{"id":254612,"date":"2024-12-27T19:23:57","date_gmt":"2024-12-27T18:23:57","guid":{"rendered":"https:\/\/r3i.org\/r3i%e7%a4%be%e8%aa%ac\/%e7%a4%be%e8%aa%ac-09-22-%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e6%ae%8b%e5%ad%98%ef%bc%9a%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bdb%e3%81%af%e6%9c%9b\/"},"modified":"2025-02-22T16:34:18","modified_gmt":"2025-02-22T15:34:18","slug":"%e7%a4%be%e8%aa%ac-09-22-%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e6%ae%8b%e5%ad%98%ef%bc%9a%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bdb%e3%81%af%e6%9c%9b","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/r3i%e7%a4%be%e8%aa%ac\/%e7%a4%be%e8%aa%ac-09-22-%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e6%ae%8b%e5%ad%98%ef%bc%9a%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bdb%e3%81%af%e6%9c%9b\/","title":{"rendered":"\u793e\u8aac 09\/22 – \u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\uff1a\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u306f\u671b\u307e\u3057\u3044\u30de\u30fc\u30ab\u30fc\u304b\uff1f"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Header” _builder_version=”4.27.4″ _module_preset=”35f37621-1062-4ae6-955d-76a3167a2aa8″ background_image=”https:\/\/r3i.org\/wp-content\/uploads\/2024\/12\/pexels-pixabay-267582.jpg&#8221<\/a>; parallax=”on” min_height=”157.9px” min_height_tablet=”100px” min_height_phone=”100px” min_height_last_edited=”on|phone” height=”116px” height_tablet=”153px” height_phone=”130px” height_last_edited=”on|phone” custom_margin_tablet=”” custom_margin_phone=”-17px||||false|false” custom_margin_last_edited=”on|phone” custom_padding=”0vw||0vw||true|false” collapsed=”on” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22background_color_gradient_stops%22%93}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_text_color=”#FFFFFF” header_2_text_color=”#FFFFFF” custom_padding=”1px|||||” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

R3i \u7de8\u96c6\u8a18\u4e8b<\/spanhelvetica><\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.3″ _module_preset=”default” custom_margin=”-49px|||||” custom_padding=”2px||40px|||” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.27.4″ _module_preset=”default” border_radii=”off|13px|13px|13px|13px” border_width_all=”4px” border_color_all=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_width_all_tablet=”4px” border_width_all_phone=”0px” border_width_all_last_edited=”on|phone” border_color_all_tablet=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_phone=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_last_edited=”on|phone” box_shadow_style=”preset2″ global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22border_color_all%22%93}”][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” header_5_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_5_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}” sticky_enabled=”0″]<\/p>\n

\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\uff1a\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u306f\u512a\u5148\u3055\u308c\u308b\u30de\u30fc\u30ab\u30fc\u304b\uff1f<\/span><\/h5>\n
Prof. Jean Charles Fruchart, Prof. Michel Hermans, Prof. Pierre Amarenco
\u7de8\u96c6\u30c7\u30b9\u30af\u304b\u3089<\/span><\/h6>\n

\u8102\u8cea\u7570\u5e38\u75c7\u306b\u95a2\u3059\u308b\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u4f4e\u6e1b\u3092\u76ee\u6307\u3057\u305f\u4ecb\u5165\u306e\u4e3b\u8981\u306a\u8102\u8cea\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u3066\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u306b\u6ce8\u76ee\u3057\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u3001\u60a3\u8005\u304cLDL-C\u306e\u76ee\u6a19\u5024\u3001\u3042\u308b\u3044\u306f\u305d\u308c\u3088\u308a\u3082\u4f4e\u3044\u6570\u5024\u3092\u9054\u6210\u3057\u3066\u3044\u308b\u5834\u5408\u3067\u3082\u3001\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u5b58\u5728\u3059\u308b\u00a0<\/span>1,2<\/sep>\u00a0\u3002\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306f\u69d8\u3005\u306a\u8981\u7d20\u304b\u3089\u306a\u308b\u304c\u3001\u30ea\u30dd\u86cb\u767d\u95a2\u9023\u306e\u30ea\u30b9\u30af\u304c\u4e3b\u8981\u306a\u8981\u7d20\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u00a0<\/span>3<\/sep>\u00a0\u3002\u554f\u984c\u306f\u3001\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3057\u3001\u6cbb\u7642\u7684\u4ecb\u5165\u306e\u6307\u91dd\u3068\u3059\u308b\u306b\u306f\u3001\u3069\u306e\u8102\u8cea\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u304c\u6700\u3082\u9069\u5207\u304b\u3068\u3044\u3046\u3053\u3068\u3067\u3042\u308b\u3002<\/span><\/p>\n

\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u3001LDL-C\u306e\u307b\u304b\u306b\u3001\u975e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08non-HDL-C\uff09\u3068\u30a2\u30dd\u30ea\u30dd\u86cb\u767d\uff08apo\uff09B\u3092\u91cd\u8981\u306a\u526f\u6b21\u7684\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3059\u308b\u3088\u3046\u63d0\u8a00\u3057\u3066\u3044\u308b\uff08<\/span>4\u3002\u3053\u308c\u3089\u306e\u30d1\u30e9\u30e1\u30fc\u30bf\u306f\u3001LDL-C\u306e\u76ee\u6a19\u5024\u3092\u9054\u6210\u3057\u3066\u3044\u308b\u5834\u5408\u3067\u3082\u9ad8\u5024\u3092\u7dad\u6301\u3059\u308b\u5834\u5408\u304c\u3042\u308b\u3002\u305f\u3068\u3048\u3070\u3001National Health and Nutrition Examination Survey and Very Large Database of Lipids\u7814\u7a76\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u305f\u3042\u308b\u89e3\u6790\u3067\u306f\u3001LDL-C\u306e\u76ee\u6a19\u5024\uff08\uff1c70 mg\/dL\uff09\u3092\u9054\u6210\u3057\u3066\u3044\u308b\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306e7\u4f8b\u306b1\u4f8b\u304cnon-HDL-C\u9ad8\u5024\u300112\u4f8b\u306b1\u4f8b\u304capoB\u9ad8\u5024\u3067\u3042\u3063\u305f\uff085\uff09\u3002\u3053\u306e\u305f\u3081\u3001non-HDL-C\u3068apoB\u306e\u4e21\u8005\u304c\u3001\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306e\u6f5c\u5728\u7684\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u63d0\u6848\u3055\u308c\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u30012019\u5e74\u306e\u6b27\u5dde\u5fc3\u81d3\u75c5\u5b66\u4f1a\uff0f\u6b27\u5dde\u52d5\u8108\u786c\u5316\u5b66\u4f1a\u306e\u8102\u8cea\u7570\u5e38\u75c7\u306b\u95a2\u3059\u308b\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u3001apoB\u304c\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6307\u6a19\u3068\u3057\u3066LDL-C\u3084HDL-C\u3088\u308a\u3082\u6b63\u78ba\u3067\u3042\u308a\u3001\u8102\u8cea\u306e\u4f4e\u4e0b\u304c\u9069\u5207\u3067\u3042\u308b\u304b\u3092\u5224\u65ad\u3059\u308b\u305f\u3081\u306e\u512a\u308c\u305f\u6307\u91dd\u3068\u306a\u308b\u3068\u7d50\u8ad6\u3057\u3066\u3044\u308b\u00a0<\/span>4\u00a0<\/span>\u3002<\/p>\n

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apoB\u306f\u3001\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u6709\u7528\u3067\u3042\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u6cbb\u7642\u7684\u4ecb\u5165\u306e\u6307\u91dd\u306b\u3082\u306a\u308a\u3046\u308b\u3002ODYSSEY OUTCOMES\u8a66\u9a13\u306e\u6700\u8fd1\u306e\u89e3\u6790\u3067\u306f\u3001\u4e21\u65b9\u306e\u7279\u6027\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u305f\uff08<\/span>10<\/sep>\u00a0\u3002ODYSSEY OUTCOMES\u8a66\u9a13\u3067\u306f\u3001\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u3092\u6700\u8fd1\u767a\u75c7\u3057\u3001\u9ad8\u5f37\u5ea6\u306e\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u30a2\u30c6\u30ed\u30fc\u30e0\u5f62\u6210\u6027\u30ea\u30dd\u86cb\u767d\u304c\u9ad8\u5024\uff3bLDL-C\u226770 mg\/dL\uff081.81 mmol\/L\uff09\u3001non-HDL-C\u2267100 mg\/dL\uff082.59 mmol\/L\uff09\u307e\u305f\u306fapoB\u226780 mg\/dL\uff3d\u306e\u60a3\u8005\u3092\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u305f\u3002\u4e3b\u8981\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08MACE\uff09\u306e\u30ea\u30b9\u30af\u304c\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eapoB\u6fc3\u5ea6\u306e\u4e0a\u6607\u306b\u4f34\u3063\u3066\u5897\u5927\u3057\u305f\u3060\u3051\u3067\u306a\u304f\uff08\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eapoB\u5024\u304c10 mg\/dL\u4e0a\u6607\u3059\u308b\u3054\u3068\u306b11%\u5897\u5927\uff09\u30014\u30f5\u6708\u6642\u306e\u6cbb\u7642\u4e2d\u306eapoB\u5024\u304c\u4f4e\u3044\u60a3\u8005\u307b\u3069\u3001MACE\u306e\u6e1b\u5c11\u304c\u76f8\u5bfe\u7684\u306b\u3082\u7d76\u5bfe\u7684\u306b\u3082\u5927\u304d\u304b\u3063\u305f\u3002\u3053\u306eapoB\u9054\u6210\u5024\u3068\u7d76\u5bfe\u7684\u306a\u81e8\u5e8a\u7684\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u3068\u306e\u95a2\u4fc2\u306f\u3001LDL-C\u5024\u3084non-HDL-C\u5024\u3088\u308a\u3082\u826f\u597d\u3067\u3042\u3063\u305f\u00a0<\/span>10<\/sep>\u00a0\u3002<\/span><\/p>\n

\u4ee5\u4e0a\u3092\u7dcf\u5408\u3059\u308b\u3068\u3001\u84c4\u7a4d\u3057\u305f\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u3088\u308a\u3001apoB\u304c\u30ea\u30dd\u86cb\u767d\u95a2\u9023\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u306e\u8a55\u4fa1\u306b\u304a\u3044\u3066\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002\u81e8\u5e8a\u533b\u306b\u3068\u3063\u3066\u306f\u3001\u3053\u306e\u77e5\u898b\u3092\u65e5\u5e38\u8a3a\u7642\u306b\u3069\u306e\u3088\u3046\u306b\u53d6\u308a\u5165\u308c\u308b\u306e\u304c\u6700\u5584\u3067\u3042\u308b\u304b\u304c\u554f\u984c\u3067\u3042\u308b\u3002\u73fe\u5728\u3067\u306fapoB\u306e\u6e2c\u5b9a\u306f\u5bb9\u6613\u306b\u5229\u7528\u3067\u304d\u3001\u5b89\u4fa1\u3067\u3001\u59a5\u5f53\u6027\u304c\u5341\u5206\u306b\u691c\u8a3c\u3055\u308c\u3066\u304a\u308a\u3001\u7a7a\u8179\u6642\u306e\u63a1\u8840\u3092\u5fc5\u8981\u3068\u305b\u305a\u3001\u8102\u8cea\u691c\u67fb\u9805\u76ee\u306b\u65e5\u5e38\u7684\u306b\u7d44\u307f\u5165\u308c\u308b\u3053\u3068\u304c\u3067\u304d\u308b\uff0811\uff09\u3002apoB\u306e\u6e2c\u5b9a\u304c\u81e8\u5e8a\u306e\u5834\u3067\u65e5\u5e38\u7684\u306b\u884c\u308f\u308c\u308b\u305f\u3081\u306b\u306f\u3001\u3053\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u8a8d\u8b58\u3057\u3053\u308c\u306b\u5bfe\u5fdc\u3057\u305f\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u306f\u660e\u3089\u304b\u3067\u3042\u308b\u3002<\/span><\/p>\n

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\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

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  1. Sabatine MS, Giugliano RP, Keech AC, et al. Evolocumab and clinical outcomes in patients with cardiovascular disease. N Engl J Med 2017; 376:1713\u201322.<\/span>
    2.<\/span>\u00a0Schwartz GG, Steg PG, Szarek M, et al. Alirocumab and cardiovascular outcomes after acute coronary syndrome. N Engl J Med 2018 379:2097\u2013107.<\/span>
    3.<\/span>\u00a0Honda S, Puri R, Anderson T, Kastelein JJP, et al. Determinants of plaque progression despite very low Low-density lipoprotein-cholesterol levels with the PCSK9 inhibitor, evolocumab. JACC Cardiovasc Imaging 2021;doi: 10.1016\/j.jcmg.2021.11.014.<\/span>
    4.<\/span>\u00a0Mach F, Baigent C, Catapano AL, et al. 2019 ESC\/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J 2020;41:111-88.<\/span>
    5.<\/span>\u00a0Sathiyakumar V, Park J, Quispe R, et al. Impact of novel low-density lipoprotein-cholesterol assessment on the utility of secondary non-high-density lipoprotein-C and apolipoprotein B targets in selected worldwide dyslipidemia guidelines. Circulation 2018;138:244-54.<\/span>
    6.<\/span>\u00a0Sniderman AD, Thanassoulis G, Glavinovic T, et al. Apolipoprotein B particles and cardiovascular disease: a narrative review. JAMA Cardiol 2019;4:1287-95.<\/span>
    7.<\/span>\u00a0Johannesen CDL, Mortensen MB, Langsted A, Nordestgaard BG. Apolipoprotein B and non-HDL cholesterol better reflect residual risk than LDL cholesterol in statin-treated patients. J Am Coll Cardiol 2021;77:1439-50.<\/span>
    8.<\/span>\u00a0Marston NA, Giugliano RP, Melloni GEM, et al. Association of Apolipoprotein B-containing lipoproteins and risk of myocardial infarction in individuals with and without atherosclerosis: distinguishing between particle concentration, type, and content. JAMA Cardiol 2022;7:250-6.<\/span>
    9.<\/span>\u00a0Ference BA, Kastelein JJP, Ray KK, et al. Association of triglyceride-lowering LPL variants and LDL-C-lowering LDLR variants with risk of coronary heart disease. JAMA 2019;321:364-73.<\/span>
    10.<\/span>\u00a0Hagstr\u00f6m E, Steg PG, Szarek M, et al. Apolipoprotein B, residual cardiovascular risk after acute coronary syndrome, and effects of alirocumab. Circulation 2022 Jun 30:101161CIRCULATIONAHA121057807. doi: 10.1161\/CIRCULATIONAHA.121.057807.<\/span>
    11.<\/span>\u00a0Langlois MR, Nordestgaard BG, Langsted A, et al. Quantifying atherogenic lipoproteins for lipid-lowering strategies: consensus-based recommendations from EAS and EFLM. Clin Chem Lab Med 2020;58:496-517.<\/span><\/li>\n<\/ol>\n

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