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R3i\u793e\u8aac<\/h2>\n

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2021\u5e7411\u6708<\/span><\/h5>\n
\u8efd\u5ea6\u304a\u3088\u3073\u4e2d\u7b49\u5ea6\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3092\u6709\u3059\u308b\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306e\u30a2\u30f3\u30e1\u30c3\u30c8\u30fb\u30af\u30ea\u30cb\u30ab\u30eb\u30fb\u30cb\u30fc\u30ba\u306b\u5fdc\u3048\u308bACC\u306e\u65b0\u30ac\u30a4\u30c0\u30f3\u30b9<\/span><\/h5>\n
Prof. Jean Charles Fruchart, Prof. Michel Hermans, Prof. Pierre Amarenco
\u30a8\u30c7\u30a3\u30bf\u30fc\u30ba\u30c7\u30b9\u30af\u3088\u308a<\/h6>\n

\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u304c\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff08ASCVD\uff09\u306e\u539f\u56e0\u3067\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u3001\u9577\u3044\u9593\u5fd8\u308c\u3089\u308c\u3066\u304d\u305f\u3002\u3057\u304b\u3057\u3001\u4eca\u6642\u4ee3\u306f\u5909\u308f\u308a\u3064\u3064\u3042\u308b\u3002\u75ab\u5b66\u8abf\u67fb\u3084\u30e1\u30f3\u30c7\u30eb\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13\u304b\u3089\u5f97\u3089\u308c\u305f\u78ba\u304b\u306a\u8a3c\u62e0\u306f\u3001TG\u304cASCVD\u306e\u56e0\u679c\u95a2\u4fc2\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u88cf\u4ed8\u3051\u3066\u3044\u308b\u00a0<\/span>1,2<\/sup>\u3002\u3055\u3089\u306b\u3001REDUCE-IT\uff08Reduction of Cardiovascular Events with Icosapent Ethyl-Interventional Trial\uff09\u3067\u306f\u3001\u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\uff08EPA\uff09\u30a8\u30c1\u30eb\u30a8\u30b9\u30c6\u30eb\u3067\u3042\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u306e\u9ad8\u7528\u91cf\u6295\u4e0e\u306b\u3088\u308bTG\u306e\u4f4e\u4e0b\u304c\u3001\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u6709\u610f\u306b\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f<\/span>3<\/sup>\u3002\u3057\u304b\u3057\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u6df7\u5408\u88fd\u5264\u3092\u7528\u3044\u305fSTRENGTH\uff08A Long-Term Outcomes Study to Assess Statin Residual Risk Reduction with Epanova in High Cardiovascular Risk Patients with Hypertriglyceridemia\uff09\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u4ed6\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001TG\u4f4e\u4e0b\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u7cfb\u306e\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u304c\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u305f\u3081\u3001\u8b70\u8ad6\u304c\u7d9a\u3044\u3066\u3044\u308b<\/span>4<\/sup>\u3002\u3057\u304b\u3057\u3001\u6b27\u7c73\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u30b0\u30eb\u30fc\u30d7\u306e\u9593\u3067\u306f\u3001TG\u306e\u4e0a\u6607\u304c\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u5897\u52a0\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u8a8d\u8b58\u3055\u308c\u3066\u3044\u308b\u3002\u4f8b\u3048\u3070\u3001REDUCE-IT\u306b\u5148\u99c6\u3051\u3066\u30012018\u5e74\u306e\u7c73\u56fd\u5fc3\u81d3\u5354\u4f1a\uff0f\u7c73\u56fd\u5fc3\u81d3\u75c5\u5b66\u4f1a\uff0f\u30de\u30eb\u30c1\u30bd\u30b5\u30a8\u30c6\u30a3\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u3001TG\u306e\u4e0a\u6607\u304c\u300c\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u8981\u56e0\u300d\u306b\u5206\u985e\u3055\u308c\u305f<\/span>5<\/sup>\u3002\u307e\u305f\u3001 2019\u5e74\u306e\u6b27\u5dde\u5fc3\u81d3\u75c5\u5b66\u4f1a\/\u6b27\u5dde\u52d5\u8108\u786c\u5316\u5b66\u4f1a\uff08ESC\/EAS\uff09\u306e\u8102\u8cea\u7570\u5e38\u75c7\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u3082\u3001TG\u9ad8\u5024\u306e\u7ba1\u7406\u306b\u304a\u3051\u308b\u671b\u307e\u3057\u3044TG\u5024\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u308b<\/span>6<\/sup>\u3002<\/span><\/p>\n

\u6700\u8fd1\u3001ACC\u306f\u8efd\u5ea6\uff5e\u4e2d\u7b49\u5ea6\u306e\u9ad8TG\u8840\u75c7\uff08\u7a7a\u8179\u6642TG \u2265 150mg\/dL\u3001\u307e\u305f\u306f\u975e\u7a7a\u8179\u6642TG \u2265 175mg\/dL\u304b\u3064< 500mg\/dL\u3068\u5b9a\u7fa9\uff09\u3092\u6301\u3064\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306e\u7ba1\u7406\u306b\u304a\u3051\u308b\u30ae\u30e3\u30c3\u30d7\u3092\u89e3\u6d88\u3059\u308b\u305f\u3081\u306b\u3001\u300cExpert Consensus Decision Pathway on Management of ASCVD Risk Reduction in Patients With Persistent Hypertriglyceridemia\u300d\u3092\u767a\u8868\u3057\u305f<\/span>7<\/sup>\u3002\u5177\u4f53\u7684\u306b\u306f\u3001\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u63a8\u5968\u3055\u308c\u3066\u3044\u308b\u751f\u6d3b\u7fd2\u6163\u3078\u306e\u4ecb\u5165\u3084\u3001\u6700\u5927\u8010\u5bb9\u91cf\u306e\u30b9\u30bf\u30c1\u30f3\u3092\u5b89\u5b9a\u7684\u306b\u6295\u4e0e\u3057\u3066\u3082TG\u306e\u4e0a\u6607\u304c\u6291\u3048\u3089\u308c\u306a\u3044\u60a3\u8005\u3078\u306e\u6cbb\u7642\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u7126\u70b9\u3092\u5f53\u3066\u305f\u3002\u6301\u7d9a\u6027\u306e\u8efd\u5ea6\uff5e\u4e2d\u7b49\u5ea6\u306e\u9ad8TG\u8840\u75c7\u3092\u4f34\u3046ASCVD\u60a3\u8005\u306e\u6cbb\u7642\u6226\u7565\u306f\u3001LDL-C\u5024\u306b\u57fa\u3065\u3044\u3066\u9078\u629e\u3055\u308c\u308b\u3002\u30b9\u30bf\u30c1\u30f3\u3092\u4f7f\u7528\u3057\u3066\u3044\u308bLDL-C\u5024 < 70mg\/dL\u306e\u60a3\u8005\u306b\u306f\u3001\u9ad8\u7528\u91cf\u306e\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u3092\u7528\u3044\u305f\u3001TG\u30ea\u30b9\u30af\u306b\u57fa\u3065\u3044\u305f\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u63a8\u5968\u3055\u308c\u308b\u3002\u4e00\u65b9\u3001LDL-C\u5024 \u2265 100mg\/dL\u306e\u60a3\u8005\u306b\u5bfe\u3057\u3066\u306f\u3001LDL-C\u5024\u306b\u57fa\u3065\u3044\u305f\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u884c\u3044\u3001\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u306e\u6700\u9069\u5316\u3068\u975e\u30b9\u30bf\u30c1\u30f3\u7cfbLDL\u4f4e\u4e0b\u85ac\u306e\u9078\u629e\u80a2\u3092\u691c\u8a0e\u3059\u308b\u3002LDL-C\u5024\u304c70\uff5e99mg\/dL\u306e\u5834\u5408\u306f\u3001\u305d\u308c\u3089\u3092\u5408\u308f\u305b\u305f\u6226\u7565\u304c\u63a8\u5968\u3055\u308c\u308b\u3002\u540c\u69d8\u306b\u3053\u306e\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u30fb\u30c9\u30ad\u30e5\u30e1\u30f3\u30c8\u3067\u306f\u3001\u7cd6\u5c3f\u75c5\u3068\u6301\u7d9a\u7684\u306a\u9ad8TG\u8840\u75c7\u3092\u6709\u3059\u308b\u4e00\u6b21\u4e88\u9632\u60a3\u8005\u3001\u3055\u3089\u306bASCVD\u3042\u308b\u3044\u306f\u7cd6\u5c3f\u75c5\u3092\u6709\u3055\u306a\u3044\u3001\u9ad8TG\u5024\u306e\u60a3\u8005\u306b\u3064\u3044\u3066\u3001\u305d\u306e\u7ba1\u7406\u306b\u3064\u3044\u3066\u691c\u8a0e\u3055\u308c\u3066\u3044\u308b\u3002\u6b27\u5dde\u306e\u63a8\u5968\u3068\u306e\u4e00\u8cab\u6027\u306f\u3042\u308b\u304c\u3001\u6b27\u5dde\u306e\u63a8\u5968\u3067\u306f\u3001\u4ed6\u306eTG\u4f4e\u4e0b\u7642\u6cd5\u306e\u7d50\u679c<\/span>6,8<\/sup>\u306b\u57fa\u3065\u3044\u305f\u7d30\u5c0f\u8840\u7ba1\u3078\u306e\u52b9\u679c\u306e\u53ef\u80fd\u6027\u3082\u8003\u616e\u3055\u308c\u3066\u3044\u308b\u3002<\/span><\/p>\n

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\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

    \n
  1. Do R, Willer CJ, Schmidt EM, et al. Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet 2013;45:1345\u201352.<\/span>
    2.<\/span>\u00a0Nordestgaard BG. Triglyceride-rich lipoproteins and atherosclerotic cardiovascular disease: new insights from epidemiology, genetics, and biology. Circ Res 2016;118:547-63.<\/span>
    3.<\/span>\u00a0Bhatt DL, Steg PG, Miller M, et al. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. N Engl J Med 2019;380:11\u201322.<\/span>
    4.<\/span>\u00a0Nicholls SJ, Lincoff AM, Garcia M, et al. Effect of high-dose omega-3 fatty acids vs corn oil on major adverse cardiovascular events in patients at high cardiovascular risk: the STRENGTH randomized clinical trial. JAMA 2020;324:2268\u201380.<\/span>
    5.<\/span>\u00a0Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA\/ACC\/AACVPR\/AAPA\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA guideline on the management of blood cholesterol: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol 2019;73:e285\u2013e350.<\/span>
    6.<\/span>\u00a0Mach F, Baigent C, Catapano AL, et al. 2019 ESC\/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J 2020;41:111-88.<\/span>
    7.<\/span>\u00a0Virani SS, Morris PB, Agarwala A et al. 2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction in Patients With Persistent Hypertriglyceridemia. A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol 2021:S0735-1097<\/span>21<\/sup>05323-<\/span>7.<\/span>\u00a0doi: 10.1016\/j.jacc.2021.06.011.<\/span>
    8.<\/span>\u00a0Averna M, Banach M, Bruckert E, et al. Practical guidance for combination lipid-modifying therapy in high- and very-high-risk patients: A statement from a European Atherosclerosis Society Task Force. Atherosclerosis 2021;325:99-109.<\/span>
    9.<\/span>\u00a0Pradhan AD, Paynter NP, Everett BM, et al. Rationale and design of the Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes (PROMINENT) study. Am Heart J 2018;206:80-93.<\/span><\/li>\n<\/ol>\n

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