{"id":254561,"date":"2025-01-31T12:37:09","date_gmt":"2025-01-31T11:37:09","guid":{"rendered":"https:\/\/r3i.org\/r3i%e7%a4%be%e8%aa%ac\/%e7%a4%be%e8%aa%ac06-24-%e6%9c%ab%e6%a2%a2%e5%8b%95%e8%84%88%e7%96%be%e6%82%a3%e3%81%ab%e5%bf%85%e8%a6%81%e3%81%aa%e3%82%a2%e3%82%af%e3%82%b7%e3%83%a7%e3%83%b3-prominent%e3%81%8b%e3%82%89%e3%81%ae\/"},"modified":"2025-03-02T19:11:56","modified_gmt":"2025-03-02T18:11:56","slug":"%e7%a4%be%e8%aa%ac06-24-%e6%9c%ab%e6%a2%a2%e5%8b%95%e8%84%88%e7%96%be%e6%82%a3%e3%81%ab%e5%bf%85%e8%a6%81%e3%81%aa%e3%82%a2%e3%82%af%e3%82%b7%e3%83%a7%e3%83%b3-prominent%e3%81%8b%e3%82%89%e3%81%ae","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/r3i%e7%a4%be%e8%aa%ac\/%e7%a4%be%e8%aa%ac06-24-%e6%9c%ab%e6%a2%a2%e5%8b%95%e8%84%88%e7%96%be%e6%82%a3%e3%81%ab%e5%bf%85%e8%a6%81%e3%81%aa%e3%82%a2%e3%82%af%e3%82%b7%e3%83%a7%e3%83%b3-prominent%e3%81%8b%e3%82%89%e3%81%ae\/","title":{"rendered":"\u793e\u8aac06\/24-\u672b\u68a2\u52d5\u8108\u75be\u60a3\u306b\u5fc5\u8981\u306a\u30a2\u30af\u30b7\u30e7\u30f3-PROMINENT\u304b\u3089\u306e\u30d2\u30f3\u30c8\u306f\uff1f"},"content":{"rendered":"

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R3i\u793e\u8aac<\/h2>\n

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2024\u5e747\u6708<\/span><\/h5>\n
\u672b\u68a2\u52d5\u8108\u75be\u60a3\u306b\u5fc5\u8981\u3068\u3055\u308c\u308b\u5bfe\u7b56\uff0dPROMINENT\u8a66\u9a13\u304b\u3089\u5f97\u305f\u30d2\u30f3\u30c8\u3068\u306f<\/i><\/b><\/h5>\n
Prof. Jean-Charles Fruchart, Prof. Michel P. Hermans, Prof. Pierre Amarenco<\/h6>\n

\u672b\u68a2\u52d5\u8108\u75be\u60a3\uff08PAD\uff09\u306e\u554f\u984c\u306f\u307e\u3059\u307e\u3059\u6df1\u523b\u5316\u3057\u3066\u3044\u308b\u3002PAD\u60a3\u8005\u306f\u4e16\u754c\u30672\u5104\u4eba\u4ee5\u4e0a\u3068\u63a8\u8a08\u3055\u308c\u3001\u305d\u306e40%\u4ee5\u4e0a\u306f\u4f4e\u30fb\u4e2d\u6240\u5f97\u56fd\u306e\u60a3\u8005\u3067\u3042\u308b\uff081,2\uff09\u3002PAD\u60a3\u8005\u306f\u3001\u56db\u80a2\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u304c\u3042\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u3082\u9ad8\u3044\uff083\uff09\u30022\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u521d\u671f\u306e\u8840\u7ba1\u5408\u4f75\u75c7\u3068\u3057\u3066\u6700\u3082\u591a\u3044\u3082\u306e\u306e\u4e00\u3064\u304cPAD\u3067\u3042\u308a\uff084\uff09\u3001\u4e00\u822c\u96c6\u56e3\u3088\u308a\u3082PAD\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u3001\u91cd\u75c7\u5ea6\u3082\u9ad8\u3044\uff085\uff09\u3002\u305d\u308c\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u30012\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3067\u306fPAD\u306e\u30ea\u30b9\u30af\u304c\u904e\u5c0f\u8a55\u4fa1\u3055\u308c\u3066\u304a\u308a\u3001\u4e00\u822c\u306b\u904e\u5c0f\u8a3a\u65ad\u3055\u308c\u3066\u6cbb\u7642\u3082\u5341\u5206\u306b\u884c\u308f\u308c\u3066\u3044\u306a\u3044\u3002<\/span><\/p>\n

PAD\u306e\u7ba1\u7406\u306b\u306f\u975e\u85ac\u7406\u5b66\u7684\u65b9\u6cd5\u3068\u85ac\u7406\u5b66\u7684\u4ecb\u5165\u304c\u3042\u308b\uff083\uff09\u3002\u30d7\u30ed\u86cb\u767d\u8ee2\u63db\u9175\u7d20\u30b5\u30d6\u30c1\u30ea\u30b7\u30f3\uff0f\u30b1\u30ad\u30b7\u30f39\u578b\u963b\u5bb3\u85ac\u3001\u30ca\u30c8\u30ea\u30a6\u30e0-\u30b0\u30eb\u30b3\u30fc\u30b9\u5171\u8f38\u9001\u4f53-2\u963b\u5bb3\u85ac\u3001\u30b0\u30eb\u30ab\u30b4\u30f3\u69d8\u30da\u30d7\u30c1\u30c9-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306a\u3069\u306e\u65b0\u3057\u3044\u6cbb\u7642\u85ac\u306f\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3068\u56db\u80a2\u30a4\u30d9\u30f3\u30c8\u306e\u4e21\u65b9\u3092\u6291\u5236\u3059\u308b\u81e8\u5e8a\u7684\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001\u6700\u8fd1\u6539\u8a02\u3055\u308c\u305fPAD\u306e\u7ba1\u7406\u306b\u95a2\u3059\u308b\u81e8\u5e8a\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u53cd\u6620\u3055\u308c\u3066\u3044\u308b\uff083\uff09\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u5b9f\u81e8\u5e8a\u3067\u306f\u307e\u3060\u5341\u5206\u306b\u5b9f\u8df5\u3055\u308c\u3066\u3044\u306a\u3044\u3002\u3055\u3089\u306b\u3001\u60a3\u8005\u306e\u751f\u6d3b\u306e\u8cea\uff08QOL\uff09\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3059\u4e0b\u80a2\u6f70\u760d\u3084\u305d\u308c\u306b\u3088\u308b\u58ca\u75bd\u306a\u3069\u3001PAD\u306b\u95a2\u9023\u3059\u308b\u672b\u68a2\u3078\u306e\u5f71\u97ff\u3092\u98df\u3044\u6b62\u3081\u308b\u305f\u3081\u306e\u6cbb\u7642\u9078\u629e\u80a2\u306b\u306f\u81e8\u5e8a\u7684\u306a\u30a2\u30f3\u30e1\u30c3\u30c8\u30e1\u30c7\u30a3\u30ab\u30eb\u30cb\u30fc\u30ba\u304c\u5b58\u5728\u3057\u3066\u3044\u308b\u3002<\/span><\/p>\n

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Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Participants with Diabetes\uff08PROMINENT\uff09\u8a66\u9a13\u3067\u306f\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u304cPAD\u306e\u6cbb\u7642\u85ac\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u305f\u3002\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3067\u3042\u308b4\u9805\u76ee\u306e\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff084-point MACE\u3001\u3059\u306a\u308f\u3061\u3001\u975e\u81f4\u6b7b\u6027\u5fc3\u7b4b\u6897\u585e\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u3001\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u307e\u305f\u306f\u5fc3\u8840\u7ba1\u6b7b\uff09\u306b\u3064\u3044\u3066\u306f\u4e2d\u7acb\u7684\u306a\u7d50\u679c\u3067\u3042\u3063\u305f\u304c\u3001\u526f\u6b21\u7684\u8a55\u4fa1\u9805\u76ee\u306e\u30a4\u30d9\u30f3\u30c8\uff08PAD\u306e\u65b0\u898f\u767a\u75c7\u307e\u305f\u306f\u60aa\u5316\uff09\u306e\u767a\u751f\u7387\u306f\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u7fa4\u306e\u65b9\u304c\u30d7\u30e9\u30bb\u30dc\u7fa4\u3088\u308a\u4f4e\u304b\u3063\u305f\uff3b\u30a4\u30d9\u30f3\u30c8\u304c\u767a\u751f\u3057\u305f\u88ab\u9a13\u8005136\u4f8b vs. 158\u4f8b\u3001\u30cf\u30b6\u30fc\u30c9\u6bd4\uff1d0.87\u300195%\u4fe1\u983c\u533a\u9593\uff1a0.69\uff5e1.09\uff3d\uff086\uff09\u3002\u526f\u6b21\u7684\u89e3\u6790\u3067\u5f97\u3089\u308c\u305f\u4e88\u5099\u7684\u306a\u30c7\u30fc\u30bf\uff08\u73fe\u6642\u70b9\u3067\u306f\u6284\u9332\u306e\u307f\u5165\u624b\u53ef\u80fd\uff09\u306b\u3088\u308b\u3068\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306b\u3088\u308a\u4e0b\u80a2\u865a\u8840\u6027\u6f70\u760d\u307e\u305f\u306f\u58ca\u75bd\u306e\u76f8\u5bfe\u30ea\u30b9\u30af\u304c37%\u4f4e\u4e0b\u3057\u305f\u304c\u3001\u3053\u308c\u3089\u306e\u30a4\u30d9\u30f3\u30c8\u306e\u7d76\u5bfe\u767a\u73fe\u6570\u306f\u5c11\u306a\u304b\u3063\u305f\uff08\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u7fa435\u4f8bvs. \u30d7\u30e9\u30bb\u30dc\u7fa456\u4f8b\uff09\uff087\uff09\u3002\u6f5c\u5728\u7684\u6a5f\u5e8f\u306f\u307e\u3060\u5b8c\u5168\u306b\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u304c\u3001PROMINENT\u8a66\u9a13\u306e\u7d50\u679c\u9593\u306e\u76f8\u9055\u306f\uff08\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee vs. PAD\u30a4\u30d9\u30f3\u30c8\uff09\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u5927\u8840\u7ba1\u306b\u5bfe\u3059\u308b\u4f5c\u7528\u3068\u5fae\u5c0f\u8840\u7ba1\u7cfb\u306b\u5bfe\u3059\u308b\u4f5c\u7528\u304c\u7570\u306a\u308b\u3053\u3068\u306b\u95a2\u9023\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u305d\u306e\u88cf\u4ed8\u3051\u3068\u3057\u3066\u3001Fenofibrate Intervention and Event Lowering Diabetes\uff08FIELD\uff09\u8a66\u9a13\u3067\u306f\u3001\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u03b1\uff08PPAR\u03b1\uff09\u30a2\u30b4\u30cb\u30b9\u30c8\u3067\u3042\u308b\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u304c\u9060\u4f4d\u3067\u306e\u4e0b\u80a2\u5207\u65ad\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\uff088\uff09\u3002\u3053\u306e\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u306b\u95a2\u4e0e\u3059\u308b\u57fa\u672c\u7684\u6a5f\u5e8f\u3068\u3057\u3066\u306f\u3001\u72ed\u7fa9\u306e\u8840\u7ba1\u65b0\u751f\uff08angiogenesis\uff09\u3001\u5e83\u7fa9\u306e\u8840\u7ba1\u65b0\u751f\uff08neovascularization\uff09\u304a\u3088\u3073\u5275\u50b7\u6cbb\u7652\u306b\u5bfe\u3059\u308b\u4f5c\u7528\u304c\u6319\u3052\u3089\u308c\u308b\uff089,10\uff09\u3002\u307e\u305f\u3001\u907a\u4f1d\u5b66\u7684\u306a\u56e0\u679c\u63a8\u8ad6\u6cd5\u306b\u3088\u308a\u3001PAD\u306e\u75c5\u614b\u751f\u7406\u306b\u304a\u3051\u308b\u4e3b\u8981\u306a\u30d1\u30b9\u30a6\u30a7\u30a4\u3092\u4ee3\u8868\u3059\u308b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\uff08\u30ea\u30dd\u86cb\u767d\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3059\u308b\u3082\u306e\u3092\u542b\u3080\uff09\u304c\u6700\u592710\u500b\u540c\u5b9a\u3055\u308c\u3001\u56e0\u679c\u95a2\u4fc2\u306e\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\uff0811\uff09\u3002<\/span><\/p>\n

PROMINENT\u8a66\u9a13\u306e\u526f\u6b21\u7684\u89e3\u6790\u306b\u95a2\u3059\u308b\u8a73\u7d30\u306a\u60c5\u5831\u304c\u5f85\u305f\u308c\u308b\u3068\u3053\u308d\u3067\u3042\u308b\u304c\u3001\u4e88\u5099\u7684\u306a\u7d50\u679c\u306f\u6709\u671b\u3067\u3042\u308a\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u304c2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308bPAD\u306e\u6cbb\u7642\u85ac\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002PAD\u306b\u4f34\u3046\u56db\u80a2\u306e\u6162\u6027\u7684\u306a\u865a\u8840\u6027\u5408\u4f75\u75c7\u3092\u4e88\u9632\u3059\u308b\u305f\u3081\u306e\u6cbb\u7642\u9078\u629e\u80a2\u304c\u306a\u3044\u3053\u3068\u3092\u8003\u616e\u3059\u308b\u3068\u3001\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3055\u3089\u306b\u7814\u7a76\u3092\u9032\u3081\u308b\u306b\u5024\u3059\u308b\u3002\u4eba\u53e3\u306e\u9ad8\u9f62\u5316\u3001\u80a5\u6e80\u7387\u306e\u5897\u52a0\u3001\u7cd6\u5c3f\u75c5\u306e\u6709\u75c5\u7387\u306e\u5897\u52a0\u306b\u4f34\u3044\u3001PAD\u306e\u8ca0\u62c5\u306f\u307e\u3059\u307e\u3059\u5897\u5927\u3059\u308b\u3053\u3068\u304c\u4e88\u60f3\u3055\u308c\u3001\u3053\u306ePAD\u306e\u7ba1\u7406\u306b\u304a\u3051\u308b\u30ae\u30e3\u30c3\u30d7\u306f\u65b0\u305f\u306b\u6ce8\u76ee\u3059\u3079\u304d\u70b9\u3067\u3042\u308b\u3002<\/span><\/p>\n

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\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

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  1. Nordestgaard BG. Triglyceride-rich lipoproteins and atherosclerotic cardiovascular disease. Insights from epidemiology, genetics, and biology, Circ Res 2016;118:547-563.
    2. Bhatt DL, Steg PG, Miller M, et al. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. N Engl J Med 2019;380:11-22.
    3. Friedrich M, Aigner A. Therapeutic siRNA: State\u2011of\u2011the\u2011Art and future perspectives. BioDrugs 2022;36:549\u2013571.
    4. Chan DC, Watts GF. ANGPTL3 and ApoC-III inhibitors for treating hypertriglyceridemia in context: horses for courses? Curr Opin Lipidol 2024;35:101-109.
    5. Giammanco A, Spina R, Cefal\u00f9 AB, Averna M. APOC-III: a gatekeeper in controlling triglyceride metabolism. Curr Atheroscler Rep 2023;25:67\u201376.
    6. Gaudet D, Clifton P, Sullivan D, et al. RNA interference therapy targeting apolipoprotein C-III in hypertriglyceridemia. NEJM Evid 2023;2(12):EVIDoa2200325.
    7. Gaudet D, Pall D, Watts GF, et al. Plozasiran (ARO-APOC3) for severe hypertriglyceridemia: the SHASTA-2 randomized clinical trial. JAMA Cardiol 2024;9:620-630.
    8. Ballantyne CM, Vasas S, Azizad M, et al. Plozasiran, an RNA interference agent targeting APOC3, for mixed hyperlipidemia. N Engl J Med 2024; doi: 10.1056\/NEJMoa2404143.
    9. Arrowhead Pharmaceuticals reports successful topline results for plozasiran from the pivotal phase 3 palisade study in patients with familial chylomicronemia syndrome. Arrowhead Pharmaceuticals Inc. June 3, 2024. Accessed June 3, 2024.     https:\/\/ir.arrowheadpharma.com\/news-releases\/news-release-details\/arrowhead-pharmaceuticals-reports-successful-topline-results<\/a>
    10. Arrowhead receives FDA Fast Track designation for aro-APOC3. Arrowhead Pharmaceuticals Inc. March 20, 2023. Accessed May 28, 2024.     https:\/\/ir.arrowheadpharma.com\/news-releases\/news-release-details\/arrowhead-receives-fda-fast-track-designation-aro-apoc3<\/a>
    11. Kersten S. ANGPTL3 as therapeutic target. Curr Opin Lipidol 2021;32:335-341.
    12. Rosenson RS, Gaudet D, Hegele RA, et al. Zodasiran, an RNAi therapeutic targeting ANGPTL3, for mixed hyperlipidemia. N Engl J Med 2024; doi: 10.1056\/NEJMoa2404147<\/li>\n<\/ol>\n

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