{"id":254598,"date":"2024-12-30T18:16:40","date_gmt":"2024-12-30T17:16:40","guid":{"rendered":"https:\/\/r3i.org\/r3i%e7%a4%be%e8%aa%ac\/%e8%ab%96%e8%aa%ac-08-21-%e9%9d%99%e8%84%88%e3%82%b0%e3%83%a9%e3%83%95%e3%83%88%e4%b8%8d%e5%85%a8%e3%81%ae%e7%90%86%e8%a7%a3%ef%bc%9a%e7%97%85%e6%85%8b%e7%94%9f%e7%89%a9%e5%ad%a6%e3%81%ab%e3%81%8a\/"},"modified":"2025-02-22T17:05:52","modified_gmt":"2025-02-22T16:05:52","slug":"%e8%ab%96%e8%aa%ac-08-21-%e9%9d%99%e8%84%88%e3%82%b0%e3%83%a9%e3%83%95%e3%83%88%e4%b8%8d%e5%85%a8%e3%81%ae%e7%90%86%e8%a7%a3%ef%bc%9a%e7%97%85%e6%85%8b%e7%94%9f%e7%89%a9%e5%ad%a6%e3%81%ab%e3%81%8a","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/r3i%e7%a4%be%e8%aa%ac\/%e8%ab%96%e8%aa%ac-08-21-%e9%9d%99%e8%84%88%e3%82%b0%e3%83%a9%e3%83%95%e3%83%88%e4%b8%8d%e5%85%a8%e3%81%ae%e7%90%86%e8%a7%a3%ef%bc%9a%e7%97%85%e6%85%8b%e7%94%9f%e7%89%a9%e5%ad%a6%e3%81%ab%e3%81%8a\/","title":{"rendered":"\u8ad6\u8aac 08\/21 – \u9759\u8108\u30b0\u30e9\u30d5\u30c8\u4e0d\u5168\u306e\u7406\u89e3\uff1a\u75c5\u614b\u751f\u7269\u5b66\u306b\u304a\u3051\u308bPPAR\u03b1\u306e\u5f79\u5272"},"content":{"rendered":"

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R3i\u793e\u8aac<\/h2>\n

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2021\u5e748\u6708<\/span><\/h5>\n
\u9759\u8108\u30b0\u30e9\u30d5\u30c8\u4e0d\u5168\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\uff1aPPAR\u03b1\u306e\u75c5\u7406\u5b66\u7684\u5f79\u5272<\/span><\/h5>\n
Prof. Jean Charles Fruchart, Prof. Michel Hermans, Prof. Pierre Amarenco<\/h6>\n
\u30a8\u30c7\u30a3\u30bf\u30fc\u30ba\u30c7\u30b9\u30af\u3088\u308a<\/h6>\n

\u672b\u68a2\u52d5\u8108\u75be\u60a3(PAD)\u306f\u4e00\u822c\u7684\u306a\u75be\u60a3\u3067\u3042\u308b\u304c\u3001\u8a3a\u65ad\u3084\u6cbb\u7642\u304c\u4e0d\u5341\u5206\u306a\u5834\u5408\u304c\u591a\u3044\u3002\u6700\u8fd1\u306e\u63a8\u5b9a\u3067\u306f\u3001PAD\u306f\u5168\u4e16\u754c\u30672\u51043,000\u4e07\u4eba\u4ee5\u4e0a\u304c\u7f79\u60a3\u3057\u3066\u3044\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u3066<\/span>1<\/sup>\u3001\u4eba\u53e3\u306e\u9ad8\u9f62\u5316\u3084\u3001\u7cd6\u5c3f\u75c5\u30fb\u8102\u8cea\u7570\u5e38\u75c7\u306a\u3069\u306e\u5fc3\u8840\u7ba1\u5371\u967a\u56e0\u5b50\u304c\u4e00\u822c\u7684\u306b\u306a\u308b\u306b\u3064\u308c\u3066\u3001\u305d\u306e\u6709\u75c5\u7387\u306f\u5897\u52a0\u3057\u3066\u3044\u308b<\/span>1,2<\/sup>\u3002\u5b9f\u969b\u30012000\u5e74\u304b\u30892015\u5e74\u306e\u9593\u306bPAD\u306e\u6709\u75c5\u7387\u306f\u7d0445\uff05\u5897\u52a0\u3057\u3066\u304a\u308a\u3001\u4e2d\u4f4e\u6240\u5f97\u56fd\u306e\u65b9\u304c\u3001\u9ad8\u6240\u5f97\u56fd\u30f3\u6bd4\u3079\u3066\u6975\u7aef\u306b\u9ad8\u304f\u306a\u3063\u3066\u3044\u308b<\/span>1<\/sup>\u3002\u305d\u306e\u75be\u60a3\u8ca0\u62c5\u306f\u6df1\u523b\u3067\u3001\u7279\u306b\u5207\u65ad\u3092\u5fc5\u8981\u3068\u3059\u308b\u91cd\u5ea6\u306ePAD\u60a3\u8005\u3067\u306f\u3001\u9577\u5e74\u306b\u308f\u305f\u308a\u969c\u5bb3\u3092\u4f34\u3063\u3066\u751f\u304d\u308b\u4e3b\u306a\u8981\u56e0\u3067\u3042\u308b<\/span>3,4<\/sup>\u3002<\/span><\/p>\n

\u85ac\u7269\u7642\u6cd5\u306b\u3088\u308b\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3042\u308b\u7a0b\u5ea6\u6539\u5584\u3055\u308c\u3066\u304d\u305f\u304c<\/span>5,6<\/sup>\u3001\u91cd\u5ea6\u306e\u9589\u585e\u6027\u75be\u60a3\u306e\u60a3\u8005\u306b\u306f\u3001\u81ea\u5bb6\u9759\u8108\u30b0\u30e9\u30d5\u30c8\u3084\u4eba\u5de5\u8840\u7ba1\u306b\u3088\u308b\u30d0\u30a4\u30d1\u30b9\u3092\u7528\u3044\u305f\u5916\u79d1\u7684\u6cbb\u7642\u304c\u5fc5\u8981\u3068\u306a\u308b\u3002\u3057\u304b\u3057\u3001\u3044\u305a\u308c\u3082\u77ed\u671f\u7684\u306a\u969c\u5bb3\u3084\u9577\u671f\u7684\u306a\u958b\u5b58\u7387\u306e\u4f4e\u3055\u3068\u3044\u3046\u5236\u7d04\u304c\u3042\u308a\u3001\u305d\u308c\u304c\u751f\u5b58\u7387\u3084\u7121\u30a4\u30d9\u30f3\u30c8\u751f\u5b58\u7387\u306b\u3082\u5f71\u97ff\u3092\u53ca\u307c\u3059<\/span>7<\/sup>\u3002\u305d\u306e\u305f\u3081\u3001\u9759\u8108\u30b0\u30e9\u30d5\u30c8\u4e0d\u5168\u306e\u539f\u56e0\u3068\u306a\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u3088\u308a\u6df1\u304f\u7406\u89e3\u3059\u308b\u3001\u3068\u3044\u3046\u30a2\u30f3\u30e1\u30c3\u30c8\u30cb\u30fc\u30ba\u304c\u53b3\u7136\u3068\u3057\u3066\u5b58\u5728\u3059\u308b\u3002<\/span><\/p>\n

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\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

    \n
  1. Song P Rudan D Zhu Y, et al. Global, regional, and national prevalence and risk factors for peripheral artery disease in 2015: an updated systematic review and analysis.<\/span>
    Lancet Glob Health 2019;7:e1020-e1030.<\/span>
    2.<\/span>\u00a0Fowkes FG, Rudan D, Rudan I, et al. Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis. Lancet 2013;382:1329\u201340.<\/span>
    3.<\/span>\u00a0Kohn CG, Alberts MJ, Peacock WF, et al. Cost and inpatient burden of peripheral artery disease: Findings from the National Inpatient Sample. Atherosclerosis 2019;286:142-6.<\/span>
    4.<\/span>\u00a0GBD 2017. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018;392:1789-858.<\/span>
    5.<\/span>\u00a0Bonaca MP, Nault P, Giugliano RP, et al. Low-density lipoprotein cholesterol lowering with evolocumab and outcomes in patients with peripheral artery disease: Insights from the FOURIER Trial (Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk). Circulation 2018;137:338-50.<\/span>
    6.<\/span>\u00a0Anand SS, Caron F, Eikelboom JW, et al. Major adverse limb events and mortality in patients with peripheral artery disease: The COMPASS Trial. J Am Coll Cardiol 2018;71:2306-15.<\/span>
    7.<\/span>\u00a0Owens CD, Gasper WJ, Rahman AS, Conte MS. Vein graft failure. J Vasc Surg 2015;61:203\u201316.<\/span>
    8.<\/span>\u00a0Decano JL, Singh SA, Gasparotto Bueno C, et al. Systems approach to discovery of therapeutic targets for vein graft disease PPAR\u03b1 pivotally regulates metabolism, activation, and heterogeneity of macrophages and lesion development. Circ Res 2021;DOI:10.1161\/CIRCULATIONAHA.119.043724<\/span><\/li>\n<\/ol>\n

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