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   <\/span><sup>7-9<\/sup><span>.<\/span><\/p>\n<p><span>\u3053\u306e\u753b\u671f\u7684\u306a\u5831\u544a\u66f8\u306f\u3001\u81e8\u5e8a\u8ee2\u5e30\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306e\u5c06\u6765\u306e\u6a19\u7684\u3068\u3057\u3066\u3001\u4e2d\u6027\u8102\u80aa\u3092\u3088\u308a\u771f\u5263\u306b\u8003\u616e\u3059\u3079\u304d\u3067\u3042\u308b\u3068\u3044\u3046\u8a3c\u62e0\u3092\u8ffd\u52a0\u3059\u308b\u3001\u91cd\u8981\u306a\u7814\u7a76\u306b\u3064\u3044\u3066\u8ff0\u3079\u3066\u3044\u308b\u3002\u3053\u306e\u524d\u63d0\u306f\u3001\u4e2d\u6027\u8102\u80aa\u306e\u4e0a\u6607\u304c\u5178\u578b\u7684\u306a\u7279\u5fb4\u3067\u3042\u308b\u7cd6\u5c3f\u75c5\u306e\u30d1\u30f3\u30c7\u30df\u30c3\u30af\uff08\u4e16\u754c\u7684\u5927\u6d41\u884c\uff09\u306b\u7167\u3089\u3057\u3066\u3082\u3001\u6975\u3081\u3066\u30c8\u30d4\u30ab\u30eb\u306a\u3082\u306e\u3067\u3042\u308b\u3002&gt;\u5b9f\u969b\u3001\u7c73\u56fd\u3067\u306f\u3001NHANES\uff08National Health and Nutrition Examination Survey\uff1a\u56fd\u6c11\u5065\u5eb7\u6804\u990a\u8abf\u67fb\uff09\u306e\u30c7\u30fc\u30bf\u304b\u3089\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u304c\u4e0a\u6607\u50be\u5411\u306b\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002    <\/span><sup>10<\/sup><span>.\u307e\u305f\u3001\u73fe\u5728\u306e\u7ba1\u7406\u624b\u6cd5\u304c\u3053\u306e\u554f\u984c\u306b\u9069\u5207\u306b\u5bfe\u51e6\u3067\u304d\u3066\u3044\u306a\u3044\u3053\u3068\u3082\u660e\u3089\u304b\u3067\u3042\u308b\u3002   <\/span><sup>11<\/sup><span>.<\/span><\/p>\n<p><span>\u3053\u308c\u3089\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u7dcf\u5408\u3059\u308b\u3068\uff0c\u5c06\u6765\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u304a\u3044\u3066\u4e2d\u6027\u8102\u80aa\u4e0a\u6607\u306e\u7ba1\u7406\u3092\u771f\u5263\u306b\u691c\u8a0e\u3059\u3079\u304d\u3067\u3042\u308a\uff0c\u3053\u306e\u898b\u89e3\u306fResidual Risk Reduction Initiative\u306b\u3088\u3063\u3066\u660e\u78ba\u306b\u5171\u6709\u3055\u308c\u3066\u3044\u308b\u3002\u30d1\u30ba\u30eb\u306e\u6b20\u3051\u3066\u3044\u308b\u90e8\u5206\u306f\u3001\u73fe\u5728\u306e\u6a19\u6e96\u6cbb\u7642\u3092\u80cc\u666f\u306b\u3001\u4e2d\u6027\u8102\u80aa\u4e0a\u6607\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3067\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u304c\u6e1b\u5c11\u3059\u308b\u304b\u3069\u3046\u304b\u3067\u3042\u308b\u3002\u3053\u306e\u70b9\u306b\u3064\u3044\u3066\u306f\uff0c\u73fe\u5728\u9032\u884c\u4e2d\u3067\u3042\u308a\uff0c\u307e\u305f\u4e88\u5b9a\u3055\u308c\u3066\u3044\u308b\uff0c\u6700\u65b0\u306e\u6a19\u6e96\u6cbb\u7642\u306b\u3088\u308b\u8102\u8cea\u7ba1\u7406\u3092\u53d7\u3051\u3066\u3044\u308b\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u8a66\u9a13\u306e\u7d50\u679c\u3092\u5f85\u3061\u671b\u3093\u3067\u3044\u308b\u3002  <\/span><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;8px&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p style=\"font-weight: 400;\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<ol>\n<li style=\"font-weight: 400;\"><span>HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u3068\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306e\u6e1b\u5c11\u306b\u3088\u308b\u4e8c\u6b21\u4e88\u9632<\/span><br \/><span>\u51a0\u52d5\u8108\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u3002Circulation 2000;102:21-7. <\/span><br \/><span class=\"ref ref2\">2.<\/span><span> KlempfnerR\u3001Erez A\u3001Zekry Sagit B\u3001Goldenberg I\u3001Fisma E\u3001Kopel E\u3001Shlomo N\u3001Israel A\u3001Tenenbaum A\u3002\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u306e\u4e0a\u6607\u306f\u3001\u78ba\u7acb\u3057\u305f\u51a0\u52d5\u8108\u6027\u5fc3\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u5168\u6b7b\u56e0\u6b7b\u4ea1\u7387\u306e\u4e0a\u6607\u3068\u72ec\u7acb\u3057\u3066\u95a2\u9023\u3057\u3066\u3044\u308b\u3002Bezafibrate Infarction Prevention Study and Registry\u306e22\u5e74\u9593\u306e\u8ffd\u8de1\u8abf\u67fb\u3002Circ Cardiovasc Qual Outcomes 2016;9:100-8.  <\/span><br \/><span class=\"ref ref3\">3.<\/span><span> Reiner Z, Catapano AL, De Backer G, Graham I, Taskinen MR, Wiklund O, Agewall S, Alegria E, Chapman MJ, Durrington P, Erdine S, Halcox J, Hobbs R, Kjekshus J, Filardi PP, Riccardi G, Storey RF, Wood D.\u8102\u8cea\u7570\u5e38\u75c7\u7ba1\u7406\u306e\u305f\u3081\u306eESC\/EAS\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\uff1a\u6b27\u5dde\u5fc3\u81d3\u75c5\u5b66\u4f1a\uff08ESC\uff09\u3068\u6b27\u5dde\u52d5\u8108\u786c\u5316\u5b66\u4f1a\uff08EAS\uff09\u306e\u8102\u8cea\u7570\u5e38\u75c7\u7ba1\u7406\u30bf\u30b9\u30af\u30d5\u30a9\u30fc\u30b9\u3002Eur Heart J 2011;32:1769-818. <\/span><br \/><span class=\"ref ref4\">4.<\/span><span> Nordestgaard BG.\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u3068\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff1a\u75ab\u5b66\u3001\u907a\u4f1d\u5b66\u3001\u751f\u7269\u5b66\u304b\u3089\u306e\u65b0\u305f\u306a\u6d1e\u5bdf\u3002Circ Res 2016;118:547-63.  <\/span><br \/><span class=\"ref ref5\">5.<\/span><span> Do R, Willer CJ, Schmidt EM et al.\u8840\u6f3f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068\u51a0\u52d5\u8108\u75be\u60a3\u30ea\u30b9\u30af\u306b\u95a2\u9023\u3059\u308b\u5171\u901a\u30d0\u30ea\u30a2\u30f3\u30c8\u3002Nat Genet 2013;45:1345-52.  <\/span><br \/><span class=\"ref ref6\">6.<\/span><span> Do R, Stitziel NO, Won HH et al. Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.Nature 2015; 518: 102-6.  <\/span><br \/><span class=\"ref ref7\">7.<\/span><span> \u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3067\u30b9\u30bf\u30c1\u30f3\u670d\u7528\u4e2d\u306e\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3051\u308bAMR101\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u6291\u5236\u80fd\u3092\u8a55\u4fa1\u3059\u308b\u8a66\u9a13\u3002\u4e3b\u8981\u76ee\u7684\u306f\u30011\u65e54g\u306eAMR101\u306e\u6700\u521d\u306e\u4e3b\u8981\u306a\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u767a\u751f\u3092\u4e88\u9632\u3059\u308b\u52b9\u679c\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3067\u3042\u308b\u3002(REDUCE-IT\uff09\u3002ClinicalTrials.gov\u8b58\u5225\u5b50\uff1ahttps:\/\/clinicaltrials.gov\/ct2\/show\/NCT01492361#.    <\/span><br \/><span class=\"ref ref8\">8.<\/span><span> \u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3092\u6709\u3059\u308b\u9ad8CV\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3051\u308b\u30a8\u30d1\u30ce\u30d0\u306b\u3088\u308bSTatin\u6b8b\u5b58\u30ea\u30b9\u30af\u4f4e\u6e1b\u3092\u8a55\u4fa1\u3059\u308b\u30a2\u30a6\u30c8\u30ab\u30e0\u8a66\u9a13\uff08STRENGTH\uff09\u3002ClinicalTrials.gov Identifier\uff1aNCT02104817. <a href=\"https:\/\/clinicaltrials.gov\/show\/NCT02104817\" rel=\"nofollow\">https:\/\/clinicaltrials.gov\/show\/NCT02104817<\/a>  <\/span><br \/><span class=\"ref ref9\">9.<\/span><span> \u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u30fb\u4f4eHDL-C\u306e\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u5fc3\u81d3\u75c5\u4e88\u9632\u3092\u691c\u8a0e\u3059\u308b\u753b\u671f\u7684\u306a\u81e8\u5e8a\u8a66\u9a13\u300cPROMINENT\u300dhttp:\/\/www.bizjournals.com\/prnewswire\/press_releases\/2016\/01\/12\/CL94522\u3002 <\/span><br \/><span class=\"ref ref10\">10.<\/span><span> Carroll MD, Kit BK, Lacher DA, Shero ST, Mussolino ME.\u7c73\u56fd\u6210\u4eba\u306b\u304a\u3051\u308b\u8102\u8cea\u3068\u30ea\u30dd\u86cb\u767d\u306e\u50be\u5411\u30011988-2010\u5e74\u3002JAMA.2012;308:1545-54.   <\/span><br \/><span class=\"ref ref11\">11.<\/span><span> \u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u60a3\u8005\u306b\u304a\u3051\u308b\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u304c\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306b\u95a2\u3059\u308bVOYAGER\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3002  Am J Cardiol 2016[Epub ahead of print].<\/span><\/li>\n<\/ol>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>R3i\u793e\u8aac\u672a\u6765\u3078\u306e\u56de\u5e30\uff1a\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u518d\u8003 \u30df\u30b7\u30a7\u30eb\u30fb\u30d8\u30eb\u30de\u30f3\u30ba\u6559\u6388\u3001\u30d4\u30a8\u30fc\u30eb\u30fb\u30a2\u30de\u30ec\u30f3\u30b3\u6559\u6388 \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9 [&hellip;]<\/p>\n","protected":false},"author":258497324,"featured_media":0,"parent":254286,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_crdt_document":"","footnotes":""},"class_list":["post-254524","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - 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