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<\/span><sup>8<\/sup><span>\u5168\u4f53\u3068\u3057\u3066\u3001TG\u4f4e\u4e0b\u306b\u3088\u308b\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u306f\u3001LDL-C\u307e\u305f\u306fnon-HDL-C\u306b\u3088\u308b\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u3088\u308a\u3082\u308f\u305a\u304b\u306b\u5c11\u306a\u3044\u3068\u7d50\u8ad6\u3055\u308c\u305f\uff08TG\u4f4e\u4e0b1mmol\/L\u5f53\u305f\u308a\u306e\u76f8\u5bfe\u30ea\u30b9\u30af\u4f4e\u4e0b16\uff05\u306b\u5bfe\u3057\u3001LDL-C\u307e\u305f\u306fnon-HDL-C\u4f4e\u4e0b1mmol\/L\u5f53\u305f\u308a\u306e\u76f8\u5bfe\u30ea\u30b9\u30af\u4f4e\u4e0b20\uff05\u304a\u3088\u307321\uff05\uff09\u3002<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf&#8221; 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400;\"><span>\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u30ea\u30b9\u30af\u306e\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u30a2\u30ddB\u3092\u7528\u3044\u305f\u5225\u306e\u5831\u544a\u3082\u3042\u308b\u3002<\/span><sup>9<\/sup><span>.\u8457\u8005\u3089\u306f\u30e1\u30f3\u30c7\u30eb\u30e9\u30f3\u30c0\u30e0\u5316\u6cd5\u3092\u7528\u3044\u3066\u3001\u30ea\u30dd\u86cb\u767d\u30ea\u30d1\u30fc\u30bc\uff08LPL\uff09\u907a\u4f1d\u5b50\u306eTG\u4f4e\u4e0b\u5909\u7570\u4f53\u304a\u3088\u3073LDLR\u907a\u4f1d\u5b50\u306eLDL-C\u4f4e\u4e0b\u5909\u7570\u4f53\u306b\u57fa\u3065\u304f\u907a\u4f1d\u5b50\u30b9\u30b3\u30a2\u3068\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u3092\u691c\u8a0e\u3057\u305f\u3002\u30c7\u30fc\u30bf\u306f\u3001\u5317\u7c73\u307e\u305f\u306f\u30e8\u30fc\u30ed\u30c3\u30d1\u3067\u884c\u308f\u308c\u305f63\u306e\u30b3\u30db\u30fc\u30c8\u307e\u305f\u306f\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76\u306e65\u4e07\u4eba\u4ee5\u4e0a\u306e\u88ab\u9a13\u8005\u304b\u3089\u5f97\u3089\u308c\u305f\u3002\u51a0\u52d5\u8108\u6027\u5fc3\u75be\u60a3\uff08CHD\uff09\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u306f\u3001\u30a2\u30ddB\u542b\u6709\u30ea\u30dd\u86cb\u767d\u306e\u6fc3\u5ea6\u304c10mg\/dL\u4f4e\u304f\u306a\u308b\u3054\u3068\u306b\u6a19\u6e96\u5316\u3055\u308c\u305f\u3002\u5168\u4f53\u3068\u3057\u3066\u3001TG\u3092\u4f4e\u4e0b\u3055\u305b\u308bLPL\u306e\u5909\u7570\u4f53\u3068LDL-C\u3092\u4f4e\u4e0b\u3055\u305b\u308bLDLR\u306e\u5909\u7570\u4f53\u306f\u3001apoB\u542b\u6709\u30ea\u30dd\u86cb\u767d\u306e\u5358\u4f4d\u6fc3\u5ea6\u4f4e\u4e0b\u3042\u305f\u308a\u306eCHD\u30ea\u30b9\u30af\u4f4e\u4e0b\u3068\u540c\u7a0b\u5ea6\u306e\u95a2\u9023\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\uff08\u30aa\u30c3\u30ba\u6bd4[95% confidence interval] TG\u4f4e\u4e0b0.771[0 .741-0.802] \u3001LDL-C\u4f4e\u4e0b0.773[0 .747-0.801] \uff09\u3002\u6ce8\u76ee\u3059\u3079\u304d\u3053\u3068\u306b\u3001\u3053\u308c\u3089\u306e\u95a2\u9023\u306f\u72ec\u7acb\u7684\u3001\u76f8\u52a0\u7684\u3067\u3042\u308a\u3001\u30a2\u30ddB\u306e\u7d76\u5bfe\u7684\u5909\u5316\u306b\u6bd4\u4f8b\u3057\u3066\u3044\u305f\u3002     <\/span><sup>9<\/sup><span> \u3053\u306e\u89e3\u6790\u304b\u3089\u5f97\u3089\u308c\u308b\u30e1\u30c3\u30bb\u30fc\u30b8\u306f\u3001TG\u307e\u305f\u306fLDL-C\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u6cbb\u7642\u306b\u3088\u308b\u81e8\u5e8a\u7684\u5229\u76ca\u306f\u3001\u30a2\u30ddB\u306e\u7d76\u5bfe\u7684\u5909\u5316\u306b\u6bd4\u4f8b\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u30e2\u30c7\u30eb\u3067\u306f\u3001REDUCE-IT\u3067\u89b3\u5bdf\u3055\u308c\u305f\u3088\u3046\u306a\u3001\u8a66\u9a13\u7d50\u679c\u3092\u6b6a\u3081\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u3001\u8102\u8cea\u4f4e\u4e0b\u3068\u306f\u7121\u95a2\u4fc2\u306e\u6f5c\u5728\u7684\u306apleiotropic\u52b9\u679c\u3092\u8003\u616e\u3057\u3066\u3044\u306a\u3044\u3053\u3068\u306b\u6ce8\u610f\u3059\u3079\u304d\u3067\u3042\u308b\u3002 <\/span><sup>10<\/sup><span>\u5168\u4f53\u3068\u3057\u3066\u3001\u3053\u306e\u7814\u7a76\u306f\u3001TG\u3068LDL-C\u306e\u4f4e\u4e0b\u306b\u3088\u308b\u8102\u8cea\u95a2\u9023\u306e\u81e8\u5e8a\u7684\u5229\u76ca\u306f\u540c\u7a0b\u5ea6\u3067\u3042\u308a\u3001\u30a2\u30ddB\u306e\u7d76\u5bfe\u7684\u5909\u5316\u3067\u8aac\u660e\u3067\u304d\u308b\u3068\u3044\u3046\u78ba\u56fa\u3068\u3057\u305f\u88cf\u4ed8\u3051\u3092\u4e0e\u3048\u3066\u3044\u308b\u3002<\/span><\/p>\n<p><span>\u307e\u3068\u3081\u308b\u3068\u3001\u8102\u8cea\u95a2\u9023\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u308b\u6cbb\u7642\u52b9\u679c\u3092\u8a55\u4fa1\u3059\u308b\u969b\u3001apoB\u306f\u6709\u76ca\u6027\u306e\u91cd\u8981\u306a\u8b58\u5225\u56e0\u5b50\u3067\u3042\u308b\u3002\u3053\u306e\u77e5\u898b\u306f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\u3068\u3044\u3046\u96e3\u554f\u306b\u5bfe\u51e6\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u3001\u9ad8TG\u3092\u6a19\u7684\u3068\u3059\u308b\u65b0\u898f\u6cbb\u7642\u6cd5\u306e\u81e8\u5e8a\u8a66\u9a13\u306e\u30c7\u30b6\u30a4\u30f3\u306b\u3068\u3063\u3066\u91cd\u8981\u306a\u610f\u5473\u3092\u6301\u3064\u3002 <\/span><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;8px&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p style=\"font-weight: 400;\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<ol>\n<li style=\"font-weight: 400;\"><span>\u30de\u30c3\u30cfF\u3001\u30d0\u30a4\u30b8\u30a7\u30f3\u30c8C\u3001\u30ab\u30bf\u30d1\u30ceAL\u3001\u4ed6\uff1a\u8102\u8cea\u7570\u5e38\u75c7\u7ba1\u7406\u306e\u305f\u3081\u306e2019\u5e74ESC\/EAS\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\uff1a\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u6e1b\u306e\u305f\u3081\u306e\u8102\u8cea\u4fee\u98fe\u3002Eur Heart J 2020;41:111-88. <\/span><br \/><span class=\"ref ref2\">2.<\/span><span> Bor\u00e9n J, Chapman MJ, Krauss RM, et al. \u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u306f\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75c5\u3092\u5f15\u304d\u8d77\u3053\u3059\uff1a\u75c5\u614b\u751f\u7406\u5b66\u7684\u3001\u907a\u4f1d\u5b66\u7684\u3001\u6cbb\u7642\u7684\u6d1e\u5bdf\uff1a\u6b27\u5dde\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u5b66\u4f1a\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u30fb\u30d1\u30cd\u30eb\u304b\u3089\u306e\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u30fb\u30b9\u30c6\u30fc\u30c8\u30e1\u30f3\u30c8\u3002Eur Heart J 2020; doi: 10.1093\/eurheartj\/ehz962.  <\/span><br \/><span class=\"ref ref3\">3.<\/span><span> Ference BA, Ginsberg HN, Graham I, et al. \u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u306f\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75c5\u3092\u5f15\u304d\u8d77\u3053\u3059\u30021.\u907a\u4f1d\u5b66\u7684\u3001\u75ab\u5b66\u7684\u3001\u81e8\u5e8a\u7684\u7814\u7a76\u304b\u3089\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3002\u6b27\u5dde\u52d5\u8108\u786c\u5316\u5b66\u4f1a\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u30d1\u30cd\u30eb\u304b\u3089\u306e\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u30b9\u30c6\u30fc\u30c8\u30e1\u30f3\u30c8\u3002Eur Heart J 2017;38:2459-72.     <\/span><br \/><span class=\"ref ref4\">4.<\/span><span> Murphy SA\u3001Pedersen TR\u3001Gaciong ZA\u3001\u4ed6\uff1a\u5fc3\u8840\u7ba1\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u7dcf\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306b\u5bfe\u3059\u308bPCSK9\u963b\u5bb3\u85ac\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u306e\u52b9\u679c\uff1aFOURIER\u8a66\u9a13\u306eprespecified\u89e3\u6790\u3002JAMA Cardiol 2019;4:613-9.  <\/span><br \/><span class=\"ref ref5\">5.<\/span><span> Szarek M\u3001White HD\u3001Schwartz GG\u3001\u4ed6\uff1a\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u306f\u7dcf\u975e\u81f4\u6b7b\u7684\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u304a\u3088\u3073\u81f4\u6b7b\u7684\u30a4\u30d9\u30f3\u30c8\u3092\u6e1b\u5c11\u3055\u305b\u308b\uff1aODYSSEY OUTCOMES\u8a66\u9a13\u3002J Am Coll Cardiol 2019;73:387-96.  <\/span><br \/><span class=\"ref ref6\">6.<\/span><span> Nordestgaard BG, Varbo A. \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u3002Lancet 2014;384:626-35. <\/span><br \/><span class=\"ref ref7\">7.<\/span><span> Sniderman AD, Thanassoulis G, Glavinovic T, et al. \u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u7c92\u5b50\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\uff1a\u30ca\u30e9\u30c6\u30a3\u30d6\u30ec\u30d3\u30e5\u30fc\u3002JAMA Cardiol 2019; doi: 10.1001\/jamacardio.2019.3780.  <\/span><br \/><span class=\"ref ref8\">8.<\/span><span> Marston NA, Giugliano RP, Im KA, et al.\u8907\u6570\u306e\u8102\u8cea\u4f4e\u4e0b\u85ac\u6cbb\u7642\u30af\u30e9\u30b9\u306b\u304a\u3051\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4f4e\u4e0b\u3068\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3068\u306e\u95a2\u9023\u3002\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u306e\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u3068\u30e1\u30bf\u56de\u5e30\u5206\u6790\u3002Circulation 2019;140:1308-17.   <\/span><br \/><span class=\"ref ref9\">9.<\/span><span> Ference BA, Kastelein JJP, Ray KK, et al. \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4f4e\u4e0bLPL\u30d0\u30ea\u30a2\u30f3\u30c8\u304a\u3088\u3073LDL-C\u4f4e\u4e0bLDLR\u30d0\u30ea\u30a2\u30f3\u30c8\u3068\u51a0\u52d5\u8108\u6027\u5fc3\u75be\u60a3\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u3002JAMA 2019;321:364-73.  <\/span><br \/><span class=\"ref ref10\">10.<\/span><span> Bhatt DL\u3001Steg PG\u3001Miller M\u3001\u4ed6\u3001\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u5bfe\u3059\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3002N Engl J Med 2019;380:11-22.  <\/span><\/li>\n<\/ol>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>R3i\u793e\u8aac\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4f4e\u4e0b\uff1a\u3069\u3061\u3089\u304c\u3088\u308a\u5927\u304d\u306a\u81e8\u5e8a\u52b9\u679c\u3092\u3082\u305f\u3089\u3059\u304b\uff1f \u30df\u30b7\u30a7 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