{"id":254454,"date":"2025-01-03T22:30:05","date_gmt":"2025-01-03T21:30:05","guid":{"rendered":"https:\/\/r3i.org\/r3i%e7%a4%be%e8%aa%ac\/%e8%ab%96%e8%aa%ac01-16%e3%80%8c2015%e5%b9%b4%e3%82%92%e6%8c%af%e3%82%8a%e8%bf%94%e3%81%a3%e3%81%a6%ef%bc%9a%e8%84%82%e8%b3%aa%e3%83%8f%e3%82%a4%e3%83%a9%e3%82%a4%e3%83%88\/"},"modified":"2025-02-16T22:50:52","modified_gmt":"2025-02-16T21:50:52","slug":"%e8%ab%96%e8%aa%ac01-16%e3%80%8c2015%e5%b9%b4%e3%82%92%e6%8c%af%e3%82%8a%e8%bf%94%e3%81%a3%e3%81%a6%ef%bc%9a%e8%84%82%e8%b3%aa%e3%83%8f%e3%82%a4%e3%83%a9%e3%82%a4%e3%83%88","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/r3i%e7%a4%be%e8%aa%ac\/%e8%ab%96%e8%aa%ac01-16%e3%80%8c2015%e5%b9%b4%e3%82%92%e6%8c%af%e3%82%8a%e8%bf%94%e3%81%a3%e3%81%a6%ef%bc%9a%e8%84%82%e8%b3%aa%e3%83%8f%e3%82%a4%e3%83%a9%e3%82%a4%e3%83%88\/","title":{"rendered":"\u8ad6\u8aac01\/16\u300c2015\u5e74\u3092\u632f\u308a\u8fd4\u3063\u3066\uff1a\u8102\u8cea\u30cf\u30a4\u30e9\u30a4\u30c8"},"content":{"rendered":"<p>[et_pb_section 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subtilisin\/kexin type 9\uff09\u6a19\u7684\u6cbb\u7642\u306e\u9032\u6b69\u306b\u727d\u5f15\u3055\u308c\u3001\u8102\u8cea\u7814\u7a76\u306b\u3068\u3063\u3066\u30a8\u30ad\u30b5\u30a4\u30c6\u30a3\u30f3\u30b0\u306a\u6642\u671f\u3067\u3042\u3063\u305f\u3002\u5b9f\u969b\u3001\u7c73\u56fd\u5fc3\u81d3\u5354\u4f1a\uff08AHA\uff09\u306fPCSK9\u963b\u5bb3\u85ac\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u3068\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u30922015\u5e74\u306e\u7814\u7a76\u9032\u6b69\u30c8\u30c3\u30d710\u306e\u3046\u3061\u306e2\u3064\u306b\u6319\u3052\u3066\u3044\u308b\u3002   <\/span><sup>1<\/sup><span>.3\u6708\u306b\u767a\u8868\u3055\u308c\u305f\u4e88\u5099\u30c7\u30fc\u30bf\u3067\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u306b\u52a0\u3048\u3066PCSK9\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3092\u6295\u4e0e\u3059\u308b\u3053\u3068\u3067\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u8005\u306b\u304a\u3044\u3066\u4e3b\u8981\u306a\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u7d0450\uff05\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\u3002   <\/span><sup>2,3<\/sup><span>.\u6c7a\u5b9a\u7684\u306a\u30a2\u30a6\u30c8\u30ab\u30e0\u30c7\u30fc\u30bf\u304c\u306a\u3044\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u3053\u306e\u30af\u30e9\u30b9\u306e\u6700\u521d\u306e2\u5264\u304c\u4eca\u5e74\u521d\u3081\u306b\u6b27\u5dde\u3068\u7c73\u56fd\u3067\u8a8d\u53ef\u3055\u308c\u305f\u3002\u3053\u308c\u3089\u306e\u85ac\u5264\u306e\u6700\u521d\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u8a66\u9a13\uff08\u30a8\u30dc\u30ed\u30af\u30de\u30d6\uff09\u306f2016\u5e74\u5f8c\u534a\u306b\u5831\u544a\u3055\u308c\u308b\u4e88\u5b9a\u3067\u3042\u308a\u3001\u3053\u308c\u3089\u306e\u65b0\u898f\u85ac\u5264\u304c\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u6301\u7d9a\u3059\u308b\u8102\u8cea\u95a2\u9023\u306e\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u3092\u6700\u7d42\u7684\u306b\u8a55\u4fa1\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3067\u3042\u308d\u3046\u3002  <\/span><\/p>\n<p><span>\u3053\u308c\u3089\u306e\u85ac\u5264\u306f\u4e3b\u306b\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\uff08LDL\uff09\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u6a19\u7684\u3068\u3059\u308b\u304c\u3001\u4ed6\u306e\u30ea\u30dd\u86cb\u767d\u3078\u306e\u5f71\u97ff\u3082\u7121\u8996\u3067\u304d\u306a\u3044\u3002\u5b9f\u969b\u3001\u30ea\u30dd\u86cb\u767d(a)[Lp(a)] \u306e\u6e1b\u5c11\u304c\u6ce8\u76ee\u3055\u308c\u3066\u304a\u308a\u3001\u5fc3\u8840\u7ba1\u7cfb\u306e\u5371\u967a\u56e0\u5b50\u3068\u3057\u3066\u78ba\u7acb\u3057\u3066\u304a\u308a\u3001\u8102\u8cea\u95a2\u9023\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002   <\/span><sup>4,5<\/sup><span>.\u5165\u624b\u53ef\u80fd\u306a\u30c7\u30fc\u30bf\u306b\u3088\u308b\u3068\u3001PCSK9\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u7642\u6cd5\u306f\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u8005\u306eLp(a)\u309225\u301c30\uff05\u4f4e\u4e0b\u3055\u305b\u308b\u3002   <\/span><sup>6,7<\/sup><span>.Lp(a)\u306f\uff08\u73fe\u5728\u30a2\u30e1\u30ea\u30ab\u5927\u9678\u3067\u306e\u307f\u5165\u624b\u53ef\u80fd\u306a\u30ca\u30a4\u30a2\u30b7\u30f3\u3092\u9664\u3044\u3066\uff09\u73fe\u5728\u306e\u6cbb\u7642\u9078\u629e\u80a2\u306b\u5bfe\u3057\u3066\u57fa\u672c\u7684\u306b\u96e3\u6cbb\u6027\u3067\u3042\u308b\u305f\u3081\u3001PCSK9\u6a19\u7684\u7642\u6cd5\u306f\u3053\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u8840\u6813\u6027\u30ea\u30dd\u86cb\u767d\u3092\u6a19\u7684\u3068\u3059\u308b\u53ef\u80fd\u6027\u3092\u63d0\u4f9b\u3059\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002\u3057\u304b\u3057\u3001\u4ed6\u306e\u65b0\u898f\u85ac\u5264\u3082\u958b\u767a\u4e2d\u3067\u3042\u308a\u3001\u7279\u306bISIS-APO(a)Rx\u306f\u3001Lp(a)\u306e\u69cb\u6210\u6210\u5206\u3067\u3042\u308b\u30a2\u30dd\u30ea\u30dd\u86cb\u767d(a)\u3092\u6a19\u7684\u3068\u3059\u308b\u7b2c2\u4e16\u4ee3\u306e\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u85ac\u5264\u3067\u3042\u308b\u3002Lp(a)\u304c\u9ad8\u5024\u306e\u88ab\u9a13\u8005\uff08&gt;25nmol\/L\uff09\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7b2cI\u76f8\u8a66\u9a13\u3067\u306f\u3001\u8907\u6570\u56de\u306e\u6295\u4e0e\u3067Lp(a)\u304c80\uff05\u4ee5\u4e0a\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u73fe\u5728\u307e\u3067\u306e\u826f\u597d\u306a\u5b89\u5168\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306b\u3088\u308a\u3001\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u958b\u767a\u7d99\u7d9a\u306e\u5f37\u3044\u6839\u62e0\u3068\u306a\u308b\u3002      <\/span><sup>8<\/sup><span>.\u3057\u305f\u304c\u3063\u3066\u3001\u5c06\u6765\u7684\u306b\u306f\u3001Lp(a)\u306e\u4e0a\u6607\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3067\u3001\u8102\u8cea\u95a2\u9023\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u304c\u4f4e\u4e0b\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u691c\u8a3c\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002 <\/span><\/p>\n<p><span>\u4eca\u6708\u306e\u30e9\u30f3\u30c9\u30de\u30fc\u30af\u30ec\u30dd\u30fc\u30c8\u3067\u53d6\u308a\u4e0a\u3052\u305f\u3088\u3046\u306b\u3001\u3053\u308c\u307e\u3067\u6cbb\u7642\u304c\u5341\u5206\u3067\u306a\u304b\u3063\u305f\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306e\u65b0\u305f\u306a\u5e0c\u671b\u3068\u306a\u308b\u9032\u5c55\u3082\u3042\u308b\u3002\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3092\u591a\u304f\u542b\u3080\u30ea\u30dd\u86cb\u767d\u306e\u4ee3\u8b1d\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u30a2\u30dd\u30ea\u30dd\u86cb\u767d\uff08\u30a2\u30dd\uff09CIII\u306f\u3001\u30a2\u30ddCIII\uff08APOC3\uff09\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u55aa\u5931\u578b\u5909\u7570\u4f53\u306e\u4fdd\u6709\u304c\u3001\u6f5c\u5728\u6027\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u304a\u3088\u3073\u51a0\u52d5\u8108\u6027\u5fc3\u75be\u60a3\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u3068\u95a2\u9023\u3059\u308b\u3068\u3044\u3046\u907a\u4f1d\u5b66\u7684\u6d1e\u5bdf\u306b\u3088\u3063\u3066\u652f\u6301\u3055\u308c\u3066\u3044\u308b\u3002   <\/span><sup>9,10<\/sup><span>.\u3055\u3089\u306b\u30012\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u8840\u6f3f\u30a2\u30ddCIII\u6fc3\u5ea6\u306e\u4e0a\u6607\u306f\u3001\u3088\u308a\u9ad8\u3044\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u3001\u3088\u308a\u597d\u307e\u3057\u304f\u306a\u3044\u5fc3\u4ee3\u8b1d\u8868\u73fe\u578b\u3001\u304a\u3088\u3073\u6f5c\u5728\u6027\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306e\u6307\u6a19\u3067\u3042\u308b\u3088\u308a\u9ad8\u3044\u51a0\u52d5\u8108\u77f3\u7070\u5316\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002   <\/span><sup>11<\/sup><span>.\u3053\u308c\u3089\u306e\u65b0\u305f\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u3001\u7b2c\u4e8c\u4e16\u4ee3\u306e\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u306b\u3088\u308b\u30a2\u30ddCIII\u5408\u6210\u963b\u5bb3\u85ac\uff08ISIS 304801\uff09\u306e\u958b\u767a\u306e\u539f\u52d5\u529b\u3068\u306a\u3063\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30e9\u30a4\u30c9\u304c4-22.6mmol\/L\uff08350-2000mg\/dl\uff09\u306e\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7b2cII\u76f8\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001ISIS 304801\u306e\u6295\u4e0e\uff08\u5358\u72ec\u307e\u305f\u306f\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u3068\u306e\u4f75\u7528\uff09\u306b\u3088\u308a\u3001\u8840\u6f3f\u4e2d\u30a2\u30ddCIII\u6fc3\u5ea6\u304c\u6700\u592780\uff05\u4f4e\u4e0b\u3057\u3001\u8840\u6f3f\u4e2d\u30c8\u30ea\u30b0\u30ea\u30bb\u30e9\u30a4\u30c9\u3082\u540c\u69d8\u306b\u4f4e\u4e0b\u3057\u305f\u3002    <\/span><sup>12<\/sup><span>.\u73fe\u5728\u307e\u3067\u306e\u5b89\u5168\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u304c\u826f\u597d\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u3055\u3089\u306a\u308b\u958b\u767a\u304c\u671b\u307e\u308c\u308b\u3002 <\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf&#8221; text_font_size=&#8221;14px&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22text_text_color%22%93}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p><span>\u3082\u3046\u4e00\u3064\u306e\u91cd\u8981\u306a\u95a2\u5fc3\u306f\u3001\u9078\u629e\u7684\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u5264\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u03b1\uff08PPAR?SPPARM?K-877\uff08\u8208\u548c(\u682a)\uff09\u306f\u3001\u65e5\u672c\u3067\u7533\u8acb\u3055\u308c\u3001\u6b27\u5dde\u304a\u3088\u3073\u305d\u306e\u4ed6\u306e\u56fd\u3005\u3067\u7b2c\u2161\/\u2162\u76f8\u8a66\u9a13\u304c\u9032\u884c\u4e2d\u3067\u3042\u308b\u304c\u3001\u7279\u306b2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u304a\u3088\u3073\u6b8b\u5b58\u6027\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306e\u7ba1\u7406\u306b\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u6700\u957724\u9031\u9593\u306e\u6295\u4e0e\u671f\u9593\u4e2d\u3001\u8840\u6e05\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u306e\u4e0a\u6607\u3084\u814e\u6a5f\u80fd\u30fb\u809d\u6a5f\u80fd\u306b\u5bfe\u3059\u308b\u81e8\u5e8a\u7684\u306b\u610f\u5473\u306e\u3042\u308b\u526f\u4f5c\u7528\u306f\u8a8d\u3081\u3089\u308c\u3066\u3044\u306a\u3044\u3002     <\/span><sup>13-15<\/sup><span>.\u4eca\u5f8c\u3001\u6ce8\u76ee\u3059\u3079\u304d\u30a8\u30fc\u30b8\u30a7\u30f3\u30c8\u3067\u3042\u308b\u3053\u3068\u306f\u660e\u3089\u304b\u3060\u3002 <\/span><\/p>\n<p><span>\u3057\u304b\u3057\u30012015\u5e74\u306f\u6b8b\u5ff5\u306a\u3053\u3068\u3082\u3042\u3063\u305f\u3002\u304a\u305d\u3089\u304f\u6700\u3082\u30cb\u30e5\u30fc\u30b9\u306b\u306a\u3063\u305f\u306e\u306f\u3001\u307e\u305f\u5225\u306e\u30b3\u30ec\u30b9\u30c6\u30ea\u30eb\u30a8\u30b9\u30c6\u30eb\u8ee2\u79fb\u30bf\u30f3\u30d1\u30af\u8cea\uff08CETP\uff09\u963b\u5bb3\u5264\u3067\u3042\u308bevacetrapib\u306e\u958b\u767a\u4e2d\u6b62\u3067\u3042\u308d\u3046\u3002\u7b2cIII\u76f8\u5fc3\u8840\u7ba1\u7cfb\u30a2\u30a6\u30c8\u30ab\u30e0\u8a66\u9a13ACCELERATE\u306f\u3001\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3092\u9054\u6210\u3059\u308b\u53ef\u80fd\u6027\u304c\u4f4e\u3044\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u5b9a\u671f\u7684\u306a\u30c7\u30fc\u30bf\u30ec\u30d3\u30e5\u30fc\u306e\u7d50\u679c\u3001\u72ec\u7acb\u30c7\u30fc\u30bf\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u59d4\u54e1\u4f1a\u306e\u52e7\u544a\u306b\u3088\u308a\u4e2d\u6b62\u3055\u308c\u305f\u3002\u30a8\u30d0\u30bb\u30c8\u30e9\u30d4\u30d6\u306f\u5b89\u5168\u6027\u306e\u554f\u984c\u306b\u3088\u308a\u4e2d\u6b62\u3055\u308c\u306a\u304b\u3063\u305f     <\/span><sup>16<\/sup><span>.\u30a2\u30ca\u30bb\u30c8\u30e9\u30d4\u30d6\u306f\u3001\u7b2cIII\u76f8\u958b\u767a\u6bb5\u968e\u306b\u3042\u308b\u6700\u5f8c\u306eCETP\u963b\u5bb3\u5264\u3067\u3042\u308b\u3002\u30e1\u30eb\u30af\u793e\u306f\u6700\u8fd1\u30ea\u30ea\u30fc\u30b9\u3092\u767a\u8868\u3057\u3001\u975e\u76f2\u691c\u8a66\u9a13\u306e\u8a08\u753b\u7684\u30ec\u30d3\u30e5\u30fc\u306e\u5f8c\u3001REVEAL\u8a66\u9a13\u306e\u30c7\u30fc\u30bf\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u59d4\u54e1\u4f1a\u304c\u5909\u66f4\u306a\u3057\u3067\u8a66\u9a13\u7d99\u7d9a\u3092\u63a8\u5968\u3057\u305f\u3053\u3068\u3092\u78ba\u8a8d\u3057\u305f\u3002    <\/span><sup>17<\/sup><span>.<\/span><\/p>\n<p><span>PCSK9\u963b\u5bb3\u5264\u3068\u30a2\u30ca\u30bb\u30c8\u30e9\u30d4\u30d6\u3092\u7528\u3044\u305f\u8a66\u9a13\u304b\u3089\u5f97\u3089\u308c\u305f\u8ee2\u5e30\u30c7\u30fc\u30bf\u306f\u3001\u4eca\u5f8c1-2\u5e74\u306e\u8102\u8cea\u7814\u7a76\u306e\u30a8\u30ad\u30b5\u30a4\u30c6\u30a3\u30f3\u30b0\u306a\u6642\u671f\u3092\u4e88\u611f\u3055\u305b\u308b\u3082\u306e\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u80a5\u6e80\u30682\u578b\u7cd6\u5c3f\u75c5\u306e\u5927\u6d41\u884c\u304c\u7c97\u98df\u3068\u5ea7\u308a\u3063\u3071\u306a\u3057\u306e\u751f\u6d3b\u7fd2\u6163\u306b\u5927\u304d\u304f\u8d77\u56e0\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u8003\u3048\u308b\u3068\u3001\u751f\u6d3b\u7fd2\u6163\u3078\u306e\u4ecb\u5165\u306e\u91cd\u8981\u6027\u3092\u518d\u78ba\u8a8d\u3059\u308b\u3053\u3068\u3082\u91cd\u8981\u3067\u3042\u308b\u3002\u751f\u6d3b\u7fd2\u6163\u3078\u306e\u4ecb\u5165\u306f2\u578b\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u3092\u6709\u610f\u306b\u6e1b\u5c11\u3055\u305b\u308b\u3060\u3051\u3067\u306a\u304f\u30017\u3064\u306e\u4e3b\u8981\u306a\u4fee\u6b63\u53ef\u80fd\u306a\u5fc3\u8840\u7ba1\u5371\u967a\u56e0\u5b50\u306e\u3046\u3061\u305f\u3063\u305f1\u3064\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3092\u6539\u5584\u3059\u308b\u3060\u3051\u3067\u3001\u305d\u306e\u5f8c4\u5e74\u9593\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u304c6\uff05\u6e1b\u5c11\u3057\u305f\u3068\u3044\u3046\u30a8\u30d3\u30c7\u30f3\u30b9\u3082\u3042\u308b\u3002    <\/span><sup>18,19<\/sup><span>.\u660e\u3089\u304b\u306b\u3001\u751f\u6d3b\u7fd2\u6163\u306b\u518d\u3073\u7126\u70b9\u3092\u5f53\u3066\u308b\u3053\u3068\u306f\u3001\u6b8b\u5b58\u3059\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u6a19\u7684\u3068\u3057\u305f\u85ac\u7269\u7642\u6cd5\u7684\u4ecb\u5165\u306e\u91cd\u8981\u306a\u57fa\u76e4\u3067\u3042\u308b\u3002 <\/span><\/p>\n<p><span>\u6700\u5f8c\u306b\u3001\u7de8\u96c6\u90e8\u4e00\u540c\u3001\u8aad\u8005\u306e\u7686\u69d8\u306e2016\u5e74\u306e\u3054\u591a\u5e78\u3092\u7948\u5ff5\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u8102\u8cea\u7814\u7a76\u306e\u4eca\u5f8c\u306e\u9032\u5c55\u306b\u3088\u308b\u30a8\u30ad\u30b5\u30a4\u30c6\u30a3\u30f3\u30b0\u306a\u30cb\u30e5\u30fc\u30b9\u3092\u697d\u3057\u307f\u306b\u3057\u3066\u3044\u308b\u3002<\/span><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;8px&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p style=\"font-weight: 400;\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<ol>\n<li style=\"font-weight: 400;\"><span>AHA\u30012015\u5e74\u306e\u30c8\u30c3\u30d7\u7814\u7a76\u9032\u6b69\u306b2\u7a2e\u985e\u306e\u6ce8\u5c04\u7528PCSK9\u963b\u5bb3\u5264\u3092\u9078\u51fa <a href=\"http:\/\/patientdaily.com\/stories\/510654421-aha-names-two-injectable-pcsk9-inhibitors-among-2015-s-top-research-advances\" rel=\"nofollow\">http:\/\/patientdaily.com\/stories\/510654421-aha-names-two-injectable-pcsk9-inhibitors-among-2015-s-top-research-advances<\/a> <\/span><br \/><span class=\"ref ref2\">2.<\/span><span> Sabatine MS, Giugliano RP, Wiviott SD, et al. \u8102\u8cea\u3068\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u6e1b\u5c11\u306b\u304a\u3051\u308b\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3002N Engl J Med 2015; 372:1500-9.  <\/span><br \/><span class=\"ref ref3\">3.<\/span><span> Robinson JG, Farnier M, Krempf M, et al. \u8102\u8cea\u3068\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u6e1b\u5c11\u306b\u304a\u3051\u308b\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3002N Engl J Med 2015; 372:1489-99.  <\/span><br \/><span class=\"ref ref4\">4.<\/span><span> Nordestgaard BG, Chapman MJ, Ray K, et al. \u5fc3\u8840\u7ba1\u7cfb\u5371\u967a\u56e0\u5b50\u3068\u3057\u3066\u306e\u30ea\u30dd\u86cb\u767d\uff08a\uff09\uff1a\u73fe\u72b6\u3002Eur Heart J 2010;31:2844-53.  <\/span><br \/><span class=\"ref ref5\">5.<\/span><span> Khera AV, Everett BM, Caulfield MP et al. \u30ea\u30dd\u86cb\u767d\uff08a\uff09\u6fc3\u5ea6\u3001\u30ed\u30b9\u30d0\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3001\u6b8b\u5b58\u8840\u7ba1\u30ea\u30b9\u30af\uff1aJUPITER\u8a66\u9a13\uff08Justification for the Use of Statins in Prevention\uff1aAn Intervention Trial Evalating Rosuvastatin\uff09\u306e\u89e3\u6790\u3002Circulation 2014;129:635-42.  <\/span><br \/><span class=\"ref ref6\">6.<\/span><span> Raal FJ, Giugliano RP, Sabatine MS et al. PCSK9\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u30a8\u30dc\u30ed\u30af\u30de\u30d6\uff08AMG 145\uff09\u306b\u3088\u308b\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u306e\u6e1b\u5c11\uff1a4\u3064\u306e\u7b2cII\u76f8\u8a66\u9a13\u306b\u304a\u3051\u308b1,300\u4eba\u4ee5\u4e0a\u306e\u60a3\u8005\u306e\u30d7\u30fc\u30eb\u89e3\u6790\u3002J Am Coll Cardiol 2014;63:1278-88.  <\/span><br \/><span class=\"ref ref7\">7.<\/span><span> Gaudet D, Kereiakes DJ, McKenney JM et al.\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u86cb\u767d\u8ee2\u63db\u9175\u7d20\u30b5\u30d6\u30c1\u30ea\u30b7\u30f3\/\u30b1\u30ad\u30b7\u30f39\u6297\u4f53\u3067\u3042\u308b\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u306e\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u6fc3\u5ea6\u306b\u5bfe\u3059\u308b\u52b9\u679c\uff08\u7b2c2\u76f8\u8a66\u9a13\u304b\u3089150mg\u30922\u9031\u9593\u3054\u3068\u306b\u6295\u4e0e\u3057\u305f\u5834\u5408\u306e\u30d7\u30fc\u30eb\u89e3\u6790\uff09\u3002Am J Cardiol 2014; 114:711-5.  <\/span><br \/><span class=\"ref ref8\">8.<\/span><span> Tsimikas S\u3001Viney NJ\u3001Hughes SG\u3089\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u3092\u6a19\u7684\u3068\u3057\u305f\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u7642\u6cd5\uff1a\u7121\u4f5c\u70ba\u5316\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u7b2c1\u76f8\u8a66\u9a13\u3002Lancet 2015;386:1472-83.  <\/span><br \/><span class=\"ref ref9\">9.<\/span><span> J\u00f8rgensen AB, Frikke-Schmidt R, Nordestgaard BG, Tybj\u00e6rg-Hansen A. APOC3\u306e\u6a5f\u80fd\u55aa\u5931\u5909\u7570\u3068\u865a\u8840\u6027\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3002N Engl J Med.2014;371:32-41. <\/span><br \/><span class=\"ref ref10\">10.<\/span><span> Blood I, Crosby J, Peloso GM, et al; Tg, Hdl Working Group of the Exome Sequencing Project NHL.apoc3\u306e\u6a5f\u80fd\u55aa\u5931\u5909\u7570\u3001\u4e2d\u6027\u8102\u80aa\u3001\u51a0\u75be\u60a3\u3002New Engl J Med 2014;371:22-31  <\/span><br \/><span class=\"ref ref11\">11.<\/span><span> Qamar A, Khetarpal SA, Khera AV et al. 2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u8840\u6f3f\u30a2\u30dd\u30ea\u30dd\u86cb\u767dC-III\u5024\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3001\u51a0\u52d5\u8108\u77f3\u7070\u5316\u3002Arterioscler Thromb Vasc Biol 2015;35:1880-8.  <\/span><br \/><span class=\"ref ref12\">12.<\/span><span> Gaudet D, Alexander VJ, Baker BF et al. Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia.N Engl J Med 2015;373:438-47.  <\/span><br \/><span class=\"ref ref13\">13.<\/span><span>Fruchart JC.\u9078\u629e\u7684\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\uff08SPPARM\uff09\uff1a\u6b21\u4e16\u4ee3\u306e\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\u3002Cardiovasc Diabetol 2013;12:82.<\/span><br \/><span class=\"ref ref14\">14.<\/span><span> Kastelein JP, Senko Y, Hounslow N, Hovingh GK, Ginsberg HN.\u9078\u629e\u7684PPAR\u03b1\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\uff08SPPARM\u03b1\uff09\u3067\u3042\u308bK-877\u306f\u3001\u8840\u6e05\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u306a\u304f\u3001\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3067LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u826f\u597d\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u60a3\u8005\u306e\u8102\u8cea\u7570\u5e38\u75c7\u3092\u6539\u5584\u3059\u308b\u3002Eur Heart J 2015;36(Abstract Supplement):1048[abstract].  <\/span><br \/><span class=\"ref ref15\">15.<\/span><span> Kastelein JJP, Senko Y, Hounslow N, Nojima T, Suganami H, Hovingh GK, Ginsberg HN.\u9078\u629e\u7684PPAR\u03b1\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\uff08SPPARM\u03b1\uff09\u3067\u3042\u308bK-877\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u305f2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u8102\u8cea\u7570\u5e38\u75c7\u3092\u6539\u5584\u3059\u308b\u3002Eur Heart J 2015;36( Abstract Supplement):1048[abstract].  <\/span><br \/><span class=\"ref ref16\">16.<\/span><span> \u30ea\u30ea\u30fc\u793e\u3001\u9ad8\u30ea\u30b9\u30af\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u6cbb\u7642\u85acEvacetrapib\u306e\u958b\u767a\u3092\u4e2d\u6b62 <a href=\"https:\/\/investor.lilly.com\/releasedetail.cfm?ReleaseID=936130\" rel=\"nofollow\">https:\/\/investor.lilly.com\/releasedetail.cfm?ReleaseID=936130<\/a> <\/span><br \/><span class=\"ref ref17\">17.<\/span><span> \u30e1\u30eb\u30af\u3001REVEAL\u30a2\u30a6\u30c8\u30ab\u30e0\u30b9\u30bf\u30c7\u30a3\u306e\u6700\u65b0\u60c5\u5831\u3092\u63d0\u4f9b <a href=\"http:\/\/www.mercknewsroom.com\/news-release\/research-and-development-news\/merck-provides-update-reveal-outcomes-study\" rel=\"nofollow\">http:\/\/www.mercknewsroom.com\/news-release\/research-and-development-news\/merck-provides-update-reveal-outcomes-study<\/a> <\/span><br \/><span class=\"ref ref18\">18.<\/span><span> \u7cd6\u5c3f\u75c5\u4e88\u9632\u30d7\u30ed\u30b0\u30e9\u30e0\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3002\u751f\u6d3b\u7fd2\u6163\u4ecb\u5165\u307e\u305f\u306f\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306e\u7cd6\u5c3f\u75c5\u767a\u75c7\u304a\u3088\u3073\u5fae\u5c0f\u8840\u7ba1\u5408\u4f75\u75c7\u306b\u5bfe\u3059\u308b15\u5e74\u9593\u306e\u8ffd\u8de1\u306b\u3088\u308b\u9577\u671f\u52b9\u679c\uff1a\u7cd6\u5c3f\u75c5\u4e88\u9632\u30d7\u30ed\u30b0\u30e9\u30e0\u30a2\u30a6\u30c8\u30ab\u30e0\u7814\u7a76\u3002Lancet Diabetes Endocrinol 2015; Published Online September 14, 2015.  <\/span><br \/><span class=\"ref ref19\">19.<\/span><span> Avanzini F, Marzona I, Baviera M et al; Risk and Prevention Study Collaborative Group.\u4e00\u822c\u8a3a\u7642\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u4e88\u9632\u306e\u6539\u5584\uff1a\u9ad8\u30ea\u30b9\u30af\u88ab\u9a13\u8005\u306b\u304a\u3051\u308b\u5305\u62ec\u7684\u500b\u5225\u5316\u6226\u7565\u306e\u7d50\u679c\u3002Eur J Prev Cardiol 2015[Epub ahead of print].  <\/span><\/li>\n<\/ol>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>R3i\u793e\u8aac2015\u5e74\u3092\u632f\u308a\u8fd4\u3063\u3066\uff1a\u8102\u8cea\u30cf\u30a4\u30e9\u30a4\u30c8 \u30df\u30b7\u30a7\u30eb\u30fb\u30d8\u30eb\u30de\u30f3\u30ba\u6559\u6388\u3001\u30d4\u30a8\u30fc\u30eb\u30fb\u30a2\u30de\u30ec\u30f3\u30b3\u6559\u6388 \u3053\u306e12 [&hellip;]<\/p>\n","protected":false},"author":258497324,"featured_media":0,"parent":254286,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_crdt_document":"","jetpack_post_was_ever_published":false,"footnotes":""},"class_list":["post-254454","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - 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