{"id":254652,"date":"2024-12-27T19:16:08","date_gmt":"2024-12-27T18:16:08","guid":{"rendered":"https:\/\/r3i.org\/r3i%e7%a4%be%e8%aa%ac\/%e8%ab%96%e8%aa%ac-12-22-%e8%84%82%e8%b3%aa%e9%96%a2%e9%80%a3%e6%ae%8b%e5%ad%98%e3%83%aa%e3%82%b9%e3%82%af%ef%bc%9aprominent%e3%81%8b%e3%82%89%e3%81%ae%e6%95%99%e8%a8%93%ef%bc%9f\/"},"modified":"2025-02-22T16:29:27","modified_gmt":"2025-02-22T15:29:27","slug":"%e8%ab%96%e8%aa%ac-12-22-%e8%84%82%e8%b3%aa%e9%96%a2%e9%80%a3%e6%ae%8b%e5%ad%98%e3%83%aa%e3%82%b9%e3%82%af%ef%bc%9aprominent%e3%81%8b%e3%82%89%e3%81%ae%e6%95%99%e8%a8%93%ef%bc%9f","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/r3i%e7%a4%be%e8%aa%ac\/%e8%ab%96%e8%aa%ac-12-22-%e8%84%82%e8%b3%aa%e9%96%a2%e9%80%a3%e6%ae%8b%e5%ad%98%e3%83%aa%e3%82%b9%e3%82%af%ef%bc%9aprominent%e3%81%8b%e3%82%89%e3%81%ae%e6%95%99%e8%a8%93%ef%bc%9f\/","title":{"rendered":"\u8ad6\u8aac 12\/22 – \u8102\u8cea\u95a2\u9023\u6b8b\u5b58\u30ea\u30b9\u30af\uff1aPROMINENT\u304b\u3089\u306e\u6559\u8a13\uff1f"},"content":{"rendered":"

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R3i\u793e\u8aac<\/h2>\n

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\u8102\u8cea\u95a2\u9023\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\uff1aPROMINENT\u304b\u3089\u5f97\u3089\u308c\u305f\u77e5\u898b\u306f\uff1f<\/span><\/h5>\n
Prof. Jean Charles Fruchart, Prof. Michel Hermans, Prof. Pierre Amarenco
\u7de8\u96c6\u30c7\u30b9\u30af\u304b\u3089<\/h6>\n

\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09-rich\u30ea\u30dd\u86cb\u767d\u306f\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3055\u305b\u308b\u305f\u3081\u306e\u6cbb\u7642\u6a19\u7684\u5019\u88dc\u3068\u3057\u3066\u5927\u304d\u306a\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u304a\u308a\u3001\u5e83\u7bc4\u306a\u75ab\u5b66\u7814\u7a76\u3001\u907a\u4f1d\u5b50\u7814\u7a76\u304a\u3088\u3073\u30e1\u30ab\u30cb\u30ba\u30e0\u7814\u7a76\u304b\u3089\u3082\u3053\u308c\u3092\u652f\u6301\u3059\u308b\u8a3c\u62e0\u304c\u5f97\u3089\u308c\u3066\u3044\u308b1 \u3002\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u6cbb\u9a13\u3067\u306f\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u52d5\u8108\u786c\u5316\u6027\u8102\u8cea\u7570\u5e38\u75c7\u3001\u3059\u306a\u308f\u3061\u8efd\u5ea6\uff5e\u4e2d\u7b49\u5ea6\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3068\u8840\u4e2d\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08HDL-C\uff09\u4f4e\u5024\u3092\u4f34\u30462\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u81e8\u5e8a\u7684\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u3092\u793a\u5506\u3059\u308b\u77e5\u898b\u304c\u5f97\u3089\u308c\u3066\u3044\u308b<\/span>2<\/sup>\u00a0\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u3053\u308c\u307e\u3067\u306e\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\u3067\u306f\u3001TG-rich\u30ea\u30dd\u86cb\u767d\u306e\u30b5\u30ed\u30b2\u30fc\u30c8\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308bTG\u3092\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306b\u3088\u308a\u4f4e\u4e0b\u3055\u305b\u3066\u3082\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u4f4e\u6e1b\u3059\u308b\u3068\u3044\u3046\u78ba\u8a3c\u306f\u5f97\u3089\u308c\u3066\u3044\u306a\u3044<\/span>3-5<\/sup>\u00a0\u3002\u3055\u3089\u306b\u3001REDUCE-IT\u3067\u8a8d\u3081\u3089\u308c\u305f\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u76f8\u5bfe\u7684\u306a\u4f4e\u4e0b\u306f\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u306b\u3088\u308bTG\u4f4e\u4e0b\u306e\u7a0b\u5ea6\u3068\u95a2\u9023\u3057\u306a\u304b\u3063\u305f<\/span>6<\/sup>\u00a0\u3002<\/span><\/p>\n

\u3053\u3046\u3057\u305f\u80cc\u666f\u304b\u3089\u3001\u65e2\u5b58\u306e\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\uff08PPAR\u03b1\u30a2\u30b4\u30cb\u30b9\u30c8\uff09\u306e\u554f\u984c\u3092\u89e3\u6c7a\u3059\u308b\u305f\u3081\u3001\u305d\u306e\u52b9\u529b\u3001\u9078\u629e\u6027\u304a\u3088\u3073\u5fcd\u5bb9\u6027\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3001\u9078\u629e\u7684\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u03b1\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\uff08SPPARM\u03b1\uff09\u3067\u3042\u308b\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u304c\u958b\u767a\u3055\u308c\u308b\u306b\u81f3\u3063\u305f\uff08<\/span>7<\/sup>\u00a0\u3002\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306f\u3001\u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3044\u3066TG\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304a\u3088\u3073\u30a2\u30dd\u30ea\u30dd\u86cb\u767d\uff08apo\uff09CIII\u3092\u78ba\u5b9f\u306b\u4f4e\u4e0b\u3055\u305b\u3001\u826f\u597d\u306a\u5b89\u5168\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u793a\u3057\u305f\uff08<\/span>8-11<\/sup>\u00a0\u3002\u6b21\u306e\u30b9\u30c6\u30c3\u30d7\u306f\u3001\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u3001\u7279\u306b\u9ad8\u5f37\u5ea6\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u3092\u4f34\u30462\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306b\u3088\u308bTG\u306e\u4f4e\u4e0b\u306b\u3088\u308a\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u4f4e\u6e1b\u3059\u308b\u304b\u5426\u304b\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3067\u3042\u3063\u305f\u3002<\/span><\/p>\n

PROMINENT\uff08Pemafibrate to Reduce cardiovascular OutcoMes by reducing triglycerides IN patiENts with diabetes\uff09\u306f\u3053\u306e\u554f\u3044\u306b\u5bfe\u3059\u308b\u7b54\u3048\u3092\u5f97\u308b\u305f\u3081\u306b\u30c7\u30b6\u30a4\u30f3\u3055\u308c\u305f\u8a66\u9a13\u3067\u3042\u308b\u00a0<\/span>12<\/sup>\u00a0\u3002\u6b8b\u5ff5\u306a\u304c\u3089\u3001\u3053\u306e\u8a66\u9a13\u304b\u3089\u306f\u6c7a\u5b9a\u7684\u306a\u7b54\u3048\u306f\u5f97\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306f\u3001\u8efd\u5ea6\uff5e\u4e2d\u7b49\u5ea6\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3092\u4f34\u3044\u3001HDL-C\u4f4e\u5024\u3067\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u304c\u5341\u5206\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u3001TG\u3001\u8d85\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304a\u3088\u3073apoCIII\u309220\uff5e30%\u4f4e\u4e0b\u3055\u305b\u305f\u304c\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u767a\u751f\u7387\u306f\u4f4e\u4e0b\u3055\u305b\u306a\u304b\u3063\u305f\uff0813\uff09\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u6709\u7121\u3084\u3001TG\u5024\u304c\u6bcd\u96c6\u56e3\u4e2d\u592e\u5024\u3092\u4e0a\u56de\u308b\u304b\u4e0b\u56de\u308b\u304b\u306b\u304b\u304b\u308f\u3089\u305a\u540c\u69d8\u3067\u3042\u3063\u305f< sup>13 \u3002<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” text_font_size=”14px” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22text_text_color%22%93}” sticky_enabled=”0″]<\/p>\n

PROMINENT\u304b\u3089\u5f97\u3089\u308c\u305f\u77e5\u898b\u306f\uff1f\uff1aLDL-C\u4f4e\u5024\uff08\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLDL-C\u4e2d\u592e\u5024\u306f78 mg\/dL\u307e\u305f\u306f2.0 mmol\/L\uff09\u306e\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3044\u3066\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306b\u3088\u308b\u6709\u610f\u306a\u52b9\u679c\u304c\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3053\u3068\u306b\u3088\u308a\u3001LDL-C\u304c\u8102\u8cea\u95a2\u9023\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u306e\u4e3b\u306a\u8981\u56e0\u3067\u3042\u308b\u3068\u3044\u3046\u898b\u65b9\u304c\u5f37\u307e\u3063\u305f\u3002\u305d\u306e\u88cf\u4ed8\u3051\u3068\u3057\u3066\u3001PCSK9\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u7642\u6cd5\u3092\u691c\u8a0e\u3059\u308b2\u3064\u306e\u4e3b\u8981\u306a\u524d\u5411\u304d\u8a66\u9a13\uff08FOURIER\u304a\u3088\u3073ODYSSEY OUTCOMES\uff09\u3067\u306f\u3001\u9ad8\u5f37\u5ea6\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u3001LDL-C\u5024\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u60a3\u8005\uff08\u7d0490 mg\/dL\u307e\u305f\u306f2.3 mmol\/L\uff09\u306b\u304a\u3044\u3066\u3001LDL-C\u5024\u304c\u3055\u3089\u306b50\uff5e60%\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u6bd4\u8f03\u7684\u77ed\u3044\u8a66\u9a13\u671f\u9593\uff083\u5e74\u672a\u6e80\uff09\u306b\u304a\u3044\u3066\u4e3b\u8981\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u304c15%\u6709\u610f\u306b\u6e1b\u5c11\u3057\u305f<\/span>14-15<\/sup>\u00a0\u3002\u3057\u304b\u3057\u3001\u3082\u3046\u3072\u3068\u3064\u306e\u89e3\u91c8\u3068\u3057\u3066\u3001TG\u4f4e\u4e0b\u306e\u4f5c\u7528\u6a5f\u5e8f\u304c\u95a2\u9023\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u8003\u3048\u3082\u3042\u308b\u3002\u5b9f\u969b\u3001TG\u6fc3\u5ea6\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3059\u308b\u7d4c\u8def\u304c\u8907\u96d1\u3067\u3042\u308b\u3053\u3068\u3001\u307e\u305fTG-rich\u30ea\u30dd\u86cb\u767d\u3068\u305d\u306e\u30ec\u30e0\u30ca\u30f3\u30c8\u306e\u4ee3\u8b1d\u30d7\u30ed\u30bb\u30b9\u3092\u8003\u3048\u308c\u3070\u3001\u3053\u306e\u89e3\u91c8\u306f\u6839\u62e0\u306e\u3042\u308b\u3082\u306e\u3067\u3042\u308b\u3002\u81e8\u5e8a\u7684\u306b\u610f\u5473\u306e\u3042\u308b\u5fc3\u8840\u7ba1\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u3092\u5f97\u308b\u306b\u306f\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u306e\u751f\u6210\u7d4c\u8def\u3068\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u7d4c\u8def\u306e\u4e21\u65b9\u3092\u6a19\u7684\u3068\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3068\u601d\u308f\u308c\u308b\u00a0<\/span>16<\/sup>\u00a0\u3002\u958b\u767a\u4e2d\u306e\u4ed6\u306e\u65b0\u898fTG\u4f4e\u4e0b\u85ac\u306b\u3088\u308a\u3001\u3053\u306e\u554f\u3044\u306b\u5bfe\u3059\u308b\u7b54\u3048\u304c\u5f97\u3089\u308c\u308b\u3082\u306e\u3068\u671f\u5f85\u3055\u308c\u308b\u3002<\/span><\/p>\n

PROMINENT\u306e\u5b89\u5168\u6027\u30c7\u30fc\u30bf\u304b\u3089\u5f97\u3089\u308c\u305f\u77e5\u898b\u3082\u8003\u5bdf\u306b\u5024\u3059\u308b\u3002\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u6bd4\u3079\u3066\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u7fa4\u3067\u306f\u9759\u8108\u8840\u6813\u585e\u6813\u4e8b\u8c61\u304a\u3088\u3073\u814e\u6709\u5bb3\u4e8b\u8c61\u304c\u591a\u304f\u8a8d\u3081\u3089\u308c\u305f\u3002\u3053\u308c\u307e\u3067\u306b\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u3067\u540c\u69d8\u306e\u7d50\u679c\u304c\u5f97\u3089\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u8003\u3048\u308b\u3068\u3001\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u304a\u305d\u3089\u304f\u610f\u5916\u306a\u3082\u306e\u3067\u306f\u306a\u3044\u00a0<\/span>17<\/sup>\u3002\u3068\u3053\u308d\u304c\u3001PROMINENT\u3067\u306f\u3001\u809d\u6709\u5bb3\u4e8b\u8c61\u306e\u6e1b\u5c11\uff08219 vs. 265\u3001\u30cf\u30b6\u30fc\u30c9\u6bd4\uff1d0.83\u300195%\u4fe1\u983c\u533a\u9593\uff1a0.69\uff5e0.99\uff09\u304a\u3088\u3073\u6cbb\u9a13\u8cac\u4efb\u533b\u5e2b\u304c\u5831\u544a\u3059\u308b\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u809d\u306e\u6e1b\u5c11\uff08155 vs. 200\u3001\u30cf\u30b6\u30fc\u30c9\u6bd4\uff1d0.78\u300195%\u4fe1\u983c\u533a\u9593\uff1a0.63\uff5e0.96\uff09\u3068\u3044\u3046\u65b0\u305f\u306a\u7d50\u679c\u3082\u5f97\u3089\u308c\u305f\u00a0<\/span>13<\/sup>\u00a0\u3002\u691c\u8a3c\u304c\u5fc5\u8981\u3067\u306f\u3042\u308b\u3082\u306e\u306e\u3001\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u304c\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u75be\u60a3\uff08NAFLD\uff09\u3001\u3042\u308b\u3044\u306f\u65b0\u3057\u3044\u5b9a\u7fa9\u306b\u3088\u308c\u3070\u4ee3\u8b1d\uff08\u7570\u5e38\uff09\u95a2\u9023\u8102\u80aa\u6027\u809d\u75be\u60a3\uff08MAFLD\uff09\u306e\u6cbb\u7642\u85ac\u3068\u306a\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u00a0<\/span>18<\/sup>\u00a0\u3002\u305d\u306e\u88cf\u4ed8\u3051\u3068\u3057\u3066\u3001\u30e1\u30ab\u30cb\u30ba\u30e0\u7814\u7a76\u3067\u306f\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u306e\u3052\u3063\u6b6f\u985e\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u304cNASH\u3092\u6539\u5584\u3059\u308b\u3068\u3068\u3082\u306b\u305d\u306e\u9032\u884c\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u00a0<\/span>19-20<\/sup>\u00a0\u3001\u7b2c2\u76f8\u8a66\u9a13\u3067\u306f\u6700\u957772\u9031\u9593\u306e\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u6295\u4e0e\u306b\u3088\u308a\u78c1\u6c17\u5171\u9cf4\u30a8\u30e9\u30b9\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u306b\u3088\u308b\u809d\u786c\u5ea6\u306e\u6539\u5584\u304c\u8a8d\u3081\u3089\u308c\u3066\u3044\u308b\u00a0<\/span>21<\/sup>\u00a0\u3002MAFLD\u306e\u6709\u75c5\u7387\u304c\u4e16\u754c\u4e2d\u3067\u4e0a\u6607\u3057\u3001\u65e2\u306b\u4e16\u754c\u306e\u4eba\u53e3\u306e\u6700\u592730%\u304cMAFLD\u306b\u7f79\u60a3\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u8003\u3048\u308b\u3068\u00a0<\/span>22<\/sup>\u00a0\u3001\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u306f\u660e\u3089\u304b\u3067\u3042\u308b\u3002\u9032\u884c\u4e2d\u306e\u6cbb\u9a13\u3067\u306f\u3001\u809d\u7dda\u7dad\u5316\u3092\u4f34\u3046NASH\u60a3\u8005\u306b\u304a\u3051\u308b\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u52b9\u679c\u304c\u691c\u8a0e\u3055\u308c\u3066\u3044\u308b\u00a0<\/span>23<\/sup>\u00a0\u3002<\/span><\/p>\n

\u4ee5\u4e0a\u306e\u3088\u3046\u306b\u3001PROMINENT\u304b\u3089\u306f\u6c7a\u5b9a\u7684\u306a\u7b54\u3048\u306f\u5f97\u3089\u308c\u306a\u304b\u3063\u305f\u304c\u3001\u305d\u306e\u63a2\u7d22\u7684\u306a\u30c7\u30fc\u30bf\u304b\u3089\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u304c\u5225\u306e\u9069\u5fdc\u75c7\u306e\u6cbb\u7642\u85ac\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u958b\u3051\u305f\u3002MAFLD\u306e\u7ba1\u7406\u306b\u306f\u5927\u304d\u306a\u30a2\u30f3\u30e1\u30c3\u30c8\u30cb\u30fc\u30ba\u304c\u6b8b\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u8003\u3048\u308b\u3068\u3001MAFLD\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u3092\u691c\u8a0e\u3057\u3066\u3044\u308b\u9032\u884c\u4e2d\u306e\u6cbb\u9a13\u306b\u3088\u3063\u3066\u65b0\u305f\u306a\u6a5f\u4f1a\u304c\u63d0\u4f9b\u3055\u308c\u308b\u3053\u3068\u306b\u306a\u308b\u3002SPPARM\u03b1\u304c\u5fc3\u4ee3\u8b1d\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3068\u3044\u3046\u30b9\u30c8\u30fc\u30ea\u30fc\u306b\u306f\u7d9a\u304d\u304c\u3042\u308b\u3002<\/span><\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”8px” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

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    3.<\/span>\u00a0Nicholls SJ, Lincoff AM, Garcia M, et al. Effect of high-dose omega-3 fatty acids vs corn oil on major adverse cardiovascular events in patients at high cardiovascular risk: the STRENGTH randomized clinical trial. JAMA 2020;324:2268-80.<\/span>
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    8.<\/span>\u00a0Ishibashi S, Yamashita S, Arai H, et al. Effects of K-877, a novel selective PPAR\u03b1 modulator (SPPARM\u03b1), in dyslipidaemic patients: a randomized, double blind, active- and placebo-controlled, phase 2 trial. Atherosclerosis 2016;249:36-43.<\/span>
    9.<\/span>\u00a0Arai H, Yamashita S, Yokote K, et al. Efficacy and safety of K-877, a novel selective peroxisome proliferator-activated receptor \u03b1 modulator (SPPARM\u03b1), in combination with statin treatment: two randomised, double-blind, placebo-controlled clinical trials in patients with dyslipidaemia. Atherosclerosis 2017;261:144-52.<\/span>
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    18.<\/span>\u00a0Eslam M, Sanyal AJ, George J, International Consensus Panel. MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease. Gastroenterol 2020;158:1999-2014.<\/span>
    19.<\/span>\u00a0Honda Y, Kessoku T, Ogawa Y, et al. Pemafibrate, a novel selective peroxisome proliferator-activated receptor alpha modulator, improves the pathogenesis in a rodent model of nonalcoholic steatohepatitis. Sci Rep 2017;7:42477.<\/span>
    20.<\/span>\u00a0Sasaki Y, Asahiyama M, Tanaka T, et al. Pemafibrate, a selective PPAR\u03b1 modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content. Sci Rep 2020;10:7818.<\/span>
    21.<\/span>\u00a0Nakajima A, Eguchi Y, Yoneda M, et al. Randomised clinical trial: Pemafibrate, a novel selective peroxisome proliferator-activated receptor \u03b1 modulator (SPPARM\u03b1), versus placebo in patients with non-alcoholic fatty liver disease. Aliment Pharmacol Ther 2021;54:1263-77.<\/span>
    22.<\/span>\u00a0Younossi Z, Anstee QM, Marietti M, et al. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol. 2018;15:11-20.<\/span>
    23.<\/span>\u00a0Study to Evaluate the Efficacy and Safety of K-877-ER and CSG452 in Participants With NASH With Liver Fibrosis. ClinicalTrials.gov Identifier: NCT05327127.     https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05327127<\/a><\/span><\/li>\n<\/ol>\n

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