{"id":254649,"date":"2024-12-30T20:10:18","date_gmt":"2024-12-30T19:10:18","guid":{"rendered":"https:\/\/r3i.org\/r3i%e7%a4%be%e8%aa%ac\/%e7%a4%be%e8%aa%ac12-19-%e8%84%b3%e5%8d%92%e4%b8%ad%e3%81%ab%e7%84%a6%e7%82%b9%e3%82%92%e5%bd%93%e3%81%a6%e3%82%88%ef%bc%9a%e5%bf%83%e8%a1%80%e7%ae%a1%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e6%ae%8b\/"},"modified":"2025-02-16T23:57:30","modified_gmt":"2025-02-16T22:57:30","slug":"%e7%a4%be%e8%aa%ac12-19-%e8%84%b3%e5%8d%92%e4%b8%ad%e3%81%ab%e7%84%a6%e7%82%b9%e3%82%92%e5%bd%93%e3%81%a6%e3%82%88%ef%bc%9a%e5%bf%83%e8%a1%80%e7%ae%a1%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e6%ae%8b","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/r3i%e7%a4%be%e8%aa%ac\/%e7%a4%be%e8%aa%ac12-19-%e8%84%b3%e5%8d%92%e4%b8%ad%e3%81%ab%e7%84%a6%e7%82%b9%e3%82%92%e5%bd%93%e3%81%a6%e3%82%88%ef%bc%9a%e5%bf%83%e8%a1%80%e7%ae%a1%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e6%ae%8b\/","title":{"rendered":"\u793e\u8aac12\/19-\u8133\u5352\u4e2d\u306b\u7126\u70b9\u3092\u5f53\u3066\u3088\uff1a\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u3001\u3088\u308a\u591a\u304f\u306e\u30a4\u30f3\u30d7\u30c3\u30c8\u3092"},"content":{"rendered":"<p>[et_pb_section 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lang=\"EN-GB\">\u30df\u30b7\u30a7\u30eb\u30fb\u30d8\u30eb\u30de\u30f3\u30ba\u6559\u6388\u3001\u30d4\u30a8\u30fc\u30eb\u30fb\u30a2\u30de\u30ec\u30f3\u30b3\u6559\u6388<\/span><\/h6>\n<p><span>\u8133\u5352\u4e2d\u306f\u3001\u865a\u8840\u6027\u5fc3\u75be\u60a3\u306b\u6b21\u3044\u3067\u4e16\u754c\u7684\u306b\u4e3b\u8981\u306a\u6b7b\u56e0\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u904e\u53bb30\u5e74\u9593\u306b\u8133\u5352\u4e2d\u306b\u3088\u308b\u6b7b\u4ea1\u7387\u304c\u6e1b\u5c11\u3057\u3066\u3044\u308b\u4e00\u65b9\u3067\u3001\u8133\u5352\u4e2d\u306e\u6709\u75c5\u7387\u306f\u5897\u52a0\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u4e00\u56e0\u306f\u3001\u4eba\u53e3\u306e\u9ad8\u9f62\u5316\u3068\u30ea\u30b9\u30af\u56e0\u5b50\u306e\u7ba1\u7406\u304c\u5411\u4e0a\u3057\u305f\u3053\u3068\u306b\u3088\u308b\u751f\u5b58\u7387\u306e\u6539\u5584\u3067\u3042\u308b\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u8133\u5352\u4e2d\u3068\u305d\u308c\u306b\u95a2\u9023\u3059\u308b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u518d\u767a\u306b\u3088\u308b\u7f79\u60a3\u7387\u3068\u95a2\u9023\u969c\u5bb3\u304c\u3082\u305f\u3089\u3059\u8ca0\u62c5\u306f\u76f8\u5f53\u306a\u3082\u306e\u3067\u3042\u308b\u3002  <\/span><sup>1<\/sup><span><\/span><\/p>\n<p><span>\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u30012017\u5e74\u4e16\u754c\u7b2c8\u4f4d\u306e\u8133\u5352\u4e2d\u6b7b\u4ea1\u7387\u6307\u6a19\u3001<\/span><sup>1<\/sup><span> \u306f\u3001\u7ba1\u7406\u304c\u6539\u5584\u3055\u308c\u305f\u4e00\u4f8b\u3067\u3042\u308b\u30022013\u5e74\u306e\u7c73\u56fd\u5fc3\u81d3\u75c5\u5b66\u4f1a\/\u7c73\u56fd\u5fc3\u81d3\u5354\u4f1a\uff08ACC\/AHA\uff09\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u6cbf\u3063\u305f\u3082\u306e\u3067\u3042\u308b\u3001 <\/span><sup>2<\/sup><span>AHA\/\u7c73\u56fd\u8133\u5352\u4e2d\u5b66\u4f1a\u306f\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u307e\u305f\u306f\u4e00\u904e\u6027\u8133\u865a\u8840\u767a\u4f5c\uff08TIA\uff09\u3092\u767a\u75c7\u3057\u3001\u305d\u306e\u539f\u56e0\u304c\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u3067\u3042\u308b\u3068\u63a8\u5b9a\u3055\u308c\u308b\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u8133\u5352\u4e2d\u304a\u3088\u3073\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u305f\u3081\u306b\u3001\u96c6\u4e2d\u7684\u306a\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u63a8\u5968\u3057\u305f\u3002<\/span><sup>3<\/sup><span>\u3057\u304b\u3057\u3001\u3053\u308c\u3089\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306f\u3001\u3053\u306e\u975e\u5e38\u306b\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u30b0\u30eb\u30fc\u30d7\u306b\u304a\u3051\u308b\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u306e\u76ee\u6a19\u5024\u3092\u5b9a\u7fa9\u3059\u308b\u306b\u306f\u4e0d\u5341\u5206\u3067\u3042\u308b\u3002<\/span><\/p>\n<p><span>\u3053\u306e\u4e0d\u78ba\u5b9f\u6027\u304c\u3001Treat Stroke to Target Study\u306e\u7126\u70b9\u3067\u3042\u3063\u305f\u3001<\/span><sup>4<\/sup><span> 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   <\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf&#8221; text_font_size=&#8221;14px&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22text_text_color%22%93}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p style=\"font-weight: 400;\"><span>\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u6297PCSK9\uff08proprotein convertase subtilisin\/kexin type 9\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\uff09\u7642\u6cd5\u3092\u542b\u3080\u3001LDL-C\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u52b9\u679c\u306e\u9ad8\u3044\u975e\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\u306e\u51fa\u73fe\u306f\u3001LDL-C\u5024\u304c70mg\/dL\u3092\u5927\u304d\u304f\u4e0b\u56de\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3042\u308b\u3053\u3068\u3092\u610f\u5473\u3059\u308b\u3002\u3053\u308c\u3089\u306e\u85ac\u5264\u3092\u7528\u3044\u305f\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u7814\u7a76\u3067\u306f\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u304c\u5927\u5e45\u306b\u6e1b\u5c11\u3059\u308b\u3053\u3068\u3082\u8a3c\u660e\u3055\u308c\u3066\u304a\u308a\u3001\u78ba\u7acb\u3057\u305f\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3059\u308b\u60a3\u8005\uff08\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u6295\u4e0e\u6642\u306eLDL-C\u4e2d\u592e\u502430mg\/dL\u307e\u305f\u306f0.78mmol\/L\uff09\u306b\u304a\u3044\u306625\uff05\u6e1b\u5c11\u3057\u305f\u3001 <\/span><sup>5<\/sup><span>\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u306e\u60a3\u8005\uff08\u6cbb\u7642\u6642\u306e\u5e73\u5747LDL-C\u306f53mg\/dL\u307e\u305f\u306f1.37mmol\/L\uff09\u3067\u306f27\uff05\u3067\u3042\u3063\u305f\u3002<\/span><sup>6<\/sup><span>\u3053\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u8e0f\u307e\u3048\u3066\u30012019\u5e74\u306e\u6b27\u5dde\u5fc3\u81d3\u75c5\u5b66\u4f1a\/\u6b27\u5dde\u52d5\u8108\u786c\u5316\u5b66\u4f1a\u8102\u8cea\u7570\u5e38\u75c7\u5408\u540c\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306f\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u304c\u975e\u5e38\u306b\u9ad8\u3044\u60a3\u8005\u306b\u5bfe\u3057\u3066\u3001LDL-C\u306e\u76ee\u6a19\u3092&lt;50 mg\/dL (&lt;1.4mmol\/L)\u3068\u63a8\u5968\u3057\u3066\u3044\u308b\u3002<\/span> <sup>7<\/sup><span>\u3053\u308c\u3089\u306e\u65b0\u305f\u306a\u77e5\u898b\u3068\u52e7\u544a\u306f\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u3084TIA\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u3088\u308a\u4f4e\u3044LDL-C\u76ee\u6a19\u5024\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3092\u691c\u8a3c\u3059\u308b\u65b0\u305f\u306a\u7814\u7a76\u306e\u5fc5\u8981\u6027\u3092\u793a\u3057\u3066\u3044\u308b\u304c\u3001\u3053\u308c\u304c\u73fe\u5b9f\u7684\u306b\u3001\u3042\u308b\u3044\u306f\u502b\u7406\u7684\u306b\u53ef\u80fd\u304b\u3069\u3046\u304b\u306f\u7591\u554f\u3067\u3042\u308b\u3002<\/span><\/p>\n<p><span>\u6700\u5f8c\u306b\u3001\u6700\u826f\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u3044\u305f\u6cbb\u7642\u3092\u80cc\u666f\u306b\u3001LDL-C\u306e\u76ee\u6a19\u5024\u3092\u4f4e\u304f\u3059\u308b\u3053\u3068\u306f\u81e8\u5e8a\u8ee2\u5e30\u306b\u3068\u3063\u3066\u3088\u308a\u826f\u3044\u3053\u3068\u3067\u3042\u308b\u304c\u3001\u3053\u308c\u3089\u306e\u8d85\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u304c\u5fc3\u8840\u7ba1\u7cfb\u30a4\u30d9\u30f3\u30c8\u3092\u7d4c\u9a13\u3057\u7d9a\u3051\u3066\u3044\u308b\u3053\u3068\u3082\u660e\u3089\u304b\u3067\u3042\u308b\u3002\u3053\u306e\u30b7\u30ca\u30ea\u30aa\u306f\u3001\u3053\u306e\u6301\u7d9a\u7684\u306b\u6b8b\u5b58\u3059\u308b\u9ad8\u3044\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306b\u3001\u4ed6\u306e\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u7126\u70b9\u3092\u5f53\u3066\u305f\u65b0\u305f\u306a\u52aa\u529b\u306e\u5fc5\u8981\u6027\u3092\u5f37\u8abf\u3057\u3066\u3044\u308b\u3002\u8102\u8cea\u306e\u6a19\u7684\u3068\u3057\u3066\u8003\u3048\u3089\u308c\u308b\u3082\u306e\u306e\u3046\u3061\u3001\u7279\u306b\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u9ad8\u3044\u307b\u3069\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3068\u3044\u3046\u6700\u8fd1\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u7167\u3089\u305b\u3070\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u305d\u306e\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002  <\/span><sup>8<\/sup><span><\/span><\/p>\n<p><span>\u8d85\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\u306f\u3001\u81e8\u5e8a\u754c\u306b\u3068\u3063\u3066\u91cd\u8981\u306a\u8ab2\u984c\u3067\u3042\u308a\u7d9a\u3051\u3066\u3044\u308b\u3002<\/span><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;8px&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p style=\"font-weight: 400;\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<ol>\n<li style=\"font-weight: 400;\"><span>Avan A, Digaleh H, Di Napoli M et al. Socioeconomic status and stroke incidence, prevalence, mortality, and worldwide burden: an ecological analysis from the Global Burden of Disease Study 2017.BMC Med 2019;17 (1):191.  <\/span><br \/><span class=\"ref ref2\">2.<\/span><span> Stone NJ, Robinson J, Lichtenstein AH et al. 2013 ACC\/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines.Circulation 2014;129(25 Suppl 2):S1-45. <\/span><br \/><span class=\"ref ref3\">3.<\/span><span> Kernan WN, Ovbiagele B, Black HR et al. \u8133\u5352\u4e2d\u304a\u3088\u3073\u4e00\u904e\u6027\u8133\u865a\u8840\u767a\u4f5c\u60a3\u8005\u306b\u304a\u3051\u308b\u8133\u5352\u4e2d\u4e88\u9632\u306e\u305f\u3081\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\uff1a\u7c73\u56fd\u5fc3\u81d3\u5354\u4f1a\/\u7c73\u56fd\u8133\u5352\u4e2d\u5354\u4f1a\u306b\u3088\u308b\u533b\u7642\u5f93\u4e8b\u8005\u5411\u3051\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3002Stroke 2014;45:2160-236.  <\/span><br \/><span class=\"ref ref4\">4.<\/span><span> Amarenco P\u3001Kim JS\u3001Labreuche J\u3089\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u5f8c\u306e2\u3064\u306eLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u76ee\u6a19\u306e\u6bd4\u8f03\u3002N Engl J Med 2019; DOI: 10.1056\/NEJMoa1910355.  <\/span><br \/><span class=\"ref ref5\">5.<\/span><span> Sabatine MS\u3001Giugliano RP\u3001Keech AC\u3089\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u3068\u81e8\u5e8a\u8ee2\u5e30\u3002N Engl J Med 2017;376:1713-22.  <\/span><br \/><span class=\"ref ref6\">6.<\/span><span> Schwartz GG\u3001Steg PG\u3001Szarek M\u3089\u3001\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u3068\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u5f8c\u306e\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u3002N Engl J Med 2018;379:2097-107.  <\/span><br \/><span class=\"ref ref7\">7.<\/span><span> Mach F, Baigent C, Catapano AL et al. 2019 ESC\/EAS Guidelines for the Management of dyslipidaemias: lipid modification to reduce cardiovascular risk.Eur Heart J 2019. doi: 10.1093\/eurheartj\/ehz455.    [Epub ahead of print]<\/span><br \/><span class=\"ref ref8\">8.<\/span><span> Varbo A, Nordestgaard BG.\u4e00\u822c\u96c6\u56e3112,512\u4eba\u306b\u304a\u3051\u308b\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u865a\u8840\u6027\u8133\u5352\u4e2d\u30ea\u30b9\u30af\u3002Ann Neurol 2019;85:550-9.  <\/span><\/li>\n<\/ol>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>R3i\u793e\u8aac\u8133\u5352\u4e2d\u306b\u7126\u70b9\u3092\u5f53\u3066\u308b\uff1a\u6b8b\u5b58\u3059\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u3001\u3088\u308a\u591a\u304f\u306e\u60c5\u5831\u63d0\u4f9b\u3092 \u30df\u30b7\u30a7\u30eb\u30fb\u30d8\u30eb\u30de\u30f3\u30ba [&hellip;]<\/p>\n","protected":false},"author":258497324,"featured_media":0,"parent":254286,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_wpcom_ai_launchpad_about_page":false,"_wpcom_ai_launchpad_gallery_page":false,"_wpcom_ai_launchpad_contact_page":false,"_wpcom_ai_launchpad_events_page":false,"_wpcom_ai_launchpad_video_page":false,"_wpcom_ai_launchpad_portfolio_piece":false,"footnotes":""},"class_list":["post-254649","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - 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