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\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u3068\u4e2d\u6027\u8102\u80aa\u306e\u4e0a\u6607\u3068\u306e\u95a2\u9023\u6027\u304c\u518d\u3073\u6ce8\u76ee\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u3001\u30b2\u30ce\u30e0\u30c7\u30fc\u30bf\u304c\u65b0\u305f\u306a\u6cbb\u7642\u6a19\u7684\u306e\u63a2\u7d22\u3092\u5f8c\u62bc\u3057\u3057\u3066\u3044\u308b\u3002\u30a2\u30dd\u30ea\u30dd\u86cb\u767dCIII\u3001\u305d\u3057\u3066\u6700\u8fd1\u3067\u306fANGPLT4\u304c\u6b21\u306e\u6a19\u7684\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u3002\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u3068\u305d\u306e\u6b8b\u6e23\u306e\u4e0a\u6607\u306f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u6b8b\u5b58\u3055\u305b\u308b\u91cd\u8981\u306a\u56e0\u5b50\u3067\u3042\u308b\u3002 <\/span>11<\/sup>\u4f8b\u3048\u3070\u3001\u7c73\u56fd\u3067\u306f\u56fd\u6c11\u5065\u5eb7\u6804\u990a\u8abf\u67fb\uff08NHANES\uff09\u306e\u30c7\u30fc\u30bf\u304b\u3089\u30012010\u5e74\u306b\u306f\u56fd\u6c11\u306e47\uff05\u304c\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024>150mg\/dl\u3092\u6709\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u5927\u90e8\u5206\u306f\u751f\u6d3b\u7fd2\u6163\u306e\u8981\u56e0\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b12\u3002<\/span> 12<\/sup>\u30b9\u30bf\u30c1\u30f3\u306f\u4e0a\u6607\u3057\u305f\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u306e\u306b\u52b9\u679c\u7684\u3067\u3042\u308b\u3053\u3068\u306f\u8ad6\u3092\u5f85\u305f\u306a\u3044\u304c\u3001\u4eca\u6708\u306eLandmark\u306e\u7814\u7a76\u3067\u53d6\u308a\u4e0a\u3052\u305fVOYAGER\u306e\u89e3\u6790\u304b\u3089\u3001\u9ad8\u7528\u91cf\u3001\u9ad8\u5f37\u5ea6\u306e\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u884c\u3063\u3066\u3082\u3001\u4e2d\u6027\u8102\u80aa\u8840\u75c7\u60a3\u8005\u306e\u7d0450\uff05\u304c\u671b\u307e\u3057\u3044\u30ec\u30d9\u30eb\uff08<1.7mmol\/l\u307e\u305f\u306f150mg\/dl\uff09\u306b\u9054\u3057\u306a\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002<\/span>13<\/sup><\/span><\/p>\n

\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306e\u7ba1\u7406\u306b\u5bfe\u3059\u308b\u65b0\u305f\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u7279\u5b9a\u3057\u3001\u6f5c\u5728\u7684\u306a\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u907a\u4f1d\u5b66\u7684\u304a\u3088\u3073\u30e1\u30ab\u30cb\u30ba\u30e0\u7684\u306a\u6d1e\u5bdf\u304c\u91cd\u8981\u3067\u3042\u308a\u3001\u4eca\u5f8c\u3082\u305d\u308c\u304c\u7d9a\u304f\u3067\u3042\u308d\u3046\u3002<\/span><\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”8px” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

    \n
  1. Do R, Willer CJ, Schmidt EM et al.\u8840\u6f3f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068\u51a0\u52d5\u8108\u75be\u60a3\u30ea\u30b9\u30af\u306b\u95a2\u9023\u3059\u308b\u5171\u901a\u30d0\u30ea\u30a2\u30f3\u30c8\u3002Nat Genet 2013;45:1345-52. <\/span>
    2.<\/span> Pollin TI, Damcott CM, Shen H et al. \u30d2\u30c8APOC3\u306e\u30cc\u30eb\u5909\u7570\u306f\u3001\u826f\u597d\u306a\u8840\u6f3f\u8102\u8cea\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3068\u660e\u3089\u304b\u306a\u5fc3\u4fdd\u8b77\u4f5c\u7528\u3092\u3082\u305f\u3089\u3059\u3002Science.2008; 322:1702-5. <\/span>
    3.<\/span> Exome Sequencing Project\u306eTG\u304a\u3088\u3073HDL\u30ef\u30fc\u30ad\u30f3\u30b0\u30b0\u30eb\u30fc\u30d7\u3002APOC3\u306e\u6a5f\u80fd\u55aa\u5931\u5909\u7570\u3001\u4e2d\u6027\u8102\u80aa\u3001\u51a0\u75be\u60a3\u3002N Engl J Med 2014;371: 22-31. <\/span>
    4.<\/span> J\u00f8rgensen AB, Frikke-Schmidt R, Nordestgaard BG, Tybj\u00e6rg-Hansen A. APOC3\u306e\u6a5f\u80fd\u55aa\u5931\u5909\u7570\u3068\u865a\u8840\u6027\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3002N Engl J Med 2014; 371: 32-41. <\/span>
    5.<\/span> Do R, Stitziel NO, Won HH et al. Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.Nature 2015; 518: 102-6. <\/span>
    6.<\/span> Mehta N, Qamar A, Qu L et al. \u8840\u6f3f\u4e2d\u30a2\u30f3\u30b8\u30aa\u30dd\u30a8\u30c1\u30f3\u69d8\u86cb\u767d\u8cea3\u304a\u3088\u30734\u3068\u8102\u8cea\u304a\u3088\u3073\u4ee3\u8b1d\u5f62\u8cea\u3068\u306e\u5dee\u7570\u306e\u3042\u308b\u95a2\u9023\u3002Arterioscler Thromb Vasc Biol 2014;34:1057-63. <\/span>
    7.<\/span> Yin W, Romeo S, Chang S et al. angptl4\u306e\u907a\u4f1d\u7684\u5909\u7570\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30d7\u30ed\u30bb\u30b7\u30f3\u30b0\u3068\u6a5f\u80fd\u306b\u95a2\u3059\u308b\u6d1e\u5bdf\u3092\u4e0e\u3048\u3066\u304f\u308c\u308b\u3002J Biol Chem 2009;284:13213-22. <\/span>
    8.<\/span> Angptl 4\u6b20\u640d\u306f\u8102\u8cea\u4ee3\u8b1d\u3092\u6539\u5584\u3057\u3001\u6ce1\u6cab\u7d30\u80de\u5f62\u6210\u3092\u6291\u5236\u3057\u3001\u52d5\u8108\u786c\u5316\u3092\u4e88\u9632\u3059\u308b\u3002Biochemical and biophysical research communications.2009;379:806-11. <\/span>
    9.<\/span> Dewey FE, Gusarova V, O’Dushlaine C et al. ANGPTL4\u306e\u4e0d\u6d3b\u6027\u5316\u30d0\u30ea\u30a2\u30f3\u30c8\u3068\u51a0\u52d5\u8108\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3002N Engl J Med 2016;374:1123-33. <\/span>
    10.<\/span> \u5fc3\u7b4b\u6897\u585e\u907a\u4f1d\u5b66\u3068CARDIoGRAM\u30a8\u30af\u30bd\u30fc\u30e0\u30b3\u30f3\u30bd\u30fc\u30b7\u30a2\u7814\u7a76\u8005\u3002ANGPTL4\u3001LPL\u3001SVEP1\u306e\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0\u5909\u7570\u3068\u51a0\u52d5\u8108\u75be\u60a3\u30ea\u30b9\u30af\u3002N Engl J Med 2016;374:1134-44. <\/span>
    11.<\/span> Nordestgaard BG\u3002\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u3068\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u3002\u75ab\u5b66\u3001\u907a\u4f1d\u5b66\u3001\u751f\u7269\u5b66\u304b\u3089\u306e\u65b0\u305f\u306a\u6d1e\u5bdf\u3002Circulation Res 2016;118:547-63. <\/span>
    12.<\/span> \u7c73\u56fd\u6210\u4eba\u306b\u304a\u3051\u308b\u8102\u8cea\u3068\u30ea\u30dd\u86cb\u767d\u306e\u50be\u5411\u30011988-2010\u5e74\u3002JAMA 2012;308:1545-54. <\/span>
    13.<\/span> \u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u60a3\u8005\u306b\u304a\u3051\u308b\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u304c\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306b\u95a2\u3059\u308bVOYAGER\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3002 <\/span><\/li>\n<\/ol>\n

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