{"id":254464,"date":"2024-12-27T18:05:34","date_gmt":"2024-12-27T17:05:34","guid":{"rendered":"https:\/\/r3i.org\/r3i%e7%a4%be%e8%aa%ac\/%e7%a4%be%e8%aa%ac01-24-%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e6%ae%8b%e5%ad%98%e3%82%92%e3%82%bf%e3%83%bc%e3%82%b2%e3%83%83%e3%83%88%e3%81%ab%ef%bc%9a%e3%83%91\/"},"modified":"2025-02-22T15:50:51","modified_gmt":"2025-02-22T14:50:51","slug":"%e7%a4%be%e8%aa%ac01-24-%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e6%ae%8b%e5%ad%98%e3%82%92%e3%82%bf%e3%83%bc%e3%82%b2%e3%83%83%e3%83%88%e3%81%ab%ef%bc%9a%e3%83%91","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/r3i%e7%a4%be%e8%aa%ac\/%e7%a4%be%e8%aa%ac01-24-%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e6%ae%8b%e5%ad%98%e3%82%92%e3%82%bf%e3%83%bc%e3%82%b2%e3%83%83%e3%83%88%e3%81%ab%ef%bc%9a%e3%83%91\/","title":{"rendered":"\u793e\u8aac01\/24 – \u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\uff1a\u30d1\u30a4\u30d7\u30e9\u30a4\u30f3\u306b\u306f\u4f55\u304c\u3042\u308b\u306e\u304b\uff1f"},"content":{"rendered":"

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R3i\u793e\u8aac<\/h2>\n

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2024\u5e741\u6708<\/span><\/h5>\n
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Prof. Jean Charles Fruchart, Prof. Michel Hermans, Prof. Pierre Amarenco
\u7de8\u96c6\u30c7\u30b9\u30af\u304b\u3089<\/h6>\n

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\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

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  1. Ray KK, Molemans B, Schoonen WM, et al. EU-wide cross-sectional observational study of lipid-modifying therapy use in secondary and primary care: the DA VINCI study. Eur J Prev Cardiol 2021;28:1279\u201389.<\/span>
    2.<\/span>\u00a0Mach F, Baigent C, Catapano AL, et al. 2019 ESC\/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J 2020;41:111\u201388.<\/span>
    3.<\/span>\u00a0Yang YS, Lee SY, Kim JS, et al. Achievement of LDL-C targets defined by ESC\/EAS (2011) guidelines in risk-stratified Korean patients with dyslipidemia receiving lipid-modifying treatments. Endocrinol Metab (Seoul) 2020;35:367\u201376.<\/span>
    4.<\/span>\u00a0Nordestgaard BG. Triglyceride-rich lipoproteins and atherosclerotic cardiovascular disease: new insights from epidemiology, genetics, and biology. Circ Res 2016;118:547-63.<\/span>
    5.<\/span>\u00a0Ginsberg HN, Packard CJ, Chapman MJ, et al. Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies-a consensus statement from the European Atherosclerosis Society. Eur Heart J 2021; 42:4791\u2013806.<\/span>
    6.<\/span>\u00a0Navarese EP, Vine D, Proctor S, et al. Independent causal effect of remnant cholesterol on atherosclerotic cardiovascular outcomes: a Mendelian Randomization Study. Arterioscler Thromb Vasc Biol 2023; doi: 10.1161\/ATVBAHA.123.319297<\/span>
    7.<\/span>\u00a0Bhatt DL, Steg PG, Miller M, et al. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. N Engl J Med 2019; 380: 11\u201322.<\/span>
    8.<\/span>\u00a0Nicholls SJ, Lincoff AM, Garcia M, et al. Effect of high-dose omega-3 fatty acids vs corn oil on major adverse cardiovascular events in patients at high cardiovascular risk: the STRENGTH randomized clinical trial. JAMA 2020; 324: 2268\u201380.<\/span>
    9.<\/span>\u00a0Das Pradhan A, Glynn RJ, Fruchart JC, et al. Triglyceride lowering with pemafibrate to reduce cardiovascular risk. N Engl J Med 2022; 387: 1923\u201334.<\/span>
    10.<\/span>\u00a0Watts GF, Schwabe C, Scott R, et al. RNA interference targeting ANGPTL3 for triglyceride and cholesterol lowering: phase 1 basket trial cohorts. Nat Med 2023; doi: 10.1038\/s41591-023-02494-2.<\/span>
    11.<\/span>\u00a0Luo H, Guo Z, Zheng S et al. RBD5044 \u2013 a novel anti-APOC3 GalNAc-siRNA drug resulted in sustained and profound reduction of triglycerides in mice and Rhesus monkeys. Presented at ESC Congress 2023, Amsterdam, The Netherlands (25-28 August). Session: Hypertriglyceridaemia treatment: icosapent ethyl and fibrates<\/span>
    12.<\/span>\u00a0Kronenberg F, Mora S, Stroes ESG, et al. Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement. Eur Heart J 2022;43:3925-46.<\/span>
    13.<\/span>\u00a0Donoghue ML, Fazio S, Giugliano RP, et al. Lipoprotein(a), PCSK9 inhibition, and cardiovascular risk. Circulation 2019;139:1483\u201392.<\/span>
    14.<\/span>\u00a0Tsimikas S, Karwatowska-Prokopczuk E, Gouni-Berthold I, et al. Lipoprotein(a) reduction in persons with cardiovascular disease. N Engl J Med 2020;382:244\u201355.<\/span>
    15.<\/span>\u00a0O’Donoghue ML, Rosenson RS, Gencer B, et al; OCEAN(a)-DOSE Trial Investigators. Small interfering RNA to reduce Lipoprotein(a) in cardiovascular disease. N Engl J Med 2022;387:1855-64.<\/span>
    16.<\/span>\u00a0Nissen SE, Wolski K, Balog C, et al. Single ascending dose study of a short interfering RNA targeting Lipoprotein(a) production in individuals with elevated plasma Lipoprotein(a) levels. JAMA 2022;327:1679-87.<\/span>
    17.<\/span>\u00a0Nicholls SJ, Nissen SE, Fleming C, et al. Muvalaplin, an oral small molecule inhibitor of lipoprotein(a) formation: a randomized clinical trial. JAMA 2023;e2316503. Doi: 10.1001\/jama.2023.16503.<\/span><\/li>\n<\/ol>\n

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