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\u3082\u3061\u308d\u3093\u3001PROMINENT\u306e\u7d50\u679c\u306f\u6570\u5e74\u5148\u306e\u3053\u3068\u3067\u3042\u308b\u3002\u3053\u306e\u65b0\u3057\u3044SPPARM? \u304c\u3001\u5229\u7528\u53ef\u80fd\u306a\u6700\u5584\u306e\u8102\u8cea\u6539\u5584\u7642\u6cd5\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u6301\u7d9a\u3059\u308b\u3001\u9ad8\u8102\u8cea\u95a2\u9023\u306e\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306b\u5bfe\u51e6\u3059\u308b\u65b0\u305f\u306a\u53ef\u80fd\u6027\u3092\u63d0\u4f9b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002\u3057\u3070\u3089\u304f\u69d8\u5b50\u3092\u898b\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3002 <\/span><\/p>\n

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\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

    \n
  1. Sacks FM\u3001Carey VJ\u3001Fruchart JC\u30022\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u8102\u8cea\u4f75\u7528\u7642\u6cd5\u3002N Engl J Med 2010;363:692-4. <\/span>
    2.<\/span>Fruchart JC.\u9078\u629e\u7684\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\uff08SPPARM\uff09\uff1a\u6b21\u4e16\u4ee3\u306e\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\u3002Cardiovasc Diabetol 2013;12:82.<\/span>
    3.<\/span> \u9ad8\u6d3b\u6027\u304b\u3064\u9078\u629e\u7684\u306a\u30d2\u30c8\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u5264\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u03b1\u30a2\u30b4\u30cb\u30b9\u30c8\u306e\u8a2d\u8a08\u3068\u5408\u6210\u3002Bioorg Med Chem Lett 2007;17:4689-93. <\/span>
    4.<\/span> Raza-Iqbal S, Tanaka T, Anai M et al. K-877 (a Novel Selective PPAR? Modulator (SPPARM?)) -regulated genes in primary human hepatocytes and the mouse liver.J Atheroscler Thromb 2015;22:754-72. <\/span>
    5.<\/span> PPAR\u03b1\u30a2\u30b4\u30cb\u30b9\u30c8K-877\u306f\u3001\u7a7a\u8179\u6642\u304a\u3088\u3073\u98df\u5f8c\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u6539\u5584\u3059\u308b\u3002Eur Heart J 2014;35(Abstract Supplement)\uff1a904[abstract]. <\/span>
    6.<\/span> \u65b0\u898f\u9078\u629e\u7684PPARa\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\uff08SPPARMa\uff09\u3067\u3042\u308bK-877\u306e\u8102\u8cea\u7570\u5e38\u75c7\u60a3\u8005\u306b\u304a\u3051\u308b\u52b9\u679c\uff1a\u7121\u4f5c\u70ba\u5316\u4e8c\u91cd\u76f2\u691c\u30a2\u30af\u30c6\u30a3\u30d6\u30fb\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u7b2c2\u76f8\u8a66\u9a13\u3002Atherosclerosis 2016;249:36-43. <\/span>
    7.<\/span> \u30d9\u30a4\u30ea\u30fcCJ\u3001\u30bf\u30cf\u30e9\u30cbAA\u3001\u30d0\u30fc\u30cd\u30c3\u30c8AH\u30022\u578b\u7cd6\u5c3f\u75c5\u306b\u5bfe\u3059\u308b\u5c06\u6765\u306e\u7cd6\u4f4e\u4e0b\u85ac\u3002Lancet Diabetes Endocrinol 2016;4:350-9. <\/span><\/li>\n<\/ol>\n

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