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R3i\u793e\u8aac<\/h2>\n

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PCSK9\u306e10\u5e74\u3092\u8d85\u3048\u3066\uff1a\u6b21\u306f\u4f55\u304b\uff1f<\/span><\/h5>\n
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\u8102\u8cea\u7814\u7a76\u306e\u3053\u306e10\u5e74\u306f\u300cPCSK9\u306e10\u5e74\u300d\u3068\u5e83\u304f\u307f\u306a\u3055\u308c\u3066\u3044\u308b\u3002\u907a\u4f1d\u5b66\u7684\u7814\u7a76\u306b\u3088\u308a\u3001\u30d7\u30ed\u30c6\u30a4\u30f3\u8ee2\u63db\u9175\u7d20\u30b5\u30d6\u30c1\u30ea\u30b7\u30f3\uff0f\u30b1\u30ad\u30b7\u30f39\u578b\uff08PCSK9\uff09\u3092\u6a19\u7684\u3068\u3059\u308b\u65b0\u898f\u6cbb\u7642\u85ac\u306e\u958b\u767a\u304c\u63a8\u9032\u3055\u308c\u3001\u305d\u306e\u6700\u521d\u306e\u6cbb\u7642\u85ac\u304c\u4eca\u5e74\u5f8c\u534a\u306b\u3082\u8a8d\u53ef\u3055\u308c\u305d\u3046\u3067\u3042\u308b\u3002 <\/span>1,2<\/sup><\/span>
\u3057\u304b\u3057\u3001IMPROVE-IT\u3084PCSK9\u963b\u5bb3\u8a66\u9a13\u306e\u4e88\u5099\u7684\u89e3\u6790\u3067\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3088\u3046\u306b\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\uff08LDL\uff09\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u73fe\u884c\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u76ee\u6a19\u5024\u4ee5\u4e0a\u306b\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u306f\u3001\u3055\u3089\u306a\u308b\u6709\u76ca\u6027\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3001<\/span>3-5<\/sup>\u3053\u306e\u3088\u3046\u306a\u6709\u52b9\u306a\u6cbb\u7642\u3092\u884c\u3063\u3066\u3082\u3001\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u3001\u7279\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306b\u7279\u5fb4\u7684\u306a\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u60a3\u8005\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u6b8b\u5b58\u3092\u306a\u304f\u3059\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u3002<\/span><\/p>\n

\u3053\u306e\u3088\u3046\u306a\u60a3\u8005\u306b\u6b8b\u5b58\u3059\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3059\u308b\u305f\u3081\u306b\u3001\u4eca\u5f8c\u3069\u306e\u3088\u3046\u306a\u65b9\u6cd5\u304c\u3042\u308b\u306e\u3060\u308d\u3046\u304b\uff1f<\/em><\/span><\/p>\n

\u7279\u306b\u3001\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\uff08HDL\uff09\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u304c\u51cb\u843d\u3057\u305f\u5f8c\u3067\u306f\u3001\u304a\u305d\u3089\u304f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u4f4e\u4e0b\u304c\u6b21\u306e10\u5e74\u306e\u7126\u70b9\u3068\u306a\u308b\u3060\u308d\u3046\u3002\u30d2\u30c8\u907a\u4f1d\u5b66\u3068\u521d\u671f\u306e\u81e8\u5e8a\u7814\u7a76\u3092\u57fa\u790e\u3068\u3057\u3066\u3001\u305d\u306e\u652f\u6301\u306f\u84c4\u7a4d\u3055\u308c\u3064\u3064\u3042\u308b\u3002 <\/span>6<\/sup> \u73fe\u5728\u3067\u306f\u3001TG\u306f\u6a19\u7684\u3067\u306f\u306a\u304f\u3001TG\u30ea\u30c3\u30c1\u306a\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u542b\u6709\u30ea\u30dd\u86cb\u767d\u306e\u4e0a\u6607\u3092\u793a\u3059\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u3053\u3068\u304c\u8a8d\u8b58\u3055\u308c\u3066\u3044\u308b\u3002\u5229\u7528\u53ef\u80fd\u306a\u8a3c\u62e0\u306f\u3001\u3057\u3070\u3057\u3070\u30ec\u30e0\u30ca\u30f3\u30c8\u3068\u547c\u3070\u308c\u308b\u3053\u308c\u3089\u306e\u7c92\u5b50\u306b\u542b\u307e\u308c\u308b\u69cb\u9020\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002 <\/span><\/p>\n

\u591a\u304f\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u3002\u4ee5\u524d\u306e\u8ad6\u8aac\u3067\u306f\u3001\u65b0\u898f\u306e\u9078\u629e\u7684\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u5264\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u03b1\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\uff08SPPARM\uff09\u306e\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u8a00\u53ca\u3057\u305f\u3002 <\/span>7<\/sup> \u5225\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u3057\u3066\u306f\u3001TG\u3092\u591a\u304f\u542b\u3080\u30ea\u30dd\u86cb\u767d\u306e\u7523\u751f\u3068\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u30a2\u30dd\u30ea\u30dd\u86cb\u767dCIII\uff08\u30a2\u30ddCIII\uff09\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u304c\u8003\u3048\u3089\u308c\u308b\u3002\u5b9f\u969b\u3001\u4eca\u6708\u306e\u30d5\u30a9\u30fc\u30ab\u30b9\u8a18\u4e8b <\/span>8<\/sup>\u6700\u8fd1\u306e\u907a\u4f1d\u5b50\u7814\u7a76\u3092\u88cf\u4ed8\u3051\u308b\u3082\u306e<\/span>9.10<\/sup>2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u3001ApoCIII\u3001TG\u306e\u4e0a\u6607\u3001\u51a0\u52d5\u8108\u30ab\u30eb\u30b7\u30a6\u30e0\u30b9\u30b3\u30a2\u3067\u6e2c\u5b9a\u3055\u308c\u308b\u6f5c\u5728\u6027\u52d5\u8108\u786c\u5316\u75c7\u306e\u5897\u52a0\u3068\u306e\u95a2\u9023\u304c\u8a3c\u660e\u3055\u308c\u305f\u3002\u3053\u306e\u60a3\u8005\u7fa4\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u7cfb\u85ac\u5264\u3092\u542b\u3080\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u3044\u305f\u6700\u5584\u306e\u6cbb\u7642\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u9ad8\u3044\u5fc3\u4ee3\u8b1d\u30ea\u30b9\u30af\u3092\u7dad\u6301\u3057\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001\u30a2\u30ddCIII\u963b\u5bb3\u306e\u6069\u6075\u3092\u53d7\u3051\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3002 <\/span><\/p>\n

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\u3053\u306e\u3088\u3046\u306b\u3001\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u3068\u95d8\u3046\u305f\u3081\u306e\u6cbb\u7642\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u63a2\u6c42\u306f\u7d76\u3048\u9593\u306a\u304f\u7d9a\u3044\u3066\u3044\u308b\u3002\u305d\u306e\u7126\u70b9\u306f\u8102\u8cea\u306b\u95a2\u9023\u3057\u305f\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\u3060\u3051\u306b\u9650\u5b9a\u3055\u308c\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u3002\u708e\u75c7\u304c\u30a2\u30c6\u30ed\u30fc\u30e0\u8840\u6813\u5f62\u6210\u306e\u5168\u904e\u7a0b\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u8003\u3048\u308b\u3068\uff0c\u7279\u7570\u7684\u30d2\u30c8\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u7642\u6cd5\u3092\u7528\u3044\u305f\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-1?Canakinumab Anti-inflammatory Thrombosis Outcomes Study\uff08CANTOS\uff09\u3067\u306f\u3001\u9ad8\u611f\u5ea6CRP\u306a\u3069\u306e\u708e\u75c7\u6027\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u304c\u5897\u52a0\u3057\u3066\u3044\u308b\u5b89\u5b9a\u51a0\u52d5\u8108\u75be\u60a3\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3001\u73fe\u5728\u3053\u306e\u53ef\u80fd\u6027\u3092\u691c\u8a3c\u3057\u3066\u3044\u308b\u3002<\/span>11<\/sup><\/span><\/p>\n

\u6211\u3005\u306f\u3001\u5fc3\u4ee3\u8b1d\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u60a3\u8005\u306b\u6b8b\u5b58\u3059\u308b\u9ad8\u3044\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u3064\u3044\u3066\u306e\u8a8d\u8b58\u3092\u9ad8\u3081\u308b\u3053\u3068\u306b\u524d\u9032\u3057\u305f\u3002PCSK9\u306f\u8102\u8cea\u7814\u7a76\u306b\u304a\u3051\u308b\u904e\u53bb10\u5e74\u9593\u306e\u30b9\u30c8\u30fc\u30ea\u30fc\u3067\u3042\u3063\u305f\u304c\u3001\u6211\u3005\u306f\u3001TG\u30ea\u30c3\u30c1\u30ea\u30dd\u86cb\u767d\u3042\u308b\u3044\u306f\u30ec\u30e0\u30ca\u30f3\u30c8\u304c\u3001\u5f53\u7136\u306e\u3053\u3068\u306a\u304c\u3089\u3001\u6b21\u306e\u7126\u70b9\u3067\u3042\u308b\u3068\u8003\u3048\u3066\u3044\u308b\u3002\u591a\u304f\u306e\u65b0\u3057\u3044\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u7528\u3044\u305f\u73fe\u5728\u9032\u884c\u4e2d\u306e\u7814\u7a76\u304c\u3001\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3051\u308b\u8102\u8cea\u95a2\u9023\u306e\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306b\u81e8\u5e8a\u533b\u304c\u5fc5\u8981\u3068\u3059\u308b\u30c4\u30fc\u30eb\u306e\u7279\u5b9a\u306b\u5f79\u7acb\u3064\u3053\u3068\u3092\u9858\u3063\u3066\u3044\u308b\u3002 <\/span><\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”8px” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

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  1. \u30ec\u30d1\u30b5\uff08\u30a8\u30dc\u30ed\u30af\u30de\u30d6\uff09\u306e\u627f\u8a8d\u72b6\u6cc1\u3002http:\/\/www.drugs.com\/history\/repatha.html\u3002 <\/span>
    2.<\/span> \u30d7\u30e9\u30eb\u30a8\u30f3\u30c8\uff08\u30a2\u30ea\u30ed\u30af\u30de\u30d6\uff09\u306e\u627f\u8a8d\u72b6\u6cc1     http:\/\/www.drugs.com\/history\/praluent.html<\/a> <\/span>
    3.<\/span> Cannon CP\u3001Blazing MA\u3001Giugliano RP\u3089\u3001\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u5f8c\u306e\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\u306b\u30a8\u30bc\u30c1\u30df\u30d6\u3092\u8ffd\u52a0\u3002N Engl J Med 2015;372:2387-97. <\/span>
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    7.<\/span>Fruchart JC.\u9078\u629e\u7684\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\uff08SPPARM\uff09\uff1a\u6b21\u4e16\u4ee3\u306e\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\u3002Cardiovasc Diabetol 2013;12:82.<\/span>
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    9.<\/span> J\u00f8rgensen AB, Frikke-Schmidt R, Nordestgaard BG, Tybj\u00e6rg-Hansen A. APOC3\u306e\u6a5f\u80fd\u55aa\u5931\u5909\u7570\u3068\u865a\u8840\u6027\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3002N Engl J Med.2014;371:32-41. <\/span>
    10.<\/span> Blood I, Crosby J, Peloso GM, et al; Tg, Hdl Working Group of the Exome Sequencing Project NHL.apoc3\u306e\u6a5f\u80fd\u55aa\u5931\u5909\u7570\u3001\u4e2d\u6027\u8102\u80aa\u3001\u51a0\u75be\u60a3\u3002New Engl J Med.2014;371:22-31. <\/span>
    11.<\/span> Interleukin-1? \u963b\u5bb3\u3068\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u518d\u767a\u4e88\u9632\uff1aCanakinumab Anti-inflammatory Thrombosis Outcomes Study\uff08CANTOS\uff09\u306e\u6839\u62e0\u3068\u30c7\u30b6\u30a4\u30f3\u3002Am Heart J 2011;162:597-605. <\/span><\/li>\n<\/ol>\n

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