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<\/span><\/p>\n<p><em>2014\u5e74\u306f\u3001REALIST-Micro\u306e\u51fa\u7248\u30012\u3064\u306e\u65b0\u3057\u3044\u884c\u52d5\u559a\u8d77\u8ad6\u6587\u306e\u767a\u8868\u3001\u30d6\u30e9\u30b8\u30eb\u3068\u65e5\u672c\u306b\u304a\u3051\u308bR3i\u306e\u6d3b\u52d5\u5831\u544a\u306a\u3069\u3001\u6b8b\u5b58\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u3064\u3044\u3066\u81e8\u5e8a\u533b\u3092\u6559\u80b2\u3059\u308b\u3068\u3044\u3046\u4f7f\u547d\u306b\u304a\u3044\u3066\u3001R3i\u304c\u518d\u51fa\u767a\u3057\u305f\u5e74\u3067\u3042\u3063\u305f\u3002R3i\u306f\u305d\u306e\u5f37\u307f\u3092\u751f\u304b\u3057\u3001<span class=\"ref ref15\">2015\u5e74\u306b\u306f\u3055\u3089\u306b\u5f37\u529b\u306a\u52e2\u529b\u3068\u306a\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u308b\u3002<\/span>  <\/em><span><\/span><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;8px&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p style=\"font-weight: 400;\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<ol>\n<li style=\"font-weight: 400;\"><span>Miller M, Cannon CP, Murphy SA, Qin J, Ray KK, Braunwald E; PROVE IT-TIMI 22 Investigators.PROVE IT-TIMI 22\u8a66\u9a13\u306b\u304a\u3051\u308b\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u5f8c\u306e\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4ee5\u5916\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u306e\u5f71\u97ff\u3002J Am Coll Cardiol 2008;51:724-730.  <\/span><br \/><span class=\"ref ref2\">2.<\/span><span> Barter P\u3001Gotto AM\u3001LaRosa JC\u3001Maroni J\u3001Szarek M\u3001Grundy SM\u3001Kastelein JJ\u3001Bittner V\u3001Fruchart JC; Treating to New Targets Investigators\u3002HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8d85\u4f4e\u5024\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3002N Engl J Med 2007;357:1301-1310.  <\/span><br \/><span class=\"ref ref3\">3.<\/span><span> Olsson AG, Schwartz GG, Szarek M, Sasiela WJ, Ezekowitz MD, Ganz P, Oliver MF, Waters D, Zeiher A. \u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30ec\u30d9\u30eb\u3067\u306f\u306a\u304f\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u30ec\u30d9\u30eb\u304c\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u5f8c\u306e\u77ed\u671f\u4e88\u5f8c\u306b\u5f71\u97ff\u3059\u308b\uff1aMIRACL\u8a66\u9a13\u306e\u7d50\u679c\u3002Eur Heart J 2005;26: 890-896. <\/span><br \/><span class=\"ref ref4\">4.<\/span><span> \u85ac\u5264\u6eb6\u51fa\u30b9\u30c6\u30f3\u30c8\u7559\u7f6e\u306b\u3088\u308b\u6cbb\u7642\u3092\u53d7\u3051\u305f\u975eST\u4e0a\u6607\u578b\u5fc3\u7b4b\u6897\u585e\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u4f4e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u304c\u9662\u5185\u30a4\u30d9\u30f3\u30c8\u304a\u3088\u30731\u5e74\u9593\u306e\u81e8\u5e8a\u8ee2\u5e30\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3002Am J Cardiol 2006;98:711-717. <\/span><br \/><span class=\"ref ref5\">5.<\/span><span> Sacks FM\u3001Carey VJ\u3001Fruchart JC\u30022\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u8102\u8cea\u4f75\u7528\u7642\u6cd5\u3002N Engl J Med 2010;363:692-4.  <\/span><br \/><span class=\"ref ref6\">6.<\/span><span> Varbo A, Benn M, Davey Smith G et al. \u80a5\u6e80\u304b\u3089\u865a\u8840\u6027\u5fc3\u75be\u60a3\u3078\u306e\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u3068\u3057\u3066\u306e\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u8840\u5727\u3002Circ Res 2014[Epub ahead of print] \u3002  <\/span><br \/><span class=\"ref ref7\">7.<\/span><span><a href=\"http:\/\/omicsonline.org\/open-access\/residual-microvascular-risk-in-type-diabetes-in-is-it-time-for-a-re-think-a-perspective-from-the-residual-risk-reduction-initiative-ri-2155-6156.1000413.php?aid=30659\" rel=\"nofollow\">http:\/\/omicsonline.org\/open-access\/residual-microvascular-risk-in-type-diabetes-in-is-it-time-for-a-re-think-a-perspective-from-the-residual-risk-reduction-initiative-ri-2155-6156.1000413.php?aid=30659<\/a><\/span><br \/><span class=\"ref ref8\">8.<\/span><span> \u7cd6\u5c3f\u75c5\u7db2\u819c\u75c7\u306b\u5bfe\u3059\u308b\u30ec\u30fc\u30b6\u30fc\u6cbb\u7642\u306e\u5fc5\u8981\u6027\u306b\u5bfe\u3059\u308b\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u52b9\u679c\uff08FIELD\u8a66\u9a13\uff09\uff1a\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\u3002Lancet 2007 ;370: 1687-97.  <\/span><br \/><span class=\"ref ref9\">9.<\/span><span> ACCORD Study Group; ACCORD Eye Study Group, Chew EY, Ambrosius WT, Davis MD\u3089: Effects of medical therapies on retinopathy progression in type 2 diabetes.N Engl J Med 2010 ;363: 233-44.  <\/span><br \/><span class=\"ref ref10\">10.<\/span><span> Hu Y, Chen Y, Ding L, He X, Takahashi Y, Gao Y, Shen W, Cheng R, Chen Q, Qi X, Boulton ME, Ma JX.\u7cd6\u5c3f\u75c5\u306b\u3088\u308bPPAR?Proc Natl Acad Sci U S A 2013;110:15401-6.   <\/span><br \/><span class=\"ref ref11\">11.<\/span><span> Sim\u00f3 R, Roy S, Behar-Cohen F, Keech A, Mitchell P, Wong TY.\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\uff1a\u7cd6\u5c3f\u75c5\u7db2\u819c\u75c7\u306e\u65b0\u3057\u3044\u6cbb\u7642\u85ac\u3002\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u4eca\u5f8c\u306e\u5c55\u671b\u3002Curr Med Chem 2013;20:3258-66.   <\/span><\/li>\n<\/ol>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>R3i\u793e\u8aac\u30dd\u30b9\u30c8IMPROVE-IT\uff1a\u6b8b\u7559\u30ea\u30b9\u30af\u306e\u884c\u65b9\u306f\uff1f \u30df\u30b7\u30a7\u30eb\u30fb\u30a8\u30eb\u30de\u30f3\u30b9\u6559\u6388\u3001\u30d4\u30a8\u30fc\u30eb\u30fb\u30a2\u30de\u30ec\u30f3\u30b3\u6559\u6388 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