{"id":254564,"date":"2024-12-27T17:27:16","date_gmt":"2024-12-27T16:27:16","guid":{"rendered":"https:\/\/r3i.org\/r3i%e7%a4%be%e8%aa%ac\/%e7%a4%be%e8%aa%ac06-24-%e6%ae%8b%e5%ad%98%e8%a1%80%e7%ae%a1%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e6%96%b0%e3%81%9f%e3%81%aa%e9%81%b8%e6%8a%9e%e8%82%a2%e3%81%ae%e7%99%bb\/"},"modified":"2025-02-22T15:36:52","modified_gmt":"2025-02-22T14:36:52","slug":"%e7%a4%be%e8%aa%ac06-24-%e6%ae%8b%e5%ad%98%e8%a1%80%e7%ae%a1%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e6%96%b0%e3%81%9f%e3%81%aa%e9%81%b8%e6%8a%9e%e8%82%a2%e3%81%ae%e7%99%bb","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/r3i%e7%a4%be%e8%aa%ac\/%e7%a4%be%e8%aa%ac06-24-%e6%ae%8b%e5%ad%98%e8%a1%80%e7%ae%a1%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e6%96%b0%e3%81%9f%e3%81%aa%e9%81%b8%e6%8a%9e%e8%82%a2%e3%81%ae%e7%99%bb\/","title":{"rendered":"\u793e\u8aac06\/24 – \u6b8b\u5b58\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308b\u65b0\u305f\u306a\u9078\u629e\u80a2\u306e\u767b\u5834\u304b\uff1f"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Header” _builder_version=”4.27.4″ _module_preset=”35f37621-1062-4ae6-955d-76a3167a2aa8″ background_image=”https:\/\/r3i.org\/wp-content\/uploads\/2024\/12\/pexels-pixabay-267582.jpg&#8221<\/a>; parallax=”on” min_height=”157.9px” min_height_tablet=”100px” min_height_phone=”100px” min_height_last_edited=”on|phone” height=”116px” height_tablet=”153px” height_phone=”130px” height_last_edited=”on|phone” custom_margin_tablet=”” custom_margin_phone=”-17px||||false|false” custom_margin_last_edited=”on|phone” custom_padding=”0vw||0vw||true|false” collapsed=”on” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22background_color_gradient_stops%22%93}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_text_color=”#FFFFFF” header_2_text_color=”#FFFFFF” custom_padding=”1px|||||” global_colors_info=”{}”]<\/p>\n

R3i\u793e\u8aac<\/h2>\n

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2024\u5e746\u6708<\/span><\/h5>\n
\u6b8b\u5b58\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308b\u65b0\u305f\u306a\u9078\u629e\u80a2\u3068\u306a\u308b\u304b<\/span><\/h5>\n
Prof. Jean Charles Fruchart, Prof. Michel Hermans, Prof. Pierre Amarenco
\u7de8\u96c6\u30c7\u30b9\u30af\u304b\u3089<\/h6>\n

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  1. \u00a0Ginsberg HN, Packard CJ, Chapman MJ, et al. Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular dis ease, and emerging therapeutic strategies: a consensus statement from the European Atherosclerosis Society. Eur Heart J 2021;42:4791-806.<\/span>
    2.<\/span>\u00a0Nordestgaard BG. Triglyceride-rich lipoproteins and atherosclerotic cardiovascular disease: new insights from epidemiology, genetics, and biology. Circ Res 2016;118:547-63.<\/span>
    3.<\/span>\u00a0Kronenberg F, Mora S, Stroes ESG, et al. Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement. Eur Heart J 2022;43:3925\u201346.<\/span>
    4.<\/span>\u00a0Bhatt DL, Steg PG, Miller M, et al. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. N Engl J Med 2019;380:11-22.<\/span>
    5.<\/span>\u00a0Nicholls SJ, Lincoff AM, Garcia M, et al. Effect of high-dose omega-3 fatty acids vs corn oil on major adverse cardiovascular events in patients at high cardiovascular risk: the STRENGTH randomized clinical trial. JAMA 2020;324: 2268-80.<\/span>
    6.<\/span>\u00a0Das Pradhan A, Glynn RJ, Fruchart JC, et al. Triglyceride lowering with pemafibrate to reduce cardiovascular risk. N Engl J Med 2022;387:1923-34.<\/span>
    7.<\/span>\u00a0Virani S. The Fibrates Story \u2014 A Tepid End to a PROMINENT Drug. N Engl J Med 2022;387:1991-2.<\/span>
    8.<\/span>\u00a0Doi T, Langsted A, Nordestgaard BG. Remnant cholesterol, LDL cholesterol, and apoB absolute mass changes explain results of the PROMINENT trial. Atherosclerosis doi.org\/10.1016\/j.atherosclerosis.2024.117556.<\/span>
    9.<\/span>\u00a0Doi T, Langsted A, Nordestgaard BG. A possible explanation for the contrasting results of REDUCE-IT vs. STRENGTH: cohort study mimicking trial designs. Eur Heart J 2021;42: 4807-17.<\/span>
    10.<\/span>\u00a0J\u00f8rgensen AB, Frikke-Schmidt R, Nordestgaard BG, Tybj\u00e6rg-Hansen A. Loss of-function mutations in APOC3 and risk of ischemic vascular disease. N Engl J Med 2014;371:32-41.<\/span>
    11.<\/span>\u00a0Pollin TI, Damcott CM, Shen H, et al. A null mutation in human APOC3 confers a favorable plasma lipid profile and ap parent cardioprotection. Science 2008;322:1702-5.<\/span>
    12.<\/span>\u00a0Crosby J, Peloso GM, Auer PL, et al. Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med 2014;371:22-31.<\/span>
    13.<\/span>\u00a0Alexander VJ, Xia S, Hurh E, et al. N-acetyl galactosamine-conjugated antisense drug to APOC3 mRNA, triglycerides and atherogenic lipoprotein levels. Eur Heart J 2019;40:2785-9.<\/span>
    14.<\/span>\u00a0Tardif JC, Karwatowska-Prokopczuk E, Amour ES, et al. Apolipoprotein C-III reduction in subjects with moderate hypertriglyceridaemia and at high cardiovascular risk. Eur Heart J 2022;43:1401-12.<\/span>
    15.<\/span>\u00a0Bergmark BA, Marston NA, Prohaska TA, et al. Olezarsen for hypertriglyceridemia in patients at high cardiovascular risk. N Engl J Med 2024; DOI: 10.1056\/NEJMoa2402309.<\/span>
    16.<\/span>\u00a0Stroes ESG, Alexander VJ, Karwatowska-Prokopczuk E, et al. Olezarsen, acute pancreatitis, and familial chylomicronemia syndrome. N Engl J Med 2024; DOI: 10.1056\/NEJMoa2400201.<\/span>
    17.<\/span>\u00a0Nissen SE, Wolski K, Watts GF, et al. Single ascending and multiple-dose trial of zerlasiran, a short interfering RNA targeting Lipoprotein(a). JAMA 2024; doi:10.1001\/jama.2024.4504<\/span>
    18.<\/span>\u00a0Faaborg-Andersen CC, Cho SMJ, Trends and disparities in lipoprotein(a) testing in a large integrated U.S. health system, 2000-2023. Eur J Prev Cardiol 2024 Apr 25:zwae155. doi: 10.1093\/eurjpc\/zwae155. Epub ahead of print. PMID: 38662783.<\/span><\/li>\n<\/ol>\n

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