{"id":254436,"date":"2025-01-31T15:17:48","date_gmt":"2025-01-31T14:17:48","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-prominent%e3%81%8b%e3%82%89%e3%81%ae%e6%b4%9e%e5%af%9f%ef%bc%9a%e3%83%9a%e3%83%9e%e3%83%95%e3%82%a3%e3%83%96%e3%83%a9%e3%83%bc%e3%83%88\/"},"modified":"2025-03-05T22:13:10","modified_gmt":"2025-03-05T21:13:10","slug":"%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-prominent%e3%81%8b%e3%82%89%e3%81%ae%e6%b4%9e%e5%af%9f%ef%bc%9a%e3%83%9a%e3%83%9e%e3%83%95%e3%82%a3%e3%83%96%e3%83%a9%e3%83%bc%e3%83%88","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-prominent%e3%81%8b%e3%82%89%e3%81%ae%e6%b4%9e%e5%af%9f%ef%bc%9a%e3%83%9a%e3%83%9e%e3%83%95%e3%82%a3%e3%83%96%e3%83%a9%e3%83%bc%e3%83%88\/","title":{"rendered":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af &#8211; PROMINENT\u304b\u3089\u306e\u6d1e\u5bdf\uff1a\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u304c2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u6f70\u760d\u307e\u305f\u306f\u58ca\u75bd\u306e\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u308b"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;1px|||||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; header_2_text_color=&#8221;gcid-primary-color&#8221; header_5_text_color=&#8221;gcid-secondary-color&#8221; text_orientation=&#8221;center&#8221; width=&#8221;99%&#8221; custom_margin=&#8221;|-147px||||&#8221; custom_padding=&#8221;|0px||||&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<h2>PROMINENT\u8a66\u9a13\u304b\u3089\u306e\u77e5\u898b\uff1a\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306f2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u6f70\u760d\u307e\u305f\u306f\u58ca\u75bd\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b<\/h2>\n<h5><span>2024\u5e749\u6708<\/span><\/h5>\n<p class=\"p1\"><span class=\"s1\"><i>POMINENT<\/i><\/span>\u8a66\u9a13\u306e\u7d50\u679c\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306b\u3088\u308a<span class=\"s1\"><i>2<\/i><\/span>\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u4e0b\u80a2\u306e\u865a\u8840\u6027\u6f70\u760d\u304a\u3088\u3073\u58ca\u75bd\u304c\u6e1b\u5c11\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u305f\u3002<\/p>\n<p class=\"p2\"><i>Marinho LL, Everett BM, Aday AW, et al. <\/i><span class=\"s2\">\u7cd6\u5c3f\u75c5\u6027\u8db3\u6f70\u760d\u304a\u3088\u3073\u58ca\u75bd\u306b\u5bfe\u3059\u308b\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u52b9\u679c\u3002<\/span><i>PROMINENT<\/i><span class=\"s2\">\u8a66\u9a13\u306e\u63a2\u7d22\u7684\u89e3\u6790\u3002<\/span><i> J Am Coll Cardiol 2024;84:408-410.<\/i><\/p>\n<p class=\"p1\"><b>\u8a66\u9a13\u306e\u8981\u7d04<\/b><\/p>\n<div>\n<div>\n<div>\n<table cellspacing=\"0\" cellpadding=\"0\" class=\"t1\">\n<tbody>\n<tr>\n<td valign=\"top\" class=\"td1\">\n<p class=\"p1\"><b>\u76ee\u7684<\/b><b><\/b><\/p>\n<\/td>\n<td valign=\"top\" class=\"td2\">\n<p class=\"p2\">Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Participants with Diabetes<span class=\"s1\">\uff08<\/span>PROMINENT<span class=\"s1\">\uff09\u8a66\u9a13\u306e\u524d\u5411\u304d\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u3001\u4e0b\u80a2\u306e\u865a\u8840\u6027\u6f70\u760d\u307e\u305f\u306f\u58ca\u75bd\u3068\u5224\u5b9a\u3055\u308c\u305f\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u5bfe\u3059\u308b\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u52b9\u679c\u3092\u8a55\u4fa1\u3059\u308b\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" class=\"td1\">\n<p class=\"p1\"><b>\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/b><b><\/b><\/p>\n<\/td>\n<td valign=\"top\" class=\"td2\">\n<p class=\"p1\">\u7121\u4f5c\u70ba\u5316\u3001\u4e8c\u91cd\u76f2\u691c\u3001\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167<span class=\"s2\">PROMINENT<\/span>\u8a66\u9a13\u306e\u4e8c\u6b21\u89e3\u6790\u3002<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" class=\"td3\">\n<p class=\"p1\"><b>\u7814\u7a76\u5bfe\u8c61\u96c6\u56e3<\/b><b><\/b><\/p>\n<\/td>\n<td valign=\"top\" class=\"td4\">\n<p class=\"p1\"><span class=\"s2\">PROMINENT<\/span>\u8a66\u9a13\u3067\u306f\u3001<span class=\"s2\">2<\/span>\u578b\u7cd6\u5c3f\u75c5\uff08<span class=\"s2\">T2DM<\/span>\uff09\u3001\u8efd\u5ea6\uff5e\u4e2d\u7b49\u5ea6\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\uff08\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024<span class=\"s2\">200<\/span>\uff5e<span class=\"s2\">499 mg\/dL<\/span>\uff09\u3001\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u5024\uff08<span class=\"s2\">40 mg\/dL<\/span>\u4ee5\u4e0b\uff09\u3001\u304a\u3088\u3073\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u57fa\u3065\u304f\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\uff08\u7d04<span class=\"s2\">3<\/span>\u5206\u306e<span class=\"s2\">2<\/span>\u304c\u9ad8\u5f37\u5ea6\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\uff09\u306b\u3088\u308a\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u60a3\u8005<span class=\"s2\">10,479<\/span>\u4f8b\u304c\u5bfe\u8c61\u3068\u3055\u308c\u305f\u3002\u5168\u4f53\u3067\u3001\u60a3\u8005\u306e<span class=\"s2\">15%<\/span>\u304c\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306b\u672b\u68a2\u52d5\u8108\u75be\u60a3\uff08<span class=\"s2\">PAD<\/span>\uff09\u306e\u65e2\u5f80\u3092\u6709\u3057\u3066\u3044\u305f\u3002<\/p>\n<p class=\"p3\">\n<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" class=\"td1\">\n<p class=\"p1\"><b>\u4e3b\u8981\u7814\u7a76\u8a55\u4fa1\u9805\u76ee<\/b><b><\/b><\/p>\n<p class=\"p3\"><b><\/b><\/p>\n<\/td>\n<td valign=\"top\" class=\"td2\">\n<p class=\"p1\"><b>\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\uff1a<\/b>\u672c\u89e3\u6790\u306e\u4e3b\u8981\u6709\u52b9\u6027\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u533b\u5e2b\u304c\u5224\u5b9a\u3057\u305f\u4e0b\u80a2\u306e\u865a\u8840\u6027\u6f70\u760d\u307e\u305f\u306f\u58ca\u75bd\u306e\u767a\u75c7\u3067\u3042\u308a\u3001\u3053\u308c\u306f\u8a3a\u65ad\u691c\u67fb\u306b\u57fa\u3065\u304f\u9589\u585e\u6027<span class=\"s2\">PAD<\/span>\u306e\u65b0\u898f\u767a\u75c7\u307e\u305f\u306f\u60aa\u5316\u3068\u5b9a\u7fa9\u3055\u308c\u305f\u3002<span class=\"s2\">PAD<\/span>\u306e\u65b0\u898f\u767a\u75c7\u307e\u305f\u306f\u60aa\u5316\u3092\u4f34\u308f\u306a\u3044\u6f70\u760d\u3084\u58ca\u75bd\u306f\u89e3\u6790\u306b\u542b\u307e\u308c\u306a\u304b\u3063\u305f\u3002<span class=\"s2\">PAD<\/span>\u306e\u65b0\u898f\u767a\u75c7\u307e\u305f\u306f\u60aa\u5316\u306f\u3001\u9593\u6b20\u6027\u8ddb\u884c\u3001\u5b89\u9759\u6642\u75bc\u75db\u3001\u4e0b\u80a2\u865a\u8840\u6027\u6f70\u760d\u3001\u4e0b\u80a2\u306e\u8840\u884c\u518d\u5efa\u8853\u307e\u305f\u306f\u5927\u5207\u65ad\u8853\u306e\u65e2\u5f80\u306e\u3044\u305a\u308c\u304b\u304c\u8a8d\u3081\u3089\u308c\u3001\u304b\u3064\u8db3\u95a2\u7bc0\u4e0a\u8155\u8840\u5727\u6bd4<span class=\"s2\">0.9<\/span>\u4ee5\u4e0b\u307e\u305f\u306f\u4ed6\u306e\u691c\u67fb\u306b\u3088\u308b<span class=\"s2\">PAD<\/span>\u306e\u8a3a\u65ad\u3068\u5b9a\u7fa9\u3055\u308c\u305f\u3002<\/p>\n<p class=\"p3\">\n<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" class=\"td1\">\n<p class=\"p1\"><b>\u65b9\u6cd5<\/b><b><\/b><\/p>\n<\/td>\n<td valign=\"top\" class=\"td5\">\n<p class=\"p1\">\u5831\u544a\u3055\u308c\u305f\u30a4\u30d9\u30f3\u30c8\u306f\u3059\u3079\u3066\u3001\u8a66\u9a13\u306e\u8a55\u4fa1\u9805\u76ee\u5be9\u67fb\u59d4\u54e1\u4f1a\u304c\u6700\u521d\u306b\u691c\u8a0e\u3057\u3001<span class=\"s2\">PAD<\/span>\u306e\u65b0\u898f\u767a\u75c7\u307e\u305f\u306f\u60aa\u5316\u306e\u6709\u7121\u3092\u5224\u5b9a\u3057\u305f\u3002\u3055\u3089\u306b\u3001<span class=\"s2\">PAD<\/span>\u306e\u5c02\u9580\u77e5\u8b58\u3092\u6709\u3059\u308b\u72ec\u7acb\u3057\u305f\u5faa\u74b0\u5668\u5c02\u9580\u533b<span class=\"s2\">2<\/span>\u540d\u304c\u4e8c\u6b21\u5224\u5b9a\u3092\u5b9f\u65bd\u3057\u3001\u6765\u9662\u6642\u306b\u6f70\u760d\u306e\u5834\u6240\u304a\u3088\u3073\u58ca\u75bd\u306e\u6709\u7121\u306a\u3069\u306e\u88dc\u8db3\u60c5\u5831\u3092\u53ce\u96c6\u3057\u305f\u3002\u30c7\u30fc\u30bf\u306e\u89e3\u6790\u306f<span class=\"s2\">intention-to-treat<\/span>\u306b\u57fa\u3065\u3044\u3066\u5b9f\u65bd\u3057\u3001\u30ab\u30d7\u30e9\u30f3\u30de\u30a4\u30e4\u30fc\u66f2\u7dda\u304a\u3088\u3073\u672a\u8abf\u6574\u306e\u30ed\u30b0\u30e9\u30f3\u30af<span class=\"s2\">P<\/span>\u5024\u306b\u3088\u308a\u3001\u7121\u4f5c\u70ba\u5272\u308a\u4ed8\u3051\u3057\u305f\u6295\u4e0e\u7fa4\u9593\u306b\u304a\u3051\u308b\u521d\u767a\u306e\u6f70\u760d\u307e\u305f\u306f\u58ca\u75bd\u306e\u7d2f\u7a4d\u767a\u751f\u7387\u3092\u6bd4\u8f03\u3057\u305f\u3002<span class=\"s2\">2<\/span>\u6295\u4e0e\u7fa4\u3067\u521d\u767a\u306e\u6f70\u760d\u307e\u305f\u306f\u58ca\u75bd\u304c\u78ba\u8a8d\u3055\u308c\u308b\u307e\u3067\u306e\u6642\u9593\u306f\u3001\u6027\u5225\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u65e2\u5f80\u3001\u304a\u3088\u3073\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306e\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u306b\u3088\u308a\u5c64\u5225\u5316\u3057\u305f<span class=\"s2\">Cox<\/span>\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30eb\u306b\u3088\u308a\u89e3\u6790\u3057\u305f\u3002\u307e\u305f\u3001\u521d\u767a\u306e\u6f70\u760d\u307e\u305f\u306f\u521d\u767a\u306e\u58ca\u75bd\u306b\u3064\u3044\u3066\u3001\u5225\u3005\u306b\u30c7\u30fc\u30bf\u3092\u89e3\u6790\u3057\u305f\u3002<\/p>\n<p class=\"p3\">\n<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" class=\"td1\">\n<p class=\"p1\"><b>\u7d50\u679c<\/b><b><\/b><\/p>\n<\/td>\n<td valign=\"top\" class=\"td5\">\n<p class=\"p1\"><span class=\"s2\">PROMINENT<\/span>\u8a66\u9a13\u306e\u8ffd\u8de1\u8abf\u67fb\u671f\u9593\u4e2d\u592e\u5024\u306f<span class=\"s2\">3.3<\/span>\u5e74\uff08\u56db\u5206\u4f4d\u7bc4\u56f2<span class=\"s2\">2.5<\/span>\uff5e<span class=\"s2\">4.0<\/span>\u5e74\uff09\u3067\u3042\u3063\u305f\u3002\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u6295\u4e0e\u306f\u4e3b\u8981\u8907\u5408\u8a55\u4fa1\u9805\u76ee\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3001\u305d\u306e\u76f8\u5bfe\u4f4e\u4e0b\u7387\u306f<span class=\"s2\">37%<\/span>\u3067\u3042\u3063\u305f\uff08<b>\u8868<\/b><span class=\"s2\"><b>1<\/b><\/span>\uff09\u3002\u8907\u5408\u8a55\u4fa1\u9805\u76ee\u306e\u5404\u8981\u7d20\u306b\u3064\u3044\u3066\u89e3\u6790\u3057\u305f\u3068\u3053\u308d\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306f\u7d71\u8a08\u5b66\u7684\u306b\u6709\u610f\u306a\u58ca\u75bd\u30ea\u30b9\u30af\u4f4e\u4e0b\uff08\u30cf\u30b6\u30fc\u30c9\u6bd4<span class=\"s2\">0.47<\/span>\u3001<span class=\"s2\">95%<\/span>\u4fe1\u983c\u533a\u9593\uff3b<span class=\"s2\">CI<\/span>\uff3d<span class=\"s2\">0.25-0.87<\/span>\u3001<span class=\"s2\">p<\/span>\uff1d<span class=\"s2\">0.01<\/span>\uff09\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3060\u3051\u3067\u306a\u304f\u3001\u6f70\u760d\u767a\u751f\u7387\u306e\u4e00\u65b9\u5411\u7684\u4f4e\u4e0b\uff08<span class=\"s2\">n<\/span>\uff1d<span class=\"s2\">62<\/span>\u3001\u30cf\u30b6\u30fc\u30c9\u6bd4<span class=\"s2\">0.68<\/span>\u3001<span class=\"s2\">95% CI 0.41-1.12<\/span>\u3001<span class=\"s2\">p<\/span>\uff1d<span class=\"s2\">0.13<\/span>\uff09\u3082\u8a8d\u3081\u3089\u308c\u305f\u3002<\/p>\n<p class=\"p3\">\n<p class=\"p1\"><b>\u8868<\/b><span class=\"s2\"><b>1.<\/b><\/span><b>\u3000<\/b><span class=\"s2\"><b>PROMINENT<\/b><\/span><b>\u8a66\u9a13\u3067\u89b3\u5bdf\u3055\u308c\u305f\u4e0b\u80a2\u306e\u865a\u8840\u6027\u6f70\u760d\u307e\u305f\u306f\u58ca\u75bd\u306b\u5bfe\u3059\u308b\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u52b9\u679c<\/b><b><\/b><\/p>\n<p class=\"p4\">\n<p class=\"p5\"><b>\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8<\/b><b><\/b><\/p>\n<p class=\"p4\"><b><\/b><\/p>\n<p class=\"p5\"><b>\u30d7\u30e9\u30bb\u30dc<\/b><b><\/b><\/p>\n<p class=\"p5\"><b>\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08<\/b><span class=\"s3\"><b>95% CI<\/b><\/span><b>\uff09<\/b><b><\/b><\/p>\n<p class=\"p6\">\n<p class=\"p5\">\u30a4\u30d9\u30f3\u30c8\u6570<\/p>\n<p class=\"p7\">35<\/p>\n<p class=\"p7\">56<\/p>\n<p class=\"p4\">\n<p class=\"p6\">\n<p class=\"p8\"><span class=\"s4\">\u767a\u751f\u7387\uff08<\/span><span class=\"s3\">1000<\/span><span class=\"s4\">\u4eba<\/span>\u30fb\u5e74\u3042\u305f\u308a\uff09<\/p>\n<p class=\"p7\">2.1<\/p>\n<p class=\"p7\">3.4<\/p>\n<p class=\"p7\">0.63 (0.41\u20130.95)<\/p>\n<p class=\"p7\">p=0.03<\/p>\n<p class=\"p6\">\n<p class=\"p3\">\n<p class=\"p3\">\n<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" class=\"td1\">\n<p class=\"p9\"><b>\u8457\u8005\u306e\u7d50\u8ad6<\/b><b><\/b><\/p>\n<\/td>\n<td valign=\"top\" class=\"td5\">\n<p class=\"p9\">\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u57fa\u3065\u304f\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u308b<span class=\"s2\">T2DM<\/span>\u3001\u8efd\u5ea6\uff5e\u4e2d\u7b49\u5ea6\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3001\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u5024\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306f\u4e0b\u80a2\u306e\u865a\u8840\u6027\u6f70\u760d\u307e\u305f\u306f\u58ca\u75bd\u306e\u30ea\u30b9\u30af\u3092\u6709\u610f\u306b\u4f4e\u4e0b\u3055\u305b\u305f\u3002\u3053\u308c\u306f\u3001\u4e0b\u80a2\u306e\u865a\u8840\u6027\u6f70\u760d\u307e\u305f\u306f\u58ca\u75bd\u306e\u767a\u75c7\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3001\u3055\u3089\u306b\u524d\u5411\u304d\u306b\u691c\u8a0e\u3059\u308b\u4fa1\u5024\u306e\u3042\u308b\u7d50\u679c\u3067\u3042\u308b\u3002<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"p10\"><b>\u30b3\u30e1\u30f3\u30c8<\/b><b><\/b><\/p>\n<p class=\"p10\"><span class=\"s2\">PAD<\/span>\u304a\u3088\u3073\u9ad8\u8840\u7cd6\u306f\u8db3\u6f70\u760d\u306e\u4e3b\u8981\u306a\u4fc3\u9032\u56e0\u5b50\u3067\u3042\u308b\u3002\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e<span class=\"s2\">20<\/span>\uff5e<span class=\"s2\">30%<\/span>\u304c<span class=\"s2\">PAD<\/span>\u3092\u5408\u4f75\u3057\u3066\u3044\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u9ad8\u9f62\u60a3\u8005\u3067\u306f\u3055\u3089\u306b\u5408\u4f75\u7387\u304c\u9ad8\u3044\u3068\u8003\u3048\u3089\u308c\u308b\uff08<span class=\"s2\">1<\/span>\uff09\u3002\u5916\u50b7\u4ee5\u5916\u306e\u539f\u56e0\u306b\u3088\u308b\u4e0b\u80a2\u306e\u5927\u5207\u65ad\u306f\u3001\u7f79\u60a3\u6b74\u304c\u9577\u3044\u307e\u305f\u306f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u4e0d\u826f\u306e\u7cd6\u5c3f\u75c5\u60a3\u8005\u3084\u672b\u671f<span class=\"s2\">PAD<\/span>\u60a3\u8005\u306e\u5408\u4f75\u75c7\u306b\u5bfe\u3057\u3066\u884c\u308f\u308c\u308b\u51e6\u7f6e\u3067\u3042\u308b\u304c\u3001\u60a3\u8005\u304a\u3088\u3073\u305d\u306e\u4ecb\u8b77\u8005\u306b\u5927\u304d\u306a\u8ca0\u62c5\u3092\u304b\u3051\u308b\u3002<span class=\"s2\">1990<\/span>\u5e74\u4ee3\u304b\u3089<span class=\"s2\">2000<\/span>\u5e74\u4ee3\u306b\u304b\u3051\u3066\u4e0b\u80a2\u5207\u65ad\u306e\u4ef6\u6570\u306f\u6e1b\u5c11\u3057\u3066\u3044\u308b\u304c\u3001\u3053\u3053<span class=\"s2\">10<\/span>\u5e74\u9593\u306f\u6a2a\u3070\u3044\u304b\u4e0a\u6607\u50be\u5411\u306b\u3042\u308a\u3001\u533b\u7642\u5236\u5ea6\u306b\u3068\u3063\u3066\u5927\u304d\u306a\u8ab2\u984c\u3068\u306a\u3063\u3066\u3044\u308b\uff08<span class=\"s2\">2<\/span>\uff09\u3002\u3053\u306e\u52d5\u5411\u306f\u3001\u7cd6\u5c3f\u75c5\u6027\u4e0b\u80a2\u75be\u60a3\u306b\u95a2\u9023\u3059\u308b\u91cd\u5ea6\u5408\u4f75\u75c7\u306e\u65b0\u3057\u3044\u4e88\u9632\u85ac\u306e\u81e8\u5e8a\u30cb\u30fc\u30ba\u304c\u6e80\u305f\u3055\u308c\u3066\u3044\u306a\u3044\u3053\u3068\u3092\u6d6e\u304d\u5f6b\u308a\u306b\u3057\u3066\u3044\u308b\u3002<\/p>\n<p class=\"p11\">\n<p class=\"p10\">\u3053\u306e<span class=\"s2\">PROMINENT<\/span>\u8a66\u9a13\u306e\u6700\u65b0\u306e\u89e3\u6790\u7d50\u679c\u306f\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u6cbb\u7642\u306e\u53ef\u80fd\u6027\u3092\u793a\u5506\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002\u3053\u306e\u5831\u544a\u3067\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u6cbb\u7642\u306f\u5207\u65ad\u524d\u306b\u591a\u304f\u307f\u3089\u308c\u308b\u4e0b\u80a2\u306e\u865a\u8840\u6027\u6f70\u760d\u307e\u305f\u306f\u58ca\u75bd\u306e\u76f8\u5bfe\u30ea\u30b9\u30af\u3092<span class=\"s2\">37%<\/span>\u4f4e\u4e0b\u3055\u305b\u305f\u3002\u3053\u306e\u7d50\u679c\u306f<span class=\"s2\">Fenofibrate Intervention and Event Lowering Diabetes<\/span>\uff08<span class=\"s2\">FIELD<\/span>\uff09\u8a66\u9a13\u306e\u30c7\u30fc\u30bf\u3068\u3082\u4e00\u81f4\u3059\u308b\u3002<span class=\"s2\">FIELD<\/span>\u8a66\u9a13\u3067\u306f\u3001\u6bd4\u8f03\u7684\u5f31\u3044\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53<span class=\"s2\">\u03b1<\/span>\u4f5c\u52d5\u85ac\u3067\u3042\u308b\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u3092<span class=\"s2\">2<\/span>\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u6295\u4e0e\u3057\u3001\u5c0f\u5207\u65ad\u767a\u751f\u7387\u304c\u4f4e\u4e0b\u3057\u305f\uff08<span class=\"s2\">3<\/span>\uff09\u3002\u8457\u8005\u3089\u306f\u3001<span class=\"s2\">PROMINENT<\/span>\u8a66\u9a13\u304b\u3089\u91cd\u5ea6<span class=\"s2\">PAD<\/span>\u60a3\u8005\u3092\u9664\u5916\u3057\u305f\u3053\u3068\u3001\u9032\u884c\u6027\u795e\u7d4c\u969c\u5bb3\u3001\u611f\u67d3\u75c7\u306e\u4f75\u767a\u3001\u8db3\u90e8\u306e\u5909\u5f62\u3001\u8db3\u5c02\u9580\u6cbb\u7642\u3084\u4e88\u9632\u7684\u8840\u7ba1\u30a4\u30f3\u30bf\u30fc\u30d9\u30f3\u30b7\u30e7\u30f3\u3078\u306e\u30a2\u30af\u30bb\u30b9\u6027\u306a\u3069\u5897\u60aa\u56e0\u5b50\u306b\u95a2\u3059\u308b\u30c7\u30fc\u30bf\u304c\u4e0d\u8db3\u3057\u3066\u3044\u305f\u3053\u3068\u3092\u30c7\u30fc\u30bf\u306e\u9650\u754c\u306b\u6319\u3052\u3066\u3044\u308b\u304c\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306b\u3088\u308b\u6cbb\u7642\u52b9\u679c\u306e\u9ad8\u3055\u306f\u3001\u4eca\u5f8c\u3082\u7814\u7a76\u3092\u7d9a\u3051\u308b\u6839\u62e0\u3068\u306a\u308b\u3002<\/p>\n<p class=\"p11\">\n<p class=\"p12\"><b>References<\/b><\/p>\n<p class=\"p12\">1. Barnes JA, Eid MA, Creager MA, et al. Epidemiology and risk of amputation in patients with diabetes mellitus and peripheral artery disease. Arterioscler Thromb Vasc Biol 2020;40:1808\u201317.<\/p>\n<p class=\"p12\">2. McDermott KM, Srinivas T, Abularrage CJ. Multidisciplinary approach to decreasing major amputation, improving outcomes, and mitigating disparities in diabetic foot and vascular disease. Semin Vasc Surg 2023;36:114-21.<\/p>\n<p class=\"p12\">3. Rajamani K, Colman PG, Li LP, et al. Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): a prespecified analysis of a randomised controlled trial. Lancet 2009;373:1780-8.<\/p>\n<p class=\"p13\"><i>Key words:<span class=\"Apple-converted-space\">\u00a0 <\/span>PROMINENT trial; pemafibrate; peripheral artery disease; ulcer; gangrene.<\/i><\/p>\n<\/div>\n<\/div>\n<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>PROMINENT\u8a66\u9a13\u304b\u3089\u306e\u77e5\u898b\uff1a\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306f2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u6f70\u760d\u307e\u305f\u306f\u58ca\u75bd\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b 2024 [&hellip;]<\/p>\n","protected":false},"author":258497325,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_crdt_document":"","footnotes":""},"class_list":["post-254436","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - 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