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<\/span><sup>8<\/sup><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf&#8221; text_font_size=&#8221;14px&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22text_text_color%22%93}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p style=\"font-weight: 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<\/span><sup>9<\/sup><span>\u81e8\u5e8a\u8a66\u9a13\u306f\u9045\u308c\u3066\u3044\u308b\u304c\u3001apoA5\u304c\u52d5\u8108\u786c\u5316\u3092\u4e88\u9632\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u652f\u6301\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u3082\u3042\u308b\uff08\u4eca\u6708\u306e\u30d5\u30a9\u30fc\u30ab\u30b9\u53c2\u7167\uff09\u3002<\/span><\/p>\n<p><span>\u4ed6\u306e\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u306f\u3001\u958b\u767a\u306e\u65b9\u5411\u6027\u304c\u7570\u306a\u3063\u3066\u3044\u308b\u3002\u3053\u3053\u3067\u306f\u3001PPAR\u306e\u30e6\u30cb\u30fc\u30af\u306a\u53d7\u5bb9\u4f53-\u88dc\u9175\u7d20\u7d50\u5408\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3067\u3001PPAR\u3092\u4ecb\u3057\u305f\u6709\u76ca\u306a\u52b9\u679c\u3092\u8a98\u767a\u3057\u3001\u540c\u6642\u306b\u671b\u307e\u3057\u304f\u306a\u3044\u526f\u4f5c\u7528\u3092\u56de\u907f\u3059\u308b\u6700\u3082\u5f37\u529b\u306a\u5206\u5b50\u3092\u540c\u5b9a\u3059\u308b\u6a5f\u4f1a\u3092\u63d0\u4f9b\u3057\u305f\u3002\u5305\u62ec\u7684\u306a\u69cb\u9020\u304a\u3088\u3073\u30bf\u30f3\u30d1\u30af\u8cea-\u30ea\u30ac\u30f3\u30c9\u7d50\u5408\u306e\u89e3\u660e\u3068\u5305\u62ec\u7684\u306ain vitro\u8a66\u9a13\u306b\u3088\u308a\u3001SPPARM\u6d3b\u6027\u306b\u3064\u3044\u3066\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3055\u308c\u305f\u7d041,400\u7a2e\u985e\u306e\u5316\u5408\u7269\u306e\u4e2d\u304b\u3089\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u304c\u65b0\u898f\u306eSPPARM?<\/span><sup>10<\/sup><span> \u7b2cII\/III\u76f8\u8a66\u9a13\u3067\u306f\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3092\u591a\u304f\u542b\u3080\u30ea\u30dd\u86cb\u767d\u3068\u305d\u306e\u6b8b\u6e23\u306e\u5927\u5e45\u306a\u4f4e\u4e0b\u3068HDL-C\u306e\u4e0a\u6607\u3092\u542b\u3080\u8102\u8cea\u6539\u5584\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u304c\u793a\u3055\u308c\u3001\u6709\u671b\u8996\u3055\u308c\u3066\u3044\u308b\u3002\u73fe\u5728\u3001\u4e3b\u8981\u306a\u5fc3\u8840\u7ba1\u7cfb\u30a2\u30a6\u30c8\u30ab\u30e0\u8a66\u9a13\u3067\u3042\u308bPROMINENT\u8a66\u9a13\u304c\u9032\u884c\u4e2d\u3067\u3042\u308a\u3001\u305d\u306e\u7d50\u679c\u304c\u5f85\u305f\u308c\u308b\u3068\u3053\u308d\u3067\u3042\u308b\u3002 <\/span><\/p>\n<p><span>\u3057\u304b\u3057\u306a\u304c\u3089\u3001CANTOS\uff08\u30ab\u30ca\u30ad\u30cc\u30de\u30d6\u6297\u708e\u75c7\u6027\u8840\u6813\u75c7\u30a2\u30a6\u30c8\u30ab\u30e0\u8a66\u9a13\uff09\u306b\u793a\u3055\u308c\u308b\u3088\u3046\u306b\u3001\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306f\u591a\u9762\u7684\u3067\u3042\u308b\u3053\u3068\u3092\u5fd8\u308c\u3066\u306f\u306a\u3089\u306a\u3044\u3002LDL-C\u5024\u306f\u826f\u597d\u306b\u7ba1\u7406\u3055\u308c\u3066\u3044\u308b\u304c\u6b8b\u5b58\u708e\u75c7\u6027\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u6297\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f31?\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3067\u3042\u308b\u30ab\u30ca\u30ad\u30cc\u30de\u30d6\u306b\u3088\u308b\u6cbb\u7642\u306f\u4e3b\u8981\u306a\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u6e1b\u5c11\u3055\u305b\u305f\u3002  <\/span><sup>11<\/sup><span>LDL-C\u4f4e\u4e0b\u3068\u540c\u69d8\u306b\u3001\u81e8\u5e8a\u7684\u6709\u7528\u6027\u306b\u3064\u3044\u3066\u3082\u7528\u91cf\u53cd\u5fdc\u95a2\u4fc2\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u3042\u308a\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eC\u53cd\u5fdc\u6027\u86cb\u767d\uff08\u708e\u75c7\u6027\u30ea\u30b9\u30af\u306e\u30de\u30fc\u30ab\u30fc\uff09\u5024\u304c\u9ad8\u3044\u60a3\u8005\u307b\u3069\u3001\u81e8\u5e8a\u7684\u6709\u7528\u6027\u306e\u7d76\u5bfe\u5024\u304c\u9ad8\u304b\u3063\u305f\u3002<\/span><sup>12<\/sup><span><\/span><\/p>\n<p><span>\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u3068\u305d\u306e\u7ba1\u7406\u306b\u5bfe\u3059\u308b\u6f5c\u5728\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u95a2\u3059\u308b\u6211\u3005\u306e\u77e5\u8b58\u306f\u62e1\u5927\u3057\u3064\u3064\u3042\u308b\u3002\u73fe\u5728\u3001\u3053\u306e\u30ea\u30b9\u30af\u3092\u6539\u5584\u3059\u308b\u9375\u3068\u306a\u308a\u305d\u3046\u306a\u65b0\u898f\u85ac\u5264\u304c\u6570\u591a\u304f\u958b\u767a\u4e2d\u3067\u3042\u308a\u3001\u4eca\u5f8c5\u5e74\u9593\u306f\u8102\u8cea\u304a\u3088\u3073\u975e\u8102\u8cea\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u7814\u7a76\u306b\u304a\u3044\u3066\u30a8\u30ad\u30b5\u30a4\u30c6\u30a3\u30f3\u30b0\u306a\u6642\u671f\u306b\u306a\u308b\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u308b\u3002 <\/span><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;8px&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p style=\"font-weight: 400;\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<ol>\n<li style=\"font-weight: 400;\"><span>Fruchart JC, Sacks F, Hermans MP et al. Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in patients with dyslipidemia.Am J Cardiol 2008;102(10 Suppl):1K-34K.  <\/span><br \/><span class=\"ref ref2\">2.<\/span><span> Fruchart JC, Davignon J, Hermans MP et al. Residual macrovascular risk in 2013: What have we learned?Cardiovasc Diabetol 2014;13:26.  <\/span><br \/><span class=\"ref ref3\">3.<\/span><span> Sabatine MS\u3001Giugliano RP\u3001Keech AC\u3089\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u3068\u81e8\u5e8a\u8ee2\u5e30\u3002N Engl J Med 2017;376):1713-22.  <\/span><br \/><span class=\"ref ref4\">4.<\/span><span> Ganda OP, Bhatt DL, Mason RP et al. \u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u7ba1\u7406\u306b\u304a\u3051\u308b\u8102\u8cea\u7570\u5e38\u75c7\u88dc\u52a9\u7642\u6cd5\u306e\u30a2\u30f3\u30e1\u30c3\u30c8\u30cb\u30fc\u30ba\u3002J Am Coll Cardiol 2018 Jun 16\uff1aS0735-1097(18)34817-4   <\/span><br \/><span class=\"ref ref5\">5.<\/span><span> Wei WQ\u3001Li X\u3001Feng Q\u3089\u3001LPA\u30d0\u30ea\u30a2\u30f3\u30c8\u306f\u30b9\u30bf\u30c1\u30f3\u6295\u4e0e\u60a3\u8005\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\u3068\u95a2\u9023\u3059\u308b\u3002Circulation 2018 doi: 10.1161\/CIRCULATIONAHA.117.031356.    [Epub ahead of print]<\/span><br \/><span class=\"ref ref6\">6.<\/span><span> Sacks FM\u3001Carey VJ\u3001Fruchart JC\u30022\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u8102\u8cea\u4f75\u7528\u7642\u6cd5\u3002N Engl J Med 2010;363:692-4.  <\/span><br \/><span class=\"ref ref7\">7.<\/span><span> \u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3067\u30b9\u30bf\u30c1\u30f3\u670d\u7528\u4e2d\u306e\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3051\u308bAMR101\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u6291\u5236\u80fd\u3092\u8a55\u4fa1\u3059\u308b\u8a66\u9a13\u3002\u4e3b\u8981\u76ee\u7684\u306f\u3001AMR101 4g\/\u65e5\u306e\u6700\u521d\u306e\u4e3b\u8981\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u767a\u751f\u4e88\u9632\u52b9\u679c\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3067\u3042\u308b\u3002https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01492361\u3002  <\/span><br \/><span class=\"ref ref8\">8.<\/span><span> Burgess S, Ference BA, Staley JR et al. LPA\u30d0\u30ea\u30a2\u30f3\u30c8\u3068\u51a0\u52d5\u8108\u75be\u60a3\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u304a\u3088\u3073\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u4f4e\u4e0b\u7642\u6cd5\u3078\u306e\u5f71\u97ff\uff1a\u30e1\u30f3\u30c7\u30eb\u30e9\u30f3\u30c0\u30e0\u5316\u89e3\u6790\u3002JAMA Cardiol 2018 Jun 20. doi: 10.1001\/jamacardio.2018.1470.     [Epub ahead of print]<\/span><br \/><span class=\"ref ref9\">9.<\/span><span> Olkkonen VM, Sinisalo J, Jauhiainen M. \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u30ea\u30c3\u30c1\u30ea\u30dd\u86cb\u767d\u3092\u6a19\u7684\u3068\u3059\u308b\u65b0\u3057\u3044\u85ac\u7269\uff1aANGPTL3\u307e\u305f\u306fapoC-III\u306e\u963b\u5bb3\u306f\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3067\u304d\u308b\u304b\uff1fAtherosclerosis 2018;272:27-32. <\/span><br \/><span class=\"ref ref10\">10.<\/span><span> Fruchart JC.\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\uff08K-877\uff09\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u7ba1\u7406\u306e\u305f\u3081\u306e\u65b0\u898f\u9078\u629e\u7684\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u5264\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u03b1\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\u3002Cardiovasc Diabetol 2017;16(1):124  <\/span><br \/><span class=\"ref ref11\">11.<\/span><span> Ridker PM, Everett BM, Thuren T et al. \u52d5\u8108\u786c\u5316\u6027\u75be\u60a3\u306b\u5bfe\u3059\u308b\u30ab\u30ca\u30ad\u30cc\u30de\u30d6\u306b\u3088\u308b\u6297\u708e\u75c7\u7642\u6cd5\u3002N Engl J Med 2017;377:1119-31.  <\/span><br \/><span class=\"ref ref12\">12.<\/span><span> Ridker PM, MacFadyen JG, Everett BM et al. \u30ab\u30ca\u30ad\u30cc\u30de\u30d6\u6cbb\u7642\u5f8c\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u6e1b\u5c11\u3068CRP\u6e1b\u5c11\u306e\u95a2\u4fc2\uff1aCANTOS\u7121\u4f5c\u70ba\u5316\u5bfe\u7167\u8a66\u9a13\u306e\u4e8c\u6b21\u89e3\u6790\u3002Lancet 2018;391:319-28.  <\/span><\/li>\n<\/ol>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>R3i\u793e\u8aac\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u3092\u7ba1\u7406\u3059\u308b\u305f\u3081\u306e\u81e8\u5e8a\u7684\u30ae\u30e3\u30c3\u30d7\uff1a\u65b0\u3057\u3044\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u9055\u3044\u3092\u3082\u305f\u3089\u3059\u304b\uff1f \u30df\u30b7\u30a7\u30eb\u30fb\u30d8 [&hellip;]<\/p>\n","protected":false},"author":258497324,"featured_media":0,"parent":254286,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-254577","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - 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