3092\u30d7\u30e9\u30bb\u30dc\u8abf\u6574\u5f8c\u3067\u6709\u610f\u306b\u6e1b\u5c11\u3055\u305b\u3001\u305d\u306e\u6e1b\u5c11\u7387\u306f100 mg\u7fa4\u306754.3%\u3001400 mg\u7fa4\u306769.8%\u3001800 mg\u7fa4\u306776.6%\u3067\u3042\u3063\u305f\uff08\u3059\u3079\u3066p&lt;0.0001\uff09\u3002<\/p>\n<p>\u8102\u8cea\u30d1\u30e9\u30e1\u30fc\u30bf\u306b\u304a\u3051\u308b\u30d7\u30e9\u30bb\u30dc\u8abf\u6574\u5f8c\u306e\u5909\u5316\u91cf\u3092\u88681\u306b\u793a\u3059\u3002180\u65e5\u76ee\u306b\u304a\u3044\u3066\u3001solbinsiran 400 mg\u7fa4\u306fapoB\u3092\u6709\u610f\u306b\u4f4e\u4e0b\u3055\u305b\u30013\u3064\u306e\u7528\u91cf\u3059\u3079\u3066\u304c\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068VLDL-C\u3092\u6709\u610f\u306b\u4f4e\u4e0b\u3055\u305b\u305f\u3002solbinsiran 400 mg\u7fa4\u3068800 mg\u7fa4\u306f\u3001\u3044\u305a\u308c\u3082LDL-C\u3068non-HDL-C\u3092180\u65e5\u76ee\u307e\u3067\u306b\u6709\u610f\u306b\u4f4e\u4e0b\u3055\u305b\u305f\u3002<\/p>\n<p>\u88681. 180\u65e5\u76ee\u304a\u3088\u3073270\u65e5\u76ee\u306b\u304a\u3051\u308b\u8102\u8cea\u30d1\u30e9\u30e1\u30fc\u30bf\u306e\u30d7\u30e9\u30bb\u30dc\u8abf\u6574\u5f8c\u5909\u5316\u7387\uff0895%\u4fe1\u983c\u533a\u9593\uff09<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"114\">\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"132\">\n<p><strong>Solbinsiran 100 mg<\/strong><\/p>\n<\/td>\n<td width=\"132\">\n<p><strong>Solbinsiran 400 mg<\/strong><\/p>\n<\/td>\n<td width=\"132\">\n<p><strong>Solbinsiran 800 mg<\/strong><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"114\">\n<p><strong>Day 180<\/strong><\/p>\n<\/td>\n<td width=\"132\">\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"132\">\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"132\">\n<p>&nbsp;<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"114\">\n<p>ApoB<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u20132.8% (\u201315.5 to -11.9) p=0.69<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u201314.3% (\u201323.6 to<\/p>\n<p>\u20133.9) p=0.0085<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u20138.3% (\u201318.3 to 2.9) p=0.14<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"114\">\n<p>Triglycerides<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u201336.3% (\u201345.8 to<\/p>\n<p>\u201325.1) p&lt;0.0001<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u201350.3% (\u201356.\u00b74 to<\/p>\n<p>\u201343.3) p&lt;0.0001<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u201352.5% (\u201358.4 to<\/p>\n<p>\u201345.9) p&lt;0.0001<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"114\">\n<p>VLDL-C<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u201341.6% (\u201352.4 to<\/p>\n<p>\u201328.3) p&lt;0.0001<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u201350.1% (\u201357.8 to<\/p>\n<p>\u201341.0) p&lt;0.0001<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u201349.6% (\u201357.4 to<\/p>\n<p>\u201340.4) p&lt;0.0001<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"114\">\n<p>LDL-C<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u20131.3% (\u201314.6 to 14.0) p=0.85<\/p>\n<\/td>\n<td width=\"132\">\n<p>16.8% ( \u201326.0 to<\/p>\n<p>\u20136.4) p=0.0025<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u201312.1% (\u201321.9 to<\/p>\n<p>\u20131.1) p=0.033<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"114\">\n<p>Non-HDL-C<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u201310.8% (\u201321.1 to 0.9) p=0.068<\/p>\n<\/td>\n<td width=\"132\">\n<p>25.5% (\u201332.6 to<\/p>\n<p>\u201317.6) p&lt;0.0001<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u201323.8% (\u201331.1 to<\/p>\n<p>\u201315.7) p&lt;0.0001<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"114\">\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"132\">\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"132\">\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"132\">\n<p>&nbsp;<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"114\">\n<p><strong>Day 270<\/strong><\/p>\n<\/td>\n<td width=\"132\">\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"132\">\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"132\">\n<p>&nbsp;<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"114\">\n<p>ApoB<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u201310.8% (\u201322.2 to 2.3) p=0.10<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u201311.3% (\u201320.6 to<\/p>\n<p>\u20131.0) p=0.033<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u201310.9% (\u201320.3 to<\/p>\n<p>\u20130.6) p=0.040<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"114\">\n<p>Triglycerides<\/p>\n<\/td>\n<td width=\"132\">\n<p>-28.3% ( \u201340.5 to<\/p>\n<p>\u00a0\u201313.6) p=0.0005<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u201342.5% (CI \u201350.5 to \u201333.2) p&lt;0.0001<\/p>\n<\/td>\n<td width=\"132\">\n<p>-44.8% (\u201352.5 to<\/p>\n<p>\u201335.9) p&lt;0.0001<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"114\">\n<p>VLDL-C<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u201326.7% (\u201340.3 to<\/p>\n<p>\u201310.1) p=0.0031<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u201343.2% (\u201351.7 to<\/p>\n<p>\u201333.1) p&lt;0.0001<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u201343.5% (\u201352.0 to<\/p>\n<p>\u201333.4) p&lt;0.0001<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"114\">\n<p>LDL-C<\/p>\n<\/td>\n<td width=\"132\">\n<p>6.5% (\u20138.4 to 23.7)<\/p>\n<p>p=0.041<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u20139.5% (\u201319.7 to 2.1) p=0.10<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u20135.4% (\u201316.2 to 6.7) p=0.36<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"114\">\n<p>Non-HDL-C<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u20134.1% (\u201315.2 to 8.5) p=0.51<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u201319.7% ( \u201327.2 to<\/p>\n<p>\u201311.3) p&lt;0.0001<\/p>\n<\/td>\n<td width=\"132\">\n<p>\u201319.4% (\u201327.0 to<\/p>\n<p>\u201311.0) p&lt;0.0001<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p>Solbinsiran\u306e\u5fcd\u5bb9\u6027\u306f\u6982\u306d\u826f\u597d\u3067\u3042\u308a\u3001\u6709\u5bb3\u4e8b\u8c61\u306e\u767a\u751f\u7387\u306f3\u3064\u306e\u7528\u91cf\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u540c\u7a0b\u5ea6\u3067\u3042\u3063\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089180\u65e5\u76ee\u307e\u3067\u306b\u3001\u3059\u3079\u3066\u306e\u7528\u91cf\u7fa4\u3067\u809d\u8102\u80aa\u5206\u753b\u306e\u6e1b\u5c11\u304c\u8a8d\u3081\u3089\u308c\u305f\uff08100 mg\u7fa4\u306726.8%\u3001400 mg\u7fa4\u306742.4%\u3001800 mg\u7fa4\u306735.9%\uff1b\u3059\u3079\u3066p&lt;0.0001\uff09\u3002<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"123\">\n<p><strong>\u7d50\u8ad6<\/strong><\/p>\n<\/td>\n<td colspan=\"3\" width=\"548\">\n<p>Solbinsiran 400 mg\u306f\u3001\u6df7\u5408\u578b\u8102\u8cea\u7570\u5e38\u75c7\u60a3\u8005\u306b\u304a\u3044\u3066apoB\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u305d\u306e\u5fcd\u5bb9\u6027\u306f\u6982\u306d\u826f\u597d\u3067\u3042\u3063\u305f\u3002Solbinsiran\u306e\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u3078\u306e\u5f71\u97ff\u306b\u3064\u3044\u3066\u306f\u3001\u4eca\u5f8c\u691c\u8a3c\u3055\u308c\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"123\"><\/td>\n<td width=\"519\"><\/td>\n<td width=\"14\"><\/td>\n<td width=\"15\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n<p>LDL-C\u304c\u5341\u5206\u306b\u7ba1\u7406\u3055\u308c\u3066\u3044\u308b\u75c7\u4f8b\u306b\u304a\u3044\u3066\u3082\u3001\u6df7\u5408\u578b\u8102\u8cea\u7570\u5e38\u75c7\u60a3\u8005\u306f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u304a\u3088\u3073\u305d\u306e\u30ec\u30e0\u30ca\u30f3\u30c8\u306e\u9ad8\u5024\u306b\u95a2\u9023\u3059\u308b\u9ad8\u3044\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u3092\u6709\u3059\u308b(1-3)\u3002\u3057\u304b\u3057\u3001\u4eca\u65e5\u307e\u3067\u3001\u4e0a\u6607\u3057\u305f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3092\u6a19\u7684\u3068\u3059\u308b\u6cbb\u7642\u6cd5\u3067\u3001\u7121\u4f5c\u70ba\u5316\u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3044\u3066\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u6e1b\u5c11\u3092\u793a\u3057\u305f\u3082\u306e\u306f\u5c11\u306a\u304f\u3001\u65b0\u305f\u306a\u6cbb\u7642\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u5fc5\u8981\u6027\u304c\u793a\u5506\u3055\u308c\u308b\u3002<\/p>\n<p>\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u4ee3\u8b1d\u306e\u8abf\u7bc0\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3046ANGPTL3\u306f\u3001\u4e3b\u306b\u907a\u4f1d\u5b66\u7684\u7814\u7a76\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u3088\u3063\u3066\u652f\u6301\u3055\u308c\u3066\u304a\u308a(4-7)\u3001\u6709\u671b\u306a\u6cbb\u7642\u6a19\u7684\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u3002ANGPTL3\u3092\u6a19\u7684\u3068\u3057\u305f\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u3067\u3042\u308bvupanorsen\u306f\u3001\u809d\u8102\u80aa\u5206\u753b\u306e\u5897\u52a0\u3068\u809d\u30a2\u30df\u30ce\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\u306e\u9855\u8457\u306a\u4e0a\u6607\u3068\u3044\u3063\u305f\u809d\u81d3\u306e\u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u61f8\u5ff5\u304b\u3089\u958b\u767a\u304c\u4e2d\u6b62\u3055\u308c\u305f(8)\u3002\u4e00\u65b9\u3067\u3001RNA\u5e72\u6e09\uff08RNAi\uff09\u3092\u7528\u3044\u305f\u4ee3\u66ff\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u6709\u671b\u306a\u7d50\u679c\u3092\u793a\u5506\u3057\u3066\u3044\u308b(9)\u3002<\/p>\n<p>\u3053\u308c\u3089\u306e\u85ac\u5264\u306e\u4e2d\u3067\u6700\u65b0\u306e\u3082\u306e\u3067\u3042\u308bsolbinsiran\u306f\u3001ANGPTL3\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fcRNA\u306e\u809d\u81d3\u306b\u304a\u3051\u308b\u7ffb\u8a33\u3092\u963b\u5bb3\u3059\u308b\u3088\u3046\u958b\u767a\u3055\u308c\u305fsiRNA\u3067\u3042\u308a\u3001\u30d2\u30c8\u3092\u5bfe\u8c61\u3068\u3057\u305f\u521d\u671f\u306e\u8a66\u9a13\u3067\u306f\u3001\u6df7\u5408\u578b\u8102\u8cea\u7570\u5e38\u75c7\u306b\u304a\u3044\u3066\u3059\u3079\u3066\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u60f9\u8d77\u6027\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u5bfe\u3059\u308b\u6709\u610f\u306a\u4f4e\u4e0b\u4f5c\u7528\u304c\u793a\u3055\u308c\u3066\u3044\u308b(10)\u3002\u672c\u7814\u7a76\u306b\u304a\u3044\u3066\u3001solbinsiran 400 mg\u306f\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u60f9\u8d77\u6027\u306e\u8102\u8cea\u304a\u3088\u3073\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\uff08apoB\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3001non-HDL-C\u3001LDL-C\uff09\u3092\u6301\u7d9a\u7684\u306b\u4f4e\u4e0b\u3055\u305b\u3001\u305d\u306e\u5fcd\u5bb9\u6027\u3082\u826f\u597d\u3067\u3042\u308a\u3001\u809d\u81d3\u306b\u95a2\u3059\u308b\u6709\u5bb3\u306a\u5b89\u5168\u6027\u30b7\u30b0\u30ca\u30eb\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001\u9ad8\u3044\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u6709\u3059\u308b\u6df7\u5408\u578b\u8102\u8cea\u7570\u5e38\u75c7\u60a3\u8005\u306b\u304a\u3051\u308bsolbinsiran\u306e\u3055\u3089\u306a\u308b\u81e8\u5e8a\u958b\u767a\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002<\/p>\n<p><strong><span>\u00a0<\/span><\/strong><\/p>\n<p><strong><span>References<\/span><\/strong><\/p>\n<ol>\n<li><span> Nordestgaard BG. Triglyceride-rich lipoproteins and atherosclerotic cardiovascular disease: new insights from epidemiology, genetics, and biology. Circ Res 2016;118:547-63.<\/span><\/li>\n<li><span> Langsted A, Madsen CM, Nordestgaard BG. Contribution of remnant cholesterol to cardiovascular risk. J Intern Med 2020;288:116-27.<\/span><\/li>\n<li><span> Ginsberg HN, Packard CJ, Chapman MJ, et al. Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies \u2014 a consensus statement from the European Atherosclerosis Society. Eur Heart J 2021;42:4791-806.<\/span><\/li>\n<li><span> Graham MJ, Lee RG, Brandt TA, et al. Cardiovascular and metabolic effects of ANGPTL3 antisense oligonucleotides. N Engl J Med 2017;377: 222\u201332.<\/span><\/li>\n<\/ol>\n<p><span>5 Stitziel NO, Khera AV, Wang X, et al. ANGPTL3 deficiency and protection against coronary artery disease. J Am Coll Cardiol 2017;69: 2054\u201363.<\/span><\/p>\n<ol start=\"6\">\n<li><span> J\u00f8rgensen AB, Frikke-Schmidt R, Nordestgaard BG, Tybj\u00e6rg-Hansen A. Loss-of-function mutations in APOC3 and risk of ischemic vascular disease. N Engl J Med 2014;371:32-41.<\/span><\/li>\n<li><span> TG and HDL Working Group of the Exome Sequencing Project, National Heart, Lung, and Blood Institute. Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med 2014;371:22-31.<\/span><\/li>\n<li><span> Bergmark BA, Marston NA, Bramson CR, et al. Effect of vupanorsen on non-high-density lipoprotein cholesterol levels in statin-treated patients with elevated cholesterol:TRANSLATE-TIMI 70. Circulation 2022; 145: 1377\u201386.<\/span><\/li>\n<li><span> Kosmas CE, Bousvarou MD, Tsamoulis D, et al. Novel RNA-Based Therapies in the management of dyslipidemias. Int J Mol Sci 2025; 26: 1026.<\/span><\/li>\n<\/ol>\n<p>10. Ray KK, Linnebjerg H, Michael LF, et al. Effect of ANGPTL3 inhibition with solbinsiran in preclinical and early human studies. 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