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Lowering via Bempedoic Acid, an ACL-Inhibiting Regimen Outcomes Trial\uff09\u306e\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u7528\u3044\u3066\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u4e88\u6e2c\u56e0\u5b50\u3068\u3057\u3066\u306e\u708e\u75c7\u304a\u3088\u3073\u9ad8\u8102\u8840\u75c7\u306e\u76f8\u5bfe\u7684\u306a\u5f71\u97ff\u304c\u691c\u8a0e\u3055\u308c\u305f<\/span><sup>11<\/sup><span>\u3002\u305d\u306e\u4e3b\u306a\u7d50\u679c\u3068\u3057\u3066\u3001hsCRP\u306b\u3088\u308a\u691c\u51fa\u3055\u308c\u308b\u708e\u75c7\u306f\u3001\u9ad8\u8102\u8840\u75c7\uff08LDL-C\u307e\u305f\u306fnon-HDL-C\u3068\u3057\u3066\u691c\u51fa\uff09\u3068\u540c\u7a0b\u5ea6\u307e\u305f\u306f\u305d\u308c\u4ee5\u4e0a\u306b\u5f37\u529b\u306a\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u4e88\u6e2c\u56e0\u5b50\u3067\u3042\u3063\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u3001LDL-C\u306e\u307f\u306a\u3089\u305ahsCRP\u306b\u3064\u3044\u3066\u3082\u3001\u300clower is better\uff08\u4e0b\u3052\u308b\u307b\u3069\u3088\u3044\uff09\u300d\u304c\u5f53\u3066\u306f\u307e\u308b\u3002<\/span><\/p>\n<p><span>\u6700\u8fd1\u306e\u81e8\u5e8a\u8a66\u9a13\u306b\u3088\u308a\u84c4\u7a4d\u3055\u308c\u305f\u77e5\u898b\u304b\u3089\u3001\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u591a\u56e0\u5b50\u6027\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u308b\u3002\u5c06\u6765\u7684\u306b\u306f\u3001\u708e\u75c7\u3092\u6a19\u7684\u3068\u3059\u308b\u6cbb\u7642\u3068\u6700\u9069\u306a\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306e\u4f75\u7528\u304c\u3001\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u305f\u3081\u306e\u6cbb\u7642\u6226\u7565\u306e\u4e2d\u5fc3\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3002<\/span><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;8px&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p style=\"font-weight: 400;\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<ol>\n<li style=\"font-weight: 400;\"><span>GBD 2017 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018;392:1859\u2013922.<\/span><br \/><span class=\"ref ref2\">2.<\/span><span>\u00a0Timmis A, Vardas P, Townsend N, et al. European Society of Cardiology: cardiovascular disease statistics 2021. Eur Heart J 2022;43:716-99.<\/span><br \/><span class=\"ref ref3\">3.<\/span><span>\u00a0Visseren FLJ, Mach F, Smulders YM, et al. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J 2021;42:3227-337.<\/span><br \/><span class=\"ref ref4\">4.<\/span><span>\u00a0Libby P. Triglycerides on the rise: should we swap seats on the seesaw? Eur Heart J 2015;36:774-6.<\/span><br \/><span class=\"ref ref5\">5.<\/span><span>\u00a0Nordestgaard BG. Triglyceride-rich lipoproteins and atherosclerotic cardiovascular disease: new insights from epidemiology, genetics, and biology. Circ Res 2016;118:547-63.<\/span><br \/><span class=\"ref ref6\">6.<\/span><span>\u00a0Matter MA, Paneni F, Libby P, et al. Inflammation in acute myocardial infarction: the good, the bad and the ugly. Eur Heart J 2024;45:89\u2013103.<\/span><br \/><span class=\"ref ref7\">7.<\/span><span>\u00a0Ridker PM, Everett BM, Thuren T, et al; CANTOS Trial Group. Antiinflammatory therapy with canakinumab for atherosclerotic disease. N Engl J Med 2017;377:1119\u20131131.<\/span><br \/><span class=\"ref ref8\">8.<\/span><span>\u00a0Tardif JC, Kouz S, Waters DD, et al. Efficacy and safety of low-dose colchicine after myocardial infarction. N Engl J Med 2019;381:2497\u2013505.<\/span><br \/><span class=\"ref ref9\">9.<\/span><span>\u00a0Ridker PM. Targeting residual inflammatory risk: The next frontier for atherosclerosis treatment and prevention. Vascul Pharmacol 2023:153:107238.<\/span><br \/><span class=\"ref ref10\">10.<\/span><span>\u00a0Ridker PM, Bhatt DL, Pradhan AD, et al. Inflammation and cholesterol as predictors of cardiovascular events among patients receiving statin therapy: a collaborative analysis of three randomized trials. Lancet 2023;401:1293\u2013301.<\/span><br \/><span class=\"ref ref11\">11.<\/span><span>\u00a0Ridker PM, Lei L, Louie MJ, et al. Inflammation and cholesterol as predictors of cardiovascular events among 13970 contemporary high-risk patients with statin intolerance. Circulation 2024;149:28\u201335.<\/span><\/li>\n<\/ol>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>R3i\u793e\u8aac2024\u5e745\u6708 \u6b8b\u5b58\u30ea\u30b9\u30af\u306e\u4f4e\u4e0b\uff1a\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u708e\u75c7\u306e\u4e21\u65b9\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u3088\u308a\u671b\u307e\u3057\u3044 Prof [&hellip;]<\/p>\n","protected":false},"author":258497324,"featured_media":0,"parent":254286,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_wpcom_ai_launchpad_about_page":false,"_wpcom_ai_launchpad_gallery_page":false,"_wpcom_ai_launchpad_contact_page":false,"_wpcom_ai_launchpad_events_page":false,"_wpcom_ai_launchpad_video_page":false,"_wpcom_ai_launchpad_portfolio_piece":false,"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"footnotes":""},"class_list":["post-254542","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - 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