{"id":255222,"date":"2025-03-06T23:02:05","date_gmt":"2025-03-06T22:02:05","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-reduce-it%ef%bc%9a%e6%80%a5%e6%80%a7%e5%86%a0%e7%97%87%e5%80%99%e7%be%a4%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%82%a4%e3%82%b3%e3%82%b5%e3%83%9a\/"},"modified":"2025-03-06T23:13:39","modified_gmt":"2025-03-06T22:13:39","slug":"%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-reduce-it%ef%bc%9a%e6%80%a5%e6%80%a7%e5%86%a0%e7%97%87%e5%80%99%e7%be%a4%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%82%a4%e3%82%b3%e3%82%b5%e3%83%9a","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-reduce-it%ef%bc%9a%e6%80%a5%e6%80%a7%e5%86%a0%e7%97%87%e5%80%99%e7%be%a4%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%82%a4%e3%82%b3%e3%82%b5%e3%83%9a\/","title":{"rendered":"\u30d5\u30a9\u30fc\u30ab\u30b9 – REDUCE-IT\uff1a\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u306b\u304a\u3051\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]<\/p>\n

REDUCE-IT\uff1a\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u306e\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u306f\u30ea\u30b9\u30af\u304c\u6700\u3082\u9ad8\u3044\u60a3\u8005\u3067\u6700\u3082\u5927\u304d\u3044<\/h2>\n

2024\u5e746\u6708<\/span><\/h5>\n
\n

REDUCE-IT<\/i><\/span>\uff08Reduction of Cardiovascular Events with Icosapent Ethyl\u2013Intervention Trial<\/i><\/span>\uff09\u306e\u6700\u65b0\u306e\u89e3\u6790\u3067\u306f\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u306f\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u9ad8\u5024\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff08ASCVD<\/i><\/span>\uff09\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u306b\u304b\u304b\u308f\u3089\u305a\u4e3b\u8981\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08MACE<\/i><\/span>\uff09\u306e\u30ea\u30b9\u30af\u3092\u4e00\u8cab\u3057\u3066\u4f4e\u4e0b\u3055\u305b\u305f\u3002\u3057\u304b\u3057\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u307b\u3069\u3001\u7d76\u5bfe\u6cbb\u7642\u52b9\u679c\u306f\u9ad8\u304b\u3063\u305f\u3002<\/p>\n

Burger PM, Bhatt DL, Dorresteijn JAN, et al. <\/i>\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u5225\u306b\u307f\u305f\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u306e\u52b9\u679c\uff1a<\/span>REDUCE-IT<\/i>\u306e\u7d50\u679c\u3002<\/span>Eur Heart J Cardiovasc Pharmacother 2024; doi: 10.1093\/ehjcvp\/pvae030.<\/i><\/p>\n<\/div>\n

\u8a66\u9a13\u306e\u8981\u7d04<\/b><\/p>\n\n\n\n\n\n\n\n
\n

\u76ee\u7684<\/b><\/b><\/p>\n<\/td>\n

\n

ASCVD<\/span>\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3001\u500b\u3005\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u5225\u306b\u3001MACE<\/span>\u306b\u5bfe\u3059\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u306e\u76f8\u5bfe\u6cbb\u7642\u52b9\u679c\u304a\u3088\u3073\u7d76\u5bfe\u6cbb\u7642\u52b9\u679c\u3092\u8a55\u4fa1\u3059\u308b\u3002<\/p>\n

\n<\/td>\n<\/tr>\n

\n

\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/b><\/b><\/p>\n<\/td>\n

\n

REDUCE-IT<\/span>\uff08\u7121\u4f5c\u70ba\u5316\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\uff09\u306e\u89e3\u6790<\/p>\n<\/td>\n<\/tr>\n

\n

\u7814\u7a76\u5bfe\u8c61\u96c6\u56e3<\/b> <\/b><\/span><\/p>\n<\/td>\n

\n

REDUCE-IT<\/span>\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u60a3\u8005\u3001\u307e\u305f\u306f\u7cd6\u5c3f\u75c5\u3068\u305d\u306e\u4ed6\u306e\u30ea\u30b9\u30af\u56e0\u5b50\u30921<\/span>\u3064\u4ee5\u4e0a\u6709\u3059\u308b50<\/span>\u6b73\u4ee5\u4e0a\u306e\u60a3\u8005\u306e\u3046\u3061\u3001\u7a7a\u8179\u6642\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u304c1.69<\/span>\uff5e5.63 mmol\/L<\/span>\uff08150<\/span>\uff5e499 mg\/dL<\/span>\uff09\u3067\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C<\/span>\uff09\u5024\u304c\u5b89\u5b9a\u3057\u3066\u3044\u308b\u60a3\u80058,179<\/span>\u4f8b\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3002\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb2 g 1<\/span>\u65e52<\/span>\u56de\u6295\u4e0e\u7fa4\u307e\u305f\u306f\u5bfe\u5fdc\u3059\u308b\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u60a3\u8005\u3092\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u305f\u3002\u3053\u306e\u89e3\u6790\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306bASVCD<\/span>\u3092\u6709\u3059\u308b5,785<\/span>\u4f8b\uff08\u5e73\u5747\u5e74\u9f6263.2<\/span>\u6b73\u3001\u7537\u602778%<\/span>\uff09\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3002\u60a3\u8005\u306e78%<\/span>\u304c\u51a0\u52d5\u8108\u75be\u60a3\u3092\u6709\u3057\u300120%<\/span>\u304c\u8133\u8840\u7ba1\u75be\u60a3\u300112%<\/span>\u304c\u672b\u68a2\u52d5\u8108\u75be\u60a3\u30011%<\/span>\u304c\u8179\u90e8\u5927\u52d5\u8108\u7624\u3092\u6709\u3057\u3066\u3044\u305f\u3002\u307b\u307c\u3059\u3079\u3066\u306e\u60a3\u8005\uff0896%<\/span>\uff09\u304c\u4e2d\uff5e\u9ad8\u5f37\u5ea6\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u305f\u3002<\/p>\n

\n<\/td>\n<\/tr>\n

\n

\u4e3b\u8981\u7814\u7a76\u8a55\u4fa1\u9805\u76ee<\/b><\/b><\/p>\n

<\/b><\/p>\n<\/td>\n

\n

\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\uff1a<\/b>\u672c\u89e3\u6790\u306b\u304a\u3051\u308b\u6709\u52b9\u6027\u306e\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u30013-point MACE<\/span>\uff08\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u6027\u5fc3\u7b4b\u6897\u585e\u307e\u305f\u306f\u975e\u81f4\u6b7b\u6027\u8133\u5352\u4e2d\u306e\u6700\u521d\u306e\u767a\u751f\u304b\u3089\u306a\u308b\u8907\u5408\u8a55\u4fa1\u9805\u76ee\uff09\u3067\u3042\u3063\u305f\u3002<\/p>\n

\n<\/td>\n<\/tr>\n

\n

\u65b9\u6cd5<\/b><\/b><\/p>\n<\/td>\n

\n

\u6b27\u5dde\u5fc3\u81d3\u75c5\u5b66\u4f1a\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306eMACE<\/span>\u306e5<\/span>\u5e74\u30ea\u30b9\u30af\u3092\u63a8\u5b9a\u3059\u308b\u969b\u306fSMART2<\/span>\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\u3092\u7528\u3044\u308b\u3088\u3046\u3001\u63a8\u5968\u3055\u308c\u3066\u3044\u308b\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30ea\u30b9\u30af\u306b\u3088\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u306e\u76f8\u5bfe\u6cbb\u7642\u52b9\u679c\u306e\u4fee\u98fe\u306b\u3064\u3044\u3066\u3001\u6cbb\u7642\u3068\u30ea\u30b9\u30af\u3068\u306e\u4ea4\u4e92\u4f5c\u7528\u3092\u542b\u3080Cox<\/span>\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30eb\u3067\u8a55\u4fa1\u3057\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30ea\u30b9\u30af\u306e\u56db\u5206\u4f4d\u3067\u5c64\u5225\u5316\u3057\u3066\u6cbb\u7642\u52b9\u679c\u3092\u8a55\u4fa1\u3057\u305f\u3002<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\n

\n\n\n\n\n
\n

\u7d50\u679c<\/b><\/b><\/p>\n<\/td>\n

\n

\u4e3b\u306a\u30ea\u30b9\u30af\u56e0\u5b50\u30683-point MACE<\/span>\u306e\u63a8\u5b9a5<\/span>\u5e74\u30ea\u30b9\u30af\u3092\u56db\u5206\u4f4d\u5225\u306b\u8868<\/b>1<\/b><\/span>\u306b\u8981\u7d04\u3059\u308b\u3002\u5168\u4f53\u3068\u3057\u3066\u3001\u30ea\u30b9\u30af\u306e\u56db\u5206\u4f4d\u304c\u4e0a\u6607\u3059\u308b\u3068\u3001\u8102\u8cea\u4ee5\u5916\u306e\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u56e0\u5b50\u306e\u30ec\u30d9\u30eb\u306f\u4e0a\u6607\u3057\u305f\u304c\u3001\u8102\u8cea\u5024\u304a\u3088\u3073\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306e\u4f7f\u7528\u306f\u6bd4\u8f03\u7684\u4e00\u5b9a\u306e\u307e\u307e\u3067\u3042\u3063\u305f\u3002<\/p>\n

\n

\u8868<\/b>1.<\/b><\/span>\u3000\u4e3b\u306a\u30ea\u30b9\u30af\u56e0\u5b50\u3068<\/b>3-point MACE<\/b><\/span>\u306e\u63a8\u5b9a<\/b>5<\/b><\/span>\u5e74\u30ea\u30b9\u30af<\/b><\/b><\/p>\n

\n

\u30ea\u30b9\u30af\u306e\u7b2c<\/b>1<\/b><\/span>\u56db\u5206\u4f4d<\/b><\/b><\/p>\n

\uff08<\/b><\/span>n<\/b>\uff1d<\/b><\/span>1,452<\/b>\uff09<\/b><\/b><\/span><\/p>\n

<\/b><\/p>\n

\u30ea\u30b9\u30af\u306e\u7b2c<\/b>2<\/b><\/span>\u56db\u5206\u4f4d<\/b><\/b><\/p>\n

\uff08<\/b><\/span>n<\/b>\uff1d<\/b><\/span>1,442<\/b>\uff09<\/b><\/b><\/span><\/p>\n

\u30ea\u30b9\u30af\u306e\u7b2c<\/b>3<\/b><\/span>\u56db\u5206\u4f4d<\/b><\/b><\/p>\n

\uff08<\/b><\/span>n<\/b>\uff1d<\/b><\/span>1,445<\/b>\uff09<\/b><\/b><\/span><\/p>\n

\u30ea\u30b9\u30af\u306e\u7b2c<\/b>4<\/b><\/span>\u56db\u5206\u4f4d<\/b><\/b><\/p>\n

\uff08<\/b><\/span>n<\/b>\uff1d<\/b><\/span>1,446<\/b>\uff09<\/b><\/b><\/span><\/p>\n

<\/b><\/p>\n

\n

SMART2<\/b>\u306b\u3088\u308b<\/b><\/span>3-point MACE<\/b>\u306e\u63a8\u5b9a<\/b><\/span>5<\/b>\u5e74\u30ea\u30b9\u30af\u3001<\/b><\/span>%<\/p>\n

\u5e73\u5747\u5024\uff08\u7bc4\u56f2\uff09<\/p>\n

\n

9.0 (3.6-11.4)<\/p>\n

\n

13.7 (11.5-16.0)<\/p>\n

\n

19.3 (16.1-23.3)<\/p>\n

\n

33.7 (23.4-83.0)<\/p>\n

\n

\u30ea\u30b9\u30af\u56e0\u5b50<\/b><\/b><\/p>\n

\n

\n

\n

\n

\n

\u55ab\u7159\u8005\u3001n<\/span>\uff08%<\/span>\uff09<\/p>\n

101 (7%)<\/p>\n

239 (17%)<\/p>\n

281 (19%)<\/p>\n

335 (23%)<\/p>\n

\n

\n

\u7cd6\u5c3f\u75c5\u3001n<\/span>\uff08%<\/span>\uff09<\/p>\n

236 (16%)<\/p>\n

516 (36%)<\/p>\n

703 (49%)<\/p>\n

946 (65%)<\/p>\n

\n

Non-HDL-C\u3001<\/span>mmol\/L<\/p>\n

3.0\u00b10.5<\/p>\n

3.1\u00b10.5<\/p>\n

3.1\u00b10.5<\/p>\n

3.2\u00b10.5<\/p>\n

\n

\n

CRP\u3001<\/span>mg\/L<\/p>\n

\u4e2d\u592e\u5024\uff08IQR<\/span>\uff09<\/p>\n

1.3 (0.7-2.4)<\/p>\n

2.1 (1.0-3.7)<\/p>\n

2.4 (1.2-4.6)<\/p>\n

3.1 (1.5-6.2)<\/p>\n

\n

\u30c7\u30fc\u30bf\u306f\u7279\u306b\u8a18\u8f09\u306e\u306a\u3044\u9650\u308an<\/span>\uff08%<\/span>\uff09\u307e\u305f\u306f\u5e73\u5747\u5024\u00b1SD<\/span>\u3067\u793a\u3059\u3002<\/p>\n

\u7565\u8a9e\uff1aCRP<\/span>\uff1aC<\/span>\u53cd\u5fdc\u6027\u86cb\u767d\u3001HDL-C<\/span>\uff1a\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001IQR<\/span>\uff1a\u56db\u5206\u4f4d\u7bc4\u56f2<\/p>\n

\n

4.8<\/span>\u5e74\u9593\uff08\u4e2d\u592e\u5024\uff09\u306e\u8ffd\u8de1\u8abf\u67fb\u671f\u9593\u4e2d\u3001MACE<\/span>\u304c\u8a8d\u3081\u3089\u308c\u305f\u60a3\u8005\u306f\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u7fa4\u3067361<\/span>\u4f8b\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067489<\/span>\u4f8b\u3067\u3042\u308a\uff3b\u30cf\u30b6\u30fc\u30c9\u6bd4\uff1d0.72<\/span>\u300195%<\/span>\u4fe1\u983c\u533a\u9593\uff08CI<\/span>\uff09\uff1a0.63<\/span>\uff5e0.82<\/span>\uff3d\u3001\u7d76\u5bfe\u30ea\u30b9\u30af\u6e1b\u5c11\u7387\uff08ARR<\/span>\uff09\u306f4.4%<\/span>\uff082.6<\/span>\uff5e6.2%<\/span>\uff09\u3067\u3042\u3063\u305f\u3002<\/p>\n

\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30ea\u30b9\u30af\u3068\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u306e\u76f8\u5bfe\u6cbb\u7642\u52b9\u679c\u3068\u306e\u9593\u306b\u6709\u610f\u306a\u4ea4\u4e92\u4f5c\u7528\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u304c\uff083-point MACE<\/span>\u306b\u3064\u3044\u3066p<\/span>\uff1d0.106<\/span>\uff09\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3068\u76f8\u5bfe\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u304c\u3084\u3084\u5f31\u307e\u308b\u3088\u3046\u3067\u3042\u3063\u305f\u3002\u3057\u304b\u3057\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u306e\u7d76\u5bfe\u6cbb\u7642\u52b9\u679c\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30ea\u30b9\u30af\u304c\u6700\u3082\u4f4e\u3044\u60a3\u8005\u3067\u3082\u3059\u3067\u306b\u5927\u304d\u304f\uff3b\u7d76\u5bfe\u30ea\u30b9\u30af\u6e1b\u5c11\u7387\uff08ARR<\/span>\uff09\uff1d3.9%<\/span>\uff3d\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u306b\u4f34\u3063\u3066\u5897\u5927\u3057\u305f\uff08\u8868<\/b>2<\/b><\/span>\uff09\u3002<\/p>\n

\n

\u8868<\/b>1.<\/b><\/span>\u3000\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30ea\u30b9\u30af\u306e\u56db\u5206\u4f4d\u5225\u306b\u307f\u305f\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u306e\u76f8\u5bfe\u6cbb\u7642\u52b9\u679c\u3068\u7d76\u5bfe\u6cbb\u7642\u52b9\u679c<\/b><\/b><\/p>\n

\n

\u30ea\u30b9\u30af\u306e\u7b2c<\/b>1<\/b><\/span>\u56db\u5206\u4f4d<\/b><\/b><\/p>\n

\uff08<\/b><\/span>n<\/b>\uff1d<\/b><\/span>1,452<\/b>\uff09<\/b><\/b><\/span><\/p>\n

\n

\u30ea\u30b9\u30af\u306e\u7b2c<\/b>2<\/b><\/span>\u56db\u5206\u4f4d<\/b><\/b><\/p>\n

\uff08<\/b><\/span>n<\/b>\uff1d<\/b><\/span>1,442<\/b>\uff09<\/b><\/b><\/span><\/p>\n

\u30ea\u30b9\u30af\u306e\u7b2c<\/b>3<\/b><\/span>\u56db\u5206\u4f4d<\/b><\/b><\/p>\n

\uff08<\/b><\/span>n<\/b>\uff1d<\/b><\/span>1,445<\/b>\uff09<\/b><\/b><\/span><\/p>\n

\u30ea\u30b9\u30af\u306e\u7b2c<\/b>4<\/b><\/span>\u56db\u5206\u4f4d<\/b><\/b><\/p>\n

\uff08<\/b><\/span>n<\/b>\uff1d<\/b><\/span>1,446<\/b>\uff09<\/b><\/b><\/span><\/p>\n

\n

\n

\u30cf\u30b6\u30fc\u30c9\u6bd4\uff0895% CI<\/span>\uff09<\/p>\n

0.62 (0.43-0.88)<\/p>\n

0.66 (0.48-0.92)<\/p>\n

0.69 (0.53-0.90)<\/p>\n

0.78 (0.63-0.96)<\/p>\n

\n

ARR\u3001<\/span>%\uff08<\/span>95% CI\uff09<\/span><\/p>\n

3.9% (1.0-6.8)<\/p>\n

4.3% (1.2-7.3)<\/p>\n

5.1% (1.4-8.7)<\/p>\n

5.6% (1.3-10.0)<\/p>\n

\n

\u6cbb\u7642\u5fc5\u8981\u6570\uff08NNT<\/span>\uff09<\/p>\n

26 (15-98)<\/p>\n

24 (14-84)<\/p>\n

20 (11-70)<\/p>\n

18 (10-77)<\/p>\n

\n

\n<\/td>\n<\/tr>\n

\n

\u8457\u8005\u306e\u7d50\u8ad6<\/b><\/b><\/p>\n<\/td>\n

\n

\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u9ad8\u5024\u306eASCVD<\/span>\u60a3\u8005\u3067\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eCVD<\/span>\u30ea\u30b9\u30af\u306e\u56db\u5206\u4f4d\u306b\u304b\u304b\u308f\u3089\u305a\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u306b\u3088\u308aMACE<\/span>\u306e\u30ea\u30b9\u30af\u304c\u6709\u610f\u306b\u4f4e\u4e0b\u3059\u308b\u3002\u7d76\u5bfe\u6cbb\u7642\u52b9\u679c\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u306b\u4f34\u3063\u3066\u5897\u5927\u3059\u308b\u304c\u3001\u30ea\u30b9\u30af\u304c\u6700\u4f4e\u56db\u5206\u4f4d\u306e\u60a3\u8005\u3067\u3082\u3059\u3067\u306b\u5927\u304d\u3044\u3002<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u30b3\u30e1\u30f3\u30c8<\/b><\/b><\/p>\n

REDUCE-IT<\/span>\u306e\u6700\u65b0\u306e\u89e3\u6790\u306b\u3088\u308a\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u306e\u7bc4\u56f2\u3092\u901a\u3058\u305f\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u9ad8\u5024\u306eASCVD<\/span>\u60a3\u8005\u306b\u304a\u3051\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u6295\u4e0e\u306e\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002\u6cbb\u7642\u306e\u7d76\u5bfe\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u306f\u3001\u814e\u6a5f\u80fd\u969c\u5bb3\uff08\u63a8\u7b97\u7cf8\u7403\u4f53\u6ffe\u904e\u91cf\uff1c60 mL\/min\/1.73 m2<\/sup><\/span>\uff09\u60a3\u8005\u3001\u51a0\u52d5\u8108\u30d0\u30a4\u30d1\u30b9\u8853\u306e\u65e2\u5f80\u6b74\u306e\u3042\u308b\u60a3\u8005\u3001\u5fc3\u7b4b\u6897\u585e\u306e\u65e2\u5f80\u6b74\u306e\u3042\u308b\u60a3\u8005\u3067\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3082\u306e\u3068\u540c\u7a0b\u5ea6\u3067\u3042\u3063\u305f\uff081-3<\/span>\uff09\u3002\u3053\u306e\u7d50\u679c\u3092\u5f37\u56fa\u306a\u3082\u306e\u3068\u3059\u308b\u8981\u56e0\u3068\u3057\u3066\u3001\u59a5\u5f53\u6027\u304c\u78ba\u8a8d\u3055\u308c\u305f\u30ea\u30b9\u30af\u30e2\u30c7\u30eb\uff08SMART2<\/span>\uff09\u3092\u7528\u3044\u305f\u3053\u3068\u3001\u307e\u305f\u3001\u56fa\u6709\u306e\u9650\u754c\u3092\u4f34\u3046\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u3092\u4f7f\u7528\u305b\u305a\u306b\u3001\u591a\u5909\u91cf\u30ea\u30b9\u30af\u30e2\u30c7\u30eb\u3067\u63a8\u5b9a\u3057\u305f\u6cbb\u7642\u3068\u500b\u3005\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30ea\u30b9\u30af\u3068\u306e\u4ea4\u4e92\u4f5c\u7528\u3092\u8a55\u4fa1\u3057\u305f\u3053\u3068\u304c\u6319\u3052\u3089\u308c\u308b\u3002<\/p>\n

\n

\u91cd\u8981\u306a\u6240\u898b\u3068\u3057\u3066\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u306e\u7d76\u5bfe\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u306b\u4f34\u3063\u3066\u5897\u5927\u3057\uff08NNT<\/span>\u3082\u6e1b\u5c11\u3057\uff09\u3001\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u8005\u306b\u304a\u3051\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u306e\u6295\u4e0e\u306b\u95a2\u3059\u308b\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306e\u63a8\u5968\u4e8b\u9805\u3068\u4e00\u81f4\u3057\u305f\uff084<\/span>\uff09\u3002\u305d\u306e\u4e00\u65b9\u3067\u3001\u6ce8\u76ee\u3059\u3079\u304d\u70b9\u3068\u3057\u3066\u3001\u30ea\u30b9\u30af\u306e\u56db\u5206\u4f4d\u304c\u6700\u3082\u4f4e\u3044\u60a3\u8005\u3067\u3082\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u6295\u4e0e\u306e\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u306f\u3059\u3067\u306b\u5927\u304d\u304b\u3063\u305f\uff08ARR<\/span>\uff1d3.9%<\/span>\uff09\u3002\u3053\u308c\u3089\u306e\u4f4e\u30ea\u30b9\u30af\u60a3\u8005\u306f\u4e00\u822c\u306b\u4f59\u547d\u304c\u9577\u3044\u3053\u3068\u3092\u8003\u616e\u3059\u308b\u3068\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u306e\u9577\u671f\u9593\u306e\u6295\u4e0e\u3067\u306f\u3001ASCVD<\/span>\u304a\u3088\u3073\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u9ad8\u5024\u3092\u4f34\u3046\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306e\u5834\u5408\u3088\u308a\u3082\u3001\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u4f4e\u6e1b\u306b\u3088\u308b\u751f\u6daf\u306e\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u306f\u5927\u304d\u304f\u306a\u308b\u3068\u4e88\u60f3\u3055\u308c\u308b\u3002<\/p>\n

\n

References<\/b><\/p>\n

1. Majithia A, Bhatt DL, Friedman AN, et al. Benefits of icosapent ethyl across the range of kidney function in patients with established cardiovascular disease or diabetes: REDUCE-IT RENAL. Circulation 2021;144:1750-9.<\/p>\n

2. Verma S, Bhatt DL, Steg PG, et al. Icosapent ethyl reduces ischemic events in patients with a history of previous coronary artery bypass grafting: REDUCE-IT CABG. Circulation 2021;144:1845-55.<\/p>\n

3. Gaba P, Bhatt DL, Steg PG, et al. Prevention of cardiovascular events and mortality with icosapent ethyl in patients with prior myocardial infarction. J Am Coll Cardiol 2022;79:1660-71.<\/p>\n

4. Visseren FLJ, Mach F, Smulders YM, et al. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J 2021;42:3227-337.<\/p>\n

Key words:\u00a0 <\/span>Residual cardiovascular risk; REDUCE-IT; absolute risk reduction; icosapent ethyl.<\/i><\/p>\n

 <\/p>\n

 <\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

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