{"id":254481,"date":"2024-12-30T18:51:00","date_gmt":"2024-12-30T17:51:00","guid":{"rendered":"https:\/\/r3i.org\/r3i%e7%a4%be%e8%aa%ac\/editorial-02-21-spparm%ce%b1%e3%81%af%e3%83%a1%e3%82%bf%e3%83%9c%e3%83%aa%e3%83%83%e3%82%af%e3%82%b7%e3%83%b3%e3%83%89%e3%83%ad%e3%83%bc%e3%83%a0%e3%81%a8nafld%e3%81%ab%e6%96%b0%e3%81%9f%e3%81%aa\/"},"modified":"2025-02-22T17:39:51","modified_gmt":"2025-02-22T16:39:51","slug":"editorial-02-21-spparm%ce%b1%e3%81%af%e3%83%a1%e3%82%bf%e3%83%9c%e3%83%aa%e3%83%83%e3%82%af%e3%82%b7%e3%83%b3%e3%83%89%e3%83%ad%e3%83%bc%e3%83%a0%e3%81%a8nafld%e3%81%ab%e6%96%b0%e3%81%9f%e3%81%aa","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/r3i%e7%a4%be%e8%aa%ac\/editorial-02-21-spparm%ce%b1%e3%81%af%e3%83%a1%e3%82%bf%e3%83%9c%e3%83%aa%e3%83%83%e3%82%af%e3%82%b7%e3%83%b3%e3%83%89%e3%83%ad%e3%83%bc%e3%83%a0%e3%81%a8nafld%e3%81%ab%e6%96%b0%e3%81%9f%e3%81%aa\/","title":{"rendered":"Editorial 02\/21 – SPPARM\u03b1\u306f\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u3068NAFLD\u306b\u65b0\u305f\u306a\u53ef\u80fd\u6027\u3092\u3082\u305f\u3089\u3059\u304b\uff1f"},"content":{"rendered":"

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R3i\u793e\u8aac<\/h2>\n

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2021\u5e742\u6708<\/span><\/h5>\n
SPPARM\u03b1\u306f\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u3068NAFLD\u306b\u65b0\u305f\u306a\u6a5f\u4f1a\u3092\u3082\u305f\u3089\u3059\u304b\uff1f<\/span><\/h5>\n
Prof. Jean Charles Fruchart, Prof. Michel Hermans, Prof. Pierre Amarenco<\/h6>\n
\u30a8\u30c7\u30a3\u30bf\u30fc\u30ba\u30c7\u30b9\u30af\u3088\u308a<\/h6>\n

\u79c1\u305f\u3061\u306f\u4eca\u3001\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u6d41\u884c\u306e\u771f\u3063\u53ea\u4e2d\u306b\u3044\u308b\u3002\u5c02\u9580\u5bb6\u30b0\u30eb\u30fc\u30d7\u306e\u5171\u540c\u58f0\u660e\u00a0<\/span>1<\/sup>\u00a0\u306e\u5b9a\u7fa9\u306b\u57fa\u3065\u304f\u3068\u3001\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u306f\u3059\u3067\u306b\u4e16\u754c\u306e\u6210\u4eba\u4eba\u53e3\u306e\u7d043\u5206\u306e1\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3066\u3044\u308b\u00a0<\/span>2<\/sup>\u300221\u4e16\u7d00\u306b\u306f\u4f4e\u6240\u5f97\u56fd\u3084\u4e2d\u6240\u5f97\u56fd\u3067\u90fd\u5e02\u5316\u304c\u9032\u307f\u3001\u6b27\u7c73\u5316\u3055\u308c\u305f\u98df\u751f\u6d3b\u304c\u666e\u53ca\u3057\u3001\u30c7\u30b9\u30af\u30ef\u30fc\u30af\u4e2d\u5fc3\u306e\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u3068\u306a\u308b\u3053\u3068\u3067\u3001\u75be\u75c5\u8ca0\u62c5\u306e\u5897\u5927\u306b\u76f4\u9762\u3059\u308b\u3053\u3068\u304c\u4e88\u60f3\u3055\u308c\u308b\u00a0<\/span>3<\/sup>\u3002\u80a5\u6e80\uff08BMI\u226730 kg\/m2\u306e\u72b6\u614b\uff09\u306f\u4e16\u754c\u7684\u306a\u8513\u5ef6\u30ec\u30d9\u30eb\u306b\u9054\u3057\u3066\u304a\u308a\u3001\u3042\u3089\u3086\u308b\u9762\u3067\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u3092\u60aa\u5316\u3055\u305b\u3066\u3044\u308b\u00a0<\/span>4<\/sup>\u3002\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u304a\u3088\u30732\u578b\u7cd6\u5c3f\u75c5\u306e\u6709\u75c5\u7387\u5897\u52a0\u306b\u4f34\u3044\u3001\u4e16\u754c\u3067\u6700\u3082\u591a\u3044\u6162\u6027\u809d\u75be\u60a3\u3067\u3042\u308b\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u75be\u60a3\uff08NAFLD\uff09\u3082\u5897\u52a0\u50be\u5411\u306b\u3042\u308a\u3001\u500b\u4eba\u304a\u3088\u3073\u793e\u4f1a\u5168\u4f53\u306b\u3068\u3063\u3066\u5927\u304d\u306a\u554f\u984c\u3068\u306a\u3063\u3066\u3044\u308b\u00a0<\/span>5<\/sup>\u3002<\/span>
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\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u5024\u306e\u4e0a\u6607\u3068\u8840\u6f3f\u4e2d\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08HDL-C\uff09\u6fc3\u5ea6\u306e\u4f4e\u4e0b\u3092\u7279\u5fb4\u3068\u3059\u308b\u8102\u8cea\u7570\u5e38\u75c7\u306f\u3001\u3053\u308c\u3089\u306e\u4ee3\u8b1d\u6027\u75be\u60a3\u306b\u5171\u901a\u3059\u308b\u7279\u5fb4\u3067\u3042\u308b\u3002\u5185\u81d3\u80a5\u6e80\u306b\u3088\u308b\u4ee3\u8b1d\u306e\u5909\u5316\u306f\u3001\u809d\u81d3\u3067\u306e\u8d85\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\uff08VLDL\uff09\u306e\u904e\u5270\u7523\u751f\u3068TG-rich\u30ea\u30dd\u86cb\u767d\u306e\u7570\u5316\u4f5c\u7528\u306e\u4f4e\u4e0b\u3092\u3082\u305f\u3089\u3059\u3002\u30ea\u30dd\u86cb\u767d\u306b\u542b\u307e\u308c\u308b\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3001\u901a\u5e38\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u547c\u3070\u308c\u308b\u3002<\/span><\/p>\n

<\/span><\/p>\n

\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u3064\u3044\u3066\u306f\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u5f62\u6210\u6027\uff08atherogenicity\uff09\u3092\u793a\u3059\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u84c4\u7a4d\u3055\u308c\u3066\u304d\u305f\u00a07<\/sup>\u3002\u5b9f\u969b\u306b\u3001\u4eca\u6708\u306eFocus\u30ec\u30dd\u30fc\u30c8\u3067\u53d6\u308a\u4e0a\u3052\u305fPREDIMED\u8a66\u9a13\u306e\u65b0\u30c7\u30fc\u30bf\u3067\u306f\u3001\u4e00\u822c\u7684\u306a\u80a5\u6e80\u3092\u6709\u3059\u308b\u9ad8\u30ea\u30b9\u30af\u4e00\u6b21\u4e88\u9632\u96c6\u56e3\u306b\u304a\u3044\u3066\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u767a\u75c7\u30ea\u30b9\u30af\u306e\u95a2\u9023\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u00a08<\/sup>\u00a0\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u2265 30 mg\/dL\uff08\u30b3\u30db\u30fc\u30c8\u306e75\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u306b\u76f8\u5f53\uff09\u306f\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u5024\u3068\u306f\u72ec\u7acb\u3057\u305f\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u9ad8\u30ea\u30b9\u30af\u96c6\u56e3\u3092\u7279\u5b9a\u3059\u308b\u56e0\u5b50\u3067\u3042\u3063\u305f\u3002\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\uff08TG\u9ad8\u5024\u304b\u3064HDL-C\u4f4e\u5024\uff09\u60a3\u8005\u306f\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c44%\u5897\u52a0\u3057\u305f\u00a08<\/sup>\u3002<\/span><\/p>\n

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\u9078\u629e\u7684\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u03b1\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\uff08Selective Peroxisome Proliferator-Activated Receptor alpha Modulator; SPPARM\u03b1\uff09\u3068\u3044\u3046\u6982\u5ff5\u306f\u3001\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u306b\u4f34\u3046\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u3084\u95a2\u9023\u3059\u308b\u4ee3\u8b1d\u6027\u75be\u60a3\u306e\u6cbb\u7642\u7ba1\u7406\u306b\u65b0\u305f\u306a\u6a5f\u4f1a\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u00a0<\/span>9<\/sup>\u3002\u6700\u65b0\u306eSPPARM\u03b1\u3067\u3042\u308b\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306f\u30012\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3092\u542b\u3081\u3066\u3001HDL-C\u4f4e\u5024\u306e\u6709\u7121\u306b\u304b\u304b\u308f\u3089\u305aTG\u9ad8\u5024\u306e\u7ba1\u7406\u306b\u304a\u3051\u308b\u6709\u52b9\u6027\u3092\u793a\u3057\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u7d0450%\u4f4e\u4e0b\u3055\u305b\u305f\u00a0<\/span>10<\/sup>\u3002\u305d\u306e\u6cbb\u7642\u52b9\u679c\u306f\u6700\u592752\u9031\u9593\u6301\u7d9a\u3057\u3001\u7a7a\u8179\u6642\u30a4\u30f3\u30b9\u30ea\u30f3\u304a\u3088\u3073\u708e\u75c7\u306e\u6539\u5584\u304c\u8a8d\u3081\u3089\u308c\u3001\u5b89\u5168\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3082\u826f\u597d\u3067\u3042\u3063\u305f\u00a0<\/span>10<\/sup>\u3002\u3055\u3089\u306b\u3001\u524d\u81e8\u5e8a\u30e2\u30c7\u30eb\u3068\u30d1\u30a4\u30ed\u30c3\u30c8\u81e8\u5e8a\u8a66\u9a13\u306e\u4e21\u65b9\u3067\u3001NAFLD\u306b\u304a\u3051\u308b\u6709\u7528\u6027\u3092\u793a\u5506\u3059\u308b\u4e88\u5099\u7684\u30c7\u30fc\u30bf\u3082\u5f97\u3089\u308c\u3066\u3044\u308b\u00a0<\/span>11-13<\/sup>\u3002<\/span><\/p>\n

\u4ee5\u4e0a\u306e\u30c7\u30fc\u30bf\u306f\u3001SPPARM\u03b1\u304c\u8102\u8cea\u4ee3\u8b1d\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u304a\u3088\u3073\u708e\u75c7\u306b\u5bfe\u3057\u3066\u597d\u307e\u3057\u3044\u6d3b\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u6301\u3061\u3001\u6709\u671b\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002PROMINENT\u8a66\u9a13\u304b\u3089\u306f\u300c2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u304c\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u6e1b\u5c11\u306b\u3064\u306a\u304c\u308b\u304b\u300d\u3068\u3044\u3046\u6839\u672c\u7684\u306a\u8cea\u554f\u306b\u5bfe\u3059\u308b\u91cd\u8981\u306a\u56de\u7b54\u304c\u5f97\u3089\u308c\u308b\u3060\u308d\u3046\u3002\u5c06\u6765\u7684\u306b\u306f\u4ee3\u8b1d\u6027\u75be\u60a3\u306e\u8ca0\u62c5\u3092\u8efd\u6e1b\u3059\u308b\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u3044\u308b\u3002<\/span><\/p>\n

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\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

    \n
  1. Alberti KG, Eckel RH, Grundy SM, et al. Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009;120:1640\u201345.<\/span>
    2.<\/span>\u00a0O’Neill S, O’Driscoll L. Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies. Obes Rev 2015;16:1\u201312.<\/span>
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    5.<\/span>\u00a0Younossi Z, Anstee QM, Marietti M, Hardy T, Henry L, Eslam M, et al. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol. 2018;15:11-20.<\/span>
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    9.<\/span>\u00a0Fruchart JC, Hermans MP, Fruchart-Najib J, Kodama T. Selective peroxisome proliferator-activated receptor alpha modulators (SPPARM\u03b1) in the metabolic syndrome: is pemafibrate light at the end of the tunnel? Curr Atheroscler Rep 2021;23<\/span>1<\/sup>:3.<\/span>
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    13.<\/span>\u00a0Seko Y, Yamaguchi K, Umemura A, et al. Effect of pemafibrate on fatty acid levels and liver enzymes in non-alcoholic fatty liver disease patients with dyslipidemia: A single-arm, pilot study. HepatolRes2020;50: 1328\u201336.<\/span><\/li>\n<\/ol>\n

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