{"id":254461,"date":"2024-12-30T18:58:40","date_gmt":"2024-12-30T17:58:40","guid":{"rendered":"https:\/\/r3i.org\/r3i%e7%a4%be%e8%aa%ac\/%e8%ab%96%e8%aa%ac-01-21-%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e6%ae%8b%e5%ad%98%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e3%82%aa%e3%83%a1%e3%82%ac3%e8%84%82%e8%82%aa\/"},"modified":"2025-02-22T17:44:32","modified_gmt":"2025-02-22T16:44:32","slug":"%e8%ab%96%e8%aa%ac-01-21-%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e6%ae%8b%e5%ad%98%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e3%82%aa%e3%83%a1%e3%82%ac3%e8%84%82%e8%82%aa","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/r3i%e7%a4%be%e8%aa%ac\/%e8%ab%96%e8%aa%ac-01-21-%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e6%ae%8b%e5%ad%98%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e3%82%aa%e3%83%a1%e3%82%ac3%e8%84%82%e8%82%aa\/","title":{"rendered":"\u8ad6\u8aac 01\/21 – \u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\u306b\u5bfe\u3059\u308b\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\uff1a\u7b54\u3048\u3088\u308a\u3082\u7591\u554f\u304c\u591a\u3044"},"content":{"rendered":"

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R3i\u793e\u8aac<\/h2>\n

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2021\u5e741\u6708<\/span><\/h5>\n
\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308b\u30aa\u30e1\u30ac-3\u8102\u80aa\u9178\uff1a\u89e3\u6c7a\u7b56\u3088\u308a\u7591\u554f\u304c\u591a\u3044<\/span><\/h5>\n
Prof. Jean Charles Fruchart, Prof. Michel Hermans, Prof. Pierre Amarenco<\/h6>\n
\u7de8\u96c6\u30c7\u30b9\u30af\u304b\u3089<\/h6>\n

\u30aa\u30e1\u30ac-3\u8102\u80aa\u9178\u306e\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u6f5c\u5728\u7684\u5f79\u5272\u304c\u9577\u5e74\u691c\u8a0e\u3055\u308c\u3066\u304d\u305f\u3002\u30e1\u30bf\u89e3\u6790\u306b\u3088\u308b\u3053\u306e\u554f\u984c\u306e\u8a55\u4fa1\u304c\u884c\u308f\u308c\u3066\u304d\u305f\u304c\u3001\u6700\u8fd1\u306e\u89e3\u6790\u3067\u51a0\u52d5\u8108\u6027\u5fc3\u75be\u60a3\uff08CHD\uff09\u3084\u5fc3\u8840\u7ba1\u75be\u60a3\u306b\u3088\u308b\u6b7b\u4ea1\u306b\u52a0\u3048\u3066\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u30ea\u30b9\u30af\u3082\u30aa\u30e1\u30ac-3\u88dc\u5145\u7642\u6cd5\u306b\u3088\u3063\u3066\u6709\u610f\u306b\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u00a0<\/span>1<\/sup>\u00a0\u3002\u305f\u3060\u3057\u3001\u3053\u308c\u3089\u306e\u8a66\u9a13\u3067\u306f\u7528\u91cf\u7bc4\u56f2\u304c\u5e83\u304f\uff08376 mg\/\u65e5\uff5e4 g\/\u65e5\uff09\u3001\u6700\u3082\u3088\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u305f\u7528\u91cf\u304c1 g\u672a\u6e80\u3067\u3042\u3063\u305f\u3053\u3068\u306f\u91cd\u8981\u3067\u3042\u308b\u00a0<\/span>1<\/sup>\u00a0\u3002<\/span><\/p>\n

\u30aa\u30e1\u30ac-3\u8102\u80aa\u9178\u306b\u95a2\u3059\u308b\u4ee5\u524d\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u7814\u7a76\u3067\u306f\u69d8\u3005\u306a\u7d50\u679c\u304c\u5f97\u3089\u308c\u3066\u3044\u308b\u3002JELIS\uff08Japan EPA Lipid Intervention Study\uff09\u3067\u306f\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\uff08EPA\uff091,800 mg\/\u65e5\u3068\u30b9\u30bf\u30c1\u30f3\u306e\u4f75\u7528\u304c\u30b9\u30bf\u30c1\u30f3\u5358\u72ec\u7642\u6cd5\u3068\u6bd4\u8f03\u3057\u3066\u5fc3\u81d3\u6b7b\u3001\u5fc3\u7b4b\u6897\u585e\u3001\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u304a\u3088\u3073\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u304b\u3089\u306a\u308b\u5fc3\u8840\u7ba1\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e19%\u306e\u76f8\u5bfe\u7684\u6e1b\u5c11\u3092\u3082\u305f\u3089\u3057\u305f\u00a0<\/span>2<\/sup>\u00a0\u3002\u5bfe\u7167\u7684\u306b\u3001\u7528\u3044\u305f\u7528\u91cf\u306f\u3088\u308a\u4f4e\u7528\u91cf\uff3b1 g\u3001840 mg EPA\u3068\u30c9\u30b3\u30b5\u30d8\u30ad\u30b5\u30a8\u30f3\u9178\uff08DHA\uff09\u3092\u542b\u6709\uff3d\u3067\u306f\u3042\u308b\u304c\u3001VITAL\uff08Vitamin D and Omega-3 Trial\uff09\u3068ASCEND\uff08A Study of Cardiovascular Events in Diabetes\uff09\u306e\u4e21\u8a66\u9a13\u3067\u306f\u3001\u81e8\u5e8a\u7684\u306b\u660e\u78ba\u306a\u30a2\u30c6\u30ed\u30fc\u30e0\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff08AtheroSclerotic CardioVascular Disease: ASCVD\uff09\u3092\u6709\u3055\u306a\u3044\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u4e3b\u8981\u5fc3\u8840\u7ba1\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u6e1b\u5c11\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u00a0<\/span>3,4<\/sup>\u00a0\u3002<\/span><\/p>\n

REDUCE-IT\uff08Reduction of Cardiovascular Events with Icosapent Ethyl\u2013Intervention Trial\uff09\u306f\u3001\u9ad8TG\u8840\u75c7\u3092\u6709\u3059\u308b\uff08ASCVD\u3042\u308a\uff0f\u306a\u3057\uff09\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u7279\u306b\u7684\u3092\u7d5e\u3063\u305f\u753b\u671f\u7684\u306a\u7814\u7a76\u3067\u3042\u308b\u00a0<\/span>5<\/sup>\u00a0\u3002\u9ad8\u7528\u91cf\uff084 g\/\u65e5\uff09\u306e\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\uff08\u9ad8\u7d14\u5ea6EPA\u30a8\u30b9\u30c6\u30eb\uff09\u306e\u6295\u4e0e\u306b\u3088\u308a\u3001\u4e3b\u8981\u8907\u5408\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\uff08\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u7684\u5fc3\u7b4b\u6897\u585e\u307e\u305f\u306f\u8133\u5352\u4e2d\u3001\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u3082\u3057\u304f\u306f\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\uff09\u304c25%\u6e1b\u5c11\u3057\u305f\u3002\u3053\u308c\u306fTG\u306e\u6e1b\u5c11\u304c\u8efd\u5ea6\uff0818%\uff09\u3067\u3042\u3063\u305f\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u9054\u6210\u3055\u308c\u305f\u00a0<\/span>5<\/sup>\u00a0\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eTG\u304c\u81e8\u5e8a\u52b9\u679c\u306e\u5927\u304d\u3055\u306b\u5f71\u97ff\u3057\u305f\u3068\u3044\u3046\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u304c\u00a0<\/span>6<\/sup>\u00a0\u3001\u9054\u6210\u3055\u308c\u305f\u8840\u6f3fEPA\u5024\u3068\u5fc3\u8840\u7ba1\u52b9\u679c\u306e\u9593\u306b\u306f\u95a2\u9023\u304c\u8a8d\u3081\u3089\u308c\u305f\u00a0<\/span>7<\/sup>\u00a0\u3002<\/span><\/p>\n

REDUCE-IT\u3067\u6709\u671b\u306a\u7d50\u679c\u304c\u5f97\u3089\u308c\u305f\u5f8c\u306e\u3001STRENGTH\uff08Outcomes Study to Assess STatin Residual Risk Reduction With EpaNova in HiGh CV Risk PatienTs With Hypertriglyceridemia\uff09\u306e\u6700\u7d42\u5831\u544a\u00a0<\/span>8<\/sup>\u00a0\u306f\u671f\u5f85\u5916\u308c\u306e\u7d50\u679c\u3067\u3042\u3063\u305f\u3002STRENGTH\u306f\u3001\u6709\u76ca\u6027\u3092\u793a\u3059\u53ef\u80fd\u6027\u304c\u4f4e\u3044\u3068\u3044\u3046\u72ec\u7acb\u30c7\u30fc\u30bf\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u59d4\u54e1\u4f1a\u306e\u52e7\u544a\u306b\u57fa\u3065\u304d2020\u5e741\u6708\u306b\u7d42\u4e86\u3057\u305f\u3002\u3053\u306e\u7d50\u679c\u306f\u3001\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u3042\u308b\u60a3\u8005\u306b\u5bfe\u3059\u308b\u3053\u308c\u3089\u306e\u85ac\u5264\u306e\u4f7f\u7528\u306b\u95a2\u3057\u3066\u591a\u304f\u306e\u8ab2\u984c\u3092\u63d0\u8d77\u3057\u305f\u3002<\/span><\/p>\n

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REDUCE-IT\u306e\u7d50\u679c\u306f\u6709\u671b\u3067\u3042\u3063\u305f\u306e\u306bSTRENGTH\u306e\u7d50\u679c\u3067\u6709\u610f\u5dee\u304c\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u306e\u306f\u306a\u305c\u304b\uff1f<\/span>
\u3053\u306e2\u8a66\u9a13\u306e\u7d50\u679c\u306e\u77db\u76fe\u306f\u3044\u304f\u3064\u304b\u306e\u539f\u56e0\u304c\u8003\u3048\u3089\u308c\u308b\u3002\u7b2c\u4e00\u306b\u3001\u5404\u8a66\u9a13\u3067\u4f7f\u7528\u3055\u308c\u305f\u30aa\u30e1\u30ac-3\u8102\u80aa\u9178\u306e\u88fd\u5264\u306f\u7570\u306a\u3063\u3066\u3044\u305f\u3002REDUCE-IT\u3067\u306f\u9ad8\u7528\u91cfEPA\u3092\u8a55\u4fa1\u3057\u305f\u306e\u306b\u5bfe\u3057\u3066\u3001STRENGTH\u3067\u306fEPA\u3068DHA\u4e21\u65b9\u3092\u542b\u6709\u3059\u308b\u30ab\u30eb\u30dc\u30f3\u9178\u88fd\u5264\uff08Epanova\uff09\u3092\u8a66\u9a13\u3057\u305f\u3002EPA\u306e\u7528\u91cf\u306f\u4f4e\u3044\u3082\u306e\u306e\u3001\u540c\u88fd\u5264\u306f\u809d\u3067\u306e\u4ee3\u8b1d\u3092\u5fc5\u8981\u3068\u305b\u305a\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u3068\u540c\u69d8\u306e\u5168\u8eab\u6027\u304a\u3088\u3073\u7d44\u7e54\u5185EPA\u5024\u3092\u9054\u6210\u53ef\u80fd\u3067\u3042\u308b\u3002\u5b9f\u969b\u306b\u300112\u30f5\u6708\u5f8c\u306e\u8840\u6e05EPA\u5024\u306e\u4e0a\u6607\u306f\u3001STRENGTH\u3067\u306f67%\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3066REDUCE-IT\u3067\u306f63%\u3067\u3042\u3063\u305f\u00a0<\/span>5,8<\/sup>\u00a0\u3002<\/span><\/p>\n

\u95a2\u4fc2\u3057\u305f\u53ef\u80fd\u6027\u306e\u3042\u308b\u305d\u306e\u4ed6\u306e\u56e0\u5b50\u3068\u3057\u3066\u3001\u8a66\u9a13\u5bfe\u8c61\u96c6\u56e3\u306e\u7279\u6027\u3001\u6cbb\u7642\u30a2\u30c9\u30d2\u30a2\u30e9\u30f3\u30b9\u3001\u5bfe\u7167\u85ac\u306e\u5f71\u97ff\u304c\u6319\u3052\u3089\u308c\u308b\u3002\u8a66\u9a13\u5bfe\u8c61\u96c6\u56e3\u306b\u95a2\u3057\u3066\u306f\u3001REDUCE-IT\u3067\u306f\u51a0\u52d5\u8108\u75be\u60a3\u306e\u3042\u308b\u767b\u9332\u60a3\u8005\u306e\u5272\u5408\u304c\u9ad8\u304b\u3063\u305f\uff0871% vs. STRENGTH\u3067\u306f56%\uff09\u3002\u6cbb\u7642\u30a2\u30c9\u30d2\u30a2\u30e9\u30f3\u30b9\u3068\u8a66\u9a13\u7d99\u7d9a\u306b\u3064\u3044\u3066\u306fREDUCE-IT\u3068STRENGTH\u306e\u9593\u306b\u660e\u3089\u304b\u306a\u5dee\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u3053\u308c\u306b\u5bfe\u3057\u3001\u5bfe\u7167\u85ac\u306f\u660e\u3089\u304b\u306b\u554f\u984c\u3067\u3042\u308b\u3002REDUCE-IT\u3067\u306f\u5bfe\u7167\u85ac\u3068\u3057\u3066\u9271\u7269\u6cb9\u304c\u4f7f\u7528\u3055\u308c\u305f\u3002\u3053\u308c\u304c\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u3068\u9ad8\u611f\u5ea6C\u53cd\u5fdc\u6027\u86cb\u767d\uff08hsCRP\uff09\u306e\u4e21\u65b9\u306b\u5bfe\u3057\u3066\u597d\u307e\u3057\u304f\u306a\u3044\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u306b\u3088\u308b\u81e8\u5e8a\u52b9\u679c\u306e\u5927\u304d\u3055\u3092\u8a87\u5f35\u3057\u305f\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u5bfe\u7167\u7684\u306b\u3001STRENGTH\u3067\u5bfe\u7167\u85ac\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u305f\u30b3\u30fc\u30f3\u30aa\u30a4\u30eb\u306fLDL-C\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u307e\u305f\u306fhsCRP\u3092\u4e0a\u6607\u3055\u305b\u306a\u304b\u3063\u305f\u3053\u3068\u304b\u3089\u3001\u30b3\u30fc\u30f3\u30aa\u30a4\u30eb\u306f\u30cb\u30e5\u30fc\u30c8\u30e9\u30eb\u306a\u5bfe\u7167\u85ac\u3067\u3042\u3063\u305f\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u308b\u3002\u6700\u5f8c\u306b\u3001\u652f\u6301\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u5b58\u5728\u3057\u306a\u3044\u304c\u3001DHA\u304cEPA\u306e\u52b9\u679c\u3092\u4e2d\u548c\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002<\/span><\/p>\n

\u7814\u7a76\u9593\u3067\u4e00\u81f4\u3057\u305f\u52b9\u679c\u306f\u3042\u3063\u305f\u306e\u304b\uff1f<\/span>
\u4e21\u7814\u7a76\u306f\u5fc3\u623f\u7d30\u52d5\uff08AF\uff09\u30ea\u30b9\u30af\u306e\u5371\u967a\u4fe1\u53f7\u3092\u793a\u3057\u305f\u70b9\u306b\u304a\u3044\u3066\u4e00\u81f4\u3057\u3066\u3044\u305f\u3002\u7279\u306b\u3001STRENGTH\u3067\u306fAF\u306e\u30ea\u30b9\u30af\u304c69%\u4e0a\u6607\u3057\u00a0<\/span>8<\/sup>\u00a0\u3001REDUCE-IT\u3067\u3082AF\u307e\u305f\u306f\u5fc3\u623f\u7c97\u52d5\u306b\u3088\u308b\u5165\u9662\u306e\u6709\u610f\u306a\u5897\u52a0\u304c\u307f\u3089\u308c\u305f\uff08p=0.004\uff09\u00a0<\/span>5<\/sup>\u00a0\u3002\u6700\u8fd1\u306eOMEMI\u8a66\u9a13\uff08OMega-3 fatty acids in Elderly patients with Myocardial Infarction\uff09\u3067\u3082\u540c\u69d8\u306eAF\u30ea\u30b9\u30af\u4e0a\u6607\u304c\u8a8d\u3081\u3089\u308c\u305f\u00a0<\/span>9<\/sup>\u00a0\u3002\u30aa\u30e1\u30ac-3\u8102\u80aa\u9178\u304c\u3001\u904e\u53bb\u306e\u8a66\u9a13\u3067\u306f\u4e3b\u306b\u5fc3\u4e0d\u5168\u307e\u305f\u306f\u5de6\u5ba4\u6a5f\u80fd\u969c\u5bb3\u3092\u6709\u3055\u306a\u3044\u60a3\u8005\u306b\u304a\u3051\u308bAF\u4e88\u9632\u3092\u76ee\u7684\u3068\u3057\u3066\u5e83\u304f\u691c\u8a0e\u3055\u308c\u305f\u3053\u3068\u3092\u8003\u3048\u308b\u3068\u3001\u3053\u306e\u77e5\u898b\u306f\u6ce8\u76ee\u306b\u5024\u3059\u308b\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001GISSI-HF\u8a66\u9a13\u306e\u89e3\u6790\u3067\u306f\u3001\u30aa\u30e1\u30ac-3\u8102\u80aa\u91781 g\/\u65e5\u306b\u3088\u3063\u3066\u6162\u6027\u5fc3\u4e0d\u5168\u60a3\u8005\u306eAF\u767a\u751f\u304c\u6e1b\u5c11\u3059\u308b\u3068\u3044\u3046\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u5f97\u3089\u308c\u306a\u304b\u3063\u305f\u00a0<\/span>10<\/sup>\u00a0\u3002<\/span><\/p>\n

\u9ad8\u9f62\u60a3\u8005\u306b\u304a\u3051\u308bAF\u6709\u75c5\u7387\u306e\u4e0a\u6607\u3092\u8003\u3048\u308b\u3068\u3001REDUCE-IT\u3001STRENGTH\u304a\u3088\u3073OMEMI\u306b\u3088\u308b\u6700\u65b0\u77e5\u898b\u306f\u660e\u3089\u304b\u306b\u81e8\u5e8a\u533b\u306b\u3068\u3063\u3066\u61f8\u5ff5\u3059\u3079\u304d\u70b9\u3067\u3042\u308b\u3002\u3055\u3089\u306b\u3001\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001TG\u3092\u6e1b\u5c11\u3055\u305b\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u6f5c\u5728\u7684\u306b\u4f4e\u4e0b\u3055\u305b\u308b\u52b9\u679c\u306e\u3042\u308b\u8ffd\u52a0\u6cbb\u7642\u306e\u5fc5\u8981\u6027\u3092\u5f37\u304f\u793a\u3059\u3082\u306e\u3067\u3042\u308b\u3002\u3053\u306e\u554f\u984c\u306b\u5bfe\u3059\u308b\u65b0\u898f\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u6c42\u3081\u308b\u7af6\u4e89\u306f\u59cb\u307e\u3063\u3066\u304a\u308a\u3001\u6211\u3005\u306f\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u3092\u7528\u3044\u305fPROMINENT\u306e\u7d50\u679c\u306b\u3088\u3063\u3066\u6700\u521d\u306e\u6d1e\u5bdf\u304c\u5f97\u3089\u308c\u308b\u3053\u3068\u3092\u671f\u5f85\u3057\u3066\u3044\u308b\u00a0<\/span>11<\/sup>\u00a0\u3002<\/span><\/p>\n

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\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

    \n
  1. Hu Y, Hu FB, Manson JE. Marine omega-3 supplementation and cardiovascular disease: an updated meta-analysis of 13 randomized controlled trials involving 127 477 participants. J Am Heart Assoc 2019;8:e013543.<\/span>
    2.<\/span>\u00a0Yokoyama M, Origasa H, Matsuzaki M, et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet. 2007;369:1090\u20131098.<\/span>
    3.<\/span>\u00a0Manson JE, Cook NR, Lee IM, et al. Marine n-3 fatty acids and prevention of cardiovascular disease and cancer. N Engl J Med 2019; 380:23\u201332.<\/span>
    4.<\/span>\u00a0Group ASC, Bowman L, Mafham M, et al. Effects of n-3 fatty acid supplements in diabetes mellitus. N Engl J Med 2018; 379:1540\u20131550.<\/span>
    5.<\/span>\u00a0Bhatt DL, Steg PG, Miller M, et al; REDUCE-IT Investigators. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. N Engl J Med 2019;380:11-22.<\/span>
    6.<\/span>\u00a0Bhatt DL, Steg PG, Miller M, et al. Reduction in first and total ischemic events with icosapent ethyl across baseline triglyceride tertiles. J Am Coll Cardiol 2019;74: 1159 \u2013 61.<\/span>
    7.<\/span>\u00a0https:\/\/www.acc.org\/latest-in-cardiology\/articles\/2020\/03\/24\/16\/41\/mon-1045-eicosapentaenoic-acid-levels-in-reduce-it-acc-2020. 2020. [Accessed December 3, 2020].<\/span>
    8.<\/span>\u00a0Nicholls SJ, Lincoff AM, Garcia M, et al. Effect of high-dose omega-3 fatty acids vs corn oil on major adverse cardiovascular events in patients at high cardiovascular risk: the STRENGTH randomized clinical trial. JAMA 2020; doi: 10.1001\/jama.2020.22258<\/span>
    9.<\/span>\u00a0Kalstad AA, Myhre PL, Laake K, et al, on behalf of the OMEMI Investigators. Effects of n-3 fatty acid supplements in elderly patients after myocardial infarction: a randomized controlled trial. Circulation 2020; doi\/10.1161\/CIRCULATIONAHA.120.052209.<\/span>
    10.<\/span>\u00a0Aleksova A, Masson S, Maggioni AP, et al. n-3 polyunsaturated fatty acids and atrial fibrillation in patients with chronic heart failure: the GISSI-HF trial. Eur J Heart Fail 2013;15:1289-95.<\/span>
    11.<\/span>\u00a0Pradhan AD, Paynter NP, Everett BM et al. Rationale and design of the Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes (PROMINENT) study. Am Heart J 2018;206:80-93.<\/span><\/li>\n<\/ol>\n

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