{"id":254515,"date":"2024-12-30T18:26:43","date_gmt":"2024-12-30T17:26:43","guid":{"rendered":"https:\/\/r3i.org\/r3i%e7%a4%be%e8%aa%ac\/%e8%ab%96%e8%aa%ac-04-21-%e3%83%a1%e3%82%bf%e3%83%9c%e3%83%aa%e3%83%83%e3%82%af%e3%82%b7%e3%83%b3%e3%83%89%e3%83%ad%e3%83%bc%e3%83%a0%e3%81%a8covid-19\/"},"modified":"2025-02-22T17:27:41","modified_gmt":"2025-02-22T16:27:41","slug":"%e8%ab%96%e8%aa%ac-04-21-%e3%83%a1%e3%82%bf%e3%83%9c%e3%83%aa%e3%83%83%e3%82%af%e3%82%b7%e3%83%b3%e3%83%89%e3%83%ad%e3%83%bc%e3%83%a0%e3%81%a8covid-19","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/r3i%e7%a4%be%e8%aa%ac\/%e8%ab%96%e8%aa%ac-04-21-%e3%83%a1%e3%82%bf%e3%83%9c%e3%83%aa%e3%83%83%e3%82%af%e3%82%b7%e3%83%b3%e3%83%89%e3%83%ad%e3%83%bc%e3%83%a0%e3%81%a8covid-19\/","title":{"rendered":"\u8ad6\u8aac 04\/21 – \u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u3068COVID-19"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Header” _builder_version=”4.27.4″ _module_preset=”35f37621-1062-4ae6-955d-76a3167a2aa8″ background_image=”https:\/\/r3i.org\/wp-content\/uploads\/2024\/12\/pexels-pixabay-267582.jpg&#8221<\/a>; parallax=”on” min_height=”157.9px” min_height_tablet=”100px” min_height_phone=”100px” min_height_last_edited=”on|phone” height=”116px” height_tablet=”153px” height_phone=”130px” height_last_edited=”on|phone” custom_margin_tablet=”” custom_margin_phone=”-17px||||false|false” custom_margin_last_edited=”on|phone” custom_padding=”0vw||0vw||true|false” collapsed=”on” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22background_color_gradient_stops%22%93}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_text_color=”#FFFFFF” header_2_text_color=”#FFFFFF” custom_padding=”1px|||||” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

R3i \u7de8\u96c6\u8a18\u4e8b<\/spanhelvetica><\/h2>\n

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2021\u5e744\u6708<\/span><\/h5>\n
\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u3068COVID-19<\/span><\/h5>\n
Prof. Jean Charles Fruchart, Prof. Michel Hermans, Prof. Pierre Amarenco
An Editorial from the R3i Trustees<\/h6>\n

\u4e2d\u56fd\u306e\u6b66\u6f22\u3067\u91cd\u75c7\u547c\u5438\u5668\u75be\u60a3COVID-19\u306b\u95a2\u9023\u3059\u308bSARSCoV-2\u611f\u67d3\u306e\u6700\u521d\u306e\u75c7\u4f8b\u304c\u5831\u544a\u3055\u308c\u3066\u4ee5\u6765\u3001\u4e16\u754c\u306f\u72ec\u7279\u306e\u4e0d\u78ba\u5b9f\u6027\u306e\u3042\u308b\u6642\u4ee3\u3092\u904e\u3054\u3057\u3066\u3044\u308b\u3002\u3053\u306e\u30d1\u30f3\u30c7\u30df\u30c3\u30af\u306e\u6025\u901f\u306a\u51fa\u73fe\u306b\u3088\u308a\u3001\u91cd\u75c7COVID-19\u306e\u4e3b\u8981\u306a\u30ea\u30b9\u30af\u8981\u56e0\u3001\u7ba1\u7406\u6226\u7565\u3001\u9769\u65b0\u7684\u306a\u6cbb\u7642\u6cd5\u306e\u96c6\u4e2d\u7684\u306a\u8abf\u67fb\u304c\u884c\u308f\u308c\u305f\u3002<\/span><\/p>\n

\u80a5\u6e80\u304a\u3088\u3073\/\u307e\u305f\u306f\u7cd6\u5c3f\u75c5\u60a3\u8005\u3067\u306f\u3001COVID-19\u306b\u95a2\u9023\u3057\u305f\u6709\u5bb3\u306a\u8ee2\u5e30\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3068\u3044\u3046\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u793a\u3055\u308c\u3001\u4ee3\u8b1d\u56e0\u5b50\u304c\u3082\u305f\u3089\u3059\u30ea\u30b9\u30af\u306b\u95a2\u3059\u308b\u7814\u7a76\u304c\u7126\u70b9\u3068\u306a\u3063\u3066\u3044\u308b(1,2)\u3002\u80a5\u6e80\u3068\u7cd6\u5c3f\u75c5\u306f\u3001COVID-19\u306b\u95a2\u9023\u3057\u305f\u6b7b\u4ea1\u30ea\u30b9\u30af\u3092\u9ad8\u3081(3,4)\u3001\u5e74\u9f62\u306b\u3088\u3063\u3066\u3055\u3089\u306b\u305d\u306e\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b (4,5)\u3002\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u306b\u4ee3\u8868\u3055\u308c\u308b\u57fa\u790e\u7684\u306a\u4ee3\u8b1d\u6a5f\u80fd\u969c\u5bb3\u306f\u3001\u80a5\u6e80\u3084\u7cd6\u5c3f\u75c5\u306e\u60a3\u8005\u306b\u5171\u901a\u3057\u3066\u898b\u3089\u308c\u308b\u305f\u3081\u3001\u3053\u308c\u3089\u306e\u3046\u3061\u3001\u3069\u306e\u56e0\u5b50\u304c\u6709\u5bb3\u306a\u8ee2\u5e30\u306b\u7d50\u3073\u3064\u304f\u306e\u304b\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3002<\/span><\/p>\n

COVID-19\u306e\u91cd\u75c7\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u3001\u9ad8\u6bd4\u91cd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08HDL-C\uff09\u306e\u4f4e\u4e0b\u306b\u52a0\u3048\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3078\u306e\u69d8\u3005\u306a\u5f71\u97ff\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001\u8102\u8cea\u7570\u5e38\u75c7\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\uff086,7\uff09\u3002\u3053\u306e\u70b9\u3092\u3055\u3089\u306b\u691c\u8a0e\u3059\u308b\u305f\u3081\u3001Hilser\u3068\u5171\u540c\u7814\u7a76\u8005\u3089\u306f\u3001UK Biobank\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u611f\u67d3\u524d\u306eHDL-C\u3068\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u3068COVID-19\u306e\u8ee2\u5e30\u306e\u9593\u306b\u56e0\u679c\u95a2\u4fc2\u304c\u3042\u308b\u304b\u3069\u3046\u304b\u3092\u8abf\u3079\u305f\uff088\uff09\u3002\u4eca\u6708\u306e\u30d5\u30a9\u30fc\u30ab\u30b9\u8a18\u4e8b\u3067\u7d39\u4ecb\u3057\u305f\u3088\u3046\u306b\u3001\u611f\u67d3\u524d\u306eHDL-C\u9ad8\u5024\u304c\u3001\u91cd\u75c7\u611f\u67d3\u75c7\u306e\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308b\u9632\u5fa1\u52b9\u679c\u304c\u3042\u308b\u3088\u3046\u3067\u3001HDL-C\u5024\u304c\uff08\u4e2d\u592e\u5024\u304b\u3089\uff0910mg\/dL\u9ad8\u3044\u5834\u5408\u3001COVID-19\u611f\u67d3\u75c7\u306e\u30ea\u30b9\u30af\u304c\u7d0410\uff05\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u307e\u305f\u3001COVID-19\u306b\u3088\u308b\u6b7b\u4ea1\u30ea\u30b9\u30af\u306f\u3001\u611f\u67d3\u524d\u306eHDL-C\u5024\u304c\u4f4e\u3044\u307b\u3069\u9ad8\u304b\u3063\u305f\u3002\u3057\u304b\u3057\u3001\u4ed6\u306e\u5831\u544a\uff089\uff09\u3068\u306f\u5bfe\u7167\u7684\u306b\u3001\u611f\u67d3\u524d\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u3068COVID-19\u306e\u91cd\u75c7\u5316\u30ea\u30b9\u30af\u3068\u306e\u9593\u306b\u95a2\u9023\u6027\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\uff088\uff09\u3002<\/span><\/p>\n

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HDL-C\u306e\u9ad8\u5024\u306f\u9632\u5fa1\u52b9\u679c\u306e\u8981\u56e0\u306a\u306e\u304b\uff1f\u3000Hisler\u3089\u306b\u3088\u308b\u30e1\u30f3\u30c7\u30eb\u7121\u4f5c\u70ba\u5316\u6cd5\u3092\u7528\u3044\u305f\u691c\u8a0e\u3067\u306f\u3001\u907a\u4f1d\u7684\u306aHDL C\u9ad8\u5024\u3068COVID-19\u306e\u767a\u75c7\u30ea\u30b9\u30af\u306e\u9593\u306e\u95a2\u9023\u6027\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\uff088\uff09\u3002\u3057\u304b\u3057\u3001\u3088\u308a\u5927\u898f\u6a21\u306a\u30b5\u30f3\u30d7\u30eb\u3092\u7528\u3044\u305f\u4ed6\u306e\u7814\u7a76\u3067\u306f\u3001HDL-C\u3068\u611f\u67d3\u75c7\u306e\u9593\u306b\u56e0\u679c\u95a2\u4fc2\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3059\u5f37\u529b\u306a\u88cf\u4ed8\u3051\u304c\u3042\u308b\uff0810,11\uff09\u3002\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001HDL\u306e\u514d\u75ab\u708e\u75c7\u6a5f\u80fd\uff0812\uff09\u3084\u3001\u81ea\u7136\u514d\u75ab\u304a\u3088\u3073\u9069\u5fdc\u514d\u75ab\u3092\u8abf\u7bc0\u3057\u3066\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u306b\u5bfe\u3059\u308b\u62b5\u6297\u529b\u3092\u9ad8\u3081\u305f\u308a\u3001SARS-CoV-2\u306a\u3069\u306b\u5bfe\u3059\u308b\u6297\u30a6\u30a4\u30eb\u30b9\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\uff0812-14\uff09\u306a\u3069\u306e\u3001\u5f93\u6765\u5831\u544a\u3055\u308c\u3066\u3044\u308bHDL\u306e\u6a5f\u80fd\u3068\u3082\u4e00\u81f4\u3057\u3066\u3044\u308b\u3002<\/span><\/p>\n

\u4e00\u65b9\u3067\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u304cCOVID-19\u91cd\u75c7\u611f\u67d3\u75c7\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u306f\u3001\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002<\/span><\/p>\n

\u3053\u306e\u30d1\u30f3\u30c7\u30df\u30c3\u30af\u304c\u9032\u884c\u3059\u308b\u306b\u3064\u308c\u3001\u80a5\u6e80\u3084\u8840\u7cd6\u5024\u306e\u4f4e\u4e0b\u306a\u3069\u306e\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u306e\u7279\u5fb4\u304c\u3001COVID-19\u306e\u91cd\u75c7\u5408\u4f75\u75c7\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u80a5\u6e80\u3068\u7cd6\u5c3f\u75c5\u306e\u6d41\u884c\u306f\u3001\u500b\u4eba\u3001\u533b\u7642\u5236\u5ea6\u3001\u793e\u4f1a\u306b\u58ca\u6ec5\u7684\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u3001COVID-19\u306e\u6709\u5bb3\u306a\u7d50\u679c\u3092\u3082\u305f\u3089\u3059\u8981\u56e0\u3068\u306a\u3063\u3066\u3044\u308b\u3002\u6c11\u65cf\u6027\u3001\u7d4c\u6e08\u7684\u56f0\u7aae\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3078\u306e\u7f79\u60a3\u7387\u306b\u3064\u3044\u3066\u3059\u3067\u306b\u77e5\u3089\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u8003\u3048\u308c\u3070\u3001SARS-CoV-2\u611f\u67d3\u3084\u91cd\u5ea6\u306eCOVID-19\u306b\u3088\u308b\u30ea\u30b9\u30af\u304c\u3001\u5c11\u6570\u6c11\u65cf\u3084\u793e\u4f1a\u7d4c\u6e08\u7684\u306b\u4f4e\u3044\u30b0\u30eb\u30fc\u30d7\u3067\u9ad8\u3044\u3053\u3068\u306f\u9a5a\u304f\u306b\u5024\u3057\u306a\u3044\u3002COVID-19\u306b\u3088\u3063\u3066\u3082\u305f\u3089\u3055\u308c\u305f\u516c\u8846\u885b\u751f\u4e0a\u306e\u5371\u6a5f\u306b\u3088\u3063\u3066\u300c\u30d1\u30fc\u30d5\u30a7\u30af\u30c8\u30fb\u30b9\u30c8\u30fc\u30e0\uff08\u7834\u6ec5\u7684\u306a\u4e8b\u614b\uff09\u300d\u304c\u62e1\u5927\u3057\u3066\u3044\u308b\u306a\u304b\u3067\u30012\u578b\u7cd6\u5c3f\u75c5\u3001\u80a5\u6e80\u3001\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u306e\u6709\u75c5\u7387\u3068\u8ee2\u5e30\u306b\u95a2\u3059\u308b\u5f93\u6765\u306e\u683c\u5dee\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u3001\u7dca\u6025\u306e\u63aa\u7f6e\u304c\u5fc5\u8981\u3068\u306a\u3063\u3066\u3044\u308b\u3002<\/span><\/p>\n

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\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

    \n
  1. \u00a0Apicella M, Campopiano MC, Mantuano M, et al. COVID-19 in people with diabetes: understanding the reasons for worse outcomes. Lancet Diabetes Endocrinol 2020;8:782\u201392.<\/span>
    2.<\/span>\u00a0Centers for Disease Control and Prevention. COVID-19: People with Certain Medical Conditions     https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/need-extra-precautions\/people-with-medical-conditions.html<\/a>. (19 March, 2021)<\/span>
    3.<\/span>\u00a0Tartof SY, Qian L, Hong V, et al. Obesity and mortality among patients diagnosed with COVID-19: results from an integrated health care organization. Ann Intern Med 2020;173:773\u201381.<\/span>
    4.<\/span>\u00a0Barron E, Bakhai C, Kar P, et al. Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: a whole-population study. Lancet Diabetes Endocrinol 2020;8:813\u201322.<\/span>
    5.<\/span>\u00a0Holman N, Knighton P, Kar P, et al. Risk factors for COVID-19-related mortality in people with type 1 and type 2 diabetes in England: a population-based cohort study. Lancet Diabetes Endocrinol 2020;8:823\u2013833.<\/span>
    6.<\/span>\u00a0Tanaka S, De Tymowski C, Assadi M, et al. Lipoprotein concentrations over time in the intensive care unit COVID-19 patients: Results from the ApoCOVID study. PLoS One 2020;15:e0239573.<\/span>
    7.<\/span>\u00a0Wei X, Zeng W, Su J, et al. Hypolipidemia is associated with the severity of COVID-19 2020. J Clin Lipidol 14: 297-304.<\/span>
    8.<\/span>\u00a0Hilser JR, Han Y, Biswas S et al. Association of serum HDL cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection. J Lipid Res 2021; doi: 10.1016\/j.jlr.2021.100061.<\/span>
    9.<\/span>\u00a0Zhang Y, Yang H, Li S, et al. Association analysis framework of genetic and exposure risks for COVID-19 in middle-aged and elderly adults. Mech Ageing Dev 2021;194: 111433.<\/span>
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    11.<\/span>\u00a0Trinder M, Walley KR, Boyd JH, Brunham LR. Causal inference for genetically determined levels of high-density lipoprotein cholesterol and risk of infectious disease. Arterioscler Thromb Vasc Biol 2020;40: 267-78.<\/span>
    12.<\/span>\u00a0Catapano AL, Pirillo A, Bonacina F, et al. HDL in innate and adaptive immunity. Cardiovascular Res 2014;103: 372\u201383.<\/span>
    13.<\/span>\u00a0Singh IP, Chopra AK, Coppenhaver DH, Ananatharamaiah GM, Baron S. Lipoproteins account for part of the broad non-specific antiviral activity of human serum. Antiviral Res 1999;42:211-8.<\/span>
    14.<\/span>\u00a0Cho KH, Kim JR, Lee IC, Kwon HJ. Native high-density lipoproteins (HDL) with higher paraoxonase exerts a potent antiviral effect against SARS-CoV-2 (COVID-19), while glycated HDL lost the antiviral activity. Antioxidants (Basel) 2021;10(2):209.<\/span><\/li>\n<\/ol>\n

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