{"id":254441,"date":"2025-01-31T15:02:53","date_gmt":"2025-01-31T14:02:53","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-reduce-it%ef%bc%9a%e6%80%a5%e6%80%a7%e5%86%a0%e7%97%87%e5%80%99%e7%be%a4%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%82%a4%e3%82%b3%e3%82%b5\/"},"modified":"2025-03-06T22:55:41","modified_gmt":"2025-03-06T21:55:41","slug":"%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-reduce-it%ef%bc%9a%e6%80%a5%e6%80%a7%e5%86%a0%e7%97%87%e5%80%99%e7%be%a4%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%82%a4%e3%82%b3%e3%82%b5","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-reduce-it%ef%bc%9a%e6%80%a5%e6%80%a7%e5%86%a0%e7%97%87%e5%80%99%e7%be%a4%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%82%a4%e3%82%b3%e3%82%b5\/","title":{"rendered":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af – REDUCE-IT\uff1a\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u306b\u304a\u3051\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]<\/p>\n

REDUCE-IT\uff1a\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u306b\u304a\u3051\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u6295\u4e0e<\/h2>\n

2024\u5e747\u6708<\/span><\/h5>\n

REDUCE-IT\uff08Reduction of Cardiovascular Events with Icosapent Ethyl\u2013Intervention Trial\uff09\u306e\u4e8b\u5f8c\u89e3\u6790\u306b\u3088\u308c\u3070\u3001\u6700\u8fd112\u30f5\u6708\u4ee5\u5185\u306b\u6025\u6027\u51a0\u75c7\u5019\u7fa4\uff08ACS\uff09\u3092\u767a\u75c7\u3057\u305f\u9ad8\u30ea\u30b9\u30af\u306e\u30b9\u30bf\u30c1\u30f3\u670d\u7528\u60a3\u8005\u3078\u306e\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u6295\u4e0e\u306b\u3088\u308a\u3001\u865a\u8840\u6027\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u4e0b\u3057\u3001\u904e\u5ea6\u306e\u51fa\u8840\u30a4\u30d9\u30f3\u30c8\u3082\u8a8d\u3081\u3089\u308c\u306a\u3044\u3002
\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u767a\u75c7\u5f8c\u306e\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u6295\u4e0e\uff1aREDUCE-IT\u8a66\u9a13\u3000Sayah N, Bhatt DL, Miller M, et al.Eur Heart J 2024;45: 1173\u201376.<\/p>\n

\u8a66\u9a13\u306e\u8981\u7d04<\/b><\/p>\n

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\n\n\n\n\n\n\n\n\n\n
\n

\u76ee\u7684<\/b><\/b><\/p>\n<\/td>\n

\n

\u6700\u8fd1ACS<\/span>\u3092\u767a\u75c7\u3057\u305f\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u306e\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u3068\u5b89\u5168\u6027\u3092\u8a55\u4fa1\u3059\u308b\u3002<\/p>\n<\/td>\n<\/tr>\n

\n

\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/b><\/b><\/p>\n<\/td>\n

\n

\u7121\u4f5c\u70ba\u5316\u3001\u4e8c\u91cd\u76f2\u691c\u3001\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13REDUCE-IT<\/span>\u306e\u4e8b\u5f8c\u89e3\u6790\u3002<\/p>\n<\/td>\n<\/tr>\n

\n

\u7814\u7a76\u5bfe\u8c61\u96c6\u56e3<\/b><\/b><\/p>\n<\/td>\n

\n

REDUCE-IT<\/span>\u306e\u5bfe\u8c61\u60a3\u8005\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u60a3\u8005\u3001\u307e\u305f\u306f\u7cd6\u5c3f\u75c5\u3068\u305d\u306e\u4ed6\u306e1<\/span>\u3064\u4ee5\u4e0a\u306e\u30ea\u30b9\u30af\u56e0\u5b50\u3092\u6709\u3059\u308b\u60a3\u8005\u306e\u3046\u3061\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C<\/span>\uff09\u5024\u306f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG<\/span>\uff09\u5024\u306f\u3084\u3084\u9ad8\u304f\u3001\u30b9\u30bf\u30c1\u30f3\u3092\u670d\u7528\u4e2d\u306e\u60a3\u80058,179<\/span>\u4f8b\u3067\u3042\u3063\u305f\u3002\u3053\u306e\u4e8b\u5f8c\u89e3\u6790\u3067\u306f\u3001\u6700\u8fd1ACS<\/span>\u3092\u767a\u75c7\u3057\u305f\u60a3\u8005\uff08\u7121\u4f5c\u70ba\u5272\u308a\u4ed8\u3051\u524d12<\/span>\u30f5\u6708\u4ee5\u5185\u306e\u5fc3\u7b4b\u6897\u585e\u307e\u305f\u306f\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u306e\u767a\u75c7\u3068\u5b9a\u7fa9\uff09840<\/span>\u4f8b\uff08\u5e74\u9f62\u4e2d\u592e\u502459.5<\/span>\u6b73\u3001\u7537\u602776.9%<\/span>\u3001\u7cd6\u5c3f\u75c536.9%<\/span>\uff09\u304c\u5bfe\u8c61\u3068\u3055\u308c\u305f\u3002\u307b\u307c\u3059\u3079\u3066\u306e\u60a3\u8005\uff0899.9%<\/span>\uff09\u304c\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u3066\u304a\u308a\u3001805<\/span>\u4f8b\uff0895.8%<\/span>\uff09\u306f\u6297\u8840\u5c0f\u677f\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u305f\u3002ACS<\/span>\u767a\u75c7\u304b\u3089\u7121\u4f5c\u70ba\u5272\u308a\u4ed8\u3051\u307e\u3067\u306e\u671f\u9593\uff08\u4e2d\u592e\u5024\uff09\u306f\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u7fa4\u304a\u3088\u3073\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u540c\u7a0b\u5ea6\u3067\u3042\u3063\u305f\uff085.5 vs. 5.6<\/span>\u30f5\u6708\uff09\u3002<\/p>\n

\n<\/td>\n<\/tr>\n

\n

\u4e3b\u8981\u7814\u7a76\u8a55\u4fa1\u9805\u76ee<\/b><\/b><\/p>\n

<\/b><\/p>\n<\/td>\n

\n

\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee<\/b>\uff1aREDUCE-IT<\/span>\u306e\u6709\u52b9\u6027\u306e\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u7684\u5fc3\u7b4b\u6897\u585e\u3001\u975e\u81f4\u6b7b\u7684\u8133\u5352\u4e2d\u3001\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u3001\u307e\u305f\u306f\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u306b\u3088\u308b\u5165\u9662\u304b\u3089\u306a\u308b\u8907\u5408\u8a55\u4fa1\u9805\u76ee\u3067\u3042\u3063\u305f\u3002\u4e3b\u306a\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u521d\u56de\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u7684\u5fc3\u7b4b\u6897\u585e\u3001\u307e\u305f\u306f\u975e\u81f4\u6b7b\u7684\u8133\u5352\u4e2d\u304b\u3089\u306a\u308b\u8907\u5408\u8a55\u4fa1\u9805\u76ee\u3067\u3042\u3063\u305f\u3002<\/p>\n

\n<\/td>\n<\/tr>\n

\n

\u65b9\u6cd5<\/b><\/b><\/p>\n<\/td>\n

\n

\u30ab\u30d7\u30e9\u30f3\u30de\u30a4\u30e4\u30fc\u6cd5\u3067\u521d\u767a\u30a4\u30d9\u30f3\u30c8\u307e\u3067\u306e\u671f\u9593\u3092\u89e3\u6790\u3057\u3001\u30ed\u30b0\u30e9\u30f3\u30af\u691c\u5b9a\u306b\u3088\u308a\u6bd4\u8f03\u3057\u305f\u3002Cox<\/span>\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30eb\u306b\u3088\u308a\u3001\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08HR<\/span>\uff09\u304a\u3088\u307395%<\/span>\u4fe1\u983c\u533a\u9593\uff08CI<\/span>\uff09\u3092\u7b97\u51fa\u3057\u305f\u3002\u5f8c\u767a\u30a4\u30d9\u30f3\u30c8\u307e\u3067\u306e\u671f\u9593\u306fWei-Lin-Weissfeld<\/span>\u30e2\u30c7\u30eb\u3067\u89e3\u6790\u3057\u3001\u6cbb\u7642\u52b9\u679c\u306eHR<\/span>\u304a\u3088\u307395% CI<\/span>\u3092\u63a8\u5b9a\u3057\u305f\u3002<\/p>\n

\n<\/td>\n<\/tr>\n

\n

\u7d50\u679c<\/b><\/b><\/p>\n<\/td>\n

\n

\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u306e\u6295\u4e0e\u306b\u3088\u308a\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u30a4\u30d9\u30f3\u30c8\u306e\u521d\u767a\u7387\u304c37%<\/span>\u4f4e\u4e0b\u3057\u3001\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u30a4\u30d9\u30f3\u30c8\u5168\u4f53\u306e\u767a\u75c7\u7387\u306f36%<\/span>\u4f4e\u4e0b\u3057\u305f\uff08\u8868<\/b>1<\/b><\/span>\uff09\u3002\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u306b\u3088\u308b\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u30a4\u30d9\u30f3\u30c8\u306e\u521d\u767a\u7387\u306e\u7d76\u5bfe\u30ea\u30b9\u30af\u4f4e\u4e0b\u306f9.3%<\/span>\u3067\u3042\u3063\u305f\uff3b\u6cbb\u7642\u5fc5\u8981\u60a3\u8005\u6570\uff08NNT<\/span>\uff0911<\/span>\u300195% CI 7<\/span>\uff5e28<\/span>\uff3d\u3002\u7121\u4f5c\u70ba\u5272\u308a\u4ed8\u3051\u306e12<\/span>\u30f5\u6708\u4ee5\u4e0a\u524d\u306bACS<\/span>\u3092\u767a\u75c7\u3057\u305f\u60a3\u80053,651<\/span>\u4f8b\u3067\u306f\u3053\u308c\u307b\u3069\u9855\u8457\u306a\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u306e\u52b9\u679c\u306f\u8a8d\u3081\u3089\u308c\u305a\u3001\u76f8\u5bfe\u30ea\u30b9\u30af\u4f4e\u4e0b\u306f22.0%<\/span>\uff08HR 0.78<\/span>\u300195% CI 0.68<\/span>\uff5e0.90<\/span>\uff09\u3001\u7d76\u5bfe\u30ea\u30b9\u30af\u4f4e\u4e0b\u306f4.7%<\/span>\uff08NNT 21<\/span>\uff09\u3067\u3042\u3063\u305f\u3002<\/p>\n

\n

\u8868<\/b>1.<\/b><\/span>\u3000<\/b>REDUCE-IT<\/b><\/span>\u306e<\/b>ACS<\/b><\/span>\u60a3\u8005\u306b\u8a8d\u3081\u3089\u308c\u305f\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u30a4\u30d9\u30f3\u30c8\u306b\u5bfe\u3059\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u306e\u52b9\u679c<\/b><\/b><\/p>\n

\n

\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb<\/b><\/b><\/p>\n

\uff08<\/b><\/span>N=433<\/b>\uff09<\/b><\/b><\/span><\/p>\n

\u30d7\u30e9\u30bb\u30dc<\/b><\/b><\/p>\n

\uff08<\/b><\/span>N=407<\/b>\uff09<\/b><\/b><\/span><\/p>\n

\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08<\/b>95% CI<\/b><\/span>\uff09<\/b><\/b><\/p>\n

\n

\u521d\u767a\u30a4\u30d9\u30f3\u30c8\u60a3\u8005\u6570\uff08%<\/span>\uff09<\/p>\n

81 (18.7)<\/p>\n

114 (28.0)<\/p>\n

0.63 (0.48\u20130.84),<\/p>\n

p 0.002<\/p>\n

\n

\u5408\u8a08\u30a4\u30d9\u30f3\u30c8\u6570<\/p>\n

153<\/p>\n

231<\/p>\n

0.64 (0.45\u20130.90),<\/p>\n

p=0.01<\/p>\n

\n

\n

\u307e\u305f\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u306e\u6295\u4e0e\u306b\u3088\u3063\u3066\u4e3b\u306a\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u30a4\u30d9\u30f3\u30c8\u306e\u521d\u767a\u7387\u304c36%<\/span>\u4f4e\u4e0b\u3057\uff08HR 0.64<\/span>\u300195% CI 0.44<\/span>\uff5e0.92<\/span>\u3001p=0.01<\/span>\uff09\u3001\u4e3b\u306a\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u30a4\u30d9\u30f3\u30c8\u306e\u7dcf\u6570\u306f28%<\/span>\u4f4e\u4e0b\u3057\u305f\uff08\u76f8\u5bfe\u30ea\u30b9\u30af0.72<\/span>\u300195% CI 0.47<\/span>\uff5e1.09<\/span>\uff09\u3002\u305f\u3060\u3057\u5f8c\u8005\u306e\u7d50\u679c\u306f\u7d71\u8a08\u7684\u306b\u975e\u6709\u610f\u3067\u3042\u3063\u305f\u3002<\/p>\n

\n

\u6700\u8fd1ACS<\/span>\u3092\u767a\u75c7\u3057\u305f\u60a3\u8005\u3067\u306f\u3001TEAE<\/span>\uff08\u6cbb\u9a13\u85ac\u6295\u4e0e\u5f8c\u306b\u767a\u73fe\u3057\u305f\u6709\u5bb3\u4e8b\u8c61\uff09\u767a\u73fe\u7387\u306b2<\/span>\u7fa4\u9593\u3067\u5dee\u306f\u306a\u304b\u3063\u305f\uff08\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u7fa478.8% vs. <\/span>\u30d7\u30e9\u30bb\u30dc\u7fa476.7%<\/span>\uff09\u3002\u7dcf\u51fa\u8840\u30a4\u30d9\u30f3\u30c8\u7387\uff086.9% vs. 8.1%<\/span>\uff09\u304a\u3088\u3073\u51fa\u8840\u95a2\u9023\u306e\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u767a\u73fe\u7387\uff081.6% vs. 3.2%<\/span>\uff09\u306b\u3082\u7fa4\u9593\u5dee\u306f\u307f\u3089\u308c\u306a\u304b\u3063\u305f\u3002<\/p>\n

\n<\/td>\n<\/tr>\n

\n

\u8457\u8005\u306e\u7d50\u8ad6<\/b><\/b><\/p>\n<\/td>\n

\n

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\u30b3\u30e1\u30f3\u30c8<\/b><\/b><\/p>\n

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\n

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\n

References<\/b><\/p>\n

1. Steen DL, Khan I, Andrade K, et al. Event rates and risk factors for recurrent cardiovascular events and mortality in a contemporary post acute coronary syndrome population representing 239 234 patients during 2005 to 2018 in the United States. J Am Heart Assoc 2022;11(9):e022198.<\/p>\n

Key words:\u00a0 <\/span>REDUCE-IT; icosapent ethyl; acute coronary syndrome; residual cardiovascular risk.<\/i><\/p>\n<\/div>\n<\/div>\n<\/div>\n

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