{"id":254592,"date":"2025-01-31T12:56:57","date_gmt":"2025-01-31T11:56:57","guid":{"rendered":"https:\/\/r3i.org\/r3i%e7%a4%be%e8%aa%ac\/%e7%a4%be%e8%aa%ac-07-24-%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e4%bd%8e%e4%b8%8b%e8%96%ac%e3%81%ae%e6%96%b0%e9%a1%94%e3%81%9f%e3%81%a1\/"},"modified":"2025-03-02T19:11:53","modified_gmt":"2025-03-02T18:11:53","slug":"%e7%a4%be%e8%aa%ac-07-24-%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e4%bd%8e%e4%b8%8b%e8%96%ac%e3%81%ae%e6%96%b0%e9%a1%94%e3%81%9f%e3%81%a1","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/r3i%e7%a4%be%e8%aa%ac\/%e7%a4%be%e8%aa%ac-07-24-%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e4%bd%8e%e4%b8%8b%e8%96%ac%e3%81%ae%e6%96%b0%e9%a1%94%e3%81%9f%e3%81%a1\/","title":{"rendered":"\u793e\u8aac 07\/24 – \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4f4e\u4e0b\u85ac\u306e\u65b0\u9854\u305f\u3061"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Header” _builder_version=”4.27.4″ _module_preset=”35f37621-1062-4ae6-955d-76a3167a2aa8″ background_image=”https:\/\/r3i.org\/wp-content\/uploads\/2024\/12\/pexels-pixabay-267582.jpg&#8221<\/a>; parallax=”on” min_height=”157.9px” min_height_tablet=”100px” min_height_phone=”100px” min_height_last_edited=”on|phone” height=”116px” height_tablet=”153px” height_phone=”130px” height_last_edited=”on|phone” custom_margin_tablet=”” custom_margin_phone=”-17px||||false|false” custom_margin_last_edited=”on|phone” custom_padding=”0vw||0vw||true|false” collapsed=”on” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22background_color_gradient_stops%22%93}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_text_color=”#FFFFFF” header_2_text_color=”#FFFFFF” custom_padding=”1px|||||” global_colors_info=”{}”]<\/p>\n

R3i\u793e\u8aac<\/h2>\n

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2024\u5e748\u6708<\/span><\/h5>\n
\u65b0\u305f\u306b\u767b\u5834\u3057\u305f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4f4e\u4e0b\u85ac<\/h5>\n
Prof. Jean-Charles Fruchart, Prof. Michel P. Hermans, Prof. Pierre Amarenco<\/h6>\n

\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u306f\u30a2\u30c6\u30ed\u30fc\u30e0\u5f62\u6210\u3092\u4fc3\u9032\u3059\u308bTG-rich\u30ea\u30dd\u86cb\u767d\u306e\u30b5\u30ed\u30b2\u30fc\u30c8\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308a\u3001\u8fd1\u5e74\u518d\u3073\u95a2\u5fc3\u3092\u96c6\u3081\u3066\u3044\u308b\u304c\u3001\u3053\u308c\u306f\u3001TG\u304c\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\u306b\u5bc4\u4e0e\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u305f\u3081\u3067\u3042\u308b\u3002\u3053\u306e\u3088\u3046\u306a\u898b\u65b9\u306e\u6839\u62e0\u306b\u306a\u3063\u3066\u3044\u308b\u306e\u306f\u3001TG-rich\u30ea\u30dd\u86cb\u767d\u9ad8\u5024\u304c\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff08ASCVD\uff09\u306e\u5f37\u529b\u306a\u72ec\u7acb\u4e88\u6e2c\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3059\u75ab\u5b66\u7684\u3001\u30e1\u30ab\u30cb\u30ba\u30e0\u7684\u3001\u304a\u3088\u3073\u907a\u4f1d\u5b66\u7684\u7814\u7a76\u306e\u84c4\u7a4d\u3055\u308c\u305f\u30a8\u30d3\u30c7\u30f3\u30b9\u3067\u3042\u308b\uff081\uff09\u3002\u3053\u306e\u5f37\u56fa\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u57fa\u76e4\u306e\u3082\u3068\u3001TG-rich\u30ea\u30dd\u86cb\u767d\u304cASCVD\u306e\u539f\u56e0\u3067\u3042\u308b\u3053\u3068\u306e\u7acb\u8a3c\u3092\u76ee\u7684\u3068\u3059\u308b\u81e8\u5e8a\u30a2\u30a6\u30c8\u30ab\u30e0\u8a66\u9a13\u304c\u9032\u3081\u3089\u308c\u305f\u3002\u3057\u304b\u3057\u3001\u305d\u3046\u3057\u305f\u81e8\u5e8a\u30a2\u30a6\u30c8\u30ab\u30e0\u8a66\u9a13\u306e\u7d4c\u904e\u306f\u9806\u8abf\u3068\u306f\u8a00\u3048\u305a\u3001\u3053\u308c\u307e\u3067\u306bTG\u4f4e\u4e0b\u306e\u81e8\u5e8a\u7684\u6709\u7528\u6027\u304c\u78ba\u8a8d\u3055\u308c\u305f\u306e\u306f\u3001\u9ad8\u7528\u91cf\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u306e\u6295\u4e0e\u306b\u3088\u308aTG\u5024\u3092\u4f4e\u4e0b\u3055\u305b\u305fREDUCE-IT\u8a66\u9a13\uff082\uff09\u306e\u307f\u3067\u3042\u308b\u3002<\/span><\/p>\n

 <\/p>\n

TG\u306e\u4f4e\u4e0b\u3068ASCVD\u3068\u306e\u95a2\u9023\u306b\u95a2\u3059\u308b\u7591\u554f\u304c\u660e\u3089\u304b\u306b\u306a\u3089\u306a\u3044\u307e\u307e\u3001\u958b\u767a\u306e\u4e2d\u5fc3\u306fTG-rich\u30ea\u30dd\u86cb\u767d\u4ee3\u8b1d\u306e\u69d8\u3005\u306a\u30dd\u30a4\u30f3\u30c8\u3067\u4f5c\u7528\u3059\u308b\u65b0\u85ac\u306e\u540c\u5b9a\u306b\u79fb\u3063\u3066\u3044\u3063\u305f\u3002\u6838\u9178\u533b\u85ac\u306e\u6280\u8853\u7684\u9032\u6b69\u3082\u3042\u308a\u3001\u7279\u7570\u6027\u304a\u3088\u3073\u6709\u52b9\u6027\u306b\u512a\u308c\u305f\u4f4e\u5206\u5b50\u5e72\u6e09RNA\uff08siRNA\uff09\u85ac\u306e\u6ce8\u76ee\u5ea6\u304c\u9ad8\u307e\u3063\u305f\u3002siRNA\u85ac\u306f\u7d30\u80de\u306b\u53d6\u308a\u8fbc\u307e\u308c\u306b\u304f\u304f\u3001\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\u306b\u3088\u308b\u5206\u89e3\u3092\u53d7\u3051\u3084\u3059\u3044\u3068\u3044\u3046\u6027\u8cea\u304c\u3042\u308b\u305f\u3081\u3001\u6a19\u7684\u7d30\u80de\u306b\u52b9\u7387\u3088\u304f\u9001\u308a\u8fbc\u3080\u306b\u306f\u62c5\u4f53\u304c\u5fc5\u8981\u3067\u3042\u3063\u305f\uff083\uff09\u3002\u6700\u521d\u306b\u627f\u8a8d\u3055\u308c\u305fsiRNA\u85ac\u30a4\u30f3\u30af\u30ea\u30b7\u30e9\u30f3\u306f\u3001\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u30db\u30e2\u63a5\u5408\u4f53\u304a\u3088\u3073\u9ad8\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u8840\u75c7\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u81e8\u5e8a\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u3002\u73fe\u5728\u3001\u3053\u306e\u9b45\u529b\u7684\u306a\u6280\u8853\u3092\u7528\u3044\u3066\u65b0\u3057\u3044TG\u4f4e\u4e0b\u85ac\u306e\u63a2\u7d22\u304c\u884c\u308f\u308c\u3066\u3044\u308b\uff084\uff09\u3002<\/span><\/p>\n

 <\/p>\n

plozasiran\uff08\u4ee5\u524d\u306fARO-APOC3\u3068\u547c\u3070\u308c\u3066\u3044\u305f\uff09\u306f\u3001\u809d\u7d30\u80de\u306e\u30a2\u30dd\u30ea\u30dd\u86cb\u767dC-III\uff08APOC3\uff09\u3092\u6a19\u7684\u3068\u3059\u308b\u30d5\u30a1\u30fc\u30b9\u30c8\u30fb\u30a4\u30f3\u30fb\u30af\u30e9\u30b9\u306eAPOC3 siRNA\u85ac\u3067\u3042\u308b\u3002APOC3\u306f\u30ea\u30dd\u86cb\u767d\u8cea\u30ea\u30d1\u30fc\u30bc\uff08LPL\uff09\u306e\u30b3\u30d5\u30a1\u30af\u30bf\u30fc\u3067\u3042\u308a\u3001\u8d85\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u8cea\u304a\u3088\u3073\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u306e\u52a0\u6c34\u5206\u89e3\u306b\u304a\u3044\u3066\u4e2d\u5fc3\u7684\u5f79\u5272\u3092\u679c\u305f\u3059\u91cd\u8981\u306a\u8102\u8cea\u4ee3\u8b1d\u5236\u5fa1\u56e0\u5b50\u3067\u3042\u308b\u3002APOC3\u306fLPL\u3092\u963b\u5bb3\u3057\u3001LPL\u975e\u4f9d\u5b58\u6027\u7d4c\u8def\u306b\u3088\u308bTG-rich\u30ea\u30dd\u86cb\u767d\u306e\u809d\u53d6\u308a\u8fbc\u307f\u306b\u5e72\u6e09\u3059\u308b\uff085\uff09\u3002plozasiran\u306fAPOC3\u306e\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066TG\u5024\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3002<\/span><\/p>\n

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TG\u4f4e\u4e0b\u85ac\u306b\u3064\u3044\u3066\u306f\u3001\u3053\u308c\u3089\u306e\u65b0\u898f\u6cbb\u7642\u85ac\u306e\u958b\u767a\u304c\u9032\u3093\u3067\u304a\u308a\u3001\u305d\u306e\u672a\u6765\u306f\u660e\u308b\u3044\u3002\u3053\u308c\u3089\u306e\u65b0\u898f\u6cbb\u7642\u85ac\u3092\u7528\u3044\u305f\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u6b8b\u5b58\u3059\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6e1b\u5c11\u306b\u5bfe\u3057\u3066TG-rich\u30ea\u30dd\u86cb\u767d\u306e\u4f4e\u4e0b\u304c\u81e8\u5e8a\u7684\u306b\u6709\u76ca\u304b\u5426\u304b\u3001\u3068\u3044\u3046\u91cd\u8981\u306a\u7591\u554f\u306b\u3064\u3044\u3066\u691c\u8a0e\u3059\u3079\u304d\u3067\u3042\u308b\u3002<\/span><\/p>\n

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\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

    \n
  1. Song P, Rudan D, Zhu Y, et al. 2015\u5e74\u306b\u304a\u3051\u308b\u672b\u68a2\u52d5\u8108\u75be\u60a3\u306e\u4e16\u754c\u3001\u5730\u57df\u3001\u56fd\u306e\u6709\u75c5\u7387\u3068\u5371\u967a\u56e0\u5b50\uff1a\u6700\u65b0\u306e\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\u3068\u5206\u6790\u3002Lancet Global Health 2019;7:e1020-30. <\/span><\/li>\n
  2. GBD 2019\u672b\u68a2\u52d5\u8108\u75be\u60a3\u5171\u540c\u7814\u7a76\u8005\u3002\u672b\u68a2\u52d5\u8108\u75be\u60a3\u3068\u305d\u306e\u5371\u967a\u56e0\u5b50\u306e\u4e16\u754c\u7684\u8ca0\u62c5\u30011990-2019\u5e74\uff1a\u4e16\u754c\u75be\u75c5\u8ca0\u62c5\u8abf\u67fb2019\u306e\u305f\u3081\u306e\u7cfb\u7d71\u7684\u5206\u6790\u3002Lancet Global Health 2023;11: E1553-E1565. <\/span><\/li>\n
  3. Gornik HL, Aronow HD, Goodney PP, et al. 2024 ACC\/AHA\/AACVPR\/APMA\/ABC\/SCAI\/SVM\/SVN\/SVS\/SIR\/VESS Guideline for the Management of Lower Extremity Peripheral Artery Disease.J Am Coll Cardiol 2024;doi.org\/10.1016\/j.jacc.2024.02.013<\/a>. <\/span><\/li>\n
  4. Shah AD, Langenberg C, Rapsomaniki E, et al. 2\u578b\u7cd6\u5c3f\u75c5\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u767a\u75c7\uff1a190\u4e07\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3002 <\/span>Lancet Diabetes Endocrinol 2015;3:105-13.<\/li>\n
  5. Nativel M, Potier L, Alexandre L, et al. \u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u4e0b\u80a2\u52d5\u8108\u75be\u60a3\uff1a\u73fe\u4ee3\u306e\u30ca\u30e9\u30c6\u30a3\u30d6\u30ec\u30d3\u30e5\u30fc\u3002Cardiovasc Diabetol 2018;17(1):138. <\/span><\/li>\n
  6. \u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306b\u3088\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4f4e\u4e0b\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3002N Engl J Med 2022;387:1923-34. <\/span><\/li>\n
  7. Marino L\u3001Everett BM\u3001Aday AY\u3001\u4ed6\uff1a\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306f\u4e0b\u80a2\u865a\u8840\u6027\u6f70\u760d\u304a\u3088\u3073\u58ca\u75bd\u306e\u767a\u751f\u7387\u3092\u6e1b\u5c11\u3055\u305b\u308b\uff1aPROMINENT\u304b\u3089\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3002 <\/span>\u8981\u65e823102.Circulation 2023;148:e282\u2013e317. <\/li>\n
  8. Rajamani K, Colman PG, Li LP, et al. 2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u5207\u65ad\u30a4\u30d9\u30f3\u30c8\u306b\u5bfe\u3059\u308b\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u52b9\u679c\uff08FIELD\u8a66\u9a13\uff09\uff1a\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\u306e\u4e8b\u524d\u898f\u5b9a\u5206\u6790\u3002Lancet 2009;373:1780-8. <\/span><\/li>\n
  9. Yuan J, Tan JTM, Rajamani K et al. Fenofibrate rescise diabetes-related impairment of ischemia-mediated angiogenesis by PPARalpha-independent modulation of thioredoxin-interacting protein.Diabetes 2019;68:1040-53. <\/span><\/li>\n
  10. Deng Y, Han X, Yao Z, et al. PPAR\u03b1\u30a2\u30b4\u30cb\u30b9\u30c8\u306f\u3001NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u7d4c\u8def\u3092\u4ecb\u3057\u3066\u5185\u76ae\u524d\u99c6\u7d30\u80de\u6a5f\u80fd\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u8840\u7ba1\u65b0\u751f\u3092\u523a\u6fc0\u3057\u305f\u3002Cell Physiol Biochem 2017;42:2255-66. <\/span><\/li>\n
  11. Sharma P, Klarin D, Voight BF, et al.\u672b\u68a2\u52d5\u8108\u75be\u60a3\u3068\u306e\u56e0\u679c\u95a2\u4fc2\u306b\u95a2\u3059\u308b\u8840\u6f3f\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u8a55\u4fa1\u3002Arterioscler Thromb Vasc Biol 2024;44:1114-23. <\/span><\/li>\n
  12. \n<\/li>\n<\/ol>\n

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