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2025\u5e744\u6708<\/h5>\n

\u6700\u65b0\u306eGlobal Burden of Disease Study 2021\u306e\u30c7\u30fc\u30bf\u306f\u3001\u5c0f\u5150\u304a\u3088\u3073\u601d\u6625\u671f\u306b\u304a\u3051\u308b\u80a5\u6e80\u304c\u4e16\u754c\u7684\u6d41\u884c\uff08\u30a8\u30d4\u30c7\u30df\u30c3\u30af\uff09\u306e\u72b6\u6cc1\u306b\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u5c06\u6765\u7684\u306a\u4e88\u6e2c\u306b\u3088\u308c\u3070\u3001\u305f\u3060\u3061\u306b\u5bfe\u7b56\u304c\u53d6\u3089\u308c\u306a\u3044\u9650\u308a\u30012050\u5e74\u307e\u3067\u306b\u4e16\u754c\u306e\u5b50\u3069\u3082\u3068\u9752\u5c11\u5e74\u306e\u7d043\u5206\u306e1\u304c\u4f53\u91cd\u904e\u591a\u307e\u305f\u306f\u80a5\u6e80\u306b\u306a\u308b\u3068\u63a8\u5b9a\u3055\u308c\u308b\u3002<\/span><\/i><\/p>\n

\u51fa\u5178\uff1a<\/span>GBD 2021 Adolescent BMI Collaborators. Global, regional, and national prevalence of child and adolescent overweight and obesity, 1990\u20132021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021. Lancet 2025; 405: 785\u2013812<\/span><\/i><\/p>\n

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1\uff0eGlobal Burden of Disease Study 2021\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u30011990\u5e74\u304b\u30892021\u5e74\u307e\u3067\u306e\u4e16\u754c\u3001\u5730\u57df\u3001\u56fd\u5bb6\u30ec\u30d9\u30eb\u3067\u306e\u5b50\u3069\u3082\u3001\u601d\u6625\u671f\u304a\u3088\u3073\u82e5\u5e74\u6210\u4eba\uff0824\u6b73\u307e\u3067\uff09\u306b\u304a\u3051\u308b\u80a5\u6e80\u30fb\u4f53\u91cd\u904e\u591a\u306e\u6709\u75c5\u7387\u306e\u52d5\u5411\u306b\u3064\u3044\u3066\u5305\u62ec\u7684\u306b\u5206\u6790\u3059\u308b<\/span><\/p>\n

2\uff0e\u3053\u308c\u3089\u306e\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u304d\u30012050\u5e74\u307e\u3067\u306e\u5c06\u6765\u4e88\u6e2c\u3092\u884c\u3046<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/b><\/p>\n<\/td>\n

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Global Burden of Disease Study\u304b\u3089\u306e\u30c7\u30fc\u30bf\u3092\u4f7f\u7528\u3057\u305f\u89e3\u6790\u00a0<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u7814\u7a76\u96c6\u56e3<\/b><\/p>\n<\/td>\n

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Global Burden of Diseases, Injuries, and Risk Factors Study 2021<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee<\/b><\/p>\n<\/td>\n

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\u4f53\u91cd\u904e\u591a\u304a\u3088\u3073\u80a5\u6e80\u306f\u4f53\u683c\u6307\u6570\uff08BMI\uff09\u306b\u3088\u308a\u5b9a\u7fa9\u3057\u305f\u300218\u301c24\u6b73\u306e\u9752\u5c11\u5e74\u306b\u304a\u3044\u3066\u306f\u3001BMI 25.0 kg\/m\u00b2\u4ee5\u4e0a30.0 kg\/m\u00b2\u672a\u6e80\u3092\u4f53\u91cd\u904e\u591a\u3001BMI 30.0 kg\/m\u00b2\u4ee5\u4e0a\u3092\u80a5\u6e80\u3068\u5b9a\u7fa9\u3057\u305f\u30025\u301c17\u6b73\u306e\u5b50\u3069\u3082\u304a\u3088\u3073\u9752\u5c11\u5e74\u306e\u5206\u985e\u306fInternational Obesity Task Force\u57fa\u6e96\u306b\u57fa\u3065\u3044\u305f\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u65b9\u6cd5<\/b><\/p>\n<\/td>\n

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\u30e2\u30c7\u30eb\u4f5c\u6210\u306e\u305f\u3081\u306e\u4e00\u6b21\u30c7\u30fc\u30bf\u3068\u3057\u3066\u3001\u8abf\u67fb\u30c7\u30fc\u30bf\u3001\u5831\u544a\u66f8\u304a\u3088\u3073\u516c\u8868\u3055\u308c\u305f\u6587\u732e\u304b\u3089\u5f97\u3089\u308c\u305f\u3001180\u30ab\u56fd\u30fb\u5730\u57df\u306e\u6e2c\u5b9a\u5024\u304a\u3088\u3073\u81ea\u5df1\u7533\u544a\u306b\u3088\u308b\u8eab\u4f53\u8a08\u6e2c\u30c7\u30fc\u30bf1321\u4ef6\u3092\u4f7f\u7528\u3057\u305f\u3002<\/span><\/p>\n

1990\u5e74\u304b\u30892021\u5e74\u307e\u3067\u306e5\u301c24\u6b73\u306e\u5b50\u3069\u3082\u30fb\u9752\u5c11\u5e74\u306e\u4f53\u91cd\u904e\u591a\u30fb\u80a5\u6e80\u6709\u75c5\u7387\uff08\u5e74\u9f62\u8abf\u6574\u6e08\u307f\uff09\u3092\u5206\u6790\u3057\u305f\u3002\u6709\u75c5\u7387\u306f5\u6b73\u3054\u3068\u306e\u5e74\u9f62\u533a\u5206\uff085\u20139\u6b73\u300110\u201314\u6b73\u300115\u201319\u6b73\u300120\u201324\u6b73\uff09\u304a\u3088\u3073\u6027\u5225\u3067\u5c64\u5225\u5316\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u30662030\u5e74\u304b\u30892050\u5e74\u307e\u3067\u306e\u52d5\u5411\u3092\u4e88\u6e2c\u3057\u305f\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u30fb2021\u5e74\u306e\u6642\u70b9\u3067\u3001\u4e16\u754c\u30674\u51049300\u4e07\u4eba\u306e\u82e5\u5e74\u5c64\u304c\u4f53\u91cd\u904e\u591a\u307e\u305f\u306f\u80a5\u6e80\u3067\u3042\u308a\u30015\uff5e14\u6b73\u306718.1%\uff0895%\u4fe1\u983c\u533a\u9593\u3000[UI]\u300017.5\u201318.7\uff09\u300115\uff5e24\u6b73\u306720.3%\uff0819.7\u201321.0\uff09\u3092\u5360\u3081\u30011990\u5e74\u306e2\u500d\u306b\u5897\u52a0\u3057\u305f\u3002\u7279\u306b\u4e16\u754c\u306e\u80a5\u6e80\u6709\u75c5\u7387\u306f1990\u5e74\u304b\u30892021\u5e74\u306b\u304b\u3051\u30663\u500d\u306b\u5897\u52a0\u3057\u30012.0%\u304b\u30896.8%\u3068\u306a\u308a\u30012021\u5e74\u306b\u306f1\u51047400\u4e07\u4eba\u306e\u5b50\u3069\u3082\u3068\u9752\u5c11\u5e74\u304c\u80a5\u6e80\u3067\u3042\u3063\u305f\u3002<\/span><\/p>\n

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\u5c0f\u5150\u304a\u3088\u3073\u601d\u6625\u671f\u306e\u4f53\u91cd\u904e\u591a\u3068\u80a5\u6e80\u306e\u4e16\u754c\u7684\u306a\u6d41\u884c\u306f\u300121\u4e16\u7d00\u306b\u304a\u3051\u308b\u6700\u5927\u306e\u516c\u8846\u885b\u751f\u4e0a\u306e\u8ab2\u984c\u3067\u3042\u308b\u3002Global Burden of Disease Study 2021\u306e\u30c7\u30fc\u30bf\u304c\u793a\u3059\u3088\u3046\u306b\u3001\u5c0f\u5150\u80a5\u6e80\u306f\u9ad8\u6240\u5f97\u56fd\u3060\u3051\u306e\u554f\u984c\u3067\u306f\u306a\u304f\u3001\u4f4e\u30fb\u4e2d\u6240\u5f97\u5730\u57df\u3067\u3088\u308a\u6df1\u523b\u3067\u3042\u308a\u3001\u5317\u30a2\u30d5\u30ea\u30ab\u3068\u4e2d\u6771\u306f\u6709\u75c5\u7387\u304c\u6700\u3082\u9ad8\u304f\u3001\u6771\u5357\u30a2\u30b8\u30a2\u3001\u6771\u30a2\u30b8\u30a2\u3001\u30aa\u30bb\u30a2\u30cb\u30a2\u3067\u306e\u5897\u52a0\u7387\u304c\u7279\u306b\u9ad8\u3044\u3002\u3053\u306e\u307e\u307e\u63a8\u79fb\u3059\u308c\u3070\u30012050\u5e74\u306b\u306f3\u51046000\u4e07\u4eba\u306e\u5b50\u3069\u3082\u30fb\u9752\u5c11\u5e74\u304c\u80a5\u6e80\u306e\u5f71\u97ff\u4e0b\u306b\u7f6e\u304b\u308c\u3001\u4f4e\u30fb\u4e2d\u6240\u5f97\u56fd\u304c\u305d\u306e\u8ca0\u62c5\u306e\u5927\u534a\u3092\u8ca0\u3046\u3053\u3068\u306b\u306a\u308b\u3060\u308d\u3046\u3002<\/span><\/p>\n

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\u80a5\u6e80\u306f\u4e88\u9632\u53ef\u80fd\u306a\u5065\u5eb7\u30ea\u30b9\u30af\u306e\u7b46\u982d\u3067\u3042\u308b\u305f\u3081\u3001\u3053\u308c\u3089\u306e\u4e88\u6e2c\u306b\u5bfe\u6297\u3059\u308b\u305f\u3081\u306e\u7dca\u6025\u304b\u3064\u5373\u6642\u306e\u884c\u52d5\u304c\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3002\u5c0f\u5150\u304a\u3088\u3073\u9752\u5c11\u5e74\u306b\u304a\u3051\u308b\u80a5\u6e80\u306e\u56fd\u5bb6\u30ec\u30d9\u30eb\u3067\u306e\u76e3\u8996\u3068\u3068\u3082\u306b\u3001\u98df\u751f\u6d3b\u3084\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u3092\u5287\u7684\u304b\u3064\u96c6\u4e2d\u7684\u306b\u6539\u5584\u3059\u308b\u53d6\u308a\u7d44\u307f\u304c\u6c42\u3081\u3089\u308c\u308b\u3002\u4f4e\u30fb\u4e2d\u6240\u5f97\u5730\u57df\u306b\u304a\u3044\u3066\u306f\u3001\u6301\u7d9a\u53ef\u80fd\u6027\u306e\u305f\u3081\u306b\u516c\u7684\u533b\u7642\u306e\u73fe\u5b9f\u306b\u5373\u3057\u305f\u5bfe\u7b56\u304c\u5fc5\u8981\u3068\u306a\u308b\u3002\u3042\u3089\u3086\u308b\u95a2\u4fc2\u8005\u304c\u7a4d\u6975\u7684\u306b\u95a2\u4e0e\u3057\u3001\u5909\u9769\u3092\u3082\u305f\u3089\u3059\u305f\u3081\u306e\u53d6\u308a\u7d44\u307f\u304c\u6c42\u3081\u3089\u308c\u308b\u3002<\/span><\/p>\n

\n

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    \n
  1. Okunogbe et al. Economic impacts of overweight and obesity.\u00a0 2nd Edition with Estimates for 161 Countries. World Obesity Federation, 2022.\u00a0<\/span><\/li>\n
  2. Simmonds M, Llewellyn A, Owen CG, Woolacott. Predicting adult obesity from childhood obesity: a systematic review and meta-analysis.<\/span> Obes Rev 2016;17:95-107.\u00a0<\/span><\/li>\n
  3. Baker JL, Olsen LW, S\u00f8rensen TI. \u00a0Childhood body-mass index and the risk of coronary heart disease in adulthood. N Engl J Med 2007;357:2329-37.\u00a0<\/span><\/li>\n
  4. Park MH, Falconer C, Viner RM, Kinra S. The impact of childhood obesity on morbidity and mortality in adulthood: a systematic review. Obes Rev 2012;13:985-1000.<\/span><\/li>\n<\/ol>\n

    [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

    \u4e16\u754c\u7684\u306a\u5c0f\u5150\u304a\u3088\u3073\u601d\u6625\u671f\u306b\u304a\u3051\u308b\u80a5\u6e80\u306e\u5897\u52a0\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306b\u65e9\u6025\u306a\u5bfe\u5fdc\u304c\u5fc5\u8981\u3067\u3042\u308b 2025\u5e744\u6708 \u6700\u65b0\u306eGlo […]<\/p>\n","protected":false},"author":258497324,"featured_media":0,"parent":254305,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"[et_pb_section fb_built=\"1\" _builder_version=\"4.27.4\" _module_preset=\"default\" custom_padding=\"1px|||||\" global_colors_info=\"{}\"][et_pb_row _builder_version=\"4.27.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.27.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.27.4\" _module_preset=\"default\" header_2_text_color=\"gcid-primary-color\" header_5_text_color=\"gcid-secondary-color\" text_orientation=\"center\" width=\"99%\" custom_margin=\"|-147px||||\" custom_padding=\"|0px||||\" hover_enabled=\"0\" global_colors_info=\"{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}\" sticky_enabled=\"0\"]

    PROMINENT\u8a66\u9a13\u304b\u3089\u306e\u77e5\u898b\uff1a\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306f2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u6f70\u760d\u307e\u305f\u306f\u58ca\u75bd\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b<\/h2>\n

    2024\u5e749\u6708<\/span><\/h5>\n

    POMINENT<\/i><\/span>\u8a66\u9a13\u306e\u7d50\u679c\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306b\u3088\u308a2<\/i><\/span>\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u4e0b\u80a2\u306e\u865a\u8840\u6027\u6f70\u760d\u304a\u3088\u3073\u58ca\u75bd\u304c\u6e1b\u5c11\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u305f\u3002<\/p>\n

    Marinho LL, Everett BM, Aday AW, et al. <\/i>\u7cd6\u5c3f\u75c5\u6027\u8db3\u6f70\u760d\u304a\u3088\u3073\u58ca\u75bd\u306b\u5bfe\u3059\u308b\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u52b9\u679c\u3002<\/span>PROMINENT<\/i>\u8a66\u9a13\u306e\u63a2\u7d22\u7684\u89e3\u6790\u3002<\/span> J Am Coll Cardiol 2024;84:408-410.<\/i><\/p>\n

    \u8a66\u9a13\u306e\u8981\u7d04<\/b><\/p>\n

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    \u76ee\u7684<\/b><\/b><\/p>\n<\/td>\n

    		\n

    Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Participants with Diabetes\uff08<\/span>PROMINENT\uff09\u8a66\u9a13\u306e\u524d\u5411\u304d\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u3001\u4e0b\u80a2\u306e\u865a\u8840\u6027\u6f70\u760d\u307e\u305f\u306f\u58ca\u75bd\u3068\u5224\u5b9a\u3055\u308c\u305f\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u5bfe\u3059\u308b\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u52b9\u679c\u3092\u8a55\u4fa1\u3059\u308b\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n

    \n

    \u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/b><\/b><\/p>\n<\/td>\n

    		\n

    \u7121\u4f5c\u70ba\u5316\u3001\u4e8c\u91cd\u76f2\u691c\u3001\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167PROMINENT<\/span>\u8a66\u9a13\u306e\u4e8c\u6b21\u89e3\u6790\u3002<\/p>\n<\/td>\n<\/tr>\n

    \n

    \u7814\u7a76\u5bfe\u8c61\u96c6\u56e3<\/b><\/b><\/p>\n<\/td>\n

    		\n

    PROMINENT<\/span>\u8a66\u9a13\u3067\u306f\u30012<\/span>\u578b\u7cd6\u5c3f\u75c5\uff08T2DM<\/span>\uff09\u3001\u8efd\u5ea6\uff5e\u4e2d\u7b49\u5ea6\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\uff08\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024200<\/span>\uff5e499 mg\/dL<\/span>\uff09\u3001\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u5024\uff0840 mg\/dL<\/span>\u4ee5\u4e0b\uff09\u3001\u304a\u3088\u3073\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u57fa\u3065\u304f\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\uff08\u7d043<\/span>\u5206\u306e2<\/span>\u304c\u9ad8\u5f37\u5ea6\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\uff09\u306b\u3088\u308a\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u60a3\u800510,479<\/span>\u4f8b\u304c\u5bfe\u8c61\u3068\u3055\u308c\u305f\u3002\u5168\u4f53\u3067\u3001\u60a3\u8005\u306e15%<\/span>\u304c\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306b\u672b\u68a2\u52d5\u8108\u75be\u60a3\uff08PAD<\/span>\uff09\u306e\u65e2\u5f80\u3092\u6709\u3057\u3066\u3044\u305f\u3002<\/p>\n

    \n<\/td>\n<\/tr>\n

    \n

    \u4e3b\u8981\u7814\u7a76\u8a55\u4fa1\u9805\u76ee<\/b><\/b><\/p>\n

    <\/b><\/p>\n<\/td>\n

    		\n

    \u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\uff1a<\/b>\u672c\u89e3\u6790\u306e\u4e3b\u8981\u6709\u52b9\u6027\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u533b\u5e2b\u304c\u5224\u5b9a\u3057\u305f\u4e0b\u80a2\u306e\u865a\u8840\u6027\u6f70\u760d\u307e\u305f\u306f\u58ca\u75bd\u306e\u767a\u75c7\u3067\u3042\u308a\u3001\u3053\u308c\u306f\u8a3a\u65ad\u691c\u67fb\u306b\u57fa\u3065\u304f\u9589\u585e\u6027PAD<\/span>\u306e\u65b0\u898f\u767a\u75c7\u307e\u305f\u306f\u60aa\u5316\u3068\u5b9a\u7fa9\u3055\u308c\u305f\u3002PAD<\/span>\u306e\u65b0\u898f\u767a\u75c7\u307e\u305f\u306f\u60aa\u5316\u3092\u4f34\u308f\u306a\u3044\u6f70\u760d\u3084\u58ca\u75bd\u306f\u89e3\u6790\u306b\u542b\u307e\u308c\u306a\u304b\u3063\u305f\u3002PAD<\/span>\u306e\u65b0\u898f\u767a\u75c7\u307e\u305f\u306f\u60aa\u5316\u306f\u3001\u9593\u6b20\u6027\u8ddb\u884c\u3001\u5b89\u9759\u6642\u75bc\u75db\u3001\u4e0b\u80a2\u865a\u8840\u6027\u6f70\u760d\u3001\u4e0b\u80a2\u306e\u8840\u884c\u518d\u5efa\u8853\u307e\u305f\u306f\u5927\u5207\u65ad\u8853\u306e\u65e2\u5f80\u306e\u3044\u305a\u308c\u304b\u304c\u8a8d\u3081\u3089\u308c\u3001\u304b\u3064\u8db3\u95a2\u7bc0\u4e0a\u8155\u8840\u5727\u6bd40.9<\/span>\u4ee5\u4e0b\u307e\u305f\u306f\u4ed6\u306e\u691c\u67fb\u306b\u3088\u308bPAD<\/span>\u306e\u8a3a\u65ad\u3068\u5b9a\u7fa9\u3055\u308c\u305f\u3002<\/p>\n

    \n<\/td>\n<\/tr>\n

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    \u65b9\u6cd5<\/b><\/b><\/p>\n<\/td>\n

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    \u5831\u544a\u3055\u308c\u305f\u30a4\u30d9\u30f3\u30c8\u306f\u3059\u3079\u3066\u3001\u8a66\u9a13\u306e\u8a55\u4fa1\u9805\u76ee\u5be9\u67fb\u59d4\u54e1\u4f1a\u304c\u6700\u521d\u306b\u691c\u8a0e\u3057\u3001PAD<\/span>\u306e\u65b0\u898f\u767a\u75c7\u307e\u305f\u306f\u60aa\u5316\u306e\u6709\u7121\u3092\u5224\u5b9a\u3057\u305f\u3002\u3055\u3089\u306b\u3001PAD<\/span>\u306e\u5c02\u9580\u77e5\u8b58\u3092\u6709\u3059\u308b\u72ec\u7acb\u3057\u305f\u5faa\u74b0\u5668\u5c02\u9580\u533b2<\/span>\u540d\u304c\u4e8c\u6b21\u5224\u5b9a\u3092\u5b9f\u65bd\u3057\u3001\u6765\u9662\u6642\u306b\u6f70\u760d\u306e\u5834\u6240\u304a\u3088\u3073\u58ca\u75bd\u306e\u6709\u7121\u306a\u3069\u306e\u88dc\u8db3\u60c5\u5831\u3092\u53ce\u96c6\u3057\u305f\u3002\u30c7\u30fc\u30bf\u306e\u89e3\u6790\u306fintention-to-treat<\/span>\u306b\u57fa\u3065\u3044\u3066\u5b9f\u65bd\u3057\u3001\u30ab\u30d7\u30e9\u30f3\u30de\u30a4\u30e4\u30fc\u66f2\u7dda\u304a\u3088\u3073\u672a\u8abf\u6574\u306e\u30ed\u30b0\u30e9\u30f3\u30afP<\/span>\u5024\u306b\u3088\u308a\u3001\u7121\u4f5c\u70ba\u5272\u308a\u4ed8\u3051\u3057\u305f\u6295\u4e0e\u7fa4\u9593\u306b\u304a\u3051\u308b\u521d\u767a\u306e\u6f70\u760d\u307e\u305f\u306f\u58ca\u75bd\u306e\u7d2f\u7a4d\u767a\u751f\u7387\u3092\u6bd4\u8f03\u3057\u305f\u30022<\/span>\u6295\u4e0e\u7fa4\u3067\u521d\u767a\u306e\u6f70\u760d\u307e\u305f\u306f\u58ca\u75bd\u304c\u78ba\u8a8d\u3055\u308c\u308b\u307e\u3067\u306e\u6642\u9593\u306f\u3001\u6027\u5225\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u65e2\u5f80\u3001\u304a\u3088\u3073\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306e\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u306b\u3088\u308a\u5c64\u5225\u5316\u3057\u305fCox<\/span>\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30eb\u306b\u3088\u308a\u89e3\u6790\u3057\u305f\u3002\u307e\u305f\u3001\u521d\u767a\u306e\u6f70\u760d\u307e\u305f\u306f\u521d\u767a\u306e\u58ca\u75bd\u306b\u3064\u3044\u3066\u3001\u5225\u3005\u306b\u30c7\u30fc\u30bf\u3092\u89e3\u6790\u3057\u305f\u3002<\/p>\n

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    \u7d50\u679c<\/b><\/b><\/p>\n<\/td>\n

    		\n

    PROMINENT<\/span>\u8a66\u9a13\u306e\u8ffd\u8de1\u8abf\u67fb\u671f\u9593\u4e2d\u592e\u5024\u306f3.3<\/span>\u5e74\uff08\u56db\u5206\u4f4d\u7bc4\u56f22.5<\/span>\uff5e4.0<\/span>\u5e74\uff09\u3067\u3042\u3063\u305f\u3002\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u6295\u4e0e\u306f\u4e3b\u8981\u8907\u5408\u8a55\u4fa1\u9805\u76ee\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3001\u305d\u306e\u76f8\u5bfe\u4f4e\u4e0b\u7387\u306f37%<\/span>\u3067\u3042\u3063\u305f\uff08\u8868<\/b>1<\/b><\/span>\uff09\u3002\u8907\u5408\u8a55\u4fa1\u9805\u76ee\u306e\u5404\u8981\u7d20\u306b\u3064\u3044\u3066\u89e3\u6790\u3057\u305f\u3068\u3053\u308d\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306f\u7d71\u8a08\u5b66\u7684\u306b\u6709\u610f\u306a\u58ca\u75bd\u30ea\u30b9\u30af\u4f4e\u4e0b\uff08\u30cf\u30b6\u30fc\u30c9\u6bd40.47<\/span>\u300195%<\/span>\u4fe1\u983c\u533a\u9593\uff3bCI<\/span>\uff3d0.25-0.87<\/span>\u3001p<\/span>\uff1d0.01<\/span>\uff09\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3060\u3051\u3067\u306a\u304f\u3001\u6f70\u760d\u767a\u751f\u7387\u306e\u4e00\u65b9\u5411\u7684\u4f4e\u4e0b\uff08n<\/span>\uff1d62<\/span>\u3001\u30cf\u30b6\u30fc\u30c9\u6bd40.68<\/span>\u300195% CI 0.41-1.12<\/span>\u3001p<\/span>\uff1d0.13<\/span>\uff09\u3082\u8a8d\u3081\u3089\u308c\u305f\u3002<\/p>\n

    \n

    \u8868<\/b>1.<\/b><\/span>\u3000<\/b>PROMINENT<\/b><\/span>\u8a66\u9a13\u3067\u89b3\u5bdf\u3055\u308c\u305f\u4e0b\u80a2\u306e\u865a\u8840\u6027\u6f70\u760d\u307e\u305f\u306f\u58ca\u75bd\u306b\u5bfe\u3059\u308b\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u52b9\u679c<\/b><\/b><\/p>\n

    \n

    \u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8<\/b><\/b><\/p>\n

    <\/b><\/p>\n

    \u30d7\u30e9\u30bb\u30dc<\/b><\/b><\/p>\n

    \u30cf\u30b6\u30fc\u30c9\u6bd4\uff08<\/b>95% CI<\/b><\/span>\uff09<\/b><\/b><\/p>\n

    \n

    \u30a4\u30d9\u30f3\u30c8\u6570<\/p>\n

    35<\/p>\n

    56<\/p>\n

    \n

    \n

    \u767a\u751f\u7387\uff08<\/span>1000<\/span>\u4eba<\/span>\u30fb\u5e74\u3042\u305f\u308a\uff09<\/p>\n

    2.1<\/p>\n

    3.4<\/p>\n

    0.63 (0.41\u20130.95)<\/p>\n

    p=0.03<\/p>\n

    \n

    \n

    \n<\/td>\n<\/tr>\n

    \n

    \u8457\u8005\u306e\u7d50\u8ad6<\/b><\/b><\/p>\n<\/td>\n

    		\n

    \u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u57fa\u3065\u304f\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u308bT2DM<\/span>\u3001\u8efd\u5ea6\uff5e\u4e2d\u7b49\u5ea6\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3001\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u5024\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306f\u4e0b\u80a2\u306e\u865a\u8840\u6027\u6f70\u760d\u307e\u305f\u306f\u58ca\u75bd\u306e\u30ea\u30b9\u30af\u3092\u6709\u610f\u306b\u4f4e\u4e0b\u3055\u305b\u305f\u3002\u3053\u308c\u306f\u3001\u4e0b\u80a2\u306e\u865a\u8840\u6027\u6f70\u760d\u307e\u305f\u306f\u58ca\u75bd\u306e\u767a\u75c7\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3001\u3055\u3089\u306b\u524d\u5411\u304d\u306b\u691c\u8a0e\u3059\u308b\u4fa1\u5024\u306e\u3042\u308b\u7d50\u679c\u3067\u3042\u308b\u3002<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    \u30b3\u30e1\u30f3\u30c8<\/b><\/b><\/p>\n

    PAD<\/span>\u304a\u3088\u3073\u9ad8\u8840\u7cd6\u306f\u8db3\u6f70\u760d\u306e\u4e3b\u8981\u306a\u4fc3\u9032\u56e0\u5b50\u3067\u3042\u308b\u3002\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e20<\/span>\uff5e30%<\/span>\u304cPAD<\/span>\u3092\u5408\u4f75\u3057\u3066\u3044\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u9ad8\u9f62\u60a3\u8005\u3067\u306f\u3055\u3089\u306b\u5408\u4f75\u7387\u304c\u9ad8\u3044\u3068\u8003\u3048\u3089\u308c\u308b\uff081<\/span>\uff09\u3002\u5916\u50b7\u4ee5\u5916\u306e\u539f\u56e0\u306b\u3088\u308b\u4e0b\u80a2\u306e\u5927\u5207\u65ad\u306f\u3001\u7f79\u60a3\u6b74\u304c\u9577\u3044\u307e\u305f\u306f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u4e0d\u826f\u306e\u7cd6\u5c3f\u75c5\u60a3\u8005\u3084\u672b\u671fPAD<\/span>\u60a3\u8005\u306e\u5408\u4f75\u75c7\u306b\u5bfe\u3057\u3066\u884c\u308f\u308c\u308b\u51e6\u7f6e\u3067\u3042\u308b\u304c\u3001\u60a3\u8005\u304a\u3088\u3073\u305d\u306e\u4ecb\u8b77\u8005\u306b\u5927\u304d\u306a\u8ca0\u62c5\u3092\u304b\u3051\u308b\u30021990<\/span>\u5e74\u4ee3\u304b\u30892000<\/span>\u5e74\u4ee3\u306b\u304b\u3051\u3066\u4e0b\u80a2\u5207\u65ad\u306e\u4ef6\u6570\u306f\u6e1b\u5c11\u3057\u3066\u3044\u308b\u304c\u3001\u3053\u305310<\/span>\u5e74\u9593\u306f\u6a2a\u3070\u3044\u304b\u4e0a\u6607\u50be\u5411\u306b\u3042\u308a\u3001\u533b\u7642\u5236\u5ea6\u306b\u3068\u3063\u3066\u5927\u304d\u306a\u8ab2\u984c\u3068\u306a\u3063\u3066\u3044\u308b\uff082<\/span>\uff09\u3002\u3053\u306e\u52d5\u5411\u306f\u3001\u7cd6\u5c3f\u75c5\u6027\u4e0b\u80a2\u75be\u60a3\u306b\u95a2\u9023\u3059\u308b\u91cd\u5ea6\u5408\u4f75\u75c7\u306e\u65b0\u3057\u3044\u4e88\u9632\u85ac\u306e\u81e8\u5e8a\u30cb\u30fc\u30ba\u304c\u6e80\u305f\u3055\u308c\u3066\u3044\u306a\u3044\u3053\u3068\u3092\u6d6e\u304d\u5f6b\u308a\u306b\u3057\u3066\u3044\u308b\u3002<\/p>\n

    \n

    \u3053\u306ePROMINENT<\/span>\u8a66\u9a13\u306e\u6700\u65b0\u306e\u89e3\u6790\u7d50\u679c\u306f\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u6cbb\u7642\u306e\u53ef\u80fd\u6027\u3092\u793a\u5506\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002\u3053\u306e\u5831\u544a\u3067\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u6cbb\u7642\u306f\u5207\u65ad\u524d\u306b\u591a\u304f\u307f\u3089\u308c\u308b\u4e0b\u80a2\u306e\u865a\u8840\u6027\u6f70\u760d\u307e\u305f\u306f\u58ca\u75bd\u306e\u76f8\u5bfe\u30ea\u30b9\u30af\u309237%<\/span>\u4f4e\u4e0b\u3055\u305b\u305f\u3002\u3053\u306e\u7d50\u679c\u306fFenofibrate Intervention and Event Lowering Diabetes<\/span>\uff08FIELD<\/span>\uff09\u8a66\u9a13\u306e\u30c7\u30fc\u30bf\u3068\u3082\u4e00\u81f4\u3059\u308b\u3002FIELD<\/span>\u8a66\u9a13\u3067\u306f\u3001\u6bd4\u8f03\u7684\u5f31\u3044\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u03b1<\/span>\u4f5c\u52d5\u85ac\u3067\u3042\u308b\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u30922<\/span>\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u6295\u4e0e\u3057\u3001\u5c0f\u5207\u65ad\u767a\u751f\u7387\u304c\u4f4e\u4e0b\u3057\u305f\uff083<\/span>\uff09\u3002\u8457\u8005\u3089\u306f\u3001PROMINENT<\/span>\u8a66\u9a13\u304b\u3089\u91cd\u5ea6PAD<\/span>\u60a3\u8005\u3092\u9664\u5916\u3057\u305f\u3053\u3068\u3001\u9032\u884c\u6027\u795e\u7d4c\u969c\u5bb3\u3001\u611f\u67d3\u75c7\u306e\u4f75\u767a\u3001\u8db3\u90e8\u306e\u5909\u5f62\u3001\u8db3\u5c02\u9580\u6cbb\u7642\u3084\u4e88\u9632\u7684\u8840\u7ba1\u30a4\u30f3\u30bf\u30fc\u30d9\u30f3\u30b7\u30e7\u30f3\u3078\u306e\u30a2\u30af\u30bb\u30b9\u6027\u306a\u3069\u5897\u60aa\u56e0\u5b50\u306b\u95a2\u3059\u308b\u30c7\u30fc\u30bf\u304c\u4e0d\u8db3\u3057\u3066\u3044\u305f\u3053\u3068\u3092\u30c7\u30fc\u30bf\u306e\u9650\u754c\u306b\u6319\u3052\u3066\u3044\u308b\u304c\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306b\u3088\u308b\u6cbb\u7642\u52b9\u679c\u306e\u9ad8\u3055\u306f\u3001\u4eca\u5f8c\u3082\u7814\u7a76\u3092\u7d9a\u3051\u308b\u6839\u62e0\u3068\u306a\u308b\u3002<\/p>\n

    \n

    References<\/b><\/p>\n

    1. Barnes JA, Eid MA, Creager MA, et al. Epidemiology and risk of amputation in patients with diabetes mellitus and peripheral artery disease. Arterioscler Thromb Vasc Biol 2020;40:1808\u201317.<\/p>\n

    2. McDermott KM, Srinivas T, Abularrage CJ. Multidisciplinary approach to decreasing major amputation, improving outcomes, and mitigating disparities in diabetic foot and vascular disease. Semin Vasc Surg 2023;36:114-21.<\/p>\n

    3. Rajamani K, Colman PG, Li LP, et al. Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): a prespecified analysis of a randomised controlled trial. Lancet 2009;373:1780-8.<\/p>\n

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