{"id":255186,"date":"2025-03-05T23:37:43","date_gmt":"2025-03-05T22:37:43","guid":{"rendered":"https:\/\/r3i.org\/prominent%e8%a9%a6%e9%a8%93%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%e3%81%ae%e6%b7%b1%e3%81%84%e6%b4%9e%e5%af%9f\/"},"modified":"2025-03-06T22:10:59","modified_gmt":"2025-03-06T21:10:59","slug":"prominent%e8%a9%a6%e9%a8%93%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%e3%81%ae%e6%b7%b1%e3%81%84%e6%b4%9e%e5%af%9f","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/prominent%e8%a9%a6%e9%a8%93%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%e3%81%ae%e6%b7%b1%e3%81%84%e6%b4%9e%e5%af%9f\/","title":{"rendered":"PROMINENT\u8a66\u9a13\u306b\u3064\u3044\u3066\u306e\u6df1\u3044\u6d1e\u5bdf"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]<\/p>\n

PROMINENT\u8a66\u9a13\u306b\u3064\u3044\u3066\u306e\u6df1\u3044\u6d1e\u5bdf<\/h2>\n

2024\u5e745\u6708<\/span><\/h5>\n

Copenhagen General Population Study Group<\/i><\/span>\u306e\u89e3\u6790\u306b\u3088\u308b\u3068\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306ePROMINENT<\/i><\/span>\u8a66\u9a13\u306b\u304a\u3051\u308b\u4e2d\u7acb\u7684\u306a\u7d50\u679c\u306f\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C<\/i><\/span>\uff09\u304a\u3088\u3073\u30a2\u30dd\u30ea\u30dd\u86cb\u767d\uff08apo<\/i><\/span>\uff09B<\/i><\/span>\u306e\u7d76\u5bfe\u8cea\u91cf\u5909\u5316\u91cf\u306b\u3088\u3063\u3066\u8aac\u660e\u3067\u304d\u308b\u3002<\/p>\n

Doi T, Langsted A, Nordestgaard BG. PROMINENT<\/i>\u8a66\u9a13\u306e\u7d50\u679c\u306f\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001<\/span>LDL<\/i>\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304a\u3088\u3073<\/span>apoB<\/i>\u306e\u7d76\u5bfe\u8cea\u91cf\u5909\u5316\u91cf\u306b\u3088\u3063\u3066\u8aac\u660e\u53ef\u80fd\u3002<\/span>Atherosclerosis 2024;393:117556<\/i><\/p>\n

\u8a66\u9a13\u306e\u8981\u7d04<\/b><\/p>\n

\n\n\n\n\n\n\n\n
\n

\u76ee\u7684<\/b><\/b><\/p>\n<\/td>\n

\n

PROMINENT\u8a66\u9a13\u306e\u5bfe\u8c61\u96c6\u56e3\u3092\u6a21\u5023\u3059\u308b\u305f\u3081\u306b<\/span>Copenhagen General Population Study\u3092\u7528\u3044\u3001<\/span>PROMINENT\uff08<\/span>Pemafibrate to Reduce Cardiovascular OutcoMes by Reducing Triglycerides IN patiENts With diabeTes\uff09\u8a66\u9a13\u306e\u7d50\u679c\u306f\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001<\/span>LDL-C\u304a\u3088\u3073<\/span>apoB\u306e\u7d76\u5bfe\u8cea\u91cf\u5909\u5316\u91cf\u306b\u3088\u3063\u3066\u8aac\u660e\u3067\u304d\u308b\u3068\u3044\u3046\u4eee\u8aac\u3092\u691c\u8a3c\u3059\u308b\u3002<\/span><\/p>\n

\n<\/td>\n<\/tr>\n

\n

\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/b><\/b><\/p>\n<\/td>\n

\n

Copenhagen General Population Study\uff08<\/span>CGPS\uff09\u306f\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3067\u3042\u308a\u3001<\/span>Danish Civil Registration System\u304b\u3089\u7121\u4f5c\u70ba\u306b\u62bd\u51fa\u3057\u305f<\/span>20\u6b73\u4ee5\u4e0a\u306e\u6210\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\uff08\u88ab\u9a13\u8005\u767b\u9332\u671f\u9593<\/span>2003\uff5e<\/span>2015\u5e74\uff09\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u7814\u7a76\u5bfe\u8c61\u96c6\u56e3<\/b><\/b><\/p>\n<\/td>\n

\n

PROMINENT<\/span>\u8a66\u9a13\u306e\u4e3b\u306a\u9078\u629e\u57fa\u6e96\u3092\u7528\u3044\u3001\u3059\u3079\u3066\u306e\u8102\u8cea\u7279\u6027\u306b\u95a2\u3059\u308b\u5b8c\u5168\u306a\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u60c5\u5831\u3092\u6709\u3059\u308b\u9069\u683c\u306a\u88ab\u9a13\u8005108,431<\/span>\u4f8b\u304b\u3089\u89e3\u6790\u30b3\u30db\u30fc\u30c8\u3092\u9078\u629e\u3057\u305f\u3002<\/p>\n

\n<\/td>\n<\/tr>\n

\n

\u4e3b\u8981\u7814\u7a76\u8a55\u4fa1\u9805\u76ee<\/b><\/b><\/p>\n

<\/b><\/p>\n<\/td>\n

\n

\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\uff1a<\/b>PROMINENT<\/span>\u8a66\u9a13\u306e\u8907\u5408\u7684\u306a\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\uff08\u5fc3\u8840\u7ba1\u6b7b\u3001\u5fc3\u7b4b\u6897\u585e\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u304a\u3088\u3073\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\uff09<\/p>\n

\u4e3b\u306a\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\uff1a<\/b>\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001LDL-C<\/span>\u3001apoB<\/span>\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG<\/span>\uff09\u304a\u3088\u3073\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff3b\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff0dLDL-C<\/span>\uff0d\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08HDL-C<\/span>\uff09\u3068\u3057\u3066\u7b97\u51fa\uff3d\u7b49\u306e\u8102\u8cea\u7279\u6027\u306e\u7d76\u5bfe\u5909\u5316\u91cf\u304a\u3088\u3073\u5909\u5316\u7387\u3002TG<\/span>\u304c354 mg\/dL<\/span>\uff084.0 mmol\/L<\/span>\uff09\u672a\u6e80\u306e\u5834\u5408\u306fLDL-C<\/span>\u306e\u7b97\u51fa\u306bFriedewald<\/span>\u5f0f\u3092\u7528\u3044\u305f\u3002<\/p>\n

\n<\/td>\n<\/tr>\n

\n

\u65b9\u6cd5<\/b><\/b><\/p>\n<\/td>\n

\n

CGPS<\/span>\u306e\u7cd6\u5c3f\u75c5\u3092\u6709\u3059\u308b\u88ab\u9a13\u8005\u306e\u3046\u3061\u3001\u8a66\u9a13\u767b\u9332\u6642\u306b\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\u3092\u53d7\u3051\u3001\uff08i<\/span>\uff09\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff08ASCVD<\/span>\uff09\u3092\u6709\u3059\u308b18<\/span>\u6b73\u4ee5\u4e0a\u306e\u88ab\u9a13\u8005\u3001\uff08ii<\/span>\uff09ASCVD<\/span>\u306e\u65e2\u5f80\u6b74\u306e\u306a\u304450<\/span>\u6b73\u4ee5\u4e0a\u306e\u7537\u6027\u3001\u307e\u305f\u306f\uff08iii<\/span>\uff09ASCVD<\/span>\u306e\u65e2\u5f80\u6b74\u306e\u306a\u304455<\/span>\u6b73\u4ee5\u4e0a\u306e\u5973\u6027\u3092\u89e3\u6790\u5bfe\u8c61\u3068\u3057\u305f\u3002\u6cbb\u7642\u6b74\u306e\u306a\u3044\u60a3\u8005\u3068\u6cbb\u7642\u6b74\u306e\u3042\u308b\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u8a66\u9a13\u30c7\u30b6\u30a4\u30f3\u3092\u6a21\u5023\u3059\u308b\u305f\u3081\u3001\u89e3\u6790\u5bfe\u8c61\u306b\u306f\u305d\u308c\u305e\u308cTG<\/span>\uff08\u307e\u305f\u306f\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff09\u9ad8\u5024\u304a\u3088\u3073\u4f4e\u5024\u306e\u4e21\u60a3\u8005\u304c\u5fc5\u8981\u3067\u3042\u308a\u3001\u8840\u6f3fTG<\/span>\u5024200 mg\/dL<\/span>\uff082.26 mmol\/L<\/span>\uff09\u672a\u6e80\u307e\u305f\u306f499 mg\/dL<\/span>\uff085.63 mmol\/L<\/span>\uff09\u8d85\u306e\u88ab\u9a13\u8005\u3092\u9664\u5916\u3057\u306a\u304b\u3063\u305f\u3002\u611f\u5ea6\u5206\u6790\u306f\u3001CGPS<\/span>\u306e\u5168\u88ab\u9a13\u8005\u306e\u3046\u3061\u3001\u8840\u6f3fTG<\/span>\u5024\u304c200<\/span>\uff5e499 mg\/dL<\/span>\uff082.26<\/span>\uff5e5.63 mmol\/L<\/span>\uff09\u306e\u88ab\u9a13\u8005\u306e\u307f\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3002\u3053\u306ePROMINENT<\/span>\u8a66\u9a13\u5bfe\u8c61\u3092\u6a21\u5023\u3057\u305fCGPS<\/span>\u30b3\u30db\u30fc\u30c8\u306b\u304a\u3044\u3066\u3001ASCVD<\/span>\u30ea\u30b9\u30af\u304c\u3001CGPS<\/span>\u3067\u89b3\u5bdf\u3055\u308c\u305f\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001LDL-C<\/span>\u304a\u3088\u3073apoB<\/span>\u306e\u7d76\u5bfe\u8cea\u91cf\u5909\u5316\u91cf\u306b\u3088\u3063\u3066\u8aac\u660e\u3067\u304d\u308b\u304b\u3092\u8a55\u4fa1\u3057\u305f\u3002\u3053\u308c\u3089\u306eASCVD<\/span>\u30ea\u30b9\u30af\u306e\u63a8\u5b9a\u5909\u5316\u91cf\u3092PROMINENT<\/span>\u8a66\u9a13\u3067\u89b3\u5bdf\u3055\u308c\u305f\u5bfe\u5fdc\u3059\u308b\u5909\u5316\u91cf\u3068\u6bd4\u8f03\u3057\u305f\u3002<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\n

\n\n\n\n\n
\n

\u7d50\u679c<\/b><\/b><\/p>\n<\/td>\n

\n

CGPS<\/span>\u306e\u88ab\u9a13\u80052,487<\/span>\u4f8b\u304cPROMINENT<\/span>\u8a66\u9a13\u306e\u4e3b\u306a\u9078\u629e\u57fa\u6e96\u3092\u6e80\u305f\u3057\u305f\uff08PROMINENT<\/span>\u8a66\u9a13\u6a21\u5023CGPS<\/span>\u30b3\u30db\u30fc\u30c8\uff09\u3002PROMINENT<\/span>\u8a66\u9a13\u304a\u3088\u3073PROMINENT<\/span>\u8a66\u9a13\u6a21\u5023CGPS<\/span>\u30b3\u30db\u30fc\u30c8\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u7279\u6027\u3092\u8868<\/b>1<\/b><\/span>\u306b\u8981\u7d04\u3059\u308b\u3002<\/p>\n

<\/b><\/p>\n

\u8868<\/b><\/span>1.<\/b>\u3000\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u7279\u6027\uff08<\/b><\/span>PROMINENT<\/b>\u8a66\u9a13<\/b><\/span> vs. PROMINENT<\/b>\u8a66\u9a13\u6a21\u5023<\/b><\/span>CGPS<\/b>\u30b3\u30db\u30fc\u30c8\uff09<\/b><\/b><\/span><\/p>\n

<\/b><\/p>\n

PROMINENT<\/b>\u8a66\u9a13<\/b><\/b><\/span><\/p>\n

\uff08<\/span>n=10,497\uff09<\/span><\/p>\n

<\/b><\/p>\n

PROMINENT<\/b>\u6a21\u5023<\/b><\/span>CGPS<\/b>\u30b3\u30db\u30fc\u30c8<\/b><\/b><\/span><\/p>\n

\uff08<\/span>n=2,487\uff09<\/span><\/p>\n

\n

\u5e73\u5747\u5e74\u9f62\u3001\u6b73<\/p>\n

64<\/p>\n

68<\/p>\n

\n

\u5973\u6027\u306e\u5272\u5408\u3001%<\/span><\/p>\n

28%<\/p>\n

39%<\/p>\n

\n

\u4f53\u683c\u6307\u6570\u3001g\/m2<\/sup><\/sup><\/span><\/p>\n

32 (29\u201336)<\/p>\n

29 (26\u201332)<\/p>\n

\n

ASCVD\u65e2\u5f80\u6b74\u3001<\/span>%<\/p>\n

67%<\/p>\n

22%<\/p>\n

\n

\u7cd6\u5c3f\u75c5\u3001%<\/span><\/p>\n

100%<\/p>\n

100%<\/p>\n

\n

\u30b9\u30bf\u30c1\u30f3\u4f7f\u7528\u3001%<\/span><\/p>\n

96%<\/p>\n

100%<\/p>\n

\n

\u8ffd\u8de1\u8abf\u67fb\u671f\u9593\u4e2d\u592e\u5024\u3001\u5e74<\/p>\n

3.4<\/p>\n

7.2<\/p>\n

\n

\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08\u7b97\u51fa\u5024\uff09\u3001mg\/dL<\/span><\/p>\n

47 (38\u201360)<\/p>\n

31 (21\u201344)<\/p>\n

\n

LDL-C\u3001<\/span>mg\/dL<\/p>\n

79 (60\u2013104)<\/p>\n

75 (60\u201393)<\/p>\n

\n

Non-HDL-C\u3001<\/span>mg\/dL<\/p>\n

128 (106\u2013159)<\/p>\n

109 (89\u2013131)<\/p>\n

\n

ApoB\u3001<\/span>mg\/dL<\/p>\n

90 (75\u2013108)<\/p>\n

89 (73\u2013110)<\/p>\n

\n

TG\u3001<\/span>mg\/dL<\/p>\n

273 (227\u2013342)<\/p>\n

159 (108\u2013230<\/p>\n

\n

\n

\n

\n

\n

\u8ffd\u8de1\u8abf\u67fb\u671f\u9593\u4e2d\u306eASCVD<\/span><\/p>\n

\n

\n

\n

\u4ef6\u6570<\/p>\n

1,132<\/p>\n

504<\/p>\n

\n

\u4ef6<\/span>\/1,000\u4eba<\/span>\u30fb\u5e74<\/span><\/p>\n

32<\/p>\n

28<\/p>\n

\n

\u7565\u8a9e\uff1aapo<\/span>\uff1a\u30a2\u30dd\u30ea\u30dd\u86cb\u767d\u3001ASCVD<\/span>\uff1a\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u3001HDL-C<\/span>\uff1a\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001LDL-C<\/span>\uff1a\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001TG<\/span>\uff1a\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9<\/p>\n

\n

PROMINENT<\/span>\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u6295\u4e0e\u306b\u3088\u308b\u5909\u5316\u91cf\u306f\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\uff0d7 mg\/dL<\/span>\uff08\uff0d0.18 mmol\/L<\/span>\u3001\uff0d18%<\/span>\uff09\u3001LDL-C<\/span>\u304c\uff0b10 mg\/dL<\/span>\uff08\uff0b0.26 mmol\/L<\/span>\u3001\uff0b12%<\/span>\uff09\u3001apoB<\/span>\u304c\uff0b5 mg\/dL<\/span>\uff08\uff0b0.05 g\/L<\/span>\u3001\uff0b5%<\/span>\uff09\u3067\u3042\u3063\u305f\u3002PROMINENT<\/span>\u8a66\u9a13\u6a21\u5023CGPS<\/span>\u30b3\u30db\u30fc\u30c8\u306b\u304a\u3051\u308b\u8102\u8cea\u5909\u5316\u91cf\u3054\u3068\u306eASCVD<\/span>\u30ea\u30b9\u30af\u3092\u3001\u5404\u8102\u8cea\u304a\u3088\u3073\u8907\u6570\u306e\u8102\u8cea\u306e\u4f75\u5408\u306b\u3064\u3044\u3066\u3001\u8868<\/b>2<\/b><\/span>\u306b\u8981\u7d04\u3059\u308b\u3002\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001LDL-C<\/span>\u304a\u3088\u3073apoB<\/span>\u306e\u7d76\u5bfe\u8cea\u91cf\u5909\u5316\u91cf\u3092\u4f75\u5408\u3057\u305f\u5834\u5408\u3001ASCVD<\/span>\u306e\u63a8\u5b9a\u30cf\u30b6\u30fc\u30c9\u6bd4\u306f\u3001PROMINENT<\/span>\u8a66\u9a13\u6a21\u5023CGPS<\/span>\u30b3\u30db\u30fc\u30c8\u30671.05<\/span>\uff080.96<\/span>\uff5e1.14<\/span>\uff09\u3001PROMINENT<\/span>\u8a66\u9a13\u30671.03<\/span>\uff080.91<\/span>\uff5e1.15<\/span>\uff09\u3067\u3042\u3063\u305f\u3002<\/p>\n

\n

\u8868<\/b>2.<\/b><\/span>\u3000<\/b>PROMINENT<\/b><\/span>\u8a66\u9a13\u306e\u8102\u8cea\u5909\u5316\u91cf\u3068<\/b>PROMINENT<\/b><\/span>\u8a66\u9a13\u6a21\u5023<\/b>CGPS<\/b><\/span>\u30b3\u30db\u30fc\u30c8\u306b\u304a\u3051\u308b\u5bfe\u5fdc\u3059\u308b<\/b>ASCVD<\/b><\/span>\u30ea\u30b9\u30af<\/b><\/b><\/p>\n

<\/b><\/p>\n

PROMINENT<\/b>\u8a66\u9a13\u306e\u8102\u8cea\u5909\u5316\u91cf<\/b><\/b><\/span><\/p>\n

PROMINENT<\/b>\u8a66\u9a13\u6a21\u5023<\/b><\/span>CGPS<\/b>\u30b3\u30db\u30fc\u30c8\u306b\u304a\u3051\u308b\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08<\/b><\/span>95% CI<\/b>\uff09<\/b><\/b><\/span><\/p>\n

<\/b><\/p>\n

\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff1a\uff0d<\/span>7 mg\/dL\uff08\uff0d<\/span>0.18 mmol\/L\uff09<\/span><\/p>\n

0.97 (0.94-0.99)<\/p>\n

\n

LDL-C\uff1a\uff0b<\/span>10 mg\/dL\uff08\uff0b<\/span>0.26 mmol\/L\uff09<\/span><\/p>\n

1.04 (1.01-1.07)<\/p>\n

\n

non-HDL-C<\/b>\uff1a\uff0b<\/b><\/span>3 mg\/dL<\/b>\uff08\uff0b<\/b><\/span>0.08 mmol\/L<\/b>\uff09<\/b><\/b><\/span><\/p>\n

1.01 (1.00-1.02)<\/p>\n

\n

apoB<\/b>\uff1a\uff0b<\/b><\/span>5 mg\/dL<\/b>\uff08\uff0b<\/b><\/span>0.05 g\/L<\/b>\uff09<\/b><\/b><\/span><\/p>\n

1.02 (1.01-1.03)<\/p>\n

\n

\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff0bLDL-C<\/span>\uff0bapoB<\/span>\u306e\u7d76\u5bfe\u8cea\u91cf\u5909\u5316\u91cf<\/p>\n

1.05 (0.96\u20131.14)<\/p>\n

\n

non-HDL-C\uff0b<\/span>apoB\u306e\u7d76\u5bfe\u5909\u5316\u91cf<\/span><\/p>\n

1.02 (1.00\u20131.03).<\/p>\n

\n

\n<\/td>\n<\/tr>\n

\n

\u8457\u8005\u306e\u7d50\u8ad6<\/b><\/b><\/p>\n<\/td>\n

\n

\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001LDL-C<\/span>\u304a\u3088\u3073apoB<\/span>\u306e\u7d76\u5bfe\u8cea\u91cf\u5909\u5316\u91cf\u306b\u3088\u3063\u3066PROMINENT<\/span>\u8a66\u9a13\u306e\u7d50\u679c\u3092\u8aac\u660e\u3067\u304d\u308b\u3002\u30a2\u30c6\u30ed\u30fc\u30e0\u4fc3\u9032\u6027\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5168\u4f53\u304c3 mg\/dL<\/span>\uff080.08 mmol\/L<\/span>\uff09\u9ad8\u304f\u3001apoB<\/span>\u304c5 mg\/dL<\/span>\uff080.05 g\/L<\/span>\uff09\u9ad8\u3044\u3053\u3068\u3067\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u7fa4\u3067ASCVD<\/span>\u304c\u591a\u3044\u50be\u5411\u3092\u8aac\u660e\u3067\u304d\u308b\u3068\u601d\u308f\u308c\u308b\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001ASCVD<\/span>\u3092\u6291\u5236\u3059\u308b\u306b\u306f\u3001TG<\/span>\u304a\u3088\u3073\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u85ac\u5264\u306b\u3088\u308a\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u4fc3\u9032\u6027\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5168\u4f53\uff08LDL-C<\/span>\u304a\u3088\u3073\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff09\u3068\u30a2\u30c6\u30ed\u30fc\u30e0\u4fc3\u9032\u6027\u30ea\u30dd\u86cb\u767d\u5168\u4f53\uff08apoB<\/span>\u304c\u6307\u6a19\uff09\u3092\u6e1b\u5c11\u3055\u305b\u308b\u5fc5\u8981\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u308b\u3002<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u30b3\u30e1\u30f3\u30c8<\/b><\/b><\/p>\n

\u6839\u62e0\u304c\u5341\u5206\u306b\u793a\u3055\u308c\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\uff081<\/span>\uff09\u3001PROMINENT<\/span>\u8a66\u9a13\u306e\u7d50\u679c\u306f\u4f9d\u7136\u3068\u3057\u3066\u4e2d\u7acb\u7684\u306a\u3082\u306e\u3067\u3042\u308a\u3001\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3067\u3042\u308b4<\/span>\u9805\u76ee\u306e\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08MACE<\/span>\uff09\u306b\u5bfe\u3059\u308b\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u52b9\u679c\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\uff082<\/span>\uff09\u3002\u3053\u306e\u7406\u7531\u306b\u3064\u3044\u3066\u306f\u591a\u304f\u8b70\u8ad6\u3055\u308c\u3066\u3044\u308b\u3002\u4eca\u56de\u306e\u6700\u65b0\u306e\u5831\u544a\u3067\u306f\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001LDL-C<\/span>\u304a\u3088\u3073apoB<\/span>\u306e\u7d76\u5bfe\u8cea\u91cf\u5909\u5316\u91cf\u3067\u3053\u308c\u3089\u306e\u7d50\u679c\u3092\u8aac\u660e\u53ef\u80fd\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002\u3059\u306a\u308f\u3061\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u4fc3\u9032\u6027\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5168\u4f53\u304c3 mg\/dL<\/span>\uff080.08 mmol\/L<\/span>\uff09\u9ad8\u304f\u3001apoB<\/span>\u304c5 mg\/dL<\/span>\uff080.05 g\/L<\/span>\uff09\u9ad8\u3044\u3053\u3068\u306b\u3088\u308a\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u7fa4\u3067MACE<\/span>\u304c\u591a\u3044\u50be\u5411\u3092\u8aac\u660e\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\u3002\u672c\u7814\u7a76\u306e\u7814\u7a76\u8005\u3089\u306f\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af\u306e\u5927\u304d\u3055\u3092\u6c7a\u3081\u308b\u4e3b\u8981\u56e0\u5b50\u306f\u52d5\u8108\u5185\u819c\u306b\u6c88\u7740\u3059\u308b\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u7dcf\u8cea\u91cf\u3067\u3042\u308a\u3001\u8cea\u91cf\u3068\u3057\u3066\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u542b\u6709\u91cf\u306e\u65b9\u304c\uff08\u8102\u8cea\u306e\u5909\u5316\u7387\u307e\u305f\u306f\u7d76\u5bfe\u5909\u5316\u91cf\u3088\u308a\u3082\uff09\u91cd\u8981\u3067\u3042\u308b\u53ef\u80fd\u6027\u3092\u63d0\u793a\u3057\u3066\u3044\u308b\u3002\u672c\u7814\u7a76\u7d50\u679c\u3092\u5f37\u56fa\u306a\u3082\u306e\u3068\u3059\u308b\u8981\u56e0\u3068\u3057\u3066\u3001PROMINENT<\/span>\u8a66\u9a13\u306e\u4e3b\u306a\u9078\u629e\u57fa\u6e96\u3092\u6e80\u305f\u3059CGPS<\/span>\u306e\u88ab\u9a13\u8005\u304c\u591a\u6570\u3044\u308b\u3053\u3068\u3001\u8102\u8cea\u5024\u3068ASCVD<\/span>\u306b\u95a2\u3059\u308b\u65e2\u77e5\u306e\u6f5c\u5728\u7684\u4ea4\u7d61\u56e0\u5b50\u304c\u8003\u616e\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3001\u8ffd\u8de1\u4e0d\u80fd\u4f8b\u304c\u3044\u306a\u3044\u3053\u3068\u304c\u6319\u3052\u3089\u308c\u308b\u3002\u307e\u305f\u3001CGPS<\/span>\u306f\u3001\u4ed6\u306e\u81e8\u5e8a\u8a66\u9a13\u306b\u306f\u53c2\u52a0\u3057\u3066\u3044\u306a\u3044\u4e00\u822c\u96c6\u56e3\u304b\u3089\u88ab\u9a13\u8005\u3092\u7d44\u307f\u5165\u308c\u3066\u304a\u308a\u3001\u9078\u629e\u30d0\u30a4\u30a2\u30b9\u304c\u6700\u5c0f\u9650\u306b\u6291\u3048\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\n

\n

\u672c\u89e3\u6790\u306f\u3001\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u60a3\u8005\u306e\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u306b\u306fLDL-C<\/span>\u3068\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u3069\u3061\u3089\u304c\u3088\u308a\u91cd\u8981\u304b\u3068\u3044\u3046\u7591\u554f\u306b\u53d6\u308a\u7d44\u3080\u3046\u3048\u3067\u3001\u81e8\u5e8a\u7684\u306b\u610f\u5473\u306e\u3042\u308b\u3082\u306e\u3067\u3042\u308b\u3002\u4eca\u56de\u306e\u7d50\u679c\u304b\u3089\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b\u85ac\u306fLDL-C<\/span>\u3068\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e21\u8005\u3001\u307e\u305fapoB<\/span>\u3092\u542b\u3080\u30a2\u30c6\u30ed\u30fc\u30e0\u4fc3\u9032\u6027\u30ea\u30dd\u86cb\u767d\u306e\u7dcf\u6570\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3059\u3079\u304d\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u308b\u3002<\/p>\n

\n

References<\/b><\/p>\n

1. Pradhan AD, Paynter NP, Everett BM, et al. Rationale and design of the Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes (PROMINENT) study. Am Heart J 2018;206:80-93.<\/p>\n

2. Das Pradhan A, Glynn RJ, Fruchart JC, et al. Triglyceride lowering with pemafibrate to reduce cardiovascular risk. N Engl J Med 2022;387:1923-34.<\/p>\n

Key words: PROMINENT; pemafibrate; Copenhagen General Population Study; total atherogenic cholesterol; total atherogenic lipoprotein particles<\/i><\/p>\n<\/div>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

PROMINENT\u8a66\u9a13\u306b\u3064\u3044\u3066\u306e\u6df1\u3044\u6d1e\u5bdf 2024\u5e745\u6708 Copenhagen General Populat […]<\/p>\n","protected":false},"author":258497325,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_crdt_document":"","jetpack_post_was_ever_published":false,"footnotes":""},"class_list":["post-255186","page","type-page","status-publish","hentry"],"yoast_head":"\nPROMINENT\u8a66\u9a13\u306b\u3064\u3044\u3066\u306e\u6df1\u3044\u6d1e\u5bdf - R3I<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/r3i.org\/ja\/prominent%e8%a9%a6%e9%a8%93%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%e3%81%ae%e6%b7%b1%e3%81%84%e6%b4%9e%e5%af%9f\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PROMINENT\u8a66\u9a13\u306b\u3064\u3044\u3066\u306e\u6df1\u3044\u6d1e\u5bdf - R3I\" \/>\n<meta property=\"og:description\" content=\"PROMINENT\u8a66\u9a13\u306b\u3064\u3044\u3066\u306e\u6df1\u3044\u6d1e\u5bdf 2024\u5e745\u6708 Copenhagen General Populat […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/r3i.org\/ja\/prominent%e8%a9%a6%e9%a8%93%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%e3%81%ae%e6%b7%b1%e3%81%84%e6%b4%9e%e5%af%9f\/\" \/>\n<meta property=\"og:site_name\" content=\"R3I\" \/>\n<meta property=\"article:modified_time\" content=\"2025-03-06T21:10:59+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/r3i.org\/ja\/prominent%e8%a9%a6%e9%a8%93%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%e3%81%ae%e6%b7%b1%e3%81%84%e6%b4%9e%e5%af%9f\/\",\"url\":\"https:\/\/r3i.org\/ja\/prominent%e8%a9%a6%e9%a8%93%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%e3%81%ae%e6%b7%b1%e3%81%84%e6%b4%9e%e5%af%9f\/\",\"name\":\"PROMINENT\u8a66\u9a13\u306b\u3064\u3044\u3066\u306e\u6df1\u3044\u6d1e\u5bdf - R3I\",\"isPartOf\":{\"@id\":\"https:\/\/r3i.org\/ja\/#website\"},\"datePublished\":\"2025-03-05T22:37:43+00:00\",\"dateModified\":\"2025-03-06T21:10:59+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/r3i.org\/ja\/prominent%e8%a9%a6%e9%a8%93%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%e3%81%ae%e6%b7%b1%e3%81%84%e6%b4%9e%e5%af%9f\/#breadcrumb\"},\"inLanguage\":\"ja\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/r3i.org\/ja\/prominent%e8%a9%a6%e9%a8%93%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%e3%81%ae%e6%b7%b1%e3%81%84%e6%b4%9e%e5%af%9f\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/r3i.org\/ja\/prominent%e8%a9%a6%e9%a8%93%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%e3%81%ae%e6%b7%b1%e3%81%84%e6%b4%9e%e5%af%9f\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/r3i.org\/ja\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"PROMINENT\u8a66\u9a13\u306b\u3064\u3044\u3066\u306e\u6df1\u3044\u6d1e\u5bdf\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/r3i.org\/ja\/#website\",\"url\":\"https:\/\/r3i.org\/ja\/\",\"name\":\"R3I\",\"description\":\"Residual Risk Reduction Initiative\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/r3i.org\/ja\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ja\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"PROMINENT\u8a66\u9a13\u306b\u3064\u3044\u3066\u306e\u6df1\u3044\u6d1e\u5bdf - R3I","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/r3i.org\/ja\/prominent%e8%a9%a6%e9%a8%93%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%e3%81%ae%e6%b7%b1%e3%81%84%e6%b4%9e%e5%af%9f\/","og_locale":"ja_JP","og_type":"article","og_title":"PROMINENT\u8a66\u9a13\u306b\u3064\u3044\u3066\u306e\u6df1\u3044\u6d1e\u5bdf - R3I","og_description":"PROMINENT\u8a66\u9a13\u306b\u3064\u3044\u3066\u306e\u6df1\u3044\u6d1e\u5bdf 2024\u5e745\u6708 Copenhagen General Populat […]","og_url":"https:\/\/r3i.org\/ja\/prominent%e8%a9%a6%e9%a8%93%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%e3%81%ae%e6%b7%b1%e3%81%84%e6%b4%9e%e5%af%9f\/","og_site_name":"R3I","article_modified_time":"2025-03-06T21:10:59+00:00","twitter_card":"summary_large_image","twitter_misc":{"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593":"2\u5206"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/r3i.org\/ja\/prominent%e8%a9%a6%e9%a8%93%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%e3%81%ae%e6%b7%b1%e3%81%84%e6%b4%9e%e5%af%9f\/","url":"https:\/\/r3i.org\/ja\/prominent%e8%a9%a6%e9%a8%93%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%e3%81%ae%e6%b7%b1%e3%81%84%e6%b4%9e%e5%af%9f\/","name":"PROMINENT\u8a66\u9a13\u306b\u3064\u3044\u3066\u306e\u6df1\u3044\u6d1e\u5bdf - R3I","isPartOf":{"@id":"https:\/\/r3i.org\/ja\/#website"},"datePublished":"2025-03-05T22:37:43+00:00","dateModified":"2025-03-06T21:10:59+00:00","breadcrumb":{"@id":"https:\/\/r3i.org\/ja\/prominent%e8%a9%a6%e9%a8%93%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%e3%81%ae%e6%b7%b1%e3%81%84%e6%b4%9e%e5%af%9f\/#breadcrumb"},"inLanguage":"ja","potentialAction":[{"@type":"ReadAction","target":["https:\/\/r3i.org\/ja\/prominent%e8%a9%a6%e9%a8%93%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%e3%81%ae%e6%b7%b1%e3%81%84%e6%b4%9e%e5%af%9f\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/r3i.org\/ja\/prominent%e8%a9%a6%e9%a8%93%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%e3%81%ae%e6%b7%b1%e3%81%84%e6%b4%9e%e5%af%9f\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/r3i.org\/ja\/"},{"@type":"ListItem","position":2,"name":"PROMINENT\u8a66\u9a13\u306b\u3064\u3044\u3066\u306e\u6df1\u3044\u6d1e\u5bdf"}]},{"@type":"WebSite","@id":"https:\/\/r3i.org\/ja\/#website","url":"https:\/\/r3i.org\/ja\/","name":"R3I","description":"Residual Risk Reduction Initiative","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/r3i.org\/ja\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ja"}]}},"jetpack_likes_enabled":true,"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/Pgbfv2-14nU","jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/pages\/255186","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/users\/258497325"}],"replies":[{"embeddable":true,"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/comments?post=255186"}],"version-history":[{"count":3,"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/pages\/255186\/revisions"}],"predecessor-version":[{"id":255191,"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/pages\/255186\/revisions\/255191"}],"wp:attachment":[{"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/media?parent=255186"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}