{"id":254602,"date":"2025-01-04T17:07:29","date_gmt":"2025-01-04T16:07:29","guid":{"rendered":"https:\/\/r3i.org\/r3i%e7%a4%be%e8%aa%ac\/%e8%ab%96%e8%aa%ac-09-15-%e5%9f%ba%e6%9c%ac%e3%81%ab%e7%ab%8b%e3%81%a1%e8%bf%94%e3%82%8b%ef%bc%9a%e4%b8%ad%e6%80%a7%e8%84%82%e8%82%aa%e3%83%aa%e3%83%83%e3%83%81%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bd\/"},"modified":"2025-02-16T23:46:32","modified_gmt":"2025-02-16T22:46:32","slug":"%e8%ab%96%e8%aa%ac-09-15-%e5%9f%ba%e6%9c%ac%e3%81%ab%e7%ab%8b%e3%81%a1%e8%bf%94%e3%82%8b%ef%bc%9a%e4%b8%ad%e6%80%a7%e8%84%82%e8%82%aa%e3%83%aa%e3%83%83%e3%83%81%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bd","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/r3i%e7%a4%be%e8%aa%ac\/%e8%ab%96%e8%aa%ac-09-15-%e5%9f%ba%e6%9c%ac%e3%81%ab%e7%ab%8b%e3%81%a1%e8%bf%94%e3%82%8b%ef%bc%9a%e4%b8%ad%e6%80%a7%e8%84%82%e8%82%aa%e3%83%aa%e3%83%83%e3%83%81%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bd\/","title":{"rendered":"\u8ad6\u8aac 09\/15 &#8211; 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<\/span><\/p>\n<p><span>\u3053\u308c\u3089\u306e\u77e5\u898b\u3092\u7dcf\u5408\u3059\u308b\u3068\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\u306b\u5bfe\u3059\u308bTRL\u306e\u91cd\u8981\u6027\u304c\u6539\u3081\u3066\u5f37\u8abf\u3055\u308c\u305f\u3060\u3051\u3067\u306a\u304f\u3001\u3053\u306e\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3059\u308b\u305f\u3081\u306e\u65b0\u898f\u6cbb\u7642\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u6f5c\u5728\u7684\u6a19\u7684\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3002\u3053\u308c\u3089\u306e\u65b0\u898f\u85ac\u5264\u306f\u3001\u81e8\u5e8a\u533b\u306b\u8102\u8cea\u95a2\u9023\u306e\u5fc3\u8840\u7ba1\u6b8b\u5b58\u30ea\u30b9\u30af\u3092\u6a19\u7684\u3068\u3059\u308b\u52b9\u679c\u7684\u306a\u6226\u7565\u3092\u63d0\u4f9b\u3059\u308b\u306e\u3067\u3042\u308d\u3046\u304b\uff1f\u305d\u308c\u306f\u6642\u9593\u304c\u7d4c\u305f\u306a\u3051\u308c\u3070\u308f\u304b\u3089\u306a\u3044\u3002  <\/span><\/p>\n<p><span>TRL\u304c\u518d\u3073\u6ce8\u76ee\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u3001\u6b21\u306e\u554f\u984c\u306f\u3053\u306e\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u3092\u3069\u306e\u3088\u3046\u306b\u6e2c\u5b9a\u3059\u308b\u306e\u304c\u6700\u5584\u304b\u3068\u3044\u3046\u3053\u3068\u3067\u3042\u308b\u3002\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306e\u6e2c\u5b9a\u306fTRL\u306e\u8cea\u91cf\u3092\u63a8\u5b9a\u3059\u308b\u306e\u306b\u4fbf\u5229\u306a\u65b9\u6cd5\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001TRL\u306b\u542b\u307e\u308c\u308b\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u306f\u3001TRL\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8ca0\u8377\u306e\u6307\u6a19\u3068\u3057\u3066\u671b\u307e\u3057\u3044\u3002\u65e5\u5e38\u8a3a\u7642\u3067\u306f\u3001\u7279\u5b9a\u306e\u30ea\u30dd\u86cb\u767d\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u305f\u3081\u3001\u5b9f\u7528\u7684\u306a\u9078\u629e\u80a2\u3068\u3057\u3066\u3001\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb-(HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb+LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb)\u3067\u8a08\u7b97\u3055\u308c\u308b\u6b8b\u4f59\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u63d0\u6848\u3059\u308b\u4eba\u3082\u3044\u308b\u3002   <\/span><sup>12<\/sup><span> \u3088\u308a\u6b63\u78ba\u306b\u306f\u3001\u3053\u306e\u5f0f\u306fTRL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u3059\u306a\u308f\u3061\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u3001VLDL\u304a\u3088\u3073\u305d\u308c\u3089\u306e\u6b8b\u4f59\u7269\u306b\u542b\u307e\u308c\u308b\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff09\u3092\u8a08\u7b97\u3059\u308b\u3002\u3057\u304b\u3057\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u63a8\u5b9a\u306b\u306fFriedewald\u5f0f\u306e\u9650\u754c\u304c\u3042\u308b\u305f\u3081\u3001\u3053\u306e\u5f0f\u306f\u975e\u7d76\u98df\u72b6\u614b\u3067\u306f\u4f7f\u7528\u3067\u304d\u307e\u305b\u3093\u3002 <\/span><\/p>\n<p><span>\u3067\u306f\u3001TRL\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u8ca0\u8377\u306f\u65e5\u5e38\u8a3a\u7642\u3067\u3069\u306e\u3088\u3046\u306b\u63a8\u5b9a\u3067\u304d\u308b\u306e\u3060\u308d\u3046\u304b\uff1f\u4eca\u6708\u306e\u30d5\u30a9\u30fc\u30ab\u30b9\u3067\u306f\u3001\u3053\u306e\u554f\u984c\u3092\u53d6\u308a\u4e0a\u3052\u3001\u65e5\u5e38\u7684\u306a\u975e\u7d76\u98df\u691c\u4f53\u304b\u3089TRL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u9ad8\u3044\u7cbe\u5ea6\u3068\u8b58\u5225\u6027\u3067\u7b97\u51fa\u3067\u304d\u308b\u5f0f\u3092\u63d0\u6848\u3059\u308b\u3002 <\/span><sup>13<\/sup><span> TRL-\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068log[triglycerides] \u306f\u3001\u975e\u7d76\u98dfTRL\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u8ca0\u8377\u306e\u8a55\u4fa1\u306b\u304a\u3044\u3066\u540c\u69d8\u306b\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff0fHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6bd4\u306e\u5909\u52d5\u306e50\uff05\u8fd1\u304f\u304c\u6b8b\u5b58\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u8d77\u56e0\u3059\u308b\u3053\u3068\u3092\u8003\u3048\u308b\u3068\u3001TRL-\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068log \u3001 <\/span><sup>14<\/sup><span>\u3053\u306e\u3053\u3068\u306f\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u306b\u4f34\u3046\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u8a55\u4fa1\u306b\u9069\u7528\u3067\u304d\u308b\u6839\u62e0\u3068\u306a\u308b\u3002<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf&#8221; text_font_size=&#8221;14px&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22text_text_color%22%93}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p><span>\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\/HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6bd4\u306f\u5fae\u5c0f\u8840\u7ba1\u6b8b\u5b58\u30ea\u30b9\u30af\u306e\u8a55\u4fa1\u306b\u3082\u95a2\u9023\u3059\u308b\u3002\u4eca\u6708\u306e\u30e9\u30f3\u30c9\u30de\u30fc\u30af\u7814\u7a76\u3067\u306f <\/span><sup>15<\/sup><span> \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\/HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6bd4\u306f\u6162\u6027\u814e\u81d3\u75c5\u306e\u767a\u75c7\u3068\u9032\u884c\u306e\u72ec\u7acb\u3057\u305f\u4e88\u6e2c\u56e0\u5b50\u3067\u3042\u308a\u3001\u7cd6\u5c3f\u75c5\u60a3\u8005\u3067\u306f\u305d\u3046\u3067\u306a\u3044\u60a3\u8005\u3068\u6bd4\u8f03\u3057\u3066\u3088\u308a\u95a2\u9023\u6027\u306e\u9ad8\u3044\u56e0\u5b50\u3067\u3042\u3063\u305f\u3002HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u5bfe\u3059\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306e\u6bd4\u7387\u304c\u9ad8\u3044\u307b\u3069\u3001\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u63a8\u7b97\u7cf8\u7403\u4f53\u6ffe\u904e\u91cf\u306e\u4f4e\u4e0b\u3068\u6162\u6027\u814e\u81d3\u75c5\u306e\u767a\u75c7\u306e\u5371\u967a\u56e0\u5b50\u3067\u3042\u3063\u305f\u3002\u3053\u306e\u3053\u3068\u306f\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u3001\u7cd6\u5c3f\u75c5\u3001\u6162\u6027\u814e\u81d3\u75c5\u306e\u9593\u306b\u60aa\u5faa\u74b0\u7684\u306a\u76f8\u4e92\u4f5c\u7528\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u306fTRL\u3068\u305d\u306e\u6b8b\u9ab8\u306e\u84c4\u7a4d\u3068\u4fee\u98fe\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002 <\/span><sup>16<\/sup><span><\/span><\/p>\n<p><span>\u3053\u306e\u3088\u3046\u306b\u3001TRL\u306b\u542b\u307e\u308c\u308b\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u8ca0\u8377\u306f\u3001\u8102\u8cea\u306b\u95a2\u9023\u3057\u305f\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\u306b\u95a2\u9023\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u7279\u306b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u6162\u6027\u814e\u81d3\u75c5\u306e\u9032\u884c\u3084\u767a\u75c7\u306b\u3082\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002\u7c73\u56fd\u306e\u65b0\u3057\u3044\u30c7\u30fc\u30bf\u306b\u3088\u308b\u3068\u3001\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u7ba1\u7406\u306b\u304b\u304b\u308b\u8cbb\u7528\u306f\u3001\u7cd6\u5c3f\u75c5\u306e\u306a\u3044\u60a3\u8005\u3068\u6bd4\u8f03\u3057\u3066\u904e\u53bb10\u5e74\u9593\u30672\u500d\u4ee5\u4e0a\u306b\u5897\u52a0\u3057\u3066\u304a\u308a\u3001\u814e\u5408\u4f75\u75c7\u3068\u5fc3\u8840\u7ba1\u7cfb\u5408\u4f75\u75c7\u304c\u3053\u306e\u50be\u5411\u306b\u91cd\u8981\u306a\u5bc4\u4e0e\u3092\u3057\u3066\u3044\u308b\u3002 <\/span><sup>17<\/sup><span> \u7cd6\u5c3f\u75c5\u3068\u80a5\u6e80\u306e\u5927\u6d25\u6ce2\u306b\u3088\u308a\u3001\u3053\u306e\u3088\u3046\u306a\u50be\u5411\u306f\u9593\u9055\u3044\u306a\u304f\u5148\u9032\u56fd\u3001\u767a\u5c55\u9014\u4e0a\u56fd\u3092\u554f\u308f\u305a\u9855\u8457\u306b\u306a\u308b\u3067\u3042\u308d\u3046\u3002\u73fe\u5728\u3001\u81e8\u5e8a\u533b\u306b\u3068\u3063\u3066\u3001\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\u306b\u3088\u308b\u81e8\u5e8a\u7684\u30fb\u7d4c\u6e08\u7684\u5f71\u97ff\u3092\u8efd\u6e1b\u3059\u308b\u305f\u3081\u306b\u3001\u3053\u306e\u3088\u3046\u306a\u60a3\u8005\u3092\u3088\u308a\u3088\u304f\u540c\u5b9a\u3057\u3001\u7ba1\u7406\u3059\u308b\u3053\u3068\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u308b\u3002TRL\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u8ca0\u8377\u306e\u63a8\u5b9a\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u306f\u3001\u65e5\u5e38\u8a3a\u7642\u306b\u304a\u3051\u308b\u7ba1\u7406\u6539\u5584\u306e\u305f\u3081\u306e\u5b9f\u969b\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u306a\u308b\u3002\u307e\u305f\u3001\u30d2\u30c8\u306e\u907a\u4f1d\u5b66\u7684\u7814\u7a76\u306f\u3001\u6700\u7d42\u7684\u306b\u8102\u8cea\u95a2\u9023\u306e\u6b8b\u5b58\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308b\u52b9\u679c\u7684\u306a\u5bfe\u6297\u7b56\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u3092\u671f\u5f85\u3057\u3066\u3001\u65b0\u3057\u3044\u6cbb\u7642\u6226\u7565\u306e\u78ba\u7acb\u306b\u5f79\u7acb\u3064\u304b\u3082\u3057\u308c\u306a\u3044\u3002   <\/span><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;8px&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p style=\"font-weight: 400;\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<ol>\n<li style=\"font-weight: 400;\"><span>Chapman MJ, Ginsberg HN, Amarenco P et al. \u5fc3\u8840\u7ba1\u75be\u60a3\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3051\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u30ea\u30c3\u30c1\u30ea\u30dd\u86cb\u767d\u3068\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff1a\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u7ba1\u7406\u6307\u91dd\u3002Eur Heart J 2011;32:1345-61.  <\/span><br \/><span class=\"ref ref2\">2.<\/span><span> Fruchart JC, Davignon J, Hermans MP, et al; Residual risk reduction initiative (R3i).2013\u5e74\u306e\u6b8b\u5b58\u5927\u8840\u7ba1\u30ea\u30b9\u30af\uff1a\u6211\u3005\u306f\u4f55\u3092\u5b66\u3093\u3060\u304b\uff1fCardiovasc Diabetol 2014, 13:26.  <\/span><br \/><span class=\"ref ref3\">3.<\/span><span> Nordestgaard BG, Varbo A. \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u3002Lancet 2014;384:626-35. <\/span><br \/><span class=\"ref ref4\">4.<\/span><span> Wittrup HH\u3001Tybjaerg-Hansen A\u3001Nordestgaard BG\u3002\u30ea\u30dd\u86cb\u767d\u30ea\u30d1\u30fc\u30bc\u5909\u7570\u3001\u8840\u6f3f\u8102\u8cea\u304a\u3088\u3073\u30ea\u30dd\u86cb\u767d\u3001\u865a\u8840\u6027\u5fc3\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3002\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3002\u30b5\u30fc\u30ad\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u30021999;99:2901-7.    <\/span><br \/><span class=\"ref ref5\">5.<\/span><span> Humphries SE, Nicaud V, Margalef J, Tiret L, Talmud PJ.\u30ea\u30dd\u86cb\u767d\u30ea\u30d1\u30fc\u30bc\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u7236\u65b9\u306e\u65e9\u767a\u51a0\u52d5\u8108\u75be\u60a3\u6b74\u304a\u3088\u3073\u7a7a\u8179\u6642\u30fb\u98df\u5f8c\u8840\u6f3f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068\u95a2\u9023\u3059\u308b\uff1aEuropean Atherosclerosis Research Study\uff08EARS\uff09\u30021998;18:526-34.   <\/span><br \/><span class=\"ref ref6\">6.<\/span><span> \u8840\u4e2d\u8102\u8cea\u306b\u95a2\u3059\u308b95\u306e\u907a\u4f1d\u5b50\u5ea7\u306e\u751f\u7269\u5b66\u7684\u3001\u81e8\u5e8a\u7684\u3001\u96c6\u56e3\u7684\u95a2\u9023\u6027\u3002Nature 2010;466:707-13.  <\/span><br \/><span class=\"ref ref7\">7.<\/span><span> Reymer PW, Gagn\u00e9 E, Groenemeyer BE et al. \u30ea\u30dd\u86cb\u767d\u30ea\u30d1\u30fc\u30bc\u5909\u7570\uff08Asn291Ser\uff09\u306f\u3001\u65e9\u767a\u6027\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306b\u304a\u3051\u308bHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3002Nat Genet 1995;10:28-34.  <\/span><br \/><span class=\"ref ref8\">8.<\/span><span> Khetarpal SA\u3001Rader DJ\u3002\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u3068\u51a0\u52d5\u8108\u75be\u60a3\u30ea\u30b9\u30af\u3002\u30d2\u30c8\u907a\u4f1d\u5b66\u304b\u3089\u306e\u65b0\u305f\u306a\u6d1e\u5bdf\u3002Arterioscler Thromb Vasc Biol 2015;35:e3-e9.   <\/span><br \/><span class=\"ref ref9\">9.<\/span><span> \u30a8\u30af\u30bd\u30fc\u30e0\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306eTG\u3068HDL\u30ef\u30fc\u30ad\u30f3\u30b0\u30b0\u30eb\u30fc\u30d7\u3001NHLBI\u3002APOC3\u306e\u6a5f\u80fd\u55aa\u5931\u5909\u7570\u3001\u4e2d\u6027\u8102\u80aa\u3001\u51a0\u75be\u60a3\u3002N Engl J Med.2014;371:22-31.  <\/span><br \/><span class=\"ref ref10\">10.<\/span><span> J\u00f8rgensen AB, Frikke-Schmidt R, Nordestgaard BG, Tybj\u00e6rg-Hansen A. APOC3\u306e\u6a5f\u80fd\u55aa\u5931\u5909\u7570\u3068\u865a\u8840\u6027\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3002N Engl J Med.2014;371:32-41. <\/span><br \/><span class=\"ref ref11\">11.<\/span><span> \u5fc3\u7b4b\u6897\u585e\u306e\u30ea\u30b9\u30af\u3092\u3082\u305f\u3089\u3059\u5e0c\u5c11\u306aldlr\u304a\u3088\u3073apoa5\u5bfe\u7acb\u907a\u4f1d\u5b50\u3092\u30a8\u30af\u30bd\u30fc\u30e0\u914d\u5217\u6c7a\u5b9a\u3067\u540c\u5b9a\u3002Nature Epub ahead of print.   <\/span><br \/><span class=\"ref ref12\">12.<\/span><span> \u30de\u30af\u30d5\u30a1\u30fc\u30bd\u30f3R\uff1a\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff1a\u51a0\u52d5\u8108\u75be\u60a3\u5371\u967a\u56e0\u5b50\u3068\u3057\u3066\u306e\u300c\u975e\uff08HDL-C\uff0bLDL-C\uff09\u300d\u3002J Am Coll Cardiol 2013, 61:437-9. <\/span><br \/><span class=\"ref ref13\">13.<\/span><span> Hermans MP\u3001Ahn SA\u3001Rousseau MF\u3002\u30eb\u30fc\u30c1\u30f3\u306e\u975e\u7d76\u98df\u8102\u8cea\u304b\u3089\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u30ea\u30c3\u30c1\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u8a08\u7b97\u3059\u308b\u305f\u3081\u306e\u65b0\u3057\u3044\u4e0d\u504f\u65b9\u7a0b\u5f0f\u3002\u5fc3\u8840\u7ba1\u7cd6\u5c3f\u75c5\u5b662014\u300113\uff1a56\u3002  <\/span><br \/><span class=\"ref ref14\">14.<\/span><span> Quispe R, Manalac RJ, Faridi KF et al. \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\/\u9ad8\u5bc6\u5ea6\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08TG\/HDLC\uff09\u6bd4\u3068\u6b8b\u308a\u306e\u8102\u8cea\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3068\u306e\u95a2\u4fc2\uff1aVery Large Database of Lipids &#8211; 4\uff08VLDL-4\uff09\u7814\u7a76\u3002Atherosclerosis 2015;Epub ahead of print.  <\/span><br \/><span class=\"ref ref15\">15.<\/span><span> CKD\u306e\u767a\u75c7\u3068\u9032\u884c\u306b\u5bfe\u3059\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff0f\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6bd4\u306e\u5f71\u97ff\uff1a\u5927\u898f\u6a21\u65e5\u672c\u4eba\u96c6\u56e3\u306b\u304a\u3051\u308b\u7e26\u65ad\u7684\u7814\u7a76\u3002Am J Kidney Dis 2015 Epub ahead of print.  <\/span><br \/><span class=\"ref ref16\">16.<\/span><span> \u6162\u6027\u814e\u81d3\u75c5\u306b\u304a\u3051\u308b\u7cd6\u5c3f\u75c5\u3068\u8102\u8cea\u7570\u5e38\u75c7\u306e\u4ee3\u8b1d\u8ca0\u62c5\u3002Nephrol Dial Transplant 2002;17(suppl 11):23-7. <\/span><br \/><span class=\"ref ref17\">17.<\/span><span> Ozieh MN, Bishu KG, Dismuke CE, Egede LE.\u7c73\u56fd\u6210\u4eba\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u533b\u7642\u8cbb\u306e\u52d5\u5411\uff1a2002-2011\u5e74\u3002Diabetes Care 2015; Published online before print July 22, 2015.  <\/span><\/li>\n<\/ol>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>R3i\u793e\u8aac\u57fa\u672c\u306b\u623b\u308b\uff1a\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u30ea\u30c3\u30c1\u30ea\u30dd\u86cb\u767d\u3001\u6b8b\u5b58\u7269\u3001\u6b8b\u5b58\u8840\u7ba1\u30ea\u30b9\u30af \u30df\u30b7\u30a7\u30eb\u30fb\u30d8\u30eb\u30de\u30f3\u30ba\u6559\u6388\u3001\u30d4\u30a8\u30fc\u30eb [&hellip;]<\/p>\n","protected":false},"author":258497324,"featured_media":0,"parent":254286,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_crdt_document":"","jetpack_post_was_ever_published":false,"footnotes":""},"class_list":["post-254602","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - 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