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\u30b5\u30a4\u30ec\u30f3\u30c8CAD\u306f\u4ee5\u524d\u8003\u3048\u3089\u308c\u3066\u3044\u305f\u3088\u308a\u3082\u4e00\u822c\u7684\u3067\u3042\u308b\u3002\u8abf\u67fb\u96c6\u56e3\u3084\u8a55\u4fa1\u65b9\u6cd5\u306b\u3088\u3063\u3066\u63a8\u5b9a\u5024\u306f\u7570\u306a\u308b\u304c\u3001\u9ad8\u30ea\u30b9\u30af\u8005\u306e15\u301c35\uff05\u304c\u7f79\u60a3\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b(2-4)\u3002\u65b0\u305f\u306b2\u578b\u7cd6\u5c3f\u75c5\u3068\u8a3a\u65ad\u3055\u308c\u305f\u60a3\u8005\u306b\u304a\u3044\u3066\u3001UK Prospective Diabetes Study\u306f\u3001\u7d046\u4eba\u306b1\u4eba\u306b\u5fc3\u96fb\u56f3\u4e0a\u30b5\u30a4\u30ec\u30f3\u30c8\u5fc3\u7b4b\u6897\u585e\uff08SMI\uff09\u306e\u6240\u898b\u304c\u3042\u308a\u3001\u3053\u308c\u306f\u81f4\u6b7b\u7684\u5fc3\u7b4b\u6897\u585e\u304a\u3088\u3073\u5168\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u3068\u72ec\u7acb\u3057\u3066\u95a2\u9023\u3057\u3066\u3044\u308b\u3068\u5831\u544a\u3057\u305f\u3002 <\/span>2<\/sup>.\u3053\u306e\u6709\u75c5\u7387\u306f\u3001\u5e74\u9f62\u304c\u9ad8\u304f\u306a\u308b\u307b\u3069\u3001\u307e\u305f\u7cd6\u5c3f\u75c5\u306e\u7f79\u75c5\u671f\u9593\u304c\u9577\u304f\u306a\u308b\u307b\u3069\u9ad8\u304b\u3063\u305f\u3002 <\/span>3,4<\/sup>.Fenofibrate Intervention and Event Lowering in Diabetes\uff08\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u4ecb\u5165\u3068\u30a4\u30d9\u30f3\u30c8\u4f4e\u4e0b\uff08FIELD\uff09\uff09\u8a66\u9a13\u3067\u306f\u3001\u521d\u767aMI\u75c7\u4f8b\u306e40\uff05\u8fd1\u304f\u304c\u30b5\u30a4\u30ec\u30f3\u30c8MI\u3067\u3042\u3063\u305f\u3002 <\/span>5<\/sup>.SMI\u306e\u4e88\u5f8c\u4e0d\u826f\u306f\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u3044\u305f\u6700\u5584\u306e\u6cbb\u7642\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u3053\u306e\u75c5\u614b\u306e\u9ad8\u3044\u6b8b\u5b58\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3059\u308b\u305f\u3081\u306b\u3001\u65e9\u671f\u767a\u898b\u3068\u9069\u5207\u306a\u6cbb\u7642\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u5fc5\u8981\u6027\u3092\u5f37\u8abf\u3057\u3066\u3044\u308b\u3002 <\/span><\/p>\n

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\u305d\u306e\u5834\u3057\u306e\u304e\u3067\u306f\u3042\u308b\u304c\u3001\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u8a66\u9a13\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u304b\u3089\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3067\u3001\u9ad8\u30ea\u30b9\u30af\u8005\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u304c\u6e1b\u5c11\u3059\u308b\u3068\u3044\u3046\u660e\u78ba\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u5f97\u3089\u308c\u3066\u3044\u308b\u3002 <\/span>6<\/sup>.\u3055\u3089\u306b\u3001Action to Control Cardiovascular Risk in Diabetes\uff08ACCORD\uff09\u8a66\u9a13\u306e\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u3067\u306f\u3001\u6700\u826f\u306e\u6a19\u6e96\u6cbb\u7642\u306b\u5f93\u3063\u3066\u7ba1\u7406\u3055\u308c\u305f\u30b9\u30bf\u30c1\u30f3\u6cbb\u76422\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u3053\u306e\u8102\u8cea\u7570\u5e38\u75c7\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3067\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u304c30\uff05\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\uff08\u5168\u60a3\u8005\u3067\u306f8\uff05\uff09\u3002 <\/span>7<\/sup>.FIELD\u8a66\u9a13\u306e\u30c7\u30fc\u30bf\u304b\u3089\u3082\u3001SMI\u306e2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306b\u3088\u308b\u6cbb\u7642\u304c\u305d\u306e\u5f8c\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u309278\uff05\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002 <\/span>8<\/sup>.<\/span><\/p>\n

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\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

    \n
  1. Valensi P, Avignon A, Sultan A. Atherogenic dyslipidemia and risk of silent coronary artery disease in asymptomatic patients with type 2 diabetes: a cross?Cardiovasc Diabetol 2016;15:104 .<\/span>
    2.<\/span> Davis TM, Coleman RL, Holman RR; UKPDS Group.\u65b0\u305f\u306b2\u578b\u7cd6\u5c3f\u75c5\u3068\u8a3a\u65ad\u3055\u308c\u305f\u60a3\u8005\u306b\u304a\u3051\u308b\u7121\u75c7\u5019\u6027\u5fc3\u7b4b\u6897\u585e\u306e\u4e88\u5f8c\u7684\u610f\u7fa9\uff1aUnited Kingdom Prospective Diabetes Study\uff08UKPDS\uff0979\u3002Circulation 2013;127:980-7. <\/span>
    3.<\/span> \u7121\u75c7\u5019\u6027\u5fc3\u7b4b\u6897\u585e\u306e\u6709\u75c5\u7387\u3001\u767a\u75c7\u7387\u3001\u4e88\u6e2c\u56e0\u5b50\u304a\u3088\u3073\u4e88\u5f8c\uff1a\u6587\u732e\u306e\u30ec\u30d3\u30e5\u30fc\u3002Arch Cardiovasc Dis 2011;104:178-88. <\/span>
    4.<\/span> \u30b5\u30a4\u30ec\u30f3\u30c8\u5fc3\u7b4b\u6897\u585e\u306e\u6709\u75c5\u7387\u3001\u7a0b\u5ea6\u3001\u72ec\u7acb\u3057\u305f\u4e88\u6e2c\u56e0\u5b50\u3002Am J Med 2013;126:515-22. <\/span>
    5.<\/span> Burgess DC\u3001Hunt D\u3001Li L\u3089\uff1a2\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u7121\u75c7\u5019\u6027\u5fc3\u7b4b\u6897\u585e\u306e\u767a\u751f\u7387\u3068\u4e88\u6e2c\u56e0\u5b50\u3001\u304a\u3088\u3073\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u52b9\u679c\uff1aFenofibrate Intervention and Event Lowering in Diabetes\uff08FIELD\uff09\u8a66\u9a13\u306e\u89e3\u6790\u3002Eur Heart J 2010;31:92-9. <\/span>
    6.<\/span> Sacks FM\u3001Carey VJ\u3001Fruchart JC\u30022\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u8102\u8cea\u4f75\u7528\u7642\u6cd5\u3002N Engl J Med 2010;363:692-4. <\/span>
    7.<\/span> ACCORD\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u30022\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u8102\u8cea\u4f75\u7528\u7642\u6cd5\u306e\u52b9\u679c\u3002N Engl J Med.2010;362:1563-74. <\/span>
    8.<\/span> Burgess DC\u3001Hunt D\u3001Li L\u3089\uff1a2\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u7121\u75c7\u5019\u6027\u5fc3\u7b4b\u6897\u585e\u306e\u767a\u751f\u7387\u3068\u4e88\u6e2c\u56e0\u5b50\u3001\u304a\u3088\u3073\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u52b9\u679c\uff1aFenofibrate Intervention and Event Lowering in Diabetes\uff08FIELD\uff09\u8a66\u9a13\u306e\u89e3\u6790\u3002Eur Heart J 2010;31:92-9. <\/span><\/li>\n<\/ol>\n

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