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  <\/span><sup>5<\/sup><span>.\u3057\u304b\u3057\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u4ecb\u5165\u306e\u52b9\u679c\u3092\u8a55\u4fa1\u3057\u305f\u7814\u7a76\u3067\u306f\u3001\u307b\u3068\u3093\u3069\u7d50\u8ad6\u304c\u51fa\u3066\u3044\u306a\u3044\u3002\u4f8b\u3048\u3070\u3001\u5927\u52d5\u8108\u5f01\u72ed\u7a84\u75c7\u306b\u304a\u3051\u308b\u30b7\u30f3\u30d0\u30b9\u30bf\u30c1\u30f3\u3068\u30a8\u30bc\u30c1\u30df\u30d6\u306e\u4f75\u7528\uff08SEAS\uff09\u8a66\u9a13\u3067\u306f\u3001\u30b7\u30f3\u30d0\u30b9\u30bf\u30c1\u30f3\u3068\u30a8\u30bc\u30c1\u30df\u30d6\u306e\u4f75\u7528\u306f\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3067\u3042\u308b\u5927\u52d5\u8108\u5f01\u30a4\u30d9\u30f3\u30c8\u3068\u865a\u8840\u6027\u30a4\u30d9\u30f3\u30c8\u306e\u8907\u5408\u3092\u6e1b\u5c11\u3055\u305b\u305a\u3001\u5927\u52d5\u8108\u5f01\u72ed\u7a84\u75c7\u306b\u95a2\u9023\u3057\u305f\u30a4\u30d9\u30f3\u30c8\u306b\u306f\u6709\u610f\u306a\u52b9\u679c\u3092\u793a\u3055\u306a\u304b\u3063\u305f\u3002    <\/span><sup>6<\/sup><span>.<\/span><\/p>\n<p><span>\u5bfe\u7167\u7684\u306b\uff0c\u4ed6\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u30ea\u30dd\u86cb\u767d\u306f\uff0c\u4ecb\u5165\u306e\u6f5c\u5728\u7684\u6a19\u7684\u3068\u3057\u3066\u6709\u671b\u3067\u3042\u308b\u3002\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u306f\u30a2\u30dd\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u306e\u4ed8\u7740\u306b\u3088\u3063\u3066\u4fee\u98fe\u3055\u308c\u305fLDL\u3067\u3042\u308a\u3001\u4e00\u822c\u96c6\u56e3\u306b\u304a\u3044\u3066\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u30ec\u30d9\u30eb\u306e\u4e0a\u6607\u304c\u5927\u52d5\u8108\u5f01\u72ed\u7a84\u75c7\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u30e1\u30f3\u30c7\u30eb\u30e9\u30f3\u30c0\u30e0\u5316\u7814\u7a76\u306b\u3088\u3063\u3066\u652f\u6301\u3055\u308c\u3066\u3044\u308b\u3002   <\/span><sup>7<\/sup><span>.\u6839\u672c\u7684\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u307e\u3060\u4e0d\u660e\u3067\u3042\u308b\u304c\u3001\u30ea\u30dd\u86cb\u767d(a)\u306b\u3088\u3063\u3066\u904b\u3070\u308c\u308b\u9178\u5316\u30ea\u30f3\u8102\u8cea\u306f\u3001\u5f01\u306e\u77f3\u7070\u5316\u3068\u75be\u60a3\u306e\u9032\u884c\u306b\u6975\u3081\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002   <\/span><sup>8<\/sup><span>.<\/span><\/p>\n<p><span>\u3053\u308c\u306b\u52a0\u3048\u3066\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u3068\u305d\u306e\u6b8b\u9ab8\u306e\u5f79\u5272\u3092\u793a\u5506\u3059\u308b\u65b0\u305f\u306a\u8a3c\u62e0\u3082\u3042\u308b\u3002 <\/span><sup>9<\/sup><span>.Kaltoft\u535a\u58eb\u3068\u5171\u540c\u7814\u7a76\u8005\u3089\u306f\u3001\u30e1\u30f3\u30c7\u30eb\u30e9\u30f3\u30c0\u30e0\u5316\u3068Copenhagen General Population Study\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u3001\u8840\u6f3f\u4e2dTG\u304a\u3088\u3073\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u9ad8\u5024\u304c\u5927\u52d5\u8108\u5f01\u72ed\u7a84\u75c7\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u3068\u95a2\u9023\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u691c\u8a0e\u3057\u305f\u3002\u3053\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u5229\u70b9\u306f\u3001\u89b3\u6e2c\u7684\u30ea\u30b9\u30af\u3068\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u306e\u4e21\u65b9\u304c\u8a55\u4fa1\u3055\u308c\u305f\u3053\u3068\u3067\u3042\u308a\u3001\u56e0\u679c\u95a2\u4fc2\u306e\u8a55\u4fa1\u306b\u304a\u3051\u308b\u4ea4\u7d61\u3084\u6e2c\u5b9a\u8aa4\u5dee\u3092\u907f\u3051\u308b\u305f\u3081\u306b\u9053\u5177\u5909\u6570\u89e3\u6790\u3092\u7528\u3044\u305f\u3053\u3068\u3067\u3042\u308b\u3002\u907a\u4f1d\u5b50\u30b9\u30b3\u30a2\u306e\u4f5c\u6210\u306b\u306f\u3001TG\u4ee3\u8b1d\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u86cb\u767d\u8cea\u306b\u95a2\u3059\u308b\u6700\u3082\u9069\u5207\u306a16\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u7528\u3044\u3089\u308c\u305f\u3002 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<\/span><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;8px&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p style=\"font-weight: 400;\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<ol>\n<li style=\"font-weight: 400;\"><span>Joseph J, Naqvi SY, Giri J, Goldberg S. Aortic stenosis: Pathophysiology, diagnosis, and therapy.Am J Med 2017;130:253-63. <\/span><br \/><span class=\"ref ref2\">2.<\/span><span> \u9ad8\u9f62\u8005\u306e\u5927\u52d5\u8108\u5f01\u72ed\u7a84\u75c7\uff1a\u75be\u60a3\u6709\u75c5\u7387\u3068\u7d4c\u30ab\u30c6\u30fc\u30c6\u30eb\u7684\u5927\u52d5\u8108\u5f01\u7f6e\u63db\u8853\u306e\u5019\u88dc\u8005\u6570\uff1a\u30e1\u30bf\u5206\u6790\u3068\u30e2\u30c7\u30ea\u30f3\u30b0\u7814\u7a76\u3002J Am Coll Cardiol 2013;62:1002-12.  <\/span><br \/><span class=\"ref ref3\">3.<\/span><span> Baumgartner H, Falk V, Bax JJ, et al. ESC\/EACTS Guidelines for the Management of valvular heart disease.Eur Heart J 2017;38:2739-91.  <\/span><br \/><span class=\"ref ref4\">4.<\/span><span> Sharma UC, Barenbrug P, Pokharel S, et al. \u5927\u52d5\u8108\u5f01\u72ed\u7a84\u75c7\u60a3\u8005\u306b\u304a\u3051\u308b\u5927\u52d5\u8108\u5f01\u7f6e\u63db\u8853\u306e\u8ee2\u5e30\u306b\u95a2\u3059\u308b\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\u3002Ann Thorac Surg 2004;78:90-9.  <\/span><br \/><span class=\"ref ref5\">5.<\/span><span> Stritzke J, Linsel-Nitschke P, Markus MRP, et al. \u5909\u6027\u5927\u52d5\u8108\u5f01\u75be\u60a3\u3068\u5fc3\u8840\u7ba1\u5371\u967a\u56e0\u5b50\u3078\u306e\u9577\u671f\u66b4\u9732\u3068\u306e\u95a2\u9023\uff1a\u7e26\u65ad\u7684\u7814\u7a76\u306e\u7d50\u679c <\/span><br \/><span>\u4f4f\u6c11\u30d9\u30fc\u30b9\u306eKORA\/MONICA\u8abf\u67fb\u3002Eur Heart J 2009;30:2044-53. <\/span><br \/><span class=\"ref ref6\">6.<\/span><span> \u5927\u52d5\u8108\u5f01\u72ed\u7a84\u75c7\u306b\u304a\u3051\u308b\u30b7\u30f3\u30d0\u30b9\u30bf\u30c1\u30f3\u3068\u30a8\u30bc\u30c1\u30df\u30d6\u306b\u3088\u308b\u96c6\u4e2d\u7684\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3002N Engl J Med 2008;359:1343-56.  <\/span><br \/><span class=\"ref ref7\">7.<\/span><span> Zheng KH, Tsimikas S, Pawade T, et al. Lipoprotein(a)\u3068\u9178\u5316\u30ea\u30f3\u8102\u8cea\u306f\u5927\u52d5\u8108\u5f01\u72ed\u7a84\u75c7\u60a3\u8005\u306e\u5f01\u77f3\u7070\u5316\u3092\u4fc3\u9032\u3059\u308b\u3002J Am Coll Cardiol 2019;73:2150-62.  <\/span><br \/><span class=\"ref ref8\">8.<\/span><span> Kamstrup PR, Tybj\u00e6rg-Hansen A, Nordestgaard BG.\u4e00\u822c\u96c6\u56e3\u306b\u304a\u3051\u308b\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u306e\u4e0a\u6607\u3068\u5927\u52d5\u8108\u5f01\u72ed\u7a84\u75c7\u306e\u30ea\u30b9\u30af\u3002J Am Coll Cardiol 2014;63:470-7.  <\/span><br \/><span class=\"ref ref9\">9.<\/span><span> Kaltoft M, Langsted A, Nordestgaard BG.\u5927\u52d5\u8108\u5f01\u72ed\u7a84\u75c7\u306e\u30ea\u30b9\u30af\u3068\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u304a\u3088\u3073\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff1a\u30b3\u30da\u30f3\u30cf\u30fc\u30b2\u30f3\u4e00\u822c\u4eba\u53e3\u7814\u7a76\u306b\u304a\u3051\u308b\u30e1\u30f3\u30c7\u30eb\u30e9\u30f3\u30c0\u30e0\u5316\u3002Eur Heart J 2020. doi: 10.1093\/eurheartj\/ehaa172.   <\/span><br \/><span class=\"ref ref10\">10.<\/span><span> Varbo A, Benn M, Tybj\u00e6rg-Hansen A, Nordestgaard BG.\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u306f\u3001\u4f4e\u60aa\u6027\u5ea6\u306e\u708e\u75c7\u3068\u865a\u8840\u6027\u5fc3\u75be\u60a3\u306e\u4e21\u65b9\u3092\u5f15\u304d\u8d77\u3053\u3059\u304c\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u306f\u3001\u708e\u75c7\u3092\u4f34\u308f\u305a\u306b\u865a\u8840\u6027\u5fc3\u75be\u60a3\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002Circulation 2013;128:1298-309.  <\/span><\/li>\n<\/ol>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>R3i\u793e\u8aac\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u6b8b\u4f59\u30ea\u30dd\u86cb\u767d\u8cea\uff1a\u5927\u52d5\u8108\u5f01\u72ed\u7a84\u75c7\u306b\u304a\u3051\u308b\u65b0\u305f\u306a\u6cbb\u7642\u6a19\u7684\u304b\uff1f \u30df\u30b7\u30a7\u30eb\u30fb\u30d8\u30eb\u30de\u30f3\u30ba\u6559 [&hellip;]<\/p>\n","protected":false},"author":258497324,"featured_media":0,"parent":254286,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_crdt_document":"","jetpack_post_was_ever_published":false,"footnotes":""},"class_list":["post-254557","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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