{"id":254627,"date":"2024-12-30T19:28:18","date_gmt":"2024-12-30T18:28:18","guid":{"rendered":"https:\/\/r3i.org\/r3i%e7%a4%be%e8%aa%ac\/%e7%a4%be%e8%aa%ac-10-20-%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e3%82%92%e3%82%bf%e3%83%bc%e3%82%b2%e3%83%83%e3%83%88%e3%81%ab%ef%bc%9a%e6%96%b0%e8%a6%8f%e8%96%ac%e5%89%a4\/"},"modified":"2025-02-22T17:49:22","modified_gmt":"2025-02-22T16:49:22","slug":"%e7%a4%be%e8%aa%ac-10-20-%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e3%82%92%e3%82%bf%e3%83%bc%e3%82%b2%e3%83%83%e3%83%88%e3%81%ab%ef%bc%9a%e6%96%b0%e8%a6%8f%e8%96%ac%e5%89%a4","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/r3i%e7%a4%be%e8%aa%ac\/%e7%a4%be%e8%aa%ac-10-20-%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e3%82%92%e3%82%bf%e3%83%bc%e3%82%b2%e3%83%83%e3%83%88%e3%81%ab%ef%bc%9a%e6%96%b0%e8%a6%8f%e8%96%ac%e5%89%a4\/","title":{"rendered":"\u793e\u8aac 10\/20 – \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\uff1a\u65b0\u898f\u85ac\u5264\u304c\u3053\u306e\u5206\u91ce\u3092\u62e1\u5927\u3059\u308b"},"content":{"rendered":"

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R3i\u793e\u8aac<\/h2>\n

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Prof. Jean Charles Fruchart, Prof. Michel Hermans, Prof. Pierre Amarenco<\/h6>\n
\u7de8\u96c6\u30c7\u30b9\u30af\u304b\u3089<\/h6>\n

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\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

    \n
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    Miller M, Stone NJ, Ballantyne C, et al. Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. Circulation 2011;123:2292\u20132333.<\/span>
    2.<\/span>\u00a0Ganda OP, Bhatt DL, Mason RP, et al. Unmet need for adjunctive dyslipidemia therapy in hypertriglyderidemia management. J Am Coll Cardiol 2018;72:330\u2013343.<\/span>
    3.<\/span>\u00a0Budoff M. Triglycerides and triglyceride-rich lipoproteins in the causal pathway of cardiovascular disease. Am J Cardiol 2016;118:138\u2013145.<\/span>
    4.<\/span>\u00a0Bhatt DL, Steg PG, Miller M, et al; REDUCE-IT Investigators. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. N Engl J Med 2019;380:11-22.<\/span>
    5.<\/span>\u00a0Yokoyama M, Origasa H, Matsuzaki M, et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet. 2007;369:1090\u20131098.<\/span>
    6.<\/span>\u00a0Mach F, Baigent C Catapano AL, et al. 2019 ESC\/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS) Eur Heart J. 2020;41:111\u2013188.<\/span>
    7.<\/span>\u00a0NLA position on the use of icosapent ethyl in high and very-high risk patients. Jacksonville, FL: National Lipid Association, 2019.     https:\/\/www.lipid.org\/nla\/nla-position-use-icosapent-ethyl-high-and-very-high-risk-patients<\/a>.<\/span>
    8.<\/span>\u00a0Skulas-Ray AC, Wilson PWF, Harris WS, et al. Omega-3 fatty acids for the management of hypertriglyceridemia: A science advisory from the American Heart Association. Circulation 2019;140:e673\u2013e691.<\/span>
    9.<\/span>\u00a0J\u00f8rgensenAB, Frikke-SchmidtR, NordestgaardBG, et al. Loss-of-function mutations in APOC3 and risk of ischemic vascular disease. N Engl J Med 2014;371:32\u201341.<\/span>
    10.<\/span>\u00a0TG and HDL Working Group of the Exome Sequencing Project NH, Lung, and Blood Institute Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med 2014;371:22\u201331.<\/span>
    11.<\/span>\u00a0Stitziel NO, KheraAV, WangX, et al. ANGPTL3 deficiency and protection against coronary artery disease. J Am Coll Cardiol 2017;69:2054\u20132063.<\/span>
    12.<\/span>\u00a0Wang Y, Gusarova V, BanfiS, et al. Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion. J Lipid Res 2015;56:1296\u20131307.<\/span>
    13.<\/span>\u00a0Ballantyne C. RNA interference targeting apolipoprotein C-III with ARO-APOC3 in healthy volunteers mimics lipid and lipoprotein findings seen in subjects with inherited apolipoprotein C-III deficiency. ESC Congress Virtual Meeting 2020.<\/span>
    14.<\/span>\u00a0Watts G. RNAi inhibition of angiopoietin-like protein 3 (ANGPTL3) with ARO-ANG3 mimics the lipid and lipoprotein profile of familial combined hypolipidemia. ESC Congress Virtual Meeting 2020.<\/span>
    15.<\/span>\u00a0Gaudet D, Karwatowska-Prokopczuk E, Baum SJ et al. Vupanorsen, an N-acetyl galactosamine-conjugated antisense drug to ANGPTL3 mRNA, lowers triglycerides and atherogenic lipoproteins in patients with diabetes, hepatic steatosis, and hypertriglyceridaemia. Eur Heart J 2020; doi:10.1093\/eurheartj\/ehaa689<\/span>
    16.<\/span>\u00a0Yamashita S, Masuda D, Matsuzawa Y. Pemafibrate, a new selective PPAR\u03b1 Modulator: drug concept and its clinical applications for dyslipidemia and metabolic diseases. Curr Atheroscler Rep 2020;22<\/span>1<\/sup>:5.<\/span>
    17.<\/span>\u00a0Fruchart JC, Hermans MP, Fruchart-Najib J. Selective Peroxisome Proliferator-Activated Receptor Alpha Modulators (SPPARM\u03b1): new opportunities to reduce residual cardiovascular risk in chronic kidney disease? Curr Atheroscler Rep 2020;22<\/span>8<\/sup>:43.<\/span>
    18.<\/span>\u00a0Pemafibrate to reduce cardiovascular outcomes by reducing triglycerides in patients with diabetes (PROMINENT) [NCT03071692]     https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03071692<\/a><\/span><\/div>\n<\/li>\n<\/ol>\n

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