{"id":254631,"date":"2025-01-04T16:59:32","date_gmt":"2025-01-04T15:59:32","guid":{"rendered":"https:\/\/r3i.org\/r3i%e7%a4%be%e8%aa%ac\/%e7%a4%be%e8%aa%ac-11-15-%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e6%ae%8b%e5%ad%98%ef%bc%9a%e8%84%82%e8%b3%aa%e3%81%a0%e3%81%91%e3%81%a7%e3%81%af%e3%81%aa%e3%81%84\/"},"modified":"2025-02-16T23:54:00","modified_gmt":"2025-02-16T22:54:00","slug":"%e7%a4%be%e8%aa%ac-11-15-%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e6%ae%8b%e5%ad%98%ef%bc%9a%e8%84%82%e8%b3%aa%e3%81%a0%e3%81%91%e3%81%a7%e3%81%af%e3%81%aa%e3%81%84","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/r3i%e7%a4%be%e8%aa%ac\/%e7%a4%be%e8%aa%ac-11-15-%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e6%ae%8b%e5%ad%98%ef%bc%9a%e8%84%82%e8%b3%aa%e3%81%a0%e3%81%91%e3%81%a7%e3%81%af%e3%81%aa%e3%81%84\/","title":{"rendered":"\u793e\u8aac 11\/15 &#8211; 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lang=\"EN-GB\">\u30df\u30b7\u30a7\u30eb\u30fb\u30d8\u30eb\u30de\u30f3\u30ba\u6559\u6388\u3001\u30d4\u30a8\u30fc\u30eb\u30fb\u30a2\u30de\u30ec\u30f3\u30b3\u6559\u6388<\/span><\/h6>\n<p><span>\u4f55\u304c\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u78ba\u304b\u306b\uff0c\u8102\u8cea\u3068\u30ea\u30dd\u86cb\u767d\u306e\u5371\u967a\u56e0\u5b50\u306f\u91cd\u8981\u3067\u3042\u308b\u3002Residual Risk Reduction Initiative\uff08R3i\uff09\u306e\u7126\u70b9\u306e\u591a\u304f\u306f\u3001\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08HDL-C\uff09\u306e\u5faa\u74b0\u30ec\u30d9\u30eb\u304c\u4f4e\u3044\u304b\u3069\u3046\u304b\u306b\u304b\u304b\u308f\u3089\u305a\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306e\u4e0a\u6607\u3092\u7ba1\u7406\u3059\u308b\u3053\u3068\u3067\u3042\u3063\u305f\u3002\u4e3b\u8981\u306a\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u81e8\u5e8a\u8a66\u9a13\u306e\u4e3b\u8981\u306a\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3067\u306f\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3067\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c35\uff05\u6e1b\u5c11\u3057\u305f\u306e\u306b\u5bfe\u3057\u3001\u3053\u306e\u3088\u3046\u306a\u8102\u8cea\u7570\u5e38\u75c7\u306e\u306a\u3044\u4eba\u3067\u306f6\uff05\u6e1b\u5c11\u3057\u305f\u3002\u51a0\u52d5\u8108\u30a4\u30d9\u30f3\u30c8\u306e\u6e1b\u5c11\u304c\u3053\u306e\u6709\u76ca\u6027\u306e\u4e3b\u306a\u8981\u56e0\u3067\u3042\u3063\u305f\u3002      <\/span><sup>1,2<\/sup><span>.2015\u5e74\u3001\u305d\u306e\u7126\u70b9\u306f\u3055\u3089\u306b\u7cbe\u7dfb\u5316\u3055\u308c\u305f\u3002\u73fe\u5728\u3067\u306f\u3001\u84c4\u7a4d\u3055\u308c\u305f\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u3001\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u304a\u3044\u3066\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u3068\u305d\u306e\u6b8b\u6e23\uff08\u8840\u6f3f\u4e2d\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u304c\u30de\u30fc\u30ab\u30fc\u3068\u306a\u308b\uff09\u306e\u4e0a\u6607\u3092\u8003\u616e\u3059\u308b\u5f37\u529b\u306a\u30b1\u30fc\u30b9\u3092\u63d0\u793a\u3057\u3066\u3044\u308b\u4e00\u65b9\u3067\u3001\u5f93\u6765\u306e\u5371\u967a\u56e0\u5b50\u3068\u3057\u3066\u306e\u7dcfHDL-C\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3078\u306e\u95a2\u5fc3\u306f\u8584\u308c\u3066\u3044\u308b\u3002\u5b9f\u969b\u3001\u8840\u6f3f\u4e2d\u306eHDL-C\u6fc3\u5ea6\u304c\u4f4e\u3044\u3053\u3068\u304c\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u3053\u3068\u306f\u9593\u9055\u3044\u306a\u3044\u304c\u3001\u305d\u306e\u3053\u3068\u306f\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u3082\u8a8d\u3081\u3089\u308c\u3066\u3044\u308b\u3002     <\/span><sup>3<\/sup><span>\u3057\u304b\u3057\u3001HDL\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u6cd5\u3001\u7279\u306b\u52d5\u8108\u786c\u5316\u3092\u4e88\u9632\u3059\u308bHDL\u30b5\u30d6\u30bf\u30a4\u30d7\u3092\u7279\u7570\u7684\u306b\u6a19\u7684\u3068\u3057\u306a\u3044\u975e\u9078\u629e\u7684\u306a\u6cbb\u7642\u6cd5\u306e\u59a5\u5f53\u6027\u306f\u3001\u3053\u308c\u307e\u3067\u307b\u3068\u3093\u3069\u7121\u8996\u3055\u308c\u3066\u304d\u305f\u3002\u6700\u8fd1\u3067\u306f\u3001\u30b3\u30ec\u30b9\u30c6\u30ea\u30eb\u30a8\u30b9\u30c6\u30eb\u8ee2\u79fb\u86cb\u767d\uff08CETP\uff09\u963b\u5bb3\u85ac\u3067\u3042\u308bevacetrapib\uff08ACCELERATE\uff09\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u8a66\u9a13\u304c\u3001\u6709\u52b9\u6027\u306e\u6b20\u5982\u3092\u7406\u7531\u306b\u4e2d\u6b62\u3055\u308c\u305f\u3002   <\/span><sup>4<\/sup><span>.\u3057\u304b\u3057\u3001\u3053\u306e\u85ac\u5264\u306fHDL-C\u8840\u6f3f\u4e2d\u6fc3\u5ea6\u3092\u8457\u3057\u304f\u4e0a\u6607\u3055\u305b\u305f\u3060\u3051\u3067\u306a\u304f\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u3092\u7d0440\uff05\u6e1b\u5c11\u3055\u305b\u305f\u3002   <\/span><sup>5<\/sup><span>.\u6709\u52b9\u6027\u306e\u6b20\u5982\u304cACCELERATE\u306e\u60a3\u8005\u96c6\u56e3\uff08\u6a19\u6e96\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u60a3\u8005\uff09\u306b\u5927\u304d\u304f\u8d77\u56e0\u3057\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u306f\u3082\u3063\u3068\u3082\u3067\u3042\u308b\u304c\u3001\u771f\u306e\u539f\u56e0\u3092\u898b\u6975\u3081\u308b\u305f\u3081\u306b\u306f\u8a66\u9a13\u7d50\u679c\u306e\u5b8c\u5168\u306a\u516c\u8868\u3092\u5f85\u3064\u5fc5\u8981\u304c\u3042\u308b\u3002\u5b9f\u969b\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u3044\u305f\u6700\u5584\u306e\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3082\u3001\u81e8\u5e8a\u7684\u8ee2\u5e30\u3092\u3053\u308c\u4ee5\u4e0a\u6709\u610f\u306b\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u306f\u4e0d\u53ef\u80fd\u3067\u3042\u308a\u3001\u304a\u305d\u3089\u304f\u30b9\u30bf\u30c1\u30f3\u9577\u671f\u6295\u4e0e\u304c\u30d7\u30e9\u30fc\u30af\u306e\u5f62\u614b\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308d\u3046\u3068\u3044\u3046\u3053\u3068\u304c\u8b70\u8ad6\u3055\u308c\u3066\u3044\u308b\u3002    <\/span><sup>6<\/sup><span>\u3057\u304b\u3057\u3001PCSK9\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3067\u3042\u308b\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u3068\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u3092\u7528\u3044\u305f\u63a2\u7d22\u7684\u89e3\u6790\u306f\u3001\u3053\u306e\u4e3b\u5f35\u306b\u53cd\u3057\u3066\u3044\u308b <\/span><sup>7,8<\/sup><span>.\u7e70\u308a\u8fd4\u3057\u306b\u306a\u308b\u304c\u3001\u3053\u308c\u3089\u306e\u85ac\u5264\u3092\u7528\u3044\u305f\u73fe\u5728\u9032\u884c\u4e2d\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u7814\u7a76\u306b\u3088\u308b\u78ba\u5b9a\u7684\u306a\u7d50\u679c\u3092\u5f85\u3064\u5fc5\u8981\u304c\u3042\u308b\u3002 <\/span><\/p>\n<p><em>\u8102\u8cea\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\u3092\u8d85\u3048\u3066<\/em><span><\/span><br \/><span>\u6b21\u306b\u3001\u9078\u629e\u7684\u30ca\u30c8\u30ea\u30a6\u30e0\u30fb\u30b0\u30eb\u30b3\u30fc\u30b9\u5171\u8f38\u9001\u4f532\uff08SGLT2\uff09\u963b\u5bb3\u85ac\u3067\u3042\u308b\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u3092\u7528\u3044\u305fEMPA-REG OUTCOME\u8a66\u9a13\u306e\u7d50\u679c\u306f\u3001\u8102\u8cea\u4ee5\u5916\u306e\u5371\u967a\u56e0\u5b50\u306e\u95a2\u9023\u6027\u3092\u660e\u78ba\u306b\u793a\u3057\u3066\u3044\u308b\u3002 <\/span><sup>9<\/sup><span>.\u3053\u306e\u8a66\u9a13\u306f\u3001\u5fc3\u8840\u7ba1\u7cfb\u75be\u60a3\u306e\u3042\u308b\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u5fc3\u7b4b\u6897\u585e\u3084\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u306b\u5bfe\u3059\u308b\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u304c\u306a\u3044\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u4e3b\u8981\u8907\u5408\u5fc3\u8840\u7ba1\u7cfb\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u304c\u5fc3\u8840\u7ba1\u7cfb\u6b7b\u4ea1\u7387\u306e\u6e1b\u5c11\uff0838\uff05\u6e1b\uff09\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u4f4e\u4e0b\u3057\u305f\u3053\u3068\u3067\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u4f4e\u4e0b\u85ac\u304c\u5fc3\u8840\u7ba1\u7cfb\u30a2\u30a6\u30c8\u30ab\u30e0\u8a66\u9a13\u306b\u304a\u3044\u3066\u512a\u8d8a\u6027\u3092\u793a\u3057\u305f\u521d\u3081\u3066\u306e\u8a66\u9a13\u3067\u3042\u308b\u3002\u91cd\u8981\u306a\u3053\u3068\u306f\u3001\u3053\u306e\u6e1b\u5c11\u304c\u3001\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u63a8\u5968\u3055\u308c\u3066\u3044\u308b\u8840\u5727\u3001\u8840\u7cd6\u5024\u3001\u8102\u8cea\u7570\u5e38\u75c7\u306e\u7ba1\u7406\u306a\u3069\u306e\u6a19\u6e96\u6cbb\u7642\u3092\u80cc\u666f\u306b\u9054\u6210\u3055\u308c\u305f\u3053\u3068\u3067\u3042\u308b\u3002\u3053\u306e\u3088\u3046\u306b\u30012015\u5e74\u73fe\u5728\u3001\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306b\u3064\u3044\u3066\u8102\u8cea\u4ee5\u5916\u306e\u5371\u967a\u56e0\u5b50\u3092\u8003\u616e\u3059\u308b\u3053\u3068\u306e\u91cd\u8981\u6027\u3092\u793a\u3059\u80af\u5b9a\u7684\u306a\u8a66\u9a13\u304c\u884c\u308f\u308c\u3066\u3044\u308b\u3002   <\/span><br \/><span>\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3092\u5909\u3048\u308b\u3060\u308d\u3046\u304b\uff1f\u9593\u9055\u3044\u306a\u304f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3059\u308b2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u3068\u3063\u3066\u6709\u76ca\u3067\u3042\u308d\u3046\u304c\u3001\u3053\u306e\u6709\u76ca\u6027\u306e\u6a5f\u5e8f\u3084\u3001\u975e\u7cd6\u5c3f\u75c5\u60a3\u8005\u3084\u4e00\u6b21\u4e88\u9632\u306e\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u3082\u5b58\u5728\u3059\u308b\u304b\u3069\u3046\u304b\u306b\u3064\u3044\u3066\u306f\u7591\u554f\u304c\u6b8b\u308b\u3002\u672c\u8a66\u9a13\u304b\u3089\u305d\u306e\u3088\u3046\u306a\u77e5\u898b\u304c\u5f97\u3089\u308c\u306a\u3044\u9650\u308a\uff0cR3i\u306f\uff0c2\u6b21\u4e88\u9632\u306e\u8a2d\u5b9a\u306b\u304a\u3044\u3066\uff0c2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308b\u8102\u8cea\u304a\u3088\u3073\u975e\u8102\u8cea\u5bc4\u4e0e\u56e0\u5b50\u306e\u4e21\u65b9\u3092\u542b\u3080\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u3092\u7ba1\u7406\u3059\u308b\u305f\u3081\u306e\u5305\u62ec\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u4eca\u3053\u305d\u5fc5\u8981\u3067\u3042\u308b\u3068\u8003\u3048\u3066\u3044\u308b\u3002  <\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf&#8221; text_font_size=&#8221;14px&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22text_text_color%22%93}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p><em>\u8102\u8cea\u4ee5\u5916\u306e\u5fae\u5c0f\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6b8b\u5b58<\/em><span><\/span><br \/><span>\u6700\u5f8c\u306b\uff0c\u5fae\u5c0f\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\u306b\u8102\u8cea\u4ee5\u5916\u306e\u5371\u967a\u56e0\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u3082\u84c4\u7a4d\u3055\u308c\u3064\u3064\u3042\u308b\u3002\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306b\u898b\u3089\u308c\u308b\u3088\u3046\u306a\u7cd6\u5c3f\u75c5\u6027\u7db2\u819c\u75c7\u3060\u3051\u3067\u306a\u304f\u3001\u52d5\u7269\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066SGLT2\u963b\u5bb3\u85ac\u306b\u3088\u308b\u814e\u4fdd\u8b77\u4f5c\u7528\u306e\u53ef\u80fd\u6027\u3092\u793a\u5506\u3059\u308b\u30c7\u30fc\u30bf\u3082\u51fa\u3066\u304d\u3066\u3044\u308b\u3002   <\/span><sup>10,11<\/sup><span>.\u3053\u308c\u306f\u3059\u3067\u306b\u81e8\u5e8a\u8a66\u9a13\u3067\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u3055\u308c\u3066\u3044\u308b   <\/span><sup>12,13<\/sup><span>.<\/span><\/p>\n<p><span>R3i\u306f\u3001\u6b8b\u5b58\u8840\u7ba1\u30ea\u30b9\u30af\u3068\u3044\u3046\u6982\u5ff5\u306f\u3001\u8ca1\u56e3\u304c\u8a2d\u7acb\u3055\u308c\u305f2008\u5e74\u3088\u308a\u30822015\u5e74\u306e\u65b9\u304c\u3088\u308a\u9069\u5207\u3067\u3042\u308b\u3068\u8003\u3048\u3066\u3044\u308b\u3002\u5c06\u6765\u7684\u306b\u306f\u3001\u8102\u8cea\u304a\u3088\u3073\u8102\u8cea\u4ee5\u5916\u306e\u5371\u967a\u56e0\u5b50\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u3001\u5fc3\u8840\u7ba1\u304a\u3088\u3073\u5fae\u5c0f\u8840\u7ba1\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u7ba1\u7406\u306e\u6a19\u6e96\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u81e8\u5e8a\u533b\u306b\u3068\u3063\u3066\u306e &#8220;\u8056\u676f &#8220;\u3067\u3042\u308b\u6b8b\u5b58\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6392\u9664\u306f\u3001\u672c\u5f53\u306b\u6211\u3005\u306e\u624b\u306e\u5c4a\u304f\u3068\u3053\u308d\u306b\u3042\u308b\u306e\u3060\u308d\u3046\u304b\uff1f  <\/span><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;8px&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p style=\"font-weight: 400;\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<ol>\n<li style=\"font-weight: 400;\"><span>Sacks FM\u3001Carey VJ\u3001Fruchart JC\u30022\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u8102\u8cea\u4f75\u7528\u7642\u6cd5\u3002N Engl J Med 2010,363:692-684.  <\/span><br \/><span class=\"ref ref2\">2.<\/span><span> \u5fc3\u8840\u7ba1\u7cfb\u306e\u8ee2\u5e30\u306b\u5bfe\u3059\u308b\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u52b9\u679c\uff1a\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\u3068\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3002Lancet 2010,375:1875-84.  <\/span><br \/><span class=\"ref ref3\">3.<\/span><span> \u6b27\u5dde\u5fc3\u81d3\u75c5\u5b66\u4f1a\uff08ESC\uff09\u3068\u6b27\u5dde\u52d5\u8108\u786c\u5316\u5b66\u4f1a\uff08EAS\uff09\u306e\u8102\u8cea\u7570\u5e38\u75c7\u7ba1\u7406\u30bf\u30b9\u30af\u30d5\u30a9\u30fc\u30b9\uff08ESC\/EAS Guidelines for the management of dyslipidaemias: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS).Eur Heart J 2011;32:1769-818.  <\/span><br \/><span class=\"ref ref4\">4.<\/span><span> \u30ea\u30ea\u30fc\u793e\u3001\u9ad8\u30ea\u30b9\u30af\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u6cbb\u7642\u85acEvacetrapib\u306e\u958b\u767a\u3092\u4e2d\u6b62 <a href=\"https:\/\/investor.lilly.com\/releasedetail.cfm?ReleaseID=936130\" rel=\"nofollow\">https:\/\/investor.lilly.com\/releasedetail.cfm?ReleaseID=936130<\/a> <\/span><br \/><span class=\"ref ref5\">5.<\/span><span> Nicholls SJ, Brewer HB, Kastelein JJ et al.CETP\u963b\u5bb3\u85acevacetrapib\u306e\u5358\u5264\u307e\u305f\u306f\u30b9\u30bf\u30c1\u30f3\u3068\u306e\u4f75\u7528\u6295\u4e0e\u306b\u3088\u308bHDL\u304a\u3088\u3073LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3078\u306e\u5f71\u97ff\uff1a\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\u3002JAMA 2011;306:2099-109.  <\/span><br \/><span class=\"ref ref6\">6.<\/span><span> \u6025\u6027\u5fc3\u7b4b\u6897\u585e\u767a\u75c7\u524d\u306e\u30b9\u30bf\u30c1\u30f3\u4f7f\u7528\u304c\u539f\u56e0\u75c5\u5909\u306e\u51a0\u52d5\u8108\u30d7\u30e9\u30fc\u30af\u5f62\u614b\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3002Angiology 2013;64:375-8.  <\/span><br \/><span class=\"ref ref7\">7.<\/span><span> Sabatine MS\u3001Giugliano RP\u3001Wiviott SD\u3089\u3001\u8102\u8cea\u3068\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u6e1b\u5c11\u306b\u304a\u3051\u308b\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3002N Engl J Med 2015;372:1500-9.  <\/span><br \/><span class=\"ref ref8\">8.<\/span><span> Robinson JG\u3001Farnier M\u3001Krempf M\u3089\u3001\u8102\u8cea\u3068\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u6e1b\u5c11\u306b\u304a\u3051\u308b\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3002N Engl J Med 2015;372:1489-99.  <\/span><br \/><span class=\"ref ref9\">9.<\/span><span> Zinman B, Wanner C, Lachin JM et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes.N Engl J Med 2015; DOI: 10.1056\/NEJMoa1504720.  <\/span><br \/><span class=\"ref ref10\">10.<\/span><span> Kojima N, Williams JM, Slaughter TN et al. \u7cd6\u5c3f\u75c5\u30c0\u30fc\u30ebS\u30e9\u30c3\u30c8\u306b\u304a\u3051\u308bSGLT2\u3068ACE\u963b\u5bb3\u85ac\u4f75\u7528\u7642\u6cd5\u306e\u814e\u4fdd\u8b77\u52b9\u679c\u3002Physiol Rep 2015;3(7). pii: e12436.   <\/span><br \/><span class=\"ref ref11\">11.<\/span><span> T2DN\u30e9\u30c3\u30c8\u306b\u304a\u3051\u308b\u65b0\u898fSGLT2\u963b\u5bb3\u85ac\u30eb\u30bb\u30aa\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u306e\u7cd6\u5c3f\u75c5\u6027\u814e\u75c7\u306b\u5bfe\u3059\u308b\u52b9\u679c.J Pharmacol Exp Ther 2013;345:464-72.  <\/span><\/li>\n<\/ol>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>R3i\u793e\u8aac\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\uff1a\u8102\u8cea\u3060\u3051\u3067\u306f\u306a\u3044\uff01 \u30df\u30b7\u30a7\u30eb\u30fb\u30d8\u30eb\u30de\u30f3\u30ba\u6559\u6388\u3001\u30d4\u30a8\u30fc\u30eb\u30fb\u30a2\u30de\u30ec\u30f3\u30b3\u6559\u6388 \u4f55\u304c\u5fc3\u8840 [&hellip;]<\/p>\n","protected":false},"author":258497324,"featured_media":0,"parent":254286,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_wpcom_ai_launchpad_about_page":false,"_wpcom_ai_launchpad_gallery_page":false,"_wpcom_ai_launchpad_contact_page":false,"_wpcom_ai_launchpad_events_page":false,"_wpcom_ai_launchpad_video_page":false,"_wpcom_ai_launchpad_portfolio_piece":false,"footnotes":""},"class_list":["post-254631","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - 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